Projects per year
Personal profile
Area of Expertise
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Education/Academic qualification
BS in Chemistry, University of Bombay
MS in Biochemistry, University of Bombay
PhD in Biochemistry, University of Bombay
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Collaborations and top research areas from the last five years
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Mechanisms Underlying Endothel
Krishnamoorthy, R. (PI), Stankowska, D. (CoI), Inman, D. (CoI) & Clark, A. (CoI)
1/06/21 → 31/08/26
Project: Research
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
Krishnamoorthy, R. (PI)
30/09/17 → 31/08/21
Project: Research
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Mechanisms underlying endothelin mediated neurodegeneration in glaucoma
KRISHNAMOORTHY, R. (CoPI) & Krishnamoorthy, R. (PI)
30/09/17 → 31/08/24
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin/Development Core
Vishwanatha, J. (PI), Mallet, R. (CoI), Krishnamoorthy, R. (CoI), Jones, H. (CoI), Fulda, K. (CoI), He, J. (CoI), Basha, R. (CoI) & Nandy, K. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells
Wang, J., Ma, H. Y., Krishnamoorthy, R. R., Yorio, T. & He, S., Sep 2017, In: PLoS ONE. 12, 9, e0185390.Research output: Contribution to journal › Article › peer-review
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Endothelin-1, endothelin A and B receptor expression and their pharmacological properties in GFAP negative human lamina cribrosa cells
Rao, V. R., Krishnamoorthy, R. R. & Yorio, T., Jun 2007, In: Experimental eye research. 84, 6, p. 1115-1124 10 p.Research output: Contribution to journal › Article › peer-review
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Upregulation of CD44 expression in the retina during the rds degeneration
Krishnamoorthy, R., Agarwal, N. & Chaitin, M. H., 14 Apr 2000, In: Molecular Brain Research. 77, 1, p. 125-130 6 p.Research output: Contribution to journal › Article › peer-review
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Erratum: Characterization of a transformed rat retinal ganglion cell line (Brain Research Molecular Brain Research (2001) 86 (1-12))
Krishnamoorthy, R. R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W., Sheedlo, H. J., Pang, I. H., Shade, D., Wordinger, R. J., Yorio, T., Clark, A. F. & Agarwal, N., 28 Jan 2014, In: Brain Research. 1544, p. 62 1 p.Research output: Contribution to journal › Comment/debate
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Role of the ETB receptor in retinal ganglion cell death in glaucoma
Krishnamoorthy, R. R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. & Yorio, T., Jun 2008, In: Canadian Journal of Physiology and Pharmacology. 86, 6, p. 380-393 14 p.Research output: Contribution to journal › Article › peer-review