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Personal profile

Area of Expertise

My lab mainly studies the details of synaptic function mediated by GABA type A and glycine ion channels and receptors and its modulation and plasticity under physiological and pathological states, using a variety of modern electrophysiological and molecular biological techniques such as patch-clamp, site-directed mutagenesis, substituted cysteine accessibility method (SCAM), immunofluorescence microscopy, pharmacological, and conventional biochemical techniques.
Projects within the lab are to study these synapses from cellular to molecular levels utilizing various preparations including brain slice and recombinant preparations. Overall, our major objective is to provide a molecular description of the therapeutically important receptors/channels; to gain a deeper understanding of their role in normal and diseased states; and eventually to develop novel therapeutic interventions which target these receptors.

Education/Academic qualification

PhD in Physiology, Shanghai Institute of Physiology

Fingerprint Dive into the research topics where Ren-Qi Huang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
GABA-A Receptors Medicine & Life Sciences
gamma-Aminobutyric Acid Medicine & Life Sciences
efavirenz Medicine & Life Sciences
Glycine Receptors Medicine & Life Sciences
Neurons Medicine & Life Sciences
Genistein Medicine & Life Sciences
Mutation Medicine & Life Sciences
Protons Medicine & Life Sciences

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Projects 2012 2018

Research Output 1993 2018

  • 1161 Citations
  • 17 h-Index
  • 37 Article
3 Citations (Scopus)

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticleResearchpeer-review

Acid Sensing Ion Channels
rats
Binding Sites
acids
Rats
7 Citations (Scopus)

“Ecstasy” to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA

Dolan, S. B., Chen, Z., Huang, R-Q. & Gatch, M. B., 1 May 2018, In : Neuropharmacology. 133, p. 171-180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

N-Methyl-3,4-methylenedioxyamphetamine
2,5-Dimethoxy-4-Methylamphetamine
Methamphetamine
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2 Citations (Scopus)

The dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites

Huang, R-Q., Chen, Z., Dolan, S., Schetz, J. & Dillon, G. H., 15 Jul 2017, In : Neuropharmacology. 121, p. 167-178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

efavirenz
GABA-A Receptors
gamma-Aminobutyric Acid
HIV-1
GABA Agents
8 Citations (Scopus)

Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz

Dalwadi, D. A., Kim, S., Amdani, S. M., Chen, Z., Huang, R-Q. & Schetz, J., 1 Aug 2016, In : Pharmacological Research. 110, p. 10-24 15 p.

Research output: Contribution to journalArticleResearchpeer-review

efavirenz
HIV-1
Receptor, Serotonin, 5-HT2A
Lysergic Acid Diethylamide
Receptor, Serotonin, 5-HT2B