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Personal profile

Area of Expertise

My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.

Education/Academic qualification

PhD in Biochemistry, Southern Methodist University

BS in Physiology, University of Mont Saint Aigna

Fingerprint Dive into the research topics where Nathalie Sumien is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Antioxidants Medicine & Life Sciences
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Vitamin E Chemical Compounds

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Projects 2010 2024

Research Output 2003 2020

  • 680 Citations
  • 14 h-Index
  • 35 Article
  • 2 Review article
  • 1 Chapter

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 1 Jan 2019, (Accepted/In press) In : Behavioural Brain Research. 378, 112278.

Research output: Contribution to journalArticle

Long-Term Potentiation
Wounds and Injuries

Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Glycerolphosphate Dehydrogenase

Supplementation with N-acetyl cysteine affects motor and cognitive function in young but not old mice

Ikonne, U. S., Vann, P. H., Wong, J. M., Forster, M. J. & Sumien, N., 1 Mar 2019, In : Journal of Nutrition. 149, 3, p. 463-470 8 p.

Research output: Contribution to journalArticle

Dietary Supplements

Creatine, creatine kinase, and aging

Sumien, N., Shetty, R. A. & Gonzales, E. B., 1 Jan 2018, Subcellular Biochemistry. Springer New York, p. 145-168 24 p. (Subcellular Biochemistry; vol. 90).

Research output: Chapter in Book/Report/Conference proceedingChapter

Creatine Kinase
Aging of materials
Dietary supplements
13 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Tyrosine 3-Monooxygenase