• 1228 Citations
  • 17 h-Index
19932018

Research output per year

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Personal profile

Area of Expertise

My lab mainly studies the details of synaptic function mediated by GABA type A and glycine ion channels and receptors and its modulation and plasticity under physiological and pathological states, using a variety of modern electrophysiological and molecular biological techniques such as patch-clamp, site-directed mutagenesis, substituted cysteine accessibility method (SCAM), immunofluorescence microscopy, pharmacological, and conventional biochemical techniques.
Projects within the lab are to study these synapses from cellular to molecular levels utilizing various preparations including brain slice and recombinant preparations. Overall, our major objective is to provide a molecular description of the therapeutically important receptors/channels; to gain a deeper understanding of their role in normal and diseased states; and eventually to develop novel therapeutic interventions which target these receptors.

Education/Academic qualification

PhD in Physiology, Shanghai Institute of Physiology

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Projects

Research Output

  • 1228 Citations
  • 17 h-Index
  • 37 Article

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticle

  • 6 Scopus citations

    “Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

    Dolan, S. B., Chen, Z., Huang, R. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Methylene blue inhibits GABAA receptors by interaction with GABA binding site

    Chen, Z., Liu, R., Yang, S. H., Dillon, G. H. & Huang, R., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

    Research output: Contribution to journalArticle

  • The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites

    Huang, R-Q., Chen, Z., Dolan, S., Schetz, J. & Dillon, G. H., 15 Jul 2017, In : Neuropharmacology. 121, p. 167-178 12 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

    Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R. Q. & Schetz, J. A., 1 Aug 2016, In : Pharmacological Research. 110, p. 10-24 15 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations