Raghu Krishnamoorthy, PhD

Research output

Research output per year 1997 1999 2000 2001 2002 2003 2005 2008 2011 2013 2014 2015 2016 2017 2019 2021 2022

• 42 Article
• 4 Comment/debate
• 2 Editorial
• 2 Review article

Research output per year

Research output per year

Search results

• Photo-oxidative stress down-modulates the activity of nuclear factor- κB via involvement of caspase-1, leading to apoptosis of photoreceptor cells

  Krishnamoorthy, R. R., Crawford, M. J., Chaturvedi, M. M., Jain, S. K., Aggarwal, B. B., Al-Ubaidi, M. R. & Agarwal, N., 5 Feb 1999, In: Journal of Biological Chemistry. 274, 6, p. 3734-3743 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Photoreceptor Cells 100%
  • Caspase 1 97%
  • Retinal 91%
  • Cell Death 84%
  • Oxidative Stress 78%

• Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

  He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R. R., 2015, In: Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelins 100%
  • Retinal Ganglion Cells 98%
  • Gene Expression 51%
  • Endothelin-2 47%
  • Endothelin-1 46%

• Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa

  Rao, V. R., Krishnamoorthy, R. R. & Yorio, T., Jun 2008, In: Experimental eye research. 86, 6, p. 886-894 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin-1 100%
  • Extracellular Matrix 77%
  • Collagen 70%
  • Collagen Type I 26%
  • BQ 610 12%

• Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy

  Parameswaran, S., Dravid, S. M., Teotia, P., Krishnamoorthy, R. R., Qiu, F., Toris, C., Morrison, J. & Ahmad, I., 1 Jun 2015, In: Stem Cells. 33, 6, p. 1743-1758 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Ganglion Cells 100%
  • Induced Pluripotent Stem Cells 17%
  • Glaucoma 15%
  • Acids 11%
  • Ocular Hypertension 9%

• Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-κB preservation

  Crawford, M. J., Krishnamoorthy, R. R., Rudick, V. L., Collier, R. J., Kapin, M., Aggarwal, B. B., Al-Ubaidi, M. R. & Agarwal, N., 2001, In: Biochemical and Biophysical Research Communications. 281, 5, p. 1304-1312 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Photoreceptor Cells 100%
  • Apoptosis 48%
  • Protein 32%
  • Cell Death 28%
  • Cell Viability 26%

• Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

  Tchedre, K. T., Huang, R. Q., Dibas, A., Krishnamoorthy, R. R., Dillon, G. H. & Yorio, T., Nov 2008, In: Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor 100%
  • Calcium Channels 68%
  • Calcium 43%
  • Potassium Chloride 22%
  • Retinal Ganglion Cells 20%

• Role of the ET_B receptor in retinal ganglion cell death in glaucoma

  Krishnamoorthy, R. R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., Jun 2008, In: Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Ganglion Cells 100%
  • Endothelin-1 94%
  • Glaucoma 82%
  • Cell Death 66%
  • Apoptosis 26%

• Levobetaxolol-induced up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy

  Agarwal, N., Martin, E., Krishnamoorthy, R. R., Landers, R., Wen, R., Krueger, S., Kapin, M. A. & Collier, R. J., 2002, In: Experimental eye research. 74, 4, p. 445-453 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ciliary Neurotrophic Factor 100%
  • Up-Regulation 51%
  • Retinal Pigments 43%
  • Messenger RNA 40%
  • Betaxolol 37%

• Upregulation of CD44 expression in the retina during the rds degeneration

  Krishnamoorthy, R., Agarwal, N. & Chaitin, M. H., 14 Apr 2000, In: Molecular Brain Research. 77, 1, p. 125-130 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Degeneration 100%
  • Retina 70%
  • Up-Regulation 58%
  • Protein Isoforms 14%
  • Proteins 13%

• High cholesterol diet down regulates the activity of activator protein-1 but not nuclear factor-kappa B in rabbit brain

  Kálmán, J., Kudchodkar, B. J., Krishnamoorthy, R., Dory, L., Lacko, A. G. & Agarwal, N., 16 Feb 2001, In: Life Sciences. 68, 13, p. 1495-1503 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Factor AP-1 100%
  • NF-kappa B 96%
  • Cholesterol 80%
  • Rabbits 64%
  • Down-Regulation 63%

• Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells

  Chaphalkar, R. M., Stankowska, D. L., He, S., Kodati, B., Phillips, N., Prah, J., Yang, S. & Krishnamoorthy, R. R., 1 Dec 2020, In: Scientific Reports. 10, 1, 3571.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Genes 100%
  • Retinal Ganglion Cells 90%
  • Endothelin-1 85%
  • Energy Metabolism 71%
  • Gene Expression 47%

• Endothelin b receptors contribute to retinal ganglion cell loss in a rat model of glaucoma

  Minton, A. Z., Phatak, N. R., Stankowska, D. L., He, S., Ma, H. Y., Mueller, B. H., Jiang, M., Luedtke, R., Yang, S., Brownlee, C. & Krishnamoorthy, R. R., 20 Aug 2012, In: PLoS ONE. 7, 8, e43199.

  Research output: Contribution to journal › Article › peer-review

  • Intraocular 100%
  • glaucoma 98%
  • Endothelin Receptors 96%
  • endothelins 90%
  • Retinal 81%

• Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells

  Wang, Y., Ding, M., Chaudhari, S., Ding, Y., Yuan, J., Stankowska, D., He, S., Krishnamoorthy, R., Cunningham, J. T. & Ma, R., 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12852-12865 14 p.

