• 767 Citations
  • 17 h-Index

Research output per year

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Personal profile

Area of Expertise

My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.

Education/Academic qualification

PhD in Biochemistry, Southern Methodist University

BS in Physiology, University of Mont Saint Aigna

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Research Output

  • 767 Citations
  • 17 h-Index
  • 36 Article
  • 3 Review article
  • 1 Chapter

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.

Research output: Contribution to journalArticle

  • Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging

    Zhao, X., Fan, Y., Vann, P. H., Wong, J. M., Sumien, N. & He, J. J., 1 Feb 2020, In : Aging and Disease. 11, 1, p. 93-107 15 p.

    Research output: Contribution to journalReview article

    Open Access
  • Pharmacologic fibroblast reprogramming into photoreceptors restores vision

    Mahato, B., Kaya, K. D., Fan, Y., Sumien, N., Shetty, R. A., Zhang, W., Davis, D., Mock, T., Batabyal, S., Ni, A., Mohanty, S., Han, Z., Farjo, R., Forster, M. J., Swaroop, A. & Chavala, S. H., 7 May 2020, In : Nature. 581, 7806, p. 83-88 6 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Metformin alters locomotor and cognitive function and brain metabolism in normoglycemic mice

    Li, W., Chaudhari, K., Shetty, R., Winters, A., Gao, X., Hu, Z., Ge, W. P., Sumien, N., Forster, M., Liu, R. & Yang, S. H., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 949-963 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Supplementation with N-acetyl cysteine affects motor and cognitive function in young but not old mice

    Ikonne, U. S., Vann, P. H., Wong, J. M., Forster, M. J. & Sumien, N., 1 Mar 2019, In : Journal of Nutrition. 149, 3, p. 463-470 8 p.

    Research output: Contribution to journalArticle