• 1297 Citations
  • 19 h-Index
1993 …2020

Research output per year

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Personal profile

Area of Expertise

My lab mainly studies the details of synaptic function mediated by GABA type A and glycine ion channels and receptors and its modulation and plasticity under physiological and pathological states, using a variety of modern electrophysiological and molecular biological techniques such as patch-clamp, site-directed mutagenesis, substituted cysteine accessibility method (SCAM), immunofluorescence microscopy, pharmacological, and conventional biochemical techniques.
Projects within the lab are to study these synapses from cellular to molecular levels utilizing various preparations including brain slice and recombinant preparations. Overall, our major objective is to provide a molecular description of the therapeutically important receptors/channels; to gain a deeper understanding of their role in normal and diseased states; and eventually to develop novel therapeutic interventions which target these receptors.

Education/Academic qualification

PhD in Physiology, Shanghai Institute of Physiology

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Projects

Research Output

  • 1297 Citations
  • 19 h-Index
  • 39 Article

Coronaridine congeners potentiate GABAA receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner

Arias, H. R., Do Rego, J. L., Do Rego, J. C., Chen, Z., Anouar, Y., Scholze, P., Gonzales, E. B., Huang, R. & Chagraoui, A., 13 Jul 2020, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 101, 109930.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

    Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.

    Research output: Contribution to journalArticle

  • Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

    Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    “Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

    Dolan, S. B., Chen, Z., Huang, R. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

    Research output: Contribution to journalArticle

  • 13 Scopus citations

    Methylene blue inhibits GABAA receptors by interaction with GABA binding site

    Chen, Z., Liu, R., Yang, S. H., Dillon, G. H. & Huang, R., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations