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Research Output 1997 2019

  • 1589 Citations
  • 20 h-Index
  • 37 Article
  • 4 Comment/debate
  • 2 Editorial
  • 2 Review article
2019
Open Access
Retinal Ganglion Cells
Glaucoma
Publications
Cell Death
Animal Models
2018
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor
2017

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

Wang, J., Ma, H. Y., Krishnamoorthy, R., Yorio, T. & He, S., 1 Sep 2017, In : PLoS ONE. 12, 9, e0185390.

Research output: Contribution to journalArticleResearchpeer-review

CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors
9 Citations (Scopus)

Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons

Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R., 28 May 2017, In : Nutritional Neuroscience. 20, 5, p. 273-283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Curcumin
Neuroprotective Agents
Endothelin-1
Cell Death
Neurons
8 Citations (Scopus)

Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma

McGrady, N. R., Minton, A. Z., Stankowska, D. L., He, S., Jefferies, H. B. & Krishnamoorthy, R., 1 Mar 2017, In : BMC Neuroscience. 18, 1, 27.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin A Receptors
Intraocular Pressure
Glaucoma
Rodentia
Up-Regulation
2016
6 Citations (Scopus)

Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

Phatak, N. R., Stankowska, D. L. & Krishnamoorthy, R., 16 Aug 2016, In : Molecular Vision. 22, p. 1048-1061 14 p.

Research output: Contribution to journalArticleResearchpeer-review

B-Cell Leukemia
Ocular Hypertension
Neuroprotective Agents
B-Cell Lymphoma
Retinal Ganglion Cells
4 Citations (Scopus)

Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy

Acharya, S., Rogers, P., Krishnamoorthy, R., Stankowska, D. L., Dias, H. V. R. & Yorio, T., 1 Mar 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1490-1494 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Nerve Diseases
Prodrugs
Optics
Photoreceptor Cells
Molecules
2015
7 Citations (Scopus)

Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy

Parameswaran, S., Dravid, S. M., Teotia, P., Krishnamoorthy, R., Qiu, F., Toris, C., Morrison, J. & Ahmad, I., 1 Jun 2015, In : Stem Cells. 33, 6, p. 1743-1758 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Induced Pluripotent Stem Cells
Glaucoma
Ocular Hypertension
Acids
9 Citations (Scopus)

Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells

He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Endothelins
Gene Expression
Endothelin-1
Endothelin-2
10 Citations (Scopus)

Neuroprotective effects of transcription factor brn3b in an ocular hypertension rat model of glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B. H., Phatak, N. R., He, S., Ma, H. Y., Forster, M. J., Yorio, T. & Krishnamoorthy, R., 1 Jan 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 893-907 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Neuroprotective Agents
Intraocular Pressure
Glaucoma
Transcription Factors
3 Citations (Scopus)

Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia

Phatak, N. R., Stankowska, D. L. & Krishnamoorthy, R., 24 Aug 2015, In : Cellular and Molecular Neurobiology. 35, 6, p. 769-783 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription Factor Brn-3B
PC12 Cells
GAP-43 Protein
Up-Regulation
Neuronal Outgrowth
2014
2 Citations (Scopus)

Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 28 Jan 2014, In : Brain Research. 1544, 1 p.

Research output: Contribution to journalComment/debateResearch

Retinal Ganglion Cells
Cell Line
Brain
Research
10 Citations (Scopus)

Multiple-pulse pumping for enhanced fluorescence detection and molecular imaging in tissue

Rich, R. M., Gryczynski, I., Fudala, R., Borejdo, J., Stankowska, D. L., Krishnamoorthy, R., Raut, S. L., Maliwal, B. P., Shumilov, D., Doan, H. & Gryczynski, Z., 15 Mar 2014, In : Methods. 66, 2, p. 292-298 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular imaging
Molecular Imaging
Optical Imaging
Ruthenium
Fluorescence
2013
73 Citations (Scopus)

A forensic path to RGC-5 cell line identification: Lessons learned

Krishnamoorthy, R., Clark, A., Daudt, D., Vishwanatha, J. K. & Yorio, T., 30 Aug 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5712-5719 8 p.

