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Personal profile

Area of Expertise

I first arrived at UNTHSC in 2007 as a Masters student in the Forensic Genetics Program, working extensively in research on expert systems and software development for the field. Upon graduating in 2009, and having found a love for research, I decided to pursue a PhD in Molecular Genetics, which was conferred in December of 2013. Throughout my experience at UNTHSC as a student and postdoctoral fellow, my research interests evolved. With my roots in forensic genetics, I began studying genetics of age-related, complex disease. In 2016, I returned to UNTHSC as a faculty member and have established a diverse research program.
Our laboratory has a several areas of interest:
1) studies of mitochondrial DNA and mitochondrial function, in the context of various disease states such as Alzheimer’s disease, type 2 diabetes and preeclampsia (in collaboration with Dr. Stella Goulopoulou);
2) genetic aspects of pain and pain management, as the Director for Genomic Research for PRECISION Texas;
3) genetic risk for age-related disease and comorbidity patterns, via genome-wide genotyping, methylation profiling, and data mining.

Education/Academic qualification

PhD in Molecular & Medical Genetics, UNT Health Science Center

MS in Forensic Genetics, UNT Health Science Center

BS in Biology, University of Houston

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 8 Similar Profiles
Mitochondrial DNA Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences
Real-Time Polymerase Chain Reaction Medicine & Life Sciences
Mexican Americans Agriculture & Biology
Alzheimer disease Agriculture & Biology
Mitochondrial Genome Medicine & Life Sciences
Gene Frequency Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2019

  • 102 Citations
  • 6 h-Index
  • 8 Article
  • 2 Review article

Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

Silzer, T., Barber, R. C., Sun, J., Pathak, G., Johnson, L. A., O'Bryant, S. & Phillips, N. R., 1 Mar 2019, In : PLoS ONE. 14, 3, e0213527.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Mexican Americans
Medical problems
Mitochondrial DNA
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
3 Citations (Scopus)

Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria

Silzer, T. K. & Phillips, N. R., 1 Nov 2018, In : Mitochondrion. 43, p. 16-24 9 p.

Research output: Contribution to journalReview articleResearchpeer-review

Type 2 Diabetes Mellitus
Alzheimer Disease
Mitochondria
Pathology
Population
6 Citations (Scopus)

Can genetic analysis of putative blood Alzheimer's disease biomarkers lead to identification of susceptibility loci?

Barber, R. C., Phillips, N. R., Tilson, J. L., Huebinger, R. M., Shewale, S. J., Koenig, J. L., Mitchel, J. S., O'Bryant, S., Waring, S. C., Diaz-Arrastia, R., Chasse, S. & Wilhelmsen, K. C., 1 Dec 2015, In : PLoS ONE. 10, 12, e0142360.

Research output: Contribution to journalArticleResearchpeer-review

Hematologic Diseases
Biomarkers
Alzheimer disease
Endophenotypes
genetic techniques and protocols
8 Citations (Scopus)

Internal validation of human mitochondrial DNA quantification using real-time PCR

Sprouse, M. L., Phillips, N. R., Kavlick, M. F. & Roby, R. K., 1 Jan 2014, In : Journal of forensic sciences. 59, 4, p. 1049-1056 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial DNA
Real-Time Polymerase Chain Reaction
Sequence Analysis
Tooth
Coloring Agents
19 Citations (Scopus)

Mitochondrial DNA deletions in Alzheimer's brains: A review

Phillips, N. R., Simpkins, J. W. & Roby, R. K., 1 Jan 2014, In : Alzheimer's and Dementia. 10, 3, p. 393-400 8 p.

Research output: Contribution to journalReview articleResearchpeer-review

Mitochondrial DNA
Alzheimer Disease
Brain
Nucleic Acids
Disease Progression