Projects per year
Personal profile
Area of Expertise
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Education/Academic qualification
BS in Chemistry, University of Bombay
MS in Biochemistry, University of Bombay
PhD in Biochemistry, University of Bombay
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Network
Projects
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
Krishnamoorthy, R. & KRISHNAMOORTHY, R.
30/09/17 → 31/08/21
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Jones, H., He, J., Basha, R., Nandy, K., Mallet, R., Krishnamoorthy, R. & Simecka, J.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J., Mallet, R., Krishnamoorthy, R., Jones, H., Fulda, K., He, J., Basha, R. & Nandy, K.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R., He, S. & Stankowska, D.
1/09/17 → 31/08/20
Project: Research
Research Output
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Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells
Chaphalkar, R. M., Stankowska, D. L., He, S., Kodati, B., Phillips, N., Prah, J., Yang, S. & Krishnamoorthy, R. R., 1 Dec 2020, In: Scientific Reports. 10, 1, 3571.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma (Cell Death Discovery, (2019), 5, 1, (112), 10.1038/s41420-019-0194-2)
Stankowska, D. L., Nam, M. H., Nahomi, R. B., Chaphalkar, R. M., Nandi, S. K., Fudala, R., Krishnamoorthy, R. R. & Nagaraj, R. H., 1 Dec 2019, In: Cell Death Discovery. 5, 1, 122.Research output: Contribution to journal › Comment/debate
Open Access -
Targets of neuroprotection in glaucoma
He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. R. & Yorio, T., 1 Jan 2018, In: Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells
Wang, J., Ma, H. Y., Krishnamoorthy, R. R., Yorio, T. & He, S., Sep 2017, In: PLoS ONE. 12, 9, e0185390.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons
Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R. R., 28 May 2017, In: Nutritional Neuroscience. 20, 5, p. 273-283 11 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations