• 582 Citations
  • 16 h-Index
20052022
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Personal profile

Area of Expertise

My research focuses on various aspects of carcinogenesis, particularly the molecular mechanisms underlying triple-negative breast cancer growth and metastasis. A major focus of our work has been on investigating the molecular basis of Annexin A2 function in promoting triple-negative breast cancer metastasis and angiogenesis. Increased expression of Annexin A2 is commonly observed in triple-negative breast cancer. Our findings demonstrated that Annexin A2 overexpression is associated with racial variation and is a potential prognostic candidate for triple-negative breast cancer in African-American women. In addition, we identified Annexin A2 as a potential metastatic target protein in modulation triple-negative breast cancer tumor microenvironments. Currently, our laboratory is validating these findings and determining if Annexin A2 contributes to the disproportionate occurrence of triple-negative breast cancer and clinical outcome in African-American women. The long-term goal of our research is to develop improved therapeutic options for aggressive triple-negative breast cancer.

Education/Academic qualification

MS in Microbiology, Dr. R.M.L. Awadh University

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Projects 2017 2022

Research Output 2005 2019

  • 582 Citations
  • 16 h-Index
  • 21 Article
  • 6 Review article
  • 1 Comment/debate

ANXA2 expression in African American triple-negative breast cancer patients

Gibbs, L. D., Chaudhary, P., Mansheim, K., Hare, R. J., Mantsch, R. A. & Vishwanatha, J. K., 28 Feb 2019, In : Breast Cancer Research and Treatment. 174, 1, p. 113-120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Annexin A2
Triple Negative Breast Neoplasms
African Americans
In Situ Hybridization
Breast Neoplasms
34 Citations (Scopus)

Exosomal annexin II promotes angiogenesis and breast cancer metastasis

Maji, S., Chaudhary, P., Akopova, I., Nguyen, P. M., Hare, R. J., Gryczynski, I. & Vishwanatha, J. K., 1 Jan 2017, In : Molecular Cancer Research. 15, 1, p. 93-105 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Annexin A2
Breast Neoplasms
Neoplasm Metastasis
Exosomes
Atomic Force Microscopy
14 Citations (Scopus)

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

Awasthi, Y. C., Ramana, K. V., Chaudhary, P., Srivastava, S. K. & Awasthi, S., 1 Oct 2017, In : Free Radical Biology and Medicine. 111, p. 235-243 9 p.

Research output: Contribution to journalReview articleResearchpeer-review

Glutathione Transferase
Toxicity
Modulation
Cell signaling
Poisons
6 Citations (Scopus)

MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics

Kpetemey, M., Chaudhary, P., Van Treuren, T. V. & Vishwanatha, J. K., 1 Jan 2016, In : Oncotarget. 7, 34, p. 54913-54924 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Focal Adhesions
Cell Movement
Actins
Breast Neoplasms
Phosphorylation
4 Citations (Scopus)

Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

Mathew, S. O., Chaudhary, P., Powers, S. B., Vishwanatha, J. K. & Mathew, P., 1 Jan 2016, In : Oncotarget. 7, 42, p. 68650-68661 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Natural Killer Cells
Prostatic Neoplasms
Natural Killer Cell Receptors
Cell Line
Second Primary Neoplasms