• 3061 Citations
  • 32 h-Index
20022024

Research output per year

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Personal profile

Area of Expertise

The principal goals of my research are focused on translational stroke research. Although rtPA is the sole FDA approved treatment for ischemic stroke, very few patients have been benefited from rtPA treatment because of its limited therapeutic window and the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We are among the first to explore the combined therapy to extend rtPA’s therapeutic window in ischemic stroke models. We have demonstrated that estrogens could extend the therapeutic window of rtPA for the treatment of ischemic stroke. In addition, our research has provided insight to target ischemic penumbra and beyond for the treatment of ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.

Education/Academic qualification

MD, Beijing Medical University

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Projects

Research Output

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress

    Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S. H., 15 Nov 2019, In : Brain Research. 1723, 146378.

    Research output: Contribution to journalArticle

  • Experimental ischemic stroke induces long-term T cell activation in the brain

    Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S. H., 1 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 11, p. 2268-2276 9 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

    Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

    Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S. H., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

    Research output: Contribution to journalArticle

  • 7 Scopus citations