Projects per year
Personal profile
Research Interests
Substance use disorders.
Aging
Alzheimers disease
In vivo small animal imaging
Cognition in neuropsychiatric disorders
URL
Area of Expertise
My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.
Techniques
MRI, Connectomics, Functional connectivity
Tractography, Network neuroscience, Graph theory, Resting state fMRI
Education/Academic qualification
PhD Physics, University of Florida
BS Physics, University of Puerto Rico
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Collaborations and top research areas from the last five years
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Determining the Effects of Bat
Colon-Perez, L. (PI)
NIDA: National Institute on Drug Abuse
1/04/22 → 31/03/25
Project: Research
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Longitudinal biophysical markers of neuroinflammation due to morphine self-administration
Colon-Perez, L. (PI)
Brain & Behavior Research Foundation
3/01/22 → 14/01/23
Project: Research
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Determining the effects of "bath salts" on cognitive control and functional brain connectivity
COLON-PEREZ, L. (CoPI) & Colon-Perez, L. (PI)
National Institute on Drug Abuse
1/04/19 → 31/03/24
Project: Research
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Metal transporter Zip14 (Slc39a14) deletion in mice increases manganese deposition and produces neurotoxic signatures and diminished motor activity
Aydemir, T. B., Kim, M. H., Kim, J., Colon-Perez, L. M., Banan, G., Mareci, T. H., Febo, M. & Cousins, R. J., 21 Jun 2017, In: Journal of Neuroscience. 37, 25, p. 5996-6006 11 p.Research output: Contribution to journal › Article › peer-review
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Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based spatial statistics, probabilistic tractography and a novel graph theory metric
Kuhn, T., Gullett, J. M., Nguyen, P., Boutzoukas, A. E., Ford, A., Colon-Perez, L. M., Triplett, W., Carney, P. R., Mareci, T. H., Price, C. C. & Bauer, R. M., 1 Jun 2016, In: Brain Imaging and Behavior. 10, 2, p. 533-547 15 p.Research output: Contribution to journal › Article › peer-review
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High-field magnetic resonance imaging of the human temporal lobe
Colon-Perez, L. M., King, M., Parekh, M., Boutzoukas, A., Carmona, E., Couret, M., Klassen, R., Mareci, T. H. & Carney, P. R., 17 Aug 2015, In: NeuroImage: Clinical. 9, p. 58-68 11 p.Research output: Contribution to journal › Article › peer-review
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Editorial: Novel tools for the study of structural and functional networks in the brain
Colon-Perez, L. M., Mareci, T. & Ding, M., 21 Feb 2018, In: Frontiers in Physics. 5, FEB, 11.Research output: Contribution to journal › Editorial
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The future of neuroimaging and gut-brain axis research for substance use disorders
Colon-Perez, L., Montesinos, J. & Monsivais, M., 15 Apr 2022, In: Brain Research. 1781, 147835.Research output: Contribution to journal › Review article › peer-review