Projects per year
Personal profile
Area of Expertise
My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
Education/Academic qualification
PhD in Biochemistry, Southern Methodist University
BS in Physiology, University of Mont Saint Aigna
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Projects
Effect of Novel Compound on Auditory Function and on Biochemical Markers in Aged Mice
1/06/19 → 30/06/20
Project: Research
Training in the Neurobiology of Aging and Alzheimer's Disease
NIA: National Institute on Aging
1/05/19 → 30/04/24
Project: Research
Training in the Neurobiology of Aging and Alzheimer's Disease
NIA: National Institute on Aging
1/05/19 → 30/04/24
Project: Research
Effects of Aging on Blood Vessels in the Cerebellar Vermis
Jin, K., Forster, M. & Sumien, N.
NIA: National Institute on Aging
1/04/19 → 31/01/21
Project: Research
Post Stroke Cognitive Impairment: Mechanism and Therapy
Yang, S., Liu, R., Sumien, N. & Jin, K.
NINDS: Neurological Disorders & Stroke
1/02/19 → 31/01/24
Project: Research
Research Output
Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke
Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.Research output: Contribution to journal › Article
Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging
Zhao, X., Fan, Y., Vann, P. H., Wong, J. M., Sumien, N. & He, J. J., 1 Feb 2020, In : Aging and Disease. 11, 1, p. 93-107 15 p.Research output: Contribution to journal › Review article
Open Access
Pharmacologic fibroblast reprogramming into photoreceptors restores vision
Mahato, B., Kaya, K. D., Fan, Y., Sumien, N., Shetty, R. A., Zhang, W., Davis, D., Mock, T., Batabyal, S., Ni, A., Mohanty, S., Han, Z., Farjo, R., Forster, M. J., Swaroop, A. & Chavala, S. H., 7 May 2020, In : Nature. 581, 7806, p. 83-88 6 p.Research output: Contribution to journal › Article
2
Scopus
citations
Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice
Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.Research output: Contribution to journal › Article
Open Access
3
Scopus
citations
Supplementation with N-acetyl cysteine affects motor and cognitive function in young but not old mice
Ikonne, U. S., Vann, P. H., Wong, J. M., Forster, M. J. & Sumien, N., 1 Mar 2019, In : Journal of Nutrition. 149, 3, p. 463-470 8 p.Research output: Contribution to journal › Article