Personal profile
Research Interests
Substance use disorders.
Aging
Alzheimers disease
In vivo small animal imaging
Cognition in neuropsychiatric disorders
URