Projects per year
Personal profile
Area of Expertise
The principal goals of my research are focused on translational stroke research. Although rtPA is the sole FDA approved treatment for ischemic stroke, very few patients have been benefited from rtPA treatment because of its limited therapeutic window and the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We are among the first to explore the combined therapy to extend rtPA’s therapeutic window in ischemic stroke models. We have demonstrated that estrogens could extend the therapeutic window of rtPA for the treatment of ischemic stroke. In addition, our research has provided insight to target ischemic penumbra and beyond for the treatment of ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.
Education/Academic qualification
MD, Beijing Medical University
Fingerprint
Dive into the research topics where Ran Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 3 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
-
Post Stroke Cognitive Impairment: Mechanism and Therapy
Yang, S., Liu, R., Sumien, N. & Jin, K.
NINDS: Neurological Disorders & Stroke
1/02/19 → 31/01/24
Project: Research
-
-
Establishment of Inducible Astrocyte Specific p38 MAPK Knockout Mouse Line
NINDS: Neurological Disorders & Stroke
15/09/14 → 28/02/18
Project: Research
-
Neuroglobin: Cell Membrane and Neuroprotection
NINDS: Neurological Disorders & Stroke
1/07/14 → 31/05/19
Project: Research
Research Output
-
Modulation of astrocyte phenotype in response to T-cell interaction
Hersh, J., Prah, J., Winters, A., Liu, R. & Yang, S. H., 15 Feb 2021, In: Journal of Neuroimmunology. 351, 577455.Research output: Contribution to journal › Article › peer-review
-
Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm
Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., Jun 2020, In: PLoS ONE. 15, 6, e0234571.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 May 2019, In: Journal of Neuroscience Methods. 320, p. 50-63 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In: Brain Research. 1723, 146378.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Experimental ischemic stroke induces long-term T cell activation in the brain
Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations