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Personal profile

Area of Expertise

My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.

Education/Academic qualification

PhD in Biochemistry, Southern Methodist University

BS in Physiology, University of Mont Saint Aigna

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2010 2024

Research Output 2003 2019

  • 636 Citations
  • 14 h-Index
  • 33 Article
  • 2 Review article
  • 1 Chapter

Supplementation with N-acetyl cysteine affects motor and cognitive function in young but not old mice

Ikonne, U. S., Vann, P. H., Wong, J. M., Forster, M. J. & Sumien, N., 1 Mar 2019, In : Journal of Nutrition. 149, 3, p. 463-470 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cognition
Cysteine
Dietary Supplements
Diet
Running

Creatine, creatine kinase, and aging

Sumien, N., Shetty, R. A. & Gonzales, E. B., 1 Jan 2018, Subcellular Biochemistry. Springer New York, p. 145-168 24 p. (Subcellular Biochemistry; vol. 90).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Creatine
Creatine Kinase
Aging of materials
Dietary supplements
Physiology
12 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia
3 Citations (Scopus)

Effects of creatine supplementation on nociception in young male and female mice

Izurieta Munoz, H., Gonzales, E. B. & Sumien, N., 1 Apr 2018, In : Pharmacological Reports. 70, 2, p. 316-321 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nociception
Creatine
Diet
Acid Sensing Ion Channels
Pain

Gait analyses in mice: Effects of age and glutathione deficiency

Thomas Mock, J., Knight, S. G., Vann, P. H., Wong, J. M., Davis, D. L., Forster, M. J. & Sumien, N., 1 Jan 2018, In : Aging and Disease. 9, 4, p. 634-646 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gait
Glutathione
Rodentia
Glutathione Disulfide
Research