  Research output: Contribution to journal › Article › peer-review

  • TRPC6 Cation Channel 100%
  • Phorbol 13-Acetate 12-Myristate 95%
  • Protein Kinase C 59%
  • Reactive Oxygen Metabolite 59%
  • Reactive Oxygen Species 50%

• Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

  Phatak, N. R., Stankowska, D. L. & Krishnamoorthy, R. R., 16 Aug 2016, In: Molecular vision. 22, p. 1048-1061 14 p.

  Research output: Contribution to journal › Article › peer-review

  • B-Cell Leukemia 100%
  • Ocular Hypertension 89%
  • B-Cell Lymphoma 73%
  • Neuroprotective Agents 72%
  • Retinal Ganglion Cells 71%

• Oral administration of a dual ET_A /ET_B receptor antagonist promotes neuroprotection in a rodent model of glaucoma

  Kodati, B., McGrady, N. R., Jefferies, H. B., Stankowska, D. L. & Krishnamoorthy, R. R., 2022, In: Molecular vision. 28, p. 165-177 13 p.

  Research output: Contribution to journal › Article › peer-review

  • macitentan 100%
  • Retinal Ganglion Cells 73%
  • Neuroprotection 67%
  • Glaucoma 60%
  • Oral Administration 55%

• Endothelin-1 Synthesis and Secretion in Human Retinal Pigment Epithelial Cells (ARPE-19): Differential Regulation by Cholinergics and TNF-α

  Narayan, S., Prasanna, G., Krishnamoorthy, R. R., Zhang, X. & Yorio, T., Nov 2003, In: Investigative Ophthalmology and Visual Science. 44, 11, p. 4885-4894 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Pigments 100%
  • Endothelin-1 88%
  • Cholinergic Agents 76%
  • Epithelial Cells 58%
  • Retinal Pigment Epithelium 23%

• Endothelin, astrocytes and glaucoma

  Prasanna, G., Krishnamoorthy, R. & Yorio, T., Aug 2011, In: Experimental eye research. 93, 2, p. 170-177 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelins 100%
  • Glaucoma 81%
  • Astrocytes 79%
  • Gliosis 25%
  • Central Nervous System 15%

• Hypoxia augments TNF-α-mediated endothelin-1 release and cell proliferation in human optic nerve head astrocytes

  Desai, D., He, S., Yorio, T., Krishnamoorthy, R. R. & Prasanna, G., 4 Jun 2004, In: Biochemical and Biophysical Research Communications. 318, 3, p. 642-648 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin-1 100%
  • Optic Disk 74%
  • Astrocytes 61%
  • Hypoxia 52%
  • Cell Proliferation 44%

• Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

  Chung, T. W., Yang, M. H., Krishnamoorthy, R. R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 2011, In: Journal of Biomedicine and Biotechnology. 2011, 901329.

  Research output: Contribution to journal › Article › peer-review

  • Retinal 100%
  • Retinal Ganglion Cells 99%
  • Epithelium 66%
  • Epithelial Cells 51%
  • Cell Line 51%

• Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

  Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In: Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

  Research output: Contribution to journal › Article › peer-review

  • rho-Associated Kinases 100%
  • Retinal Pigments 98%
  • Endothelin-1 87%
  • Thrombin 80%
  • Epithelial Cells 57%

• Apolipoprotein B gene regulatory factor-2 (BRF-2) is structurally and immunologically highly related to hepatitis B virus X associated protein-i (XAP-1)

  Krishnamoorthy, R. R., Lee, T. H., Butel, J. S. & Das, H. K., 28 Jan 1997, In: Biochemistry. 36, 4, p. 960-969 10 p.

  Research output: Contribution to journal › Article › peer-review

  • hepatitis B virus X protein 100%
  • Apolipoproteins B 73%
  • Regulator Genes 68%
  • Protein Isoforms 33%
  • Peptides 31%

• A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

  Wang, J., Ma, H. Y., Krishnamoorthy, R. R., Yorio, T. & He, S., Sep 2017, In: PLoS ONE. 12, 9, e0185390.

  Research output: Contribution to journal › Article › peer-review

  • endothelin receptors 100%
  • food law 85%
  • CCAAT-Enhancer-Binding Proteins 85%
  • Endothelin Receptors 84%
  • Endothelin B Receptors 76%

• Serum deprivation induces apoptotic cell death of transformed rat retinal ganglion cells via mitochondrial signaling pathways

  Charles, I., Khalyfa, A., Kumar, D. M., Krishnamoorthy, R. R., Roque, R. S., Cooper, N. & Agarwal, N., Apr 2005, In: Investigative Ophthalmology and Visual Science. 46, 4, p. 1330-1338 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Ganglion Cells 100%
  • Cell Death 66%
  • Serum 39%
  • 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine 22%
  • Neutral Red 22%

• Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells

  Zhang, X., Krishnamoorthy, R. R., Prasanna, G., Narayan, S., Clark, A. & Yorio, T., 1 Mar 2003, In: Experimental eye research. 76, 3, p. 261-272 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin Receptors 100%
  • Endothelin A Receptors 98%
  • Endothelin B Receptors 70%
  • Dexamethasone 66%
  • Endothelin-1 61%

• Characterization of a transformed rat retinal ganglion cell line

  Krishnamoorthy, R. R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I. H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. F. & Agarwal, N., 31 Jan 2001, In: Molecular Brain Research. 86, 1-2, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Ganglion Cells 100%
  • Cell Line 51%
  • Nerve Growth Factors 26%
  • Clone Cells 19%
  • Qa-SNARE Proteins 17%