Ran Liu public CV

Ran Liu, MD

Graduate School of Biomedical Sciences
Research Assistant Professor, Pharmacology & Neuroscience
Member, Institute for Healthy Aging

EmailRan.Liu@unthsc.edu

3164 Citations
32 h-Index

Research output per year

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Personal profile

Area of Expertise

The principal goals of my research are focused on translational stroke research. Although rtPA is the sole FDA approved treatment for ischemic stroke, very few patients have been benefited from rtPA treatment because of its limited therapeutic window and the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We are among the first to explore the combined therapy to extend rtPA’s therapeutic window in ischemic stroke models. We have demonstrated that estrogens could extend the therapeutic window of rtPA for the treatment of ischemic stroke. In addition, our research has provided insight to target ischemic penumbra and beyond for the treatment of ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.

Education/Academic qualification

MD, Beijing Medical University

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Projects

1 Active
7 Finished

Post Stroke Cognitive Impairment: Mechanism and Therapy

Yang, S., Liu, R., Sumien, N. & Jin, K.

NINDS: Neurological Disorders & Stroke

1/02/19 → 31/01/24

Project: Research

Assessment of the Effects of Novel Nestle Diets on balance (Phase I) and cognitive function (Phase II) in Female 5XFAD Transgenic Mice (Project VII)

Yang, S. & Liu, R.

Nestle Purina

18/10/16 → 18/10/18

Project: Research

Metformin and Cognition

Liu, R., Huang, R., Yang, S. & Sumien, N.

Intramural Research(UNTHSC)

1/05/16 → 31/08/17

Project: Research

Establishment of Inducible Astrocyte Specific p38 MAPK Knockout Mouse Line

Yang, S. & Liu, R.

NINDS: Neurological Disorders & Stroke

15/09/14 → 28/02/18

Project: Research

Neuroglobin: Cell Membrane and Neuroprotection

Yang, S., Liu, R. & Jin, K.

NINDS: Neurological Disorders & Stroke

1/07/14 → 31/05/19

Project: Research

Research Output

3164 Citations
32 h-Index
53 Article
5 Review article
2 Chapter
2 Editorial
1 More
- 1 Comment/debate

Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Chaudhari, K., Wang, J., Xu, Y., Winters, A., Wang, L., Dong, X., Cheng, E. Y., Liu, R. & Yang, S. H., 1 Jan 2020, In : PLoS ONE. 15, 6, p. e0234571