Projects per year
Personal profile
Area of Expertise
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.
Education/Academic qualification
MD, Beijing Medical University
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Collaborations and top research areas from the last five years
Projects
- 9 Finished
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Post Stroke Cognitive Impairment: Mechanism and Therapy
Yang, S. (PI), Liu, R. (CoI), Sumien, N. (CoI) & Jin, K. (CoI)
NINDS: Neurological Disorders & Stroke
1/02/19 → 31/01/24
Project: Research
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Post Stroke Cognitive Impairme
Yang, S. (PI), Liu, R. (CoI), Sumien, N. (CoI) & Jin, K. (CoI)
NINDS: Neurological Disorders & Stroke
1/02/19 → 30/06/24
Project: Research
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Metformin and Cognition
Liu, R. (PI), Huang, R.-Q. (CoI), Yang, S. (CoI) & Sumien, N. (CoI)
1/05/16 → 31/08/17
Project: Research
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Establishment of Inducible Astrocyte Specific p38 MAPK Knockout Mouse Line
NINDS: Neurological Disorders & Stroke
15/09/14 → 28/02/18
Project: Research
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Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model
Wang, L., Chaudhari, K., Winters, A., Sun, Y., Berry, R., Tang, C., Yang, S. H. & Liu, R., Oct 2023, In: Translational Stroke Research. 14, 5, p. 740-751 12 p.Research output: Contribution to journal › Article › peer-review
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Endovascular middle cerebral artery occlusion in rats as a model for studying vascular dementia
Yang, S. H., Shetty, R. A., Liu, R., Sumien, N., Heinrich, K. R., Rutledge, M., Thangthaeng, N., Brun-Zinkernagel, A. M. & Forster, M. J., Sep 2006, In: Age. 28, 3, p. 297-307 11 p.Research output: Contribution to journal › Article › peer-review
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The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia
Yang, S. H., Liu, R., Wu, S. S. & Simpkins, J. W., 2003, In: Annals of the New York Academy of Sciences. 1007, p. 101-107 7 p.Research output: Contribution to journal › Article › peer-review
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Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model
Li, W., Huang, R., Shetty, R. A., Thangthaeng, N., Liu, R., Chen, Z., Sumien, N., Rutledge, M., Dillon, G. H., Yuan, F., Forster, M. J., Simpkins, J. W. & Yang, S. H., Nov 2013, In: Neurobiology of Disease. 59, p. 18-25 8 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotective effects of 17β-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
Wang, X., Dykens, J. A., Perez, E., Liu, R., Yang, S., Covey, D. F. & Simpkins, J. W., 2006, In: Molecular Pharmacology. 70, 1, p. 395-404 10 p.Research output: Contribution to journal › Article › peer-review