• 133 Citations
  • 6 h-Index
20092022

Research output per year

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Personal profile

Area of Expertise

I first arrived at UNTHSC in 2007 as a Masters student in the Forensic Genetics Program, working extensively in research on expert systems and software development for the field. Upon graduating in 2009, and having found a love for research, I decided to pursue a PhD in Molecular Genetics, which was conferred in December of 2013. Throughout my experience at UNTHSC as a student and postdoctoral fellow, my research interests evolved. With my roots in forensic genetics, I began studying genetics of age-related, complex disease. In 2016, I returned to UNTHSC as a faculty member and have established a diverse research program.
Our laboratory has a several areas of interest:
1) studies of mitochondrial DNA and mitochondrial function, in the context of various disease states such as Alzheimer’s disease, type 2 diabetes and preeclampsia (in collaboration with Dr. Stella Goulopoulou);
2) genetic aspects of pain and pain management, as the Director for Genomic Research for PRECISION Texas;
3) genetic risk for age-related disease and comorbidity patterns, via genome-wide genotyping, methylation profiling, and data mining.

Education/Academic qualification

PhD in Molecular & Medical Genetics, UNT Health Science Center

Award Date: 1 Jan 2002

MS in Forensic Genetics, UNT Health Science Center

Award Date: 1 Jan 2001

BS in Biology, University of Houston

Award Date: 1 Jan 2000

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Projects

Research Output

  • 133 Citations
  • 6 h-Index
  • 11 Article
  • 2 Review article

Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer

for the Alzheimer's Disease Neuroimaging Initiative, Breast and Prostate Cancer Cohort Consortium, and Alzheimer's Disease Genetics Consortium, 1 Jan 2020, In : Alzheimer's and Dementia. 16, 1, p. 162-177 16 p.

Research output: Contribution to journalArticle

Open Access
  • Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

    Silzer, T., Barber, R., Sun, J., Pathak, G., Johnson, L., O’Bryant, S. & Phillips, N., Mar 2019, In : PLoS ONE. 14, 3, e0213527.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities

    Pathak, G. A., Silzer, T. K., Sun, J., Zhou, Z., Daniel, A. A., Johnson, L., O'Bryant, S., Phillips, N. R. & Barber, R. C., 1 Jan 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 733-749 17 p.

    Research output: Contribution to journalArticle

  • Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria

    Silzer, T. K. & Phillips, N. R., Nov 2018, In : Mitochondrion. 43, p. 16-24 9 p.

    Research output: Contribution to journalReview article

  • 10 Scopus citations
  • 4 Scopus citations