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Personal profile

Area of Expertise

I aim to understand the molecular basis for locomotor impairment in aging and Parkinson's disease. My immediate and long-term goals are to discover molecular, pharmacological, and non-invasive (exercise, calorie restriction) approaches that can target proteins associated with motor impairment, thereby reducing or eliminating locomotor impairment associated with aging and Parkinson’s disease.

Education/Academic qualification

PhD in Neuroscience, Louisiana State University Health Sciences Center

BA, Ohio Wesleyan University

Fingerprint Dive into the research topics where Michael Salvatore is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Tyrosine 3-Monooxygenase Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences
Substantia Nigra Medicine & Life Sciences
Phosphorylation Chemical Compounds
Parkinson Disease Medicine & Life Sciences
Glial Cell Line-Derived Neurotrophic Factor Medicine & Life Sciences
Oxidopamine Medicine & Life Sciences

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Projects 2015 2022

Research Output 1997 2019

  • 1046 Citations
  • 19 h-Index
  • 41 Article
  • 2 Review article
  • 1 Chapter

GFR-α1 Expression in Substantia Nigra Increases Bilaterally following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss following 6-OHDA Nigrostriatal Lesion

Kasanga, E. A., Owens, C. L., Cantu, M. A., Richard, A. D., Davis, R. W., McDivitt, L. M., Blancher, B., Pruett, B. S., Tan, C., Gajewski, A., Manfredsson, F. P., Nejtek, V. A. & Salvatore, M. F., 16 Oct 2019, In : ACS Chemical Neuroscience. 10, 10, p. 4237-4249 13 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Corpus Striatum
Oxidopamine
Tyrosine 3-Monooxygenase
Substantia Nigra
1 Citation (Scopus)

Glatiramer Acetate Reverses Motor Dysfunction and the Decrease in Tyrosine Hydroxylase Levels in a Mouse Model of Parkinson's Disease

Churchill, M. J., Cantu, M. A., Kasanga, E. A., Moore, C., Salvatore, M. F. & Meshul, C. K., 21 Aug 2019, In : Neuroscience. 414, p. 8-27 20 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Tyrosine 3-Monooxygenase
Parkinson Disease
Dopamine
3,4-Dihydroxyphenylacetic Acid
1 Citation (Scopus)

Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency

Salvatore, M. F., McInnis, T. R., Cantu, M. A., Apple, D. M. & Pruett, B. S., 1 Apr 2019, In : Molecular Neurobiology. 56, 4, p. 2728-2740 13 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Substantia Nigra
Dopamine
Hypokinesia
Corpus Striatum
2 Citations (Scopus)

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myöhänen, T. T., Rannanpää, S., Salvatore, M. F., Andressoo, J. O. & Piepponen, T. P., 1 Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Amphetamine
Dopamine
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
13 Citations (Scopus)

Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: Evidence from calorie restriction intervention

Salvatore, M. F., Terrebonne, J., Cantu, M. A., McInnis, T. R., Venable, K., Kelley, P., Kasanga, E. A., Latimer, B., Owens, C. L., Pruett, B. S., Yu, Y., Luedtke, R. T., Forster, M. J., Sumien, N. & Ingram, D. K., 1 Jan 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia