Projects per year
Personal profile
Area of Expertise
My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
Education/Academic qualification
PhD in Biochemistry, Southern Methodist University
BS in Physiology, University of Mont Saint Aigna
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Training in the Neurobiology of Aging and Alzheimer's Disease
NIA: National Institute on Aging
1/05/19 → 30/04/24
Project: Research
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Training in the Neurobiology of Aging and Alzheimer's Disease
NIA: National Institute on Aging
1/05/19 → 30/04/24
Project: Research
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Post Stroke Cognitive Impairment: Mechanism and Therapy
Yang, S., Liu, R., Sumien, N. & Jin, K.
NINDS: Neurological Disorders & Stroke
1/02/19 → 31/01/24
Project: Research
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Using rodent behavioral models to identify substance abuse pharmacotherapies
Forster, M., Gatch, M., Sumien, N. & Shetty, R.
NIDA: National Institute on Drug Abuse
20/09/18 → 3/01/23
Project: Research
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Behavioral effects of four novel synthetic cathinone analogs in rodents
Gatch, M. B., Shetty, R. A., Sumien, N. & Forster, M. J., Jul 2021, In: Addiction Biology. 26, 4, e12987.Research output: Contribution to journal › Article › peer-review
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Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease
Chaudhari, K., Wang, L., Kruse, J., Winters, A., Sumien, N., Shetty, R., Prah, J., Liu, R., Shi, J., Forster, M. & Yang, S. H., 2021, In: Neurological Research. 43, 7, p. 570-581 12 p.Research output: Contribution to journal › Article › peer-review
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Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment
Nguyen, D. H., Cunningham, J. T. & Sumien, N., Feb 2021, In: GeroScience. 43, 1, p. 159-166 8 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Evaluation of substituted n-phenylpiperazine analogs as D3 vs. D2 dopamine receptor subtype selective ligands
Lee, B., Taylor, M., Griffin, S. A., McInnis, T., Sumien, N., Mach, R. H. & Luedtke, R. R., 1 Jun 2021, In: Molecules. 26, 11, 3182.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease
Sumien, N., Wells, M. S., Sidhu, A., Wong, J. M., Forster, M. J., Zheng, Q. X. & Kelleher-Andersson, J. A., Dec 2021, In: Stem Cell Research and Therapy. 12, 1, 59.Research output: Contribution to journal › Article › peer-review
Open Access