Projects per year
Personal profile
Area of Expertise
My laboratory works on the development of endothelin receptor antagonists as neuroprotective agents for the treatment of glaucoma. Glaucoma is often referred to as the “sneak thief of sight” since the disease generally produces minimal pain or discomfort. Glaucoma is an optic neuropathy, commonly associated with an elevation of intraocular pressure, resulting in the degeneration of the optic nerve and loss of retinal ganglion cells, which could lead to loss of vision. Currently, the mainstay of glaucoma treatment is reduction in intraocular pressure, however, neurodegenerative effects persist in some patients. Hence, there is an unmet need for neuroprotective treatments for glaucoma.
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Our prior studies have shown that endothelin receptors are increased in a rodent model of glaucoma and contribute to damage to the optic nerve and death of retinal ganglion cells. We are currently testing endothelin receptor antagonists for their ability to promote neuroprotection, following elevation of intraocular pressure in rats. The long term goal is to understand mechanisms by which a blockade of the endothelin receptor could promote neuroprotection and develop neuroprotective treatments for glaucoma patients.
Education/Academic qualification
PhD in Biochemistry, University of Bombay
Award Date: 1 Jan 2002
MS in Biochemistry, University of Bombay
Award Date: 1 Jan 2001
BS in Chemistry, University of Bombay
Award Date: 1 Jan 2000
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Projects
Mechanisms Underlying Endothelin Mediated Neurodegeneration in Glaucoma
Krishnamoorthy, R., He, S. & Stankowska, D.
1/09/17 → 31/08/20
Project: Research
europrotection by Endothelin Antagonists in a Rodent Model of Glaucoma
1/05/16 → 28/02/18
Project: Research
Research Output
Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma (Cell Death Discovery, (2019), 5, 1, (112), 10.1038/s41420-019-0194-2)
Stankowska, D. L., Nam, M. H., Nahomi, R. B., Chaphalkar, R. M., Nandi, S. K., Fudala, R., Krishnamoorthy, R. & Nagaraj, R. H., 1 Dec 2019, In : Cell Death Discovery. 5, 1, 122.Research output: Contribution to journal › Comment/debate
Open Access
Targets of neuroprotection in glaucoma
He, S., Stankowska, D. L., Ellis, D. Z., Krishnamoorthy, R. R. & Yorio, T., 1 Jan 2018, In : Journal of Ocular Pharmacology and Therapeutics. 34, 1-2, p. 85-106 22 p.Research output: Contribution to journal › Article
6
Scopus
citations
A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells
Wang, J., Ma, H. Y., Krishnamoorthy, R. R., Yorio, T. & He, S., Sep 2017, In : PLoS ONE. 12, 9, e0185390.Research output: Contribution to journal › Article
Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons
Stankowska, D. L., Krishnamoorthy, V. R., Ellis, D. Z. & Krishnamoorthy, R. R., 28 May 2017, In : Nutritional Neuroscience. 20, 5, p. 273-283 11 p.Research output: Contribution to journal › Article
10
Scopus
citations
Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma
McGrady, N. R., Minton, A. Z., Stankowska, D. L., He, S., Jefferies, H. B. & Krishnamoorthy, R. R., 1 Mar 2017, In : BMC Neuroscience. 18, 1, 27.Research output: Contribution to journal › Article
8
Scopus
citations