Projects per year
Personal profile
Area of Expertise
My scientific interests are focused on identifying interventions improving motor and cognitive function during aging and disease state. Our focus has been on the interaction between antioxidant supplementation and exercise, and whether combining the two anti-aging interventions would further their benefit on brain function declines associated with aging and Alzheimer’s disease.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
My laboratory also works on other interventions for other conditions: sigma 1 compounds and chemobrain (brain dysfunction associated with chemotherapy), hyperbaric oxygen therapy to alleviate the symptoms of Alzheimer’s disease, and new antiaging therapy manipulating internal acidity. Identifying successful interventions and their interaction with factors such as genes and gender will lead to specialized recommendations to patients. Furthermore, it will allow us to determine specific mechanisms involved in positive outcomes leading to the development of therapeutic methods to ultimately improve health span of individuals.
Another project of the laboratory is to study the interaction of stroke and/or aging with drugs of abuse and to determine whether drug use makes individuals more susceptible to stroke and development of accelerated aging.
Education/Academic qualification
PhD in Biochemistry, Southern Methodist University
BS in Physiology, University of Mont Saint Aigna
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Collaborations and top research areas from the last five years
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A Novel Neuroprotective Approa
Prokai-Tatrai, K. (PI), Sumien, N. (CoI) & Prokai, L. (CoI)
1/02/23 → 31/01/28
Project: Research
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Using rodent behavioral models
Forster, M. (PI), Gatch, M. (CoI), Shetty, R. (CoI) & Sumien, N. (CoI)
NIDA: National Institute on Drug Abuse
4/01/23 → 3/01/28
Project: Research
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Pharmacologic fibroblast reprogramming into photoreceptors restores vision
Mahato, B., Kaya, K. D., Fan, Y., Sumien, N., Shetty, R. A., Zhang, W., Davis, D., Mock, T., Batabyal, S., Ni, A., Mohanty, S., Han, Z., Farjo, R., Forster, M. J., Swaroop, A. & Chavala, S. H., 7 May 2020, In: Nature. 581, 7806, p. 83-88 6 p.Research output: Contribution to journal › Article › peer-review
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Once Used, Once Counted
Aguilar, C., Garcia, K. & Sumien, N., Mar 2023, In: Lab Animal. 52, 3, p. 53-54 2 p.Research output: Contribution to journal › Comment/debate
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Exercise training and antioxidant supplementation independently improve cognitive function in adult male and female GFAP-APOE mice
Chaudhari, K., Wong, J. M., Vann, P. H. & Sumien, N., Sep 2014, In: Journal of Sport and Health Science. 3, 3, p. 196-205 10 p.Research output: Contribution to journal › Article › peer-review
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Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes
Wu, J., Luo, X., Thangthaeng, N., Sumien, N., Chen, Z., Rutledge, M. A., Jing, S., Forster, M. J. & Yan, L. J., Sep 2017, In: Biochemistry and Biophysics Reports. 11, p. 119-129 11 p.Research output: Contribution to journal › Article › peer-review
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Gait analyses in mice: Effects of age and glutathione deficiency
Thomas Mock, J., Knight, S. G., Vann, P. H., Wong, J. M., Davis, D. L., Forster, M. J. & Sumien, N., 2018, In: Aging and Disease. 9, 4, p. 634-646 13 p.Research output: Contribution to journal › Article › peer-review