Projects per year
Personal profile
URL
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Research Interests
Genomics, epigenomics, transcriptomics
Mitochondrial genetics and biology
Aging and Alzheimer's disease
Health disparities in complex disease
Preeclampsia
Area of Expertise
Dr. Nicole Phillips serves as the Project Lead for the Genomics Core in the Institute of Translational Research (ITR), and her team collaborates closely with Dr. Robert Barber (TCOM, Director of ITR Genomics Core). Her research program has several areas of focus, including:
- Application of multi-omics methods to further our understanding of the biological sources of health disparities in complex age-related diseases, such as Alzheimer's Disease (TARCC and NIH-funded);
- Studies of mitochondrial DNA and mitochondrial function, in the context of various disease states such as Alzheimer’s disease, type 2 diabetes, and preeclampsia (in collaboration with Dr. Stella Goulopoulou at Loma Linda University, NIH-funded);
- Development of novel, nanopore-based sequencing applications for advancing detection of base modifications and human identification methods (NIJ-funded).
Education/Academic qualification
MS in Forensic Genetics, UNT Health Science Center
PhD in Molecular & Medical Genetics, UNT Health Science Center
BS in Biology, University of Houston
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Collaborations and top research areas from the last five years
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Projects
- 8 Finished
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Circulating Cell-Free Mitochondrial DNA in a Preclinical Model of Preeclampsia with Placental Ischemia
Goulopoulou, S. & Phillips, N.
1/07/19 → 30/06/22
Project: Research
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Epigenetic Risk Factors for Early Age at Onset of Alzheimer¿s & MCI Among Non-Caribbean Hispanics
Barber, R., Phillips, N. & Zhou, Z.
22/08/18 → 31/08/20
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Admin Suppliment
Vishwanatha, J., Phillips, N., Barber, R. & Zhou, Z.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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The Osteopathic Approach to Chronic Pain Management: Assessing its Biopsychosocial Processes and Relationships to Clinical Outcomes
Licciardone, J., Phillips, N. & Aryal, S.
American Osteopathic Association
1/09/17 → 31/08/19
Project: Research
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Nanosensing of Oxidized Cell-free mtDNA: Biomarkers of Inflammation and Mitochondrial Dysfunction
Phillips, N., Planz, J. & Goulopoulou, S.
1/06/17 → 31/05/18
Project: Research
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Multiomics investigation of hypertension and white matter hyperintensi-ty as a source of vascular dementia or a comorbidity to alzheimer’s disease
Pathak, G. A., Barber, R. C. & Phillips, N. R., 2021, In: Current Alzheimer Research. 18, 2, p. 171-177 7 p.Research output: Contribution to journal › Article › peer-review
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Mitochondrial genome Interrogation for forensic casework and research studies
Roby, R. K., Sprouse, M., Phillips, N., Alicea-Centeno, A., Shewale, S., Shore, S. & Paul, N., 2014, In: Current Protocols in Human Genetics. SUPPL.81, 14.9.Research output: Contribution to journal › Article › peer-review
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The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States
Jones, H. P. & Phillips, N. R., Oct 2021, In: Nature Immunology. 22, 10, p. 1188-1189 2 p.Research output: Contribution to journal › Article › peer-review
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Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites
HABS-HD Study Team, 2022, In: Journal of Alzheimer's Disease. 90, 2, p. 905-915 11 p.Research output: Contribution to journal › Article › peer-review
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Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer
for the Alzheimer's Disease Neuroimaging Initiative, Breast and Prostate Cancer Cohort Consortium, and Alzheimer's Disease Genetics Consortium, 1 Jan 2020, In: Alzheimer's and Dementia. 16, 1, p. 162-177 16 p.Research output: Contribution to journal › Article › peer-review