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Personal profile

Area of Expertise

My laboratory works on the development of endothelin receptor antagonists as neuroprotective agents for the treatment of glaucoma. Glaucoma is often referred to as the “sneak thief of sight” since the disease generally produces minimal pain or discomfort. Glaucoma is an optic neuropathy, commonly associated with an elevation of intraocular pressure, resulting in the degeneration of the optic nerve and loss of retinal ganglion cells, which could lead to loss of vision. Currently, the mainstay of glaucoma treatment is reduction in intraocular pressure, however, neurodegenerative effects persist in some patients. Hence, there is an unmet need for neuroprotective treatments for glaucoma.
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.

Education/Academic qualification

PhD in Biochemistry, University of Bombay

MS in Biochemistry, University of Bombay

BS in Chemistry, University of Bombay

Fingerprint Dive into the research topics where Raghu Krishnamoorthy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Retinal Ganglion Cells Medicine & Life Sciences
Endothelin-1 Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Endothelin B Receptors Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Intraocular Pressure Medicine & Life Sciences
Endothelins Medicine & Life Sciences
Endothelin Receptors Medicine & Life Sciences

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Projects 2010 2022

Research Output 1997 2019

  • 1592 Citations
  • 20 h-Index
  • 37 Article
  • 4 Comment/debate
  • 2 Editorial
  • 2 Review article
Open Access
Retinal Ganglion Cells
Glaucoma
Publications
Cell Death
Animal Models
4 Citations (Scopus)

Targets of neuroprotection in glaucoma

He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Glaucoma
Retinal Diseases
Western World
Retinal Ganglion Cells
Aqueous Humor

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells

Wang, J., Ma, H. Y., Krishnamoorthy, R., Yorio, T. & He, S., 1 Sep 2017, In : PLoS ONE. 12, 9, e0185390.

Research output: Contribution to journalArticleResearchpeer-review

CCAAT-Enhancer-Binding Proteins
Endothelin Receptors
food law
endothelins
Endothelin B Receptors
9 Citations (Scopus)

Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons

Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R., 28 May 2017, In : Nutritional Neuroscience. 20, 5, p. 273-283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Curcumin
Neuroprotective Agents
Endothelin-1
Cell Death
Neurons
8 Citations (Scopus)

Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma

McGrady, N. R., Minton, A. Z., Stankowska, D. L., He, S., Jefferies, H. B. & Krishnamoorthy, R., 1 Mar 2017, In : BMC Neuroscience. 18, 1, 27.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin A Receptors
Intraocular Pressure
Glaucoma
Rodentia
Up-Regulation