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Research Output 1993 2018

  • 1161 Citations
  • 17 h-Index
  • 37 Article
2018
3 Citations (Scopus)

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticleResearchpeer-review

Acid Sensing Ion Channels
rats
Binding Sites
acids
Rats
7 Citations (Scopus)

“Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

Dolan, S. B., Chen, Z., Huang, R-Q. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

N-Methyl-3,4-methylenedioxyamphetamine
2,5-Dimethoxy-4-Methylamphetamine
Methamphetamine
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
2017

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2 Citations (Scopus)

The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites

Huang, R-Q., Chen, Z., Dolan, S., Schetz, J. & Dillon, G. H., 15 Jul 2017, In : Neuropharmacology. 121, p. 167-178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

efavirenz
GABA-A Receptors
gamma-Aminobutyric Acid
HIV-1
GABA Agents
2016
8 Citations (Scopus)

Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R-Q. & Schetz, J., 1 Aug 2016, In : Pharmacological Research. 110, p. 10-24 15 p.

Research output: Contribution to journalArticleResearchpeer-review

efavirenz
HIV-1
Receptor, Serotonin, 5-HT2A
Lysergic Acid Diethylamide
Receptor, Serotonin, 5-HT2B
8 Citations (Scopus)

Pgrmc1/BDNF signaling plays a critical role in mediating glia-neuron cross talk

Sun, F., Nguyen, T., Jin, X., Huang, R-Q., Chen, Z., Cunningham, R. L., Singh, M. & Su, C., 1 May 2016, In : Endocrinology. 157, 5, p. 2067-2079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Brain-Derived Neurotrophic Factor
Neuroglia
Neurons
Conditioned Culture Medium
Astrocytes
2015
16 Citations (Scopus)

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

Malik, M., Rangel-Barajas, C., Sumien, N., Su, C., Singh, M., Chen, Z., Huang, R-Q., Meunier, J., Maurice, T., Mach, R. H. & Luedtke, R. T., 1 May 2015, In : British Journal of Pharmacology. 172, 10, p. 2519-2531 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscarinic Antagonists
Muscarinic Receptors
Ligands
Scopolamine Hydrobromide
Nootropic Agents
2014
6 Citations (Scopus)

Extracellular pH modulates GABAergic neurotransmission in rat hypothalamus

Chen, Z. L. & Huang, R-Q., 20 Jun 2014, In : Neuroscience. 271, p. 64-76 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synaptic Transmission
Hypothalamus
gamma-Aminobutyric Acid
Inhibitory Postsynaptic Potentials
GABA-A Receptors
13 Citations (Scopus)

PTEN degradation after ischemic stroke: A double-edged sword

Li, W., Huang, R-Q., Chen, Z., Yan, L-J., Simpkins, J. W. & Yang, S., 22 Aug 2014, In : Neuroscience. 274, p. 153-161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphoric Monoester Hydrolases
Stroke
GABA-A Receptors
Brain Ischemia
Astrocytes
2013
2 Citations (Scopus)

The effect of SV 293, a D2 dopamine receptor-selective antagonist, on D2 receptor-mediated GIRK channel activation and adenylyl cyclase inhibition

Huang, R-Q., Griffin, S. A., Taylor, M., Vangveravong, S., Mach, R. H., Dillon, G. H. & Luedtke, R. T., 1 Jan 2013, In : Pharmacology. 92, 1-2, p. 84-89 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenylyl Cyclases
Dopamine D2 Receptors
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Dopamine D4 Receptors
Dopamine D3 Receptors
45 Citations (Scopus)

The HIV antiretroviral drug efavirenz has LSD-like properties

Gatch, M. B., Kozlenkov, A., Huang, R-Q., Yang, W., Nguyen, J. D., González-Maeso, J., Rice, K. C., France, C. P., Dillon, G. H., Forster, M. J. & Schetz, J., 1 Nov 2013, In : Neuropsychopharmacology. 38, 12, p. 2373-2384 12 p.

Research output: Contribution to journalArticleResearchpeer-review

efavirenz
Lysergic Acid
HIV
Receptor, Serotonin, 5-HT2A
Pharmaceutical Preparations
41 Citations (Scopus)

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R-Q., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient Ischemic Attack
Cognition
Long-Term Potentiation
Stroke
Hippocampus
2012
23 Citations (Scopus)

Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds

Luedtke, R. T., Mishra, Y., Wang, Q., Griffin, S. A., Bell-Horner, C., Taylor, M., Vangveravong, S., Dillon, G. H., Huang, R-Q., Reichert, D. E. & MacH, R. H., 19 Dec 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1050-1062 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Dopamine D3 Receptors
Dopamine D2 Receptors
Assays
Adenylyl Cyclases
G Protein-Coupled Inwardly-Rectifying Potassium Channels
2010
10 Citations (Scopus)

Genistein directly inhibits native and recombinant NMDA receptors

Huang, R-Q., Singh, M. & Dillon, G. H., 1 Jun 2010, In : Neuropharmacology. 58, 8, p. 1246-1251 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Genistein
Aspartic Acid
Protein-Tyrosine Kinases
Protein Kinase Inhibitors
aspartic acid receptor
2008
76 Citations (Scopus)

Estrogens directly potentiate neuronal L-type Ca2+ channels

Sarkar, S. N., Huang, R-Q., Logan, S. M., Kun, D. Y., Dillon, G. H. & Simpkins, J. W., 30 Sep 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 39, p. 15148-15153 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrogens
Neuronal Plasticity
Neurons
HEK293 Cells
Estrogen Receptors
90 Citations (Scopus)

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium Channels
Calcium
Potassium Chloride
Retinal Ganglion Cells
Homeostasis
13 Citations (Scopus)

Stoichiometric analysis of the TM2 6′ phenylalanine mutation on desensitization in α1β2 and α1β2γ2 GABAA receptors

Gonzales, E. B., Bell-Horner, C. L., Dibas, M. I., Huang, R-Q. & Dillon, G. H., 31 Jan 2008, In : Neuroscience Letters. 431, 2, p. 184-189 6 p.

Research output: Contribution to journalArticleResearchpeer-review

GABA-A Receptors
Phenylalanine
Ligand-Gated Ion Channels
Mutation
Nicotinic Receptors
2007
6 Citations (Scopus)

Identification of residues mediating inhibition of glycine receptors by protons

Chen, Z. & Huang, R-Q., 1 Jun 2007, In : Neuropharmacology. 52, 8, p. 1606-1615 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Protons
Histidine
Glycine
Mutation
14 Citations (Scopus)

Mechanisms of homomeric α1 glycine receptor endocytosis

Huang, R-Q., He, S., Chen, Z., Dillon, G. H. & Leidenheimer, N. J., 16 Oct 2007, In : Biochemistry. 46, 41, p. 11484-11493 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Endocytosis
Dynamins
Acetates
Dialysis
2006
7 Citations (Scopus)

Identification of residues critical for Cu2+-mediated inhibition of glycine α1 receptors

Chen, Z., Dillon, G. H. & Huang, R-Q., 1 Sep 2006, In : Neuropharmacology. 51, 4, p. 701-708 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Mutation
Histidine
Glycine
Divalent Cations
13 Citations (Scopus)

Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels

Machu, T. K., Dillon, G. H., Huang, R-Q., Lovinger, D. M. & Leidenheimer, N. J., 1 May 2006, In : Brain Research. 1086, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-Gated Ion Channels
Temperature
Oocytes
Kidney
Acetates
2005
47 Citations (Scopus)

PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β2 subunit

Herring, D., Huang, R-Q., Singh, M., Dillon, G. H. & Leidenheimer, N. J., 1 Jan 2005, In : Neuropharmacology. 48, 2, p. 181-194 14 p.

Research output: Contribution to journalArticleResearchpeer-review

GABA-A Receptors
Endocytosis
Mutation
Dynamins
gamma-Aminobutyric Acid
2004
30 Citations (Scopus)

Inhibition of type a GABA receptors by L-type calcium channel blockers

Das, P., Bell-Horner, C. L., Huang, R-Q., Raut, A., Gonzales, E. B., Chen, Z. L., Covey, D. F. & Dillon, G. H., 1 Jan 2004, In : Neuroscience. 124, 1, p. 195-206 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitrendipine
L-Type Calcium Channels
GABA Receptors
Calcium Channel Blockers
GABA-A Receptors
17 Citations (Scopus)

Molecular basis for modulation of recombinant α1β2γ2 GABAA receptors by protons

Huang, R-Q., Chen, Z. & Dillon, G. H., 1 Aug 2004, In : Journal of neurophysiology. 92, 2, p. 883-894 12 p.

Research output: Contribution to journalArticleResearchpeer-review

GABA-A Receptors
Protons
gamma-Aminobutyric Acid
Mutation
Binding Sites
29 Citations (Scopus)

Molecular Determinants of Proton Modulation of Glycine Receptors

Chen, Z., Dillon, G. H. & Huang, R-Q., 9 Jan 2004, In : Journal of Biological Chemistry. 279, 2, p. 876-883 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Protons
Glycine
Modulation
Mutation
2003
73 Citations (Scopus)

Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β2 subunit of the receptor

Herring, D., Huang, R-Q., Singh, M., Robinson, L. C., Dillon, G. H. & Leidenheimer, N. J., 27 Jul 2003, In : Journal of Biological Chemistry. 278, 26, p. 24046-24052 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamins
GABA-A Receptors
Endocytosis
gamma-Aminobutyric Acid
Chlorides
2002
13 Citations (Scopus)

Functional characterization of GABAA receptors in neonatal hypothalamic brain slice

Huang, R-Q. & Dillon, G. H., 1 Oct 2002, In : Journal of neurophysiology. 88, 4, p. 1655-1663 9 p.

Research output: Contribution to journalArticleResearchpeer-review

GABA-A Receptors
Brain
Neurons
Inhibitory Concentration 50
Hypothalamus
2001
7 Citations (Scopus)

Functional analysis of GABAA receptors in nucleus tractus solitarius neurons from neonatal rats

Huang, R-Q. & Dillon, G. H., 7 Dec 2001, In : Brain Research. 921, 1-2, p. 183-194 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Solitary Nucleus
GABA-A Receptors
Neurons
gamma-Aminobutyric Acid
Inhibitory Concentration 50
219 Citations (Scopus)

Pentylenetetrazole-induced inhibition of recombinant γ-aminobutyric acid type A (GABAA) receptors: Mechanism and site of action

Huang, R-Q., Bell-Horner, C. L., Dibas, M. I., Covey, D. F., Drewe, J. A. & Dillon, G. H., 29 Aug 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 986-995 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Aminobutyrates
Pentylenetetrazole
GABA-A Receptors
Picrotoxin
gamma-Aminobutyric Acid
2000
33 Citations (Scopus)

Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor

Huang, R-Q. & Dillon, G. H., 1 Oct 2000, In : Neuropharmacology. 39, 11, p. 2195-2204 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycine Receptors
Genistein
Protein-Tyrosine Kinases
Glycine
Strychnine
27 Citations (Scopus)

Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors

Bell-Horner, C. L., Dibas, M., Huang, R-Q., Drewe, J. A. & Dillon, G. H., 10 Mar 2000, In : Molecular Brain Research. 76, 1, p. 47-55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Picrotoxin
GABA-A Receptors
Ligands
Inhibitory Concentration 50
gamma-Aminobutyric Acid
1999
49 Citations (Scopus)

Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices

Huang, R-Q. & Dillon, G. H., 1 Jan 1999, In : Journal of neurophysiology. 82, 3, p. 1233-1243 11 p.

Research output: Contribution to journalArticleResearchpeer-review

gamma-Aminobutyric Acid
GABA-A Receptors
Aminobutyrates
GABA Receptors
HEK293 Cells
49 Citations (Scopus)

The tyrosine kinase inhibitor genistein directly inhibits GABA(A) receptors

Huang, R-Q., Fang, M. J. & Dillon, G. H., 6 Apr 1999, In : Molecular Brain Research. 67, 1, p. 177-183 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Genistein
GABA-A Receptors
Protein-Tyrosine Kinases
gamma-Aminobutyric Acid
HEK293 Cells
1998
56 Citations (Scopus)

Maintenance of recombinant type a γ-aminobutyric acid receptor function: Role of protein tyrosine phosphorylation and calcineurin

Huang, R-Q. & Dillon, G. H., 1 Jul 1998, In : Journal of Pharmacology and Experimental Therapeutics. 286, 1, p. 243-255 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Aminobutyrates
Calcineurin
gamma-Aminobutyric Acid
Tyrosine
Maintenance
1997
61 Citations (Scopus)

Cell-cell coupling between CO2-excited neurons in the dorsal medulla oblongata

Huang, R-Q., Erlichman, J. S. & Dean, J. B., 25 Jun 1997, In : Neuroscience. 80, 1, p. 41-57 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Medulla Oblongata
Neurons
Acidosis
Synaptic Potentials
Solitary Nucleus
48 Citations (Scopus)

Cell-cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts

Dean, J. B., Huang, R-Q., Erlichman, J. S., Southard, T. L. & Hellard, D. T., 25 Jun 1997, In : Neuroscience. 80, 1, p. 21-40 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Artifacts
Amphotericin B
Neurons
Synaptic Potentials
Staining and Labeling
1993

Involvement of endorphins in the central mechanism of hypoxia-induced respiratory inhibition

Huang, R-Q., 1 Oct 1993, In : Sheng li ke xue jin zhan [Progress in physiology]. 24, 4, p. 338-340 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Endorphins
Medulla Oblongata
Respiration
Hypoxia