Research output: Contribution to journalEditorialResearch

Retinal Ganglion Cells
Cell Line
Transformed Cell Line
Karyotyping
Photoreceptor Cells
35 Citations (Scopus)

Elimination of autofluorescence background from fluorescence tissue images by use of time-gated detection and the AzaDiOxaTriAngulenium (ADOTA) fluorophore

Rich, R. M., Stankowska, D. L., Maliwal, B. P., Sørensen, T. J., Laursen, B. W., Krishnamoorthy, R., Gryczynski, Z., Borejdo, J., Gryczynski, I. & Fudala, R., 1 Jan 2013, In : Analytical and Bioanalytical Chemistry. 405, 6, p. 2065-2075 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorophores
Fluorescence
Tissue
Coloring Agents
Biological Phenomena
9 Citations (Scopus)

Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma

He, S., Minton, A. Z., Ma, H. Y., Stankowska, D. L., Sun, X. L. & Krishnamoorthy, R., 12 Nov 2013, In : PLoS ONE. 8, 11, e79183.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin B Receptors
glaucoma
endothelins
Transcription Factor AP-1
Glaucoma
29 Citations (Scopus)

Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells

Wang, Y., Ding, M., Chaudhari, S., Ding, Y., Yuan, J. P., Stankowska, D. L., He, S., Krishnamoorthy, R., Cunningham, J. T. & Ma, R., 3 May 2013, In : Journal of Biological Chemistry. 288, 18, p. 12852-12865 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein Kinase C
Reactive Oxygen Species
Acetates
Kidney
Phosphorylation
2012
35 Citations (Scopus)

Endothelin b receptors contribute to retinal ganglion cell loss in a rat model of glaucoma

Minton, A. Z., Phatak, N. R., Stankowska, D. L., He, S., Ma, H. Y., Mueller, B. H., Jiang, M., Luedtke, R. T., Yang, S., Brownlee, C. & Krishnamoorthy, R., 20 Aug 2012, In : PLoS ONE. 7, 8, e43199.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin Receptors
glaucoma
endothelins
Retinal Ganglion Cells
Endothelins
2011
42 Citations (Scopus)

Endothelin, astrocytes and glaucoma

Prasanna, G., Krishnamoorthy, R. & Yorio, T., 1 Aug 2011, In : Experimental eye research. 93, 2, p. 170-177 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelins
Astrocytes
Glaucoma
Gliosis
Central Nervous System

Erratum: Protein profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line (Journal of Biomedicine and Biotechnology 2011 (1))

Yang, M. H., Krishnamoorthy, R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Chung, T. W. & Tyan, Y. C., 1 Dec 2011, In : Journal of Biomedicine and Biotechnology. 2011, 239089.

Research output: Contribution to journalComment/debateResearch

Retinal Ganglion Cells
Biotechnology
Epithelium
Cell Line
Proteins
5 Citations (Scopus)

Protein Profiling of human nonpigmented ciliary epithelium cell secretome: The differentiation factors characterization for retinal ganglion cell line

Chung, T. W., Yang, M. H., Krishnamoorthy, R., Jong, S. B., Chu, P. Y., Yang, Y. H., Chen, W. C., Chen, S. C. J., Dibas, A., Yorio, T. & Tyan, Y. C., 12 Oct 2011, In : Journal of Biomedicine and Biotechnology. 2011, 901329.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Epithelium
Cell Line
Epithelial Cells
Proteins
2010
6 Citations (Scopus)

Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is Rho kinase dependent

Narayan, S., Prasanna, G., Tchedre, K., Krishnamoorthy, R. & Yorio, T., 1 Oct 2010, In : Journal of Ocular Pharmacology and Therapeutics. 26, 5, p. 389-397 9 p.

Research output: Contribution to journalArticleResearchpeer-review

rho-Associated Kinases
Retinal Pigments
Endothelin-1
Thrombin
Epithelial Cells
2008
20 Citations (Scopus)

Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa

Rao, V. R., Krishnamoorthy, R. & Yorio, T., 1 Jun 2008, In : Experimental eye research. 86, 6, p. 886-894 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Extracellular Matrix
Collagen
Collagen Type I
Collagen Type VI
34 Citations (Scopus)

Role of the ETB receptor in retinal ganglion cell death in glaucoma

Krishnamoorthy, R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., 1 Jun 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Endothelin-1
Glaucoma
Cell Death
Apoptosis
90 Citations (Scopus)

Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

Tchedre, K. T., Huang, R-Q., Dibas, A., Krishnamoorthy, R., Dillon, G. H. & Yorio, T., 1 Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4993-5002 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium Channels
Calcium
Potassium Chloride
Retinal Ganglion Cells
Homeostasis
2007
16 Citations (Scopus)

Endothelin-1, endothelin A and B receptor expression and their pharmacological properties in GFAP negative human lamina cribrosa cells

Rao, V. R., Krishnamoorthy, R. & Yorio, T., 1 Jun 2007, In : Experimental Eye Research. 84, 6, p. 1115-1124 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin B Receptors
Endothelin A Receptors
Endothelin-1
Pharmacology
Optic Nerve Diseases
2005
75 Citations (Scopus)

Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma

Prasanna, G., Hulet, C., Desai, D., Krishnamoorthy, R., Narayan, S., Brun, A. M., Suburo, A. M. & Yorio, T., 1 Jan 2005, In : Pharmacological Research. 51, 1, p. 41-50 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Intraocular Pressure
Glaucoma
Optic Disk
Optic Nerve
78 Citations (Scopus)

Serum deprivation induces apoptotic cell death of transformed rat retinal ganglion cells via mitochondrial signaling pathways

Charles, I., Khalyfa, A., Kumar, D. M., Krishnamoorthy, R., Roque, R. S., Cooper, N. & Agarwal, N., 1 Apr 2005, In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1330-1338 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Cell Death
Serum
Apoptosis
Neutral Red
2004
41 Citations (Scopus)

Hypoxia augments TNF-α-mediated endothelin-1 release and cell proliferation in human optic nerve head astrocytes

Desai, D., He, S., Yorio, T., Krishnamoorthy, R. & Prasanna, G., 4 Jun 2004, In : Biochemical and Biophysical Research Communications. 318, 3, p. 642-648 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Disk
Cell proliferation
Endothelin-1
Astrocytes
Optics
2003
25 Citations (Scopus)

Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells

Zhang, X., Krishnamoorthy, R., Prasanna, G., Narayan, S., Clark, A. & Yorio, T., 1 Mar 2003, In : Experimental eye research. 76, 3, p. 261-272 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin A Receptors
Endothelin Receptors
Dexamethasone
Endothelin B Receptors
Endothelin-1
48 Citations (Scopus)

Endothelin-1 Synthesis and Secretion in Human Retinal Pigment Epithelial Cells (ARPE-19): Differential Regulation by Cholinergics and TNF-α

Narayan, S., Prasanna, G., Krishnamoorthy, R., Zhang, X. & Yorio, T., 1 Nov 2003, In : Investigative Ophthalmology and Visual Science. 44, 11, p. 4885-4894 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Pigments
Endothelin-1
Cholinergic Agents
Epithelial Cells
Retinal Pigment Epithelium
45 Citations (Scopus)

Eyeing endothelins: A cellular perspective

Prasanna, G., Narayan, S., Krishnamoorthy, R. & Yorio, T., 1 Nov 2003, In : Molecular and Cellular Biochemistry. 253, 1-2, p. 71-88 18 p.

Research output: Contribution to journalReview articleResearchpeer-review

Endothelin Receptors
Endothelins
Vasoconstrictor Agents
Glaucoma
Peptides
5 Citations (Scopus)

Regulation of Na,K-ATPase Expression by Endothelin-1 in Transformed Human Ciliary Non-Pigmented Epithelial (HNPE) Cells

Krishnamoorthy, R., Prasanna, G., Dauphin, R., Hulet, C., Agarwal, N. & Yorio, T., 1 Jan 2003, In : Journal of Ocular Pharmacology and Therapeutics. 19, 5, p. 465-481 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-1
Epithelial Cells
Monensin
Aqueous Humor
Ouabain
2002
124 Citations (Scopus)

Endothelin: Is it a contributor to glaucoma pathophysiology?

Yorio, T., Krishnamoorthy, R. & Prasanna, G., 1 Jan 2002, In : Journal of Glaucoma. 11, 3, p. 259-270 12 p.

Research output: Contribution to journalReview articleResearchpeer-review

Endothelins
Glaucoma
Endothelin Receptors
Aqueous Humor
Optic Disk
99 Citations (Scopus)

Human optic nerve head astrocytes as a target for endothelin-1

Prasanna, G., Krishnamoorthy, R., Clark, A., Wordinger, R. J. & Yorio, T., 5 Aug 2002, In : Investigative Ophthalmology and Visual Science. 43, 8, p. 2704-2713 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Optic Disk
Endothelin-1
Astrocytes
Cell Proliferation
Glaucoma
20 Citations (Scopus)

Levobetaxolol-induced up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy

Agarwal, N., Martin, E., Krishnamoorthy, R., Landers, R., Wen, R., Krueger, S., Kapin, M. A. & Collier, R. J., 1 Jan 2002, In : Experimental eye research. 74, 4, p. 445-453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ciliary Neurotrophic Factor
Up-Regulation
Messenger RNA
Retinal Pigments
Betaxolol
2001
58 Citations (Scopus)

Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-κB preservation

Crawford, M. J., Krishnamoorthy, R., Rudick, V. L., Collier, R. J., Kapin, M., Aggarwal, B. B., Al-Ubaidi, M. R. & Agarwal, N., 1 Jan 2001, In : Biochemical and Biophysical Research Communications. 281, 5, p. 1304-1312 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Photoreceptor Cells
Apoptosis
Assays
Formazans
Electrophoretic mobility
296 Citations (Scopus)

Characterization of a transformed rat retinal ganglion cell line

Krishnamoorthy, R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I-H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. & Agarwal, N., 31 Jan 2001, In : Molecular Brain Research. 86, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Ganglion Cells
Cell Line
Nerve Growth Factors
Clone Cells
Apoptosis

Erratum: Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-κB preservation (Biochemical and Biophysical Research Communications (2001) 281:5 (1304-1312))

Crawford, M. J., Krishnamoorthy, R., Rudick, V. L., Collier, R. J., Kapin, M., Aggarwal, B. B., Al-Ubaidi, M. R. & Agarwal, N., 14 Oct 2001, In : Biochemical and Biophysical Research Communications. 283, 2, 1 p.

Research output: Contribution to journalComment/debateResearch

Photoreceptor Cells
Apoptosis
Research
14 Citations (Scopus)

High cholesterol diet down regulates the activity of activator protein-1 but not nuclear factor-kappa B in rabbit brain

Kálmán, J., Kudchodkar, B. J., Krishnamoorthy, R., Dory, L., Lacko, A. G. & Agarwal, N., 16 Feb 2001, In : Life Sciences. 68, 13, p. 1495-1503 9 p.

Research output: Contribution to journalArticleResearchpeer-review

NF-kappa B
Transcription Factor AP-1
Nutrition
Brain
Down-Regulation
2000
14 Citations (Scopus)

Endothelin-1 induces nitric oxide synthase-2 expression in human non-pigmented ciliary epithelial cells

Prasanna, G., Krishnamoorthy, R., Hulet, C., Zhang, H., Zhang, X. & Yorio, T., 1 Jan 2000, In : Experimental eye research. 71, 5, p. 535-539 5 p.

Research output: Contribution to journalEditorialResearch

Endothelin-1
Nitric Oxide Synthase
Epithelial Cells
26 Citations (Scopus)

Upregulation of CD44 expression in the retina during the rds degeneration

Krishnamoorthy, R., Agarwal, N. & Chaitin, M. H., 14 Apr 2000, In : Molecular Brain Research. 77, 1, p. 125-130 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinal Degeneration
Retina
Up-Regulation
Protein Isoforms
Proteins
1999
127 Citations (Scopus)

Photo-oxidative stress down-modulates the activity of nuclear factor- κB via involvement of caspase-1, leading to apoptosis of photoreceptor cells

Krishnamoorthy, R., Crawford, M. J., Chaturvedi, M. M., Jain, S. K., Aggarwal, B. B., Al-Ubaidi, M. R. & Agarwal, N., 5 Feb 1999, In : Journal of Biological Chemistry. 274, 6, p. 3734-3743 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Caspase 1
Photoreceptor Cells
Oxidative stress
Oxidative Stress
Apoptosis
3 Citations (Scopus)

Retina-derived fetuin (RDF): Analysis by immunocytochemistry, reverse transcriptase-polymerase chain reaction and Southern blot

Sheedlo, H. J., Krishnamoorthy, R., Nelson, T., Agarwal, N., Liu, J., Roque, R. S., Wordinger, R. J., Jaynes, C. D., Brun-Zinkelnagel, A. M., O'Brian, P., Aschenbrenner, J. E. & Turner, J. E., 1 Jan 1999, In : Current Eye Research. 19, 6, p. 465-471 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetuins
Southern Blotting
Reverse Transcriptase Polymerase Chain Reaction
Retina
Immunohistochemistry
1997
25 Citations (Scopus)

Apolipoprotein B gene regulatory factor-2 (BRF-2) is structurally and immunologically highly related to hepatitis B virus X associated protein-i (XAP-1)

Krishnamoorthy, R., Lee, T. H., Butel, J. S. & Das, H., 28 Jan 1997, In : Biochemistry. 36, 4, p. 960-969 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Apolipoproteins B
Regulator Genes
Viruses
Genes
Protein Isoforms