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Personal profile

Area of Expertise

Dr. Rebecca Cunningham studies the role of steroid hormones, specifically androgens, from prenatal development to aging. Most of her team’s research has been focused on androgen signaling mechanisms and defining the effects of androgens on central nervous system function. One of Dr. Cunningham’s long-term research goals is to determine how development and aging alters neuronal steroid hormonal responses in an oxidative stress environment, a key characteristic of aging, developmental disorders, and neurodegeneration. She has shown that androgens can either be neuroprotective or damaging, and these effects are dependent on the oxidative stress environment. In pursuing this goal, Dr. Cunningham and team use in vitro, in vivo, and clinical approaches to understand how androgens affect brain function. Hopefully this research will expand the understanding of how steroid hormones impact the brain. At the same time, she seeks to gain new insights that can lead to a better understanding of the role of sex in central nervous system disorders.

Education/Academic qualification

PhD in Neurobiology, University of Texas at San Antonio

BS in Psychology, Truman State University

Fingerprint Dive into the research topics where Rebecca Cunningham is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2010 2022

Research Output 2006 2019

  • 411 Citations
  • 14 h-Index
  • 28 Article

Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension

Shell, B., Farmer, G. E., Nedungadi, T. P., Wang, L. A., Marciante, A. B., Snyder, B., Cunningham, R. L. & Cunningham, J. T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R651-R665

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin Type 1 Receptor
Preoptic Area
Hypertension
Small Interfering RNA
Angiotensins

NADPH oxidase mediates membrane androgen receptor-induced neurodegeneration

Tenkorang, M. A. A., Duong, P. & Cunningham, R. L., 1 Jan 2019, In : Endocrinology. 160, 4, p. 947-963 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Androgen Receptors
NAD
Oxidoreductases
Oxidative Stress
Phosphates
2 Citations (Scopus)

Androgens modulate chronic intermittent hypoxia effects on brain and behavior

Snyder, B., Duong, P., Trieu, J. & Cunningham, R. L., 1 Nov 2018, In : Hormones and Behavior. 106, p. 62-73 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Androgens
Brain
Dihydrotestosterone
Sleep Apnea Syndromes
Oxidative Stress
5 Citations (Scopus)

Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging

Wilson, E. N., Anderson, M., Snyder, B., Duong, P., Trieu, J., Schreihofer, D. & Cunningham, R. L., 15 May 2018, In : Physiology and Behavior. 189, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Sleep Apnea Syndromes
Oxidative Stress
Testosterone
Sexual Behavior
Hypoxia

N-terminal truncations in sex steroid receptors and rapid steroid actions

Schreihofer, D., Duong, P. & Cunningham, R. L., 1 May 2018, In : Steroids. 133, p. 15-20 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Steroid Receptors
Steroids
Cell Membrane
Cell membranes
Caveolins