• 1243 Citations
  • 18 h-Index
1993 …2020

Research output per year

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Research Output

  • 1243 Citations
  • 18 h-Index
  • 39 Article
2020

Coronaridine congeners potentiate GABAA receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner

Arias, H. R., Do Rego, J. L., Do Rego, J. C., Chen, Z., Anouar, Y., Scholze, P., Gonzales, E. B., Huang, R. & Chagraoui, A., 13 Jul 2020, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 101, 109930.

Research output: Contribution to journalArticle

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.

Research output: Contribution to journalArticle

2018

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticle

6 Scopus citations

“Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

Dolan, S. B., Chen, Z., Huang, R. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S. H., Dillon, G. H. & Huang, R., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites

Huang, R-Q., Chen, Z., Dolan, S., Schetz, J. & Dillon, G. H., 15 Jul 2017, In : Neuropharmacology. 121, p. 167-178 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R. Q. & Schetz, J. A., 1 Aug 2016, In : Pharmacological Research. 110, p. 10-24 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pgrmc1/BDNF signaling plays a critical role in mediating glia-neuron cross talk

Sun, F., Nguyen, T., Jin, X., Huang, R., Chen, Z., Cunningham, R. L., Singh, M. & Su, C., May 2016, In : Endocrinology. 157, 5, p. 2067-2079 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

Malik, M., Rangel-Barajas, C., Sumien, N., Su, C., Singh, M., Chen, Z., Huang, R. Q., Meunier, J., Maurice, T., Mach, R. H. & Luedtke, R. R., 1 May 2015, In : British Journal of Pharmacology. 172, 10, p. 2519-2531 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Extracellular pH modulates GABAergic neurotransmission in rat hypothalamus

Chen, Z. L. & Huang, R. Q., 20 Jun 2014, In : Neuroscience. 271, p. 64-76 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

PTEN degradation after ischemic stroke: A double-edged sword

Li, W., Huang, R., Chen, Z., Yan, L. J., Simpkins, J. W. & Yang, S. H., 22 Aug 2014, In : Neuroscience. 274, p. 153-161 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

The effect of SV 293, a D2 dopamine receptor-selective antagonist, on D2 receptor-mediated GIRK channel activation and adenylyl cyclase inhibition

Huang, R., Griffin, S. A., Taylor, M., Vangveravong, S., Mach, R. H., Dillon, G. H. & Luedtke, R. R., 1 Jan 2013, In : Pharmacology. 92, 1-2, p. 84-89 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The HIV antiretroviral drug efavirenz has LSD-like properties

Gatch, M. B., Kozlenkov, A., Huang, R. Q., Yang, W., Nguyen, J. D., González-Maeso, J., Rice, K. C., France, C. P., Dillon, G. H., Forster, M. J. & Schetz, J. A., 1 Nov 2013, In : Neuropsychopharmacology. 38, 12, p. 2373-2384 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S. H., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
2012

Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds

Luedtke, R. T., Mishra, Y., Wang, Q., Griffin, S. A., Bell-Horner, C., Taylor, M., Vangveravong, S., Dillon, G. H., Huang, R-Q., Reichert, D. E. & MacH, R. H., 19 Dec 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Genistein directly inhibits native and recombinant NMDA receptors

Huang, R., Singh, M. & Dillon, G. H., 1 Jun 2010, In : Neuropharmacology. 58, 8, p. 1246-1251 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

Estrogens directly potentiate neuronal L-type Ca2+ channels

Sarkar, S. N., Huang, R. Q., Logan, S. M., Kun, D. Y., Dillon, G. H. & Simpkins, J. W., 30 Sep 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 39, p. 15148-15153 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticle

98 Scopus citations

Stoichiometric analysis of the TM2 6′ phenylalanine mutation on desensitization in α1β2 and α1β2γ2 GABAA receptors

Gonzales, E. B., Bell-Horner, C. L., Dibas, M. I., Huang, R. Q. & Dillon, G. H., 31 Jan 2008, In : Neuroscience Letters. 431, 2, p. 184-189 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

Identification of residues mediating inhibition of glycine receptors by protons

Chen, Z. & Huang, R., 1 Jun 2007, In : Neuropharmacology. 52, 8, p. 1606-1615 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanisms of homomeric α1 glycine receptor endocytosis

Huang, R-Q., He, S., Chen, Z., Dillon, G. H. & Leidenheimer, N. J., 16 Oct 2007, In : Biochemistry. 46, 41, p. 11484-11493 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

Identification of residues critical for Cu2+-mediated inhibition of glycine α1 receptors

Chen, Z., Dillon, G. H. & Huang, R., 1 Sep 2006, In : Neuropharmacology. 51, 4, p. 701-708 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels

Machu, T. K., Dillon, G. H., Huang, R-Q., Lovinger, D. M. & Leidenheimer, N. J., 1 May 2006, In : Brain Research. 1086, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β2 subunit

Herring, D., Huang, R. Q., Singh, M., Dillon, G. H. & Leidenheimer, N. J., Feb 2005, In : Neuropharmacology. 48, 2, p. 181-194 14 p.

Research output: Contribution to journalArticle

47 Scopus citations
2004

Inhibition of type a GABA receptors by L-type calcium channel blockers

Das, P., Bell-Horner, C. L., Huang, R. Q., Raut, A., Gonzales, E. B., Chen, Z. L., Covey, D. F. & Dillon, G. H., 1 Jan 2004, In : Neuroscience. 124, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Molecular basis for modulation of recombinant α1β2γ2 GABAA receptors by protons

Huang, R. Q., Chen, Z. & Dillon, G. H., 1 Aug 2004, In : Journal of Neurophysiology. 92, 2, p. 883-894 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Molecular Determinants of Proton Modulation of Glycine Receptors

Chen, Z., Dillon, G. H. & Huang, R., 9 Jan 2004, In : Journal of Biological Chemistry. 279, 2, p. 876-883 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2003

Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β2 subunit of the receptor

Herring, D., Huang, R-Q., Singh, M., Robinson, L. C., Dillon, G. H. & Leidenheimer, N. J., 27 Jul 2003, In : Journal of Biological Chemistry. 278, 26, p. 24046-24052 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
2002

Functional characterization of GABAA receptors in neonatal hypothalamic brain slice

Huang, R-Q. & Dillon, G. H., 1 Oct 2002, In : Journal of Neurophysiology. 88, 4, p. 1655-1663 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

Functional analysis of GABAA receptors in nucleus tractus solitarius neurons from neonatal rats

Huang, R. Q. & Dillon, G. H., 7 Dec 2001, In : Brain Research. 921, 1-2, p. 183-194 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pentylenetetrazole-induced inhibition of recombinant γ-aminobutyric acid type A (GABAA) receptors: Mechanism and site of action

Huang, R-Q., Bell-Horner, C. L., Dibas, M. I., Covey, D. F., Drewe, J. A. & Dillon, G. H., 29 Aug 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 986-995 10 p.

Research output: Contribution to journalArticle

232 Scopus citations
2000

Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor

Huang, R. Q. & Dillon, G. H., 1 Oct 2000, In : Neuropharmacology. 39, 11, p. 2195-2204 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors

Bell-Horner, C. L., Dibas, M., Huang, R. Q., Drewe, J. A. & Dillon, G. H., 10 Mar 2000, In : Molecular Brain Research. 76, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
1999

Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices

Huang, R. Q. & Dillon, G. H., 1 Jan 1999, In : Journal of Neurophysiology. 82, 3, p. 1233-1243 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

The tyrosine kinase inhibitor genistein directly inhibits GABA(A) receptors

Huang, R. Q., Fang, M. J. & Dillon, G. H., 6 Apr 1999, In : Molecular Brain Research. 67, 1, p. 177-183 7 p.

Research output: Contribution to journalArticle

50 Scopus citations
1998
56 Scopus citations
1997

Cell-cell coupling between CO2-excited neurons in the dorsal medulla oblongata

Huang, R. Q., Erlichman, J. S. & Dean, J. B., 25 Jun 1997, In : Neuroscience. 80, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cell-cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts

Dean, J. B., Huang, R. Q., Erlichman, J. S., Southard, T. L. & Hellard, D. T., 25 Jun 1997, In : Neuroscience. 80, 1, p. 21-40 20 p.

Research output: Contribution to journalArticle

48 Scopus citations