Projects per year
Personal profile
Area of Expertise
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Education/Academic qualification
BS in Chemistry, University of Bombay
MS in Biochemistry, University of Bombay
PhD in Biochemistry, University of Bombay
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Collaborations and top research areas from the last five years
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
Krishnamoorthy, R. (PI)
30/09/17 → 31/08/21
Project: Research
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
KRISHNAMOORTHY, R. (CoPI) & Krishnamoorthy, R. (PI)
30/09/17 → 31/08/24
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J. (PI), Jones, H. (CoI), He, J. (CoI), Basha, R. (CoI), Nandy, K. (CoI), Mallet, R. (CoI), Krishnamoorthy, R. (CoI) & Simecka, J. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia
Phatak, N. R., Stankowska, D. L. & Krishnamoorthy, R. R., 24 Aug 2015, In: Cellular and Molecular Neurobiology. 35, 6, p. 769-783 15 p.Research output: Contribution to journal › Article › peer-review
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Endothelin-mediated changes in gene expression in isolated purified rat retinal ganglion cells
He, S., Park, Y. H., Yorio, T. & Krishnamoorthy, R. R., 2015, In: Investigative Ophthalmology and Visual Science. 56, 10, p. 6144-6161 18 p.Research output: Contribution to journal › Article › peer-review
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Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells
Wang, Y., Ding, M., Chaudhari, S., Ding, Y., Yuan, J., Stankowska, D., He, S., Krishnamoorthy, R., Cunningham, J. T. & Ma, R., 3 May 2013, In: Journal of Biological Chemistry. 288, 18, p. 12852-12865 14 p.Research output: Contribution to journal › Article › peer-review
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Upregulation of CD44 expression in the retina during the rds degeneration
Krishnamoorthy, R., Agarwal, N. & Chaitin, M. H., 14 Apr 2000, In: Molecular Brain Research. 77, 1, p. 125-130 6 p.Research output: Contribution to journal › Article › peer-review
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Involvement of AP-1 and C/EBPβ in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma
He, S., Minton, A. Z., Ma, H. Y., Stankowska, D. L., Sun, X. & Krishnamoorthy, R. R., 12 Nov 2013, In: PLoS ONE. 8, 11, e79183.Research output: Contribution to journal › Article › peer-review