Projects per year
Personal profile
Area of Expertise
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Education/Academic qualification
BS in Chemistry, University of Bombay
MS in Biochemistry, University of Bombay
PhD in Biochemistry, University of Bombay
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Network
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
KRISHNAMOORTHY, R. & Krishnamoorthy, R.
30/09/17 → 31/08/23
Project: Research
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
30/09/17 → 31/08/21
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Mallet, R., Krishnamoorthy, R., Jones, H., Fulda, K., He, J., Basha, R. & Nandy, K.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Jones, H., He, J., Basha, R., Nandy, K., Mallet, R., Krishnamoorthy, R. & Simecka, J.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R., He, S. & Stankowska, D.
1/09/17 → 31/08/20
Project: Research
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Oral administration of a dual ETA /ETB receptor antagonist promotes neuroprotection in a rodent model of glaucoma
Kodati, B., McGrady, N. R., Jefferies, H. B., Stankowska, D. L. & Krishnamoorthy, R. R., 2022, In: Molecular vision. 28, p. 165-177 13 p.Research output: Contribution to journal › Article › peer-review
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Involvement of c-Jun N-terminal kinase 2 (JNK2) in endothelin-1 (ET-1) mediated neurodegeneration of retinal ganglion cells
Kodati, B., Stankowska, D. L., Krishnamoorthy, V. R. & Krishnamoorthy, R. R., May 2021, In: Investigative Ophthalmology and Visual Science. 62, 6, 13.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Nanoencapsulated hybrid compound sa-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
Stankowska, D. L., Millar, J. C., Kodati, B., Behera, S., Chaphalkar, R. M., Nguyen, T., Nguyen, K. T., Krishnamoorthy, R. R., Ellis, D. Z. & Acharya, S., 2021, In: Molecular vision. 27, p. 37-49 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells
Chaphalkar, R. M., Stankowska, D. L., He, S., Kodati, B., Phillips, N., Prah, J., Yang, S. & Krishnamoorthy, R. R., 1 Dec 2020, In: Scientific Reports. 10, 1, 3571.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma (Cell Death Discovery, (2019), 5, 1, (112), 10.1038/s41420-019-0194-2)
Stankowska, D. L., Nam, M. H., Nahomi, R. B., Chaphalkar, R. M., Nandi, S. K., Fudala, R., Krishnamoorthy, R. R. & Nagaraj, R. H., 1 Dec 2019, In: Cell Death Discovery. 5, 1, 122.Research output: Contribution to journal › Comment/debate
Open Access