Projects per year
Personal profile
Area of Expertise
The principal goals of my research are focused on translational stroke research. Although rtPA is the sole FDA approved treatment for ischemic stroke, very few patients have been benefited from rtPA treatment because of its limited therapeutic window and the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We are among the first to explore the combined therapy to extend rtPA’s therapeutic window in ischemic stroke models. We have demonstrated that estrogens could extend the therapeutic window of rtPA for the treatment of ischemic stroke. In addition, our research has provided insight to target ischemic penumbra and beyond for the treatment of ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.
Education/Academic qualification
MD, Beijing Medical University
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Post Stroke Cognitive Impairment: Mechanism and Therapy
Yang, S., Liu, R., Sumien, N. & Jin, K.
NINDS: Neurological Disorders & Stroke
1/02/19 → 31/01/24
Project: Research
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Establishment of Inducible Astrocyte Specific p38 MAPK Knockout Mouse Line
NINDS: Neurological Disorders & Stroke
15/09/14 → 28/02/18
Project: Research
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Neuroglobin: Cell Membrane and Neuroprotection
NINDS: Neurological Disorders & Stroke
1/07/14 → 31/05/19
Project: Research
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Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease
Chaudhari, K., Wang, L., Kruse, J., Winters, A., Sumien, N., Shetty, R., Prah, J., Liu, R., Shi, J., Forster, M. & Yang, S. H., 2021, In: Neurological Research. 43, 7, p. 570-581 12 p.Research output: Contribution to journal › Article › peer-review
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Four Decades of Ischemic Penumbra and Its Implication for Ischemic Stroke
Yang, S. H. & Liu, R., 2021, (Accepted/In press) In: Translational Stroke Research.Research output: Contribution to journal › Review article › peer-review
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Modulation of astrocyte phenotype in response to T-cell interaction
Hersh, J., Prah, J., Winters, A., Liu, R. & Yang, S. H., 15 Feb 2021, In: Journal of Neuroimmunology. 351, 577455.Research output: Contribution to journal › Article › peer-review
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Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm
Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., Jun 2020, In: PLoS ONE. 15, 6, e0234571.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 May 2019, In: Journal of Neuroscience Methods. 320, p. 50-63 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations