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Area of Expertise

The principal goals of my research are focused on translational stroke research. Although rtPA is the sole FDA approved treatment for ischemic stroke, very few patients have been benefited from rtPA treatment because of its limited therapeutic window and the increased risk of hemorrhage transformation due to blood-brain barrier breakdown. We are among the first to explore the combined therapy to extend rtPA’s therapeutic window in ischemic stroke models. We have demonstrated that estrogens could extend the therapeutic window of rtPA for the treatment of ischemic stroke. In addition, our research has provided insight to target ischemic penumbra and beyond for the treatment of ischemic stroke.
Currently we repurpose a century-old drug, methylene blue, for the treatment of ischemic stroke. Our study demonstrates that large MCA territory infarct may induce long-lasting elevated GABAergic tonic inhibition in the hippocampus and, thus, contributes to cognitive impairment after ischemic stroke. All these results have led us to explore the role of GABAA receptor mediated neurotransmission in the cognitive impairment after large MCA territory infarct and to determine the effect of methylene blue on cognitive impairment after ischemic stroke.

Education/Academic qualification

MD, Beijing Medical University

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Stroke Medicine & Life Sciences
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Neuroprotective Agents Medicine & Life Sciences
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Projects 2012 2024

Research Output 2002 2019

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype

Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. & Yang, S., 15 May 2019, In : Journal of Neuroscience Methods. 320, p. 50-63 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Phenotype
Serum
Fibroblast Growth Factor 2
Epidermal Growth Factor
1 Citation (Scopus)

Artemisinin prevents glutamate-induced neuronal cell death via Akt pathway activation

Lin, S. P., Li, W., Winters, A., Liu, R. & Yang, S., 20 Apr 2018, In : Frontiers in Cellular Neuroscience. 12, 108.

Research output: Contribution to journalArticleResearchpeer-review

Glutamic Acid
Cell Death
artemisinine
Mitochondrial Membrane Potential
Antimalarials
1 Citation (Scopus)

Experimental ischemic stroke induces long-term T cell activation in the brain

Xie, L., Li, W., Hersh, J., Liu, R. & Yang, S., 1 Jan 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticleResearchpeer-review

Stroke
T-Lymphocytes
Brain
Perforin
Interleukin-17

Hyperglycemia alters astrocyte metabolism and inhibits astrocyte proliferation

Li, W., Choudhury, G. R., Winters, A., Prah, J., Lin, W., Liu, R. & Yang, S., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 674-684 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Hyperglycemia
Glucose
Energy Metabolism
Cyclin D3
1 Citation (Scopus)

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

Yang, S., Lou, M., Luo, B., Jiang, W. J. & Liu, R., 1 Apr 2018, In : Translational Stroke Research. 9, 2, p. 93-95 3 p.

Research output: Contribution to journalEditorialResearch

Precision Medicine
Stroke
Brain