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Personal profile

Area of Expertise

The general research area of Dr. Mathew’s laboratory is Cancer Immunology. His research focuses on the Cellular and Molecular Biology of human natural killer (NK) cells and their recognition by cancer cells. NK cells are a subpopulation of lymphocytes that play an important role against cancer and various viral and bacterial infections.
Dr. Mathew is one of the pioneers who identified, cloned, and characterized several receptors expressed on human NK cells including 2B4 (CD244, SLAMF4), CS1 (CD319, SLAMF7) and LLT1 (CLEC-­2D). Research in his laboratory has identified their ligands, elucidated the signaling pathways, and also determined the transcriptional regulation of these genes in health and disease conditions. Dr. Mathew has shown that anti-­CS1 antibody activates NK cell cytotoxicity against various cancer cells. The FDA has approved a humanized anti-­CS1 mAb, Empliciti, as a breakthrough drug for multiple myeloma treatment. Thus, his research has led to the development of novel NK cell based immunotherapy for cancer. Current focus is identification of markers for cancer stem cells (CSCs) and targeting CSCs to NK cell mediated killing.

Education/Academic qualification

PhD in Biochemistry, University of Poona

MS in Biochemistry, University of Poona

BS in Physics, University of Kerala

Fingerprint Dive into the research topics where Porunelloor Mathew is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Natural Killer Cells Medicine & Life Sciences
Natural Killer Cell Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Genes Medicine & Life Sciences
T-cells Chemical Compounds
Immunoglobulins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Organism Cloning Medicine & Life Sciences

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Projects 2012 2019

Research Output 1989 2019

  • 3813 Citations
  • 30 h-Index
  • 57 Article
  • 5 Review article
  • 1 Chapter
  • 1 Short survey

2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer

Malaer, J. D., Marrufo, A. M. & Mathew, P., 1 Jul 2019, In : Clinical Immunology. 204, p. 50-56 7 p.

Research output: Contribution to journalReview article

Natural Killer Cells
Systemic Lupus Erythematosus
Multiple Myeloma
Natural Killer Cell Receptors
1 Citation (Scopus)

A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells

Bowen, K. E., Mathew, S. O., Borgmann, K., Ghorpade, A. & Mathew, P. A., Feb 2018, In : PLoS ONE. 13, 2, e0193008.

Research output: Contribution to journalArticle

Natural Cytotoxicity Triggering Receptor 2
natural killer cells

CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma

Malaer, J. D. & Mathew, P., 1 Jan 2017, In : American Journal of Cancer Research. 7, 8, p. 1637-1641 5 p.

Research output: Contribution to journalReview article

Multiple Myeloma
Natural Killer Cells
Natural Killer Cell Receptors
Antibody-Dependent Cell Cytotoxicity
7 Citations (Scopus)

Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells

Kim, J. R., Mathew, S. O. & Mathew, P., 1 Jan 2016, In : Immunobiology. 221, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Multiple Myeloma
Genetic Promoter Regions
9 Citations (Scopus)
Natural Killer Cells
Prostatic Neoplasms
Natural Killer Cell Receptors
Cell Line
Second Primary Neoplasms