Projects per year
Personal profile
Area of Expertise
Dr. Rebecca Cunningham studies the role of steroid hormones, specifically androgens, from prenatal development to aging. Most of her team’s research has been focused on androgen signaling mechanisms and defining the effects of androgens on central nervous system function. One of Dr. Cunningham’s long-term research goals is to determine how development and aging alters neuronal steroid hormonal responses in an oxidative stress environment, a key characteristic of aging, developmental disorders, and neurodegeneration. She has shown that androgens can either be neuroprotective or damaging, and these effects are dependent on the oxidative stress environment. In pursuing this goal, Dr. Cunningham and team use in vitro, in vivo, and clinical approaches to understand how androgens affect brain function. Hopefully this research will expand the understanding of how steroid hormones impact the brain. At the same time, she seeks to gain new insights that can lead to a better understanding of the role of sex in central nervous system disorders.
Education/Academic qualification
BS in Psychology, Truman State University
PhD in Neurobiology, University of Texas at San Antonio
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Projects
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Neural Regulation of Vasopresson Release in a model of Dilutaional Hyponatremia
Cunningham, T. & Cunningham, R.
NHLBI: Nat Heart, Lung & Blood Institute
15/04/18 → 31/03/22
Project: Research
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Interactions between testosterone and oxidative stress in dopamine neurons
Cunningham, R. & CUNNINGHAM, R.
1/07/15 → 30/06/21
Project: Research
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Brain Region Specific Neurodegeneration in Chronic Intermittent Hypoxia (For: Lincoln Downs)
15/10/15 → 15/02/16
Project: Research
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Pilot study on the risks of testosterone replacement to the brain
Cunningham, R. & Schreihofer, D.
15/08/15 → 31/05/18
Project: Research
Research Output
- 574 Citations
- 15 h-Index
- 30 Article
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Chronic Testosterone Deprivation Sensitizes the Middle-Aged Rat Brain to Damaging Effects of Testosterone Replacement
Smith, C., Contreras-Garza, J., Cunningham, R. L., Wong, J. M., Vann, P. H., Metzger, D., Kasanga, E., Oppong-Gyebi, A., Sumien, N. & Schreihofer, D., 1 Oct 2020, In: Neuroendocrinology. 110, 11-12, p. 914-928 15 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment
Duong, P., Tenkorang, M. A. A., Trieu, J., McCuiston, C., Rybalchenko, N. & Cunningham, R. L., 29 Mar 2020, In: Biology of Sex Differences. 11, 1, 12.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension
Shell, B., Farmer, G. E., Nedungadi, T. P., Wang, L. A., Marciante, A. B., Snyder, B., Cunningham, R. L. & Cunningham, J. T., 1 May 2019, In: American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R651-R665Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
NADPH oxidase mediates membrane androgen receptor-induced neurodegeneration
Tenkorang, M. A. A., Duong, P. & Cunningham, R. L., 2019, In: Endocrinology. 160, 4, p. 947-963 17 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Androgens modulate chronic intermittent hypoxia effects on brain and behavior
Snyder, B., Duong, P., Trieu, J. & Cunningham, R. L., Nov 2018, In: Hormones and Behavior. 106, p. 62-73 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations