Projects per year
Personal profile
Area of Expertise
I aim to understand the molecular basis for locomotor impairment in aging and Parkinson's disease. My immediate and long-term goals are to discover molecular, pharmacological, and non-invasive (exercise, calorie restriction) approaches that can target proteins associated with motor impairment, thereby reducing or eliminating locomotor impairment associated with aging and Parkinson’s disease.
Education/Academic qualification
PhD in Neuroscience, Louisiana State University Health Sciences Center
BA, Ohio Wesleyan University
Fingerprint Dive into the research topics where Michael Salvatore is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Tyrosine 3-Monooxygenase
Medicine & Life Sciences
Dopamine
Medicine & Life Sciences
Corpus Striatum
Medicine & Life Sciences
Substantia Nigra
Medicine & Life Sciences
Phosphorylation
Chemical Compounds
Parkinson Disease
Medicine & Life Sciences
Glial Cell Line-Derived Neurotrophic Factor
Medicine & Life Sciences
Oxidopamine
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2015 2022
Translation of Evaluating Exercise-impact on Aging-related Motor Function Between Rats and Humans
1/01/17 → 30/06/18
Project: Research
Targeting Nigral Tyrosine Hydroxylase to Improve Locomotion in Aging
NIA: National Institute on Aging
5/01/15 → 31/03/16
Project: Research
Research Output 1997 2019
GFR-α1 Expression in Substantia Nigra Increases Bilaterally following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss following 6-OHDA Nigrostriatal Lesion
Kasanga, E. A., Owens, C. L., Cantu, M. A., Richard, A. D., Davis, R. W., McDivitt, L. M., Blancher, B., Pruett, B. S., Tan, C., Gajewski, A., Manfredsson, F. P., Nejtek, V. A. & Salvatore, M. F., 16 Oct 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4237-4249 13 p.Research output: Contribution to journal › Article
Glial Cell Line-Derived Neurotrophic Factor
Corpus Striatum
Oxidopamine
Tyrosine 3-Monooxygenase
Substantia Nigra
1
Citation
(Scopus)
Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease
Churchill, M. J., Cantu, M. A., Kasanga, E. A., Moore, C., Salvatore, M. F. & Meshul, C. K., 21 Aug 2019, In : Neuroscience. 414, p. 8-27 20 p.Research output: Contribution to journal › Article
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Tyrosine 3-Monooxygenase
Parkinson Disease
Dopamine
3,4-Dihydroxyphenylacetic Acid
1
Citation
(Scopus)
Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency
Salvatore, M. F., McInnis, T. R., Cantu, M. A., Apple, D. M. & Pruett, B. S., 1 Apr 2019, In : Molecular Neurobiology. 56, 4, p. 2728-2740 13 p.Research output: Contribution to journal › Article
Tyrosine 3-Monooxygenase
Substantia Nigra
Dopamine
Hypokinesia
Corpus Striatum
2
Citations
(Scopus)
Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine
Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myöhänen, T. T., Rannanpää, S., Salvatore, M. F., Andressoo, J. O. & Piepponen, T. P., 1 Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.Research output: Contribution to journal › Article
Glial Cell Line-Derived Neurotrophic Factor
Amphetamine
Dopamine
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
13
Citations
(Scopus)
Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention
Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.Research output: Contribution to journal › Article
Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia