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Research Output 2002 2019

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2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticle

Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor

Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In : Brain Research. 1723, 146378.

Research output: Contribution to journalArticle

Astrocytes
Oxidative Stress
Neuroprotective Agents
Energy Metabolism
Glutamic Acid
6 Citations (Scopus)

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.

Research output: Contribution to journalArticle

Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17

Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

Research output: Contribution to journalArticle

Open Access
Metformin
Cognition
Brain
Energy Metabolism
Glycerolphosphate Dehydrogenase
2018
6 Citations (Scopus)

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticle

Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
3 Citations (Scopus)

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S. H., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticle

Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
2017
5 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Ischemic Preconditioning
Stroke
Wounds and Injuries
5-methoxyindole-2-carboxylic acid

Methylene blue inhibits GABAA receptors by interaction with GABA binding site

Chen, Z., Liu, R., Yang, S., Dillon, G. H. & Huang, R-Q., 1 Jun 2017, In : Neuropharmacology. 119, p. 100-110 11 p.

Research output: Contribution to journalArticle

Methylene Blue
GABA-A Receptors
gamma-Aminobutyric Acid
Binding Sites
Picrotoxin
2016
9 Citations (Scopus)

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Cai, B., Li, W., Mao, X. O., Winters, A., Ryou, M. G., Liu, R., Greenberg, D. A., Wang, N., Jin, K. & Yang, S., 1 Mar 2016, In : Molecular Neurobiology. 53, 2, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Glycogen
Globins
Neurons
Brain
2015
18 Citations (Scopus)

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas

He, W., Liu, R., Yang, S. H. & Yuan, F., Mar 2015, In : Anti-Cancer Drugs. 26, 3, p. 293-300 8 p.

Research output: Contribution to journalArticle

temozolomide
Tamoxifen
Glioma
Cell Line
Apoptosis
33 Citations (Scopus)

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Ryou, M. G., Choudhury, G. R., Li, W., Winters, A., Yuan, F., Liu, R. & Yang, S., 1 Aug 2015, In : Neuroscience. 301, p. 193-203 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Methylene Blue
Glucose
Erythropoietin
Oxygen
15 Citations (Scopus)

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Choudhury, G. R., Winters, A., Rich, R. M., Ryou, M. G., Gryczynski, Z., Yuan, F., Yang, S. H. & Liu, R., 7 Apr 2015, In : PLoS ONE. 10, 4, e0123096.

Research output: Contribution to journalArticle

Cell Respiration
methylene blue
Methylene Blue
astrocytes
cell respiration
2014
8 Citations (Scopus)

In vitro protection by pyruvate against cadmium-induced cytotoxicity in hippocampal HT-22 cells

Poteet, E., Winters, A., Xie, L., Ryou, M. G., Liu, R. & Yang, S., 1 Jan 2014, In : Journal of Applied Toxicology. 34, 8, p. 903-913 11 p.

Research output: Contribution to journalArticle

Cytotoxicity
Pyruvic Acid
Cadmium
Mitochondrial Membrane Potential
Glycolysis
4 Citations (Scopus)

Methylene blue promotes quiescence of rat neural progenitor cells

Xie, L., Choudhury, G. R., Wang, J., Park, Y., Liu, R., Yuan, F., Zhang, C. L., Yorio, T., Jin, K. & Yang, S., 7 Oct 2014, In : Frontiers in Cellular Neuroscience. 8, OCT, 315.

Research output: Contribution to journalArticle

Methylene Blue
Stem Cells
Intraventricular Infusions
Cyclins
Neural Stem Cells
2013
9 Citations (Scopus)

Astroglial PTEN loss disrupts neuronal lamination by dysregulating radial glia-guided neuronal migration

Wen, Y., Li, W., Choudhury, G. R., He, R., Yang, T., Liu, R., Jin, K. & Yang, S., 1 Jan 2013, In : Aging and Disease. 4, 3, p. 113-126 14 p.

Research output: Contribution to journalArticle

Neuroglia
Transgenic Mice
Cerebellum
Hippocampus
Central Nervous System
43 Citations (Scopus)

Reversing the Warburg effect as a treatment for glioblastoma

Poteet, E., Choudhury, G. R., Winters, A., Li, W., Ryou, M. G., Liu, R., Tang, L., Ghorpade, A., Wen, Y., Yuan, F., Keir, S. T., Yan, H., Bigner, D. D., Simpkins, J. W. & Yang, S., 29 Mar 2013, In : Journal of Biological Chemistry. 288, 13, p. 9153-9164 12 p.

Research output: Contribution to journalArticle

Methylene Blue
Glioblastoma
Cell proliferation
Energy Metabolism
AMP-Activated Protein Kinases
49 Citations (Scopus)

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

Li, W., Huang, R-Q., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S., 1 Nov 2013, In : Neurobiology of Disease. 59, p. 18-25 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Cognition
Long-Term Potentiation
Stroke
Hippocampus
2012
11 Citations (Scopus)

Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat

Ren, M., Lin, Z. J., Qian, H., Choudhury, G. R., Liu, R., Liu, H. & Yang, S., 15 Nov 2012, In : Journal of Neuroscience Methods. 211, 2, p. 296-304 9 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Thrombin
Fibrinogen
Middle Cerebral Artery
Stroke
47 Citations (Scopus)

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

Lin, A. L., Poteet, E., Du, F., Gourav, R. C., Liu, R., Wen, Y., Bresnen, A., Huang, S., Fox, P. T., Yang, S. H. & Duong, T. Q., 9 Oct 2012, In : PLoS ONE. 7, 10, e46585.

Research output: Contribution to journalArticle

methylene blue
Methylene Blue
Hemodynamics
hemodynamics
Brain
18 Citations (Scopus)

Neuroprotective effects of high affinity sigma 1 receptor selective compounds

Luedtke, R. R., Perez, E., Yang, S. H., Liu, R., Vangveravong, S., Tu, Z., MacH, R. H. & Simpkins, J. W., 2 Mar 2012, In : Brain Research. 1441, p. 17-26 10 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Haloperidol
Stroke
sigma Receptors
Pentazocine
56 Citations (Scopus)

Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway

Ryou, M. G., Liu, R., Ren, M., Sun, J., Mallet, R. T. & Yang, S., 1 Apr 2012, In : Stroke. 43, 4, p. 1101-1107 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Reperfusion Injury
Brain Ischemia
Pyruvic Acid
Hypoxia-Inducible Factor 1
15 Citations (Scopus)

Transient Focal Cerebral Ischemia Induces Long-term Cerebral Vasculature Dysfunction in a Rodent Experimental Stroke Model

Winters, A., Taylor, J. C., Ren, M., Ma, R., Liu, R. & Yang, S., 1 Jun 2012, In : Translational Stroke Research. 3, 2, p. 279-285 7 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Rodentia
Theoretical Models
Stroke
Phenylephrine
13 Citations (Scopus)

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas

Wang, X., Zhang, H., Zhang, A., Han, L., Wang, K., Liu, R., Yang, S., Pu, P., Shen, C., Kang, C. & Yu, C., 1 Oct 2012, In : Oncology Reports. 28, 4, p. 1293-1300 8 p.

Research output: Contribution to journalArticle

Glioma
Brain Stem
Up-Regulation
Pediatrics
MicroRNAs
2011
143 Citations (Scopus)

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

Wen, Y., Li, W., Poteet, E. C., Xie, L., Tan, C., Yan, L. J., Ju, X., Liu, R., Qian, H., Marvin, M. A., Goldberg, M. S., She, H., Mao, Z., Simpkins, J. W. & Yang, S. H., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 16504-16515 12 p.

Research output: Contribution to journalArticle

Methylene Blue
Electrons
Rotenone
Neuroprotection
Animal Disease Models
29 Citations (Scopus)

Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein

Li, W., Poteet, E., Xie, L., Liu, R., Wen, Y. & Yang, S., 28 Apr 2011, In : Brain Research. 1387, p. 141-148 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Astrocytes
Alzheimer Disease
2010
36 Citations (Scopus)
Tissue Plasminogen Activator
Estradiol
Stroke
Middle Cerebral Artery Infarction
Transient Ischemic Attack
17 Citations (Scopus)

Modulation of polymorphonuclear neutrophil functions by astrocytes

Xie, L., Poteet, E. C., Li, W., Scott, A. E., Liu, R., Wen, Y., Ghorpade, A., Simpkins, J. W. & Yang, S. H., 9 Sep 2010, In : Journal of neuroinflammation. 7, 53.

Research output: Contribution to journalArticle

Astrocytes
Neutrophils
Phagocytosis
Respiratory Burst
Inbred C57BL Mouse
2009
56 Citations (Scopus)

Estrogen receptor β as a mitochondrial vulnerability factor

Yang, S., Sarkar, S. N., Liu, R., Perez, E. J., Wang, X., Wen, Y., Yan, L-J. & Simpkins, J. W., 3 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9540-9548 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Neurons
Adenosine Triphosphate
Mitochondria
Oxidative stress
2008
13 Citations (Scopus)

Brainstem glioma progression in juvenile and adult rats: Laboratory investigation

Liu, Q., Liu, R., Kashyap, M. V., Agarwal, R., Shi, X., Wang, C. C. & Yang, S., 1 Nov 2008, In : Journal of Neurosurgery. 109, 5, p. 849-855 7 p.

Research output: Contribution to journalArticle

Glioma
Brain Stem
Age Groups
Young Adult
Cell Count
2007
41 Citations (Scopus)

A prototypical Sigma-1 receptor antagonist protects against brain ischemia

Schetz, J. A., Perez, E., Liu, R., Chen, S., Lee, I. & Simpkins, J. W., 21 Nov 2007, In : Brain Research. 1181, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Brain Ischemia
Haloperidol
Stroke
Butyrophenones
Protective Agents
90 Citations (Scopus)

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats

Wen, Y., Yang, S. H., Liu, R., Perez, E. J., Brun-Zinkernagel, A. M., Koulen, P. & Simpkins, J. W., 1 Apr 2007, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1772, 4, p. 473-483 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Tauopathies
Neurofibrillary Tangles
Transient Ischemic Attack
Alzheimer Disease
43 Citations (Scopus)

Dose dependence and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

Liu, R., Wang, X., Liu, Q., Yang, S. & Simpkins, J. W., 30 Mar 2007, In : Neuroscience Letters. 415, 3, p. 237-241 5 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Brain Ischemia
Estradiol
Estrogens
Ischemia
107 Citations (Scopus)

Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells

Wang, X., Perez, E., Liu, R., Yan, L. J., Mallet, R. T. & Yang, S. H., 9 Feb 2007, In : Brain Research. 1132, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Neuroblastoma
Mitochondria
Oxidative Stress
Hydrogen Peroxide
2006
9 Citations (Scopus)

Endovascular middle cerebral artery occlusion in rats as a model for studying vascular dementia

Yang, S. H., Shetty, R. A., Liu, R., Sumien, N., Heinrich, K. R., Rutledge, M., Thangthaeng, N., Brun-Zinkernagel, A. M. & Forster, M. J., 1 Sep 2006, In : Age. 28, 3, p. 297-307 11 p.

Research output: Contribution to journalArticle

Vascular Dementia
Middle Cerebral Artery Infarction
Alzheimer Disease
Cerebrovascular Disorders
Brain Ischemia
42 Citations (Scopus)

Immunohistochemical localization of EGF, TGF-α, TGF-β, and their receptors in rat corneas during healing of excimer laser ablation

Tuli, S. S., Liu, R., Chen, C., Blalock, T. D., Goldstein, M. & Schultz, G. S., 1 Sep 2006, In : Current Eye Research. 31, 9, p. 709-719 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta Receptors
Excimer Lasers
Laser Therapy
Epidermal Growth Factor
Transforming Growth Factor beta
70 Citations (Scopus)

Neuroprotective effects of 17β-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells

Wang, X., Dykens, J. A., Perez, E., Liu, R., Yang, S., Covey, D. F. & Simpkins, J. W., 27 Jun 2006, In : Molecular Pharmacology. 70, 1, p. 395-404 10 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Neuroblastoma
Estradiol
Estrogens
Lipid Peroxidation
2005
82 Citations (Scopus)

17β-Estradiol attenuates blood-brain barrier disruption induced by cerebral ischemia-reperfusion injury in female rats

Liu, R., Wen, Y., Perez, E., Wang, X., Day, A. L., Simpkins, J. W. & Yang, S., 26 Oct 2005, In : Brain Research. 1060, 1-2, p. 55-61 7 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Brain Ischemia
Blood-Brain Barrier
Estradiol
Transient Ischemic Attack
52 Citations (Scopus)

Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats

Wen, Y., Yang, S., Liu, R. & Simpkins, J. W., 29 Aug 2005, In : FEBS Letters. 579, 21, p. 4591-4599 9 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Reperfusion
Rats
Cell Cycle
Cells
35 Citations (Scopus)

Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats

Yang, S., Liu, R., Wen, Y., Perez, E., Cutright, J., Brun-Zinkernagel, A. M., Singh, M., Day, A. L. & Simpkins, J. W., 15 Feb 2005, In : Journal of Neurobiology. 62, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Brain Ischemia
Testosterone
HSP90 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
64 Citations (Scopus)

Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo

Perez, E., Liu, R., Yang, S., Cai, Z. Y., Covey, D. F. & Simpkins, J. W., 21 Mar 2005, In : Brain Research. 1038, 2, p. 216-222 7 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Estrogen Receptors
Estrogens
Estrone
Middle Cerebral Artery Infarction
2004
125 Citations (Scopus)

Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia

Wen, Y., Yang, S., Liu, R., Perez, E., Yi, K. D., Koulen, P. & Simpkins, J. W., 22 May 2004, In : Brain Research. 1008, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

NF-kappa B
Transient Ischemic Attack
Estrogens
Inflammation
Molecular Models
68 Citations (Scopus)

Estrogen-like compounds for ischemic neuroprotection

Simpkins, J. W., Yang, S. H., Liu, R., Perez, E., Zu, Y. C., Covey, D. F. & Green, P. S., 1 Nov 2004, In : Stroke. 35, 11 SUPPL. 1, p. 2648-2651 4 p.

Research output: Contribution to journalArticle

Estradiol Congeners
Estrogen Receptors
Estrogens
Reperfusion Injury
Brain Ischemia
160 Citations (Scopus)

Increased β-secretase activity and expression in rats following transient cerebral ischemia

Wen, Y., Onyewuchi, O., Yang, S., Liu, R. & Simpkins, J. W., 29 May 2004, In : Brain Research. 1009, 1-2, p. 1-8 8 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Transient Ischemic Attack
Alzheimer Disease
Amyloid beta-Protein Precursor
Dementia
365 Citations (Scopus)

Mitochondrial localization of estrogen receptor β

Yang, S. H., Liu, R., Perez, E. J., Wen, Y., Stevens, S. M., Valencia, T., Brun-Zinkernagel, A. M., Prokai, L., Will, Y., Dykens, J., Koulen, P. & Simpkins, J. W., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4130-4135 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Immunohistochemistry
Immunoblotting
Organelles
Mitochondria
95 Citations (Scopus)

Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats

Wen, Y., Yang, S., Liu, R., Brun-Zinkernagel, A. M., Koulen, P. & Simpkins, J. W., 21 May 2004, In : Journal of Biological Chemistry. 279, 21, p. 22684-22692 9 p.

Research output: Contribution to journalArticle

Tauopathies
Reentry
Transient Ischemic Attack
Mitosis
Rats
81 Citations (Scopus)

Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein

Wen, Y., Yang, S., Liu, R. & Simpkins, J. W., 1 Oct 2004, In : Brain Research. 1022, 1-2, p. 30-38 9 p.

Research output: Contribution to journalArticle

tau Proteins
Neurofibrillary Tangles
Transient Ischemic Attack
Neurodegenerative Diseases
Tauopathies
2003
56 Citations (Scopus)

Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections

Kaja, S., Yang, S. H., Wei, J., Fujitani, K., Liu, R., Brun-Zinkernagel, A. M., Simpkins, J. W., Inokuchi, K. & Koulen, P., 1 Jul 2003, In : Investigative Ophthalmology and Visual Science. 44, 7, p. 3155-3162 8 p.

Research output: Contribution to journalArticle

Retina
Estrogens
Ischemia
Apoptosis
Ganglia
137 Citations (Scopus)

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

Prokai, L., Prokai-Tatrai, K., Perjesi, P., Zharikova, A. D., Perez, E. J., Liu, R. & Simpkins, J. W., 30 Sep 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 20, p. 11741-11746 6 p.

Research output: Contribution to journalArticle

Hydroquinones
Estrogens
Antioxidants
Reactive Oxygen Species
Oxidative Stress
70 Citations (Scopus)

The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia

Yang, S., Liu, R., Wu, S. S. & Simpkins, J. W., 1 Jan 2003, In : Annals of the New York Academy of Sciences. 1007, p. 101-107 7 p.

Research output: Contribution to journalArticle

Brain Ischemia
Brain
Estrogens
Stroke
Enantiomers
2002
59 Citations (Scopus)

Neuroprotective effects of a novel non-receptor-binding estrogen analogue: In vitro and in vivo analysis

Liu, R., Yang, S. H., Perez, E., Yi, K. D., Wu, S. S., Eberst, K., Prokai, L., Prokai-Tatrai, K., Cai, Z. Y., Covey, D. F., Day, A. L. & Simpkins, J. W., 1 Oct 2002, In : Stroke. 33, 10, p. 2485-2491 7 p.

Research output: Contribution to journalArticle

Estradiol Congeners
Cerebrovascular Circulation
Middle Cerebral Artery Infarction
Neuroprotective Agents
Glutamic Acid