If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Area of Expertise

My lab mainly studies the details of synaptic function mediated by GABA type A and glycine ion channels and receptors and its modulation and plasticity under physiological and pathological states, using a variety of modern electrophysiological and molecular biological techniques such as patch-clamp, site-directed mutagenesis, substituted cysteine accessibility method (SCAM), immunofluorescence microscopy, pharmacological, and conventional biochemical techniques.
Projects within the lab are to study these synapses from cellular to molecular levels utilizing various preparations including brain slice and recombinant preparations. Overall, our major objective is to provide a molecular description of the therapeutically important receptors/channels; to gain a deeper understanding of their role in normal and diseased states; and eventually to develop novel therapeutic interventions which target these receptors.

Education/Academic qualification

PhD in Physiology, Shanghai Institute of Physiology

Fingerprint Dive into the research topics where Ren-Qi Huang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
GABA-A Receptors Medicine & Life Sciences
gamma-Aminobutyric Acid Medicine & Life Sciences
efavirenz Medicine & Life Sciences
Glycine Receptors Medicine & Life Sciences
Neurons Medicine & Life Sciences
Genistein Medicine & Life Sciences
Mutation Medicine & Life Sciences
Protons Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2018

Research Output 1993 2018

  • 1211 Citations
  • 17 h-Index
  • 37 Article
6 Citations (Scopus)

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Binding Sites
8 Citations (Scopus)

“Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

Dolan, S. B., Chen, Z., Huang, R-Q. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S. H., Dillon, G. H. & Huang, R., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticle

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
2 Citations (Scopus)

The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites

Huang, R-Q., Chen, Z., Dolan, S., Schetz, J. & Dillon, G. H., 15 Jul 2017, In : Neuropharmacology. 121, p. 167-178 12 p.

Research output: Contribution to journalArticle

GABA-A Receptors
gamma-Aminobutyric Acid
GABA Agents
9 Citations (Scopus)

Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R. Q. & Schetz, J. A., 1 Aug 2016, In : Pharmacological Research. 110, p. 10-24 15 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2A
Lysergic Acid Diethylamide
Receptor, Serotonin, 5-HT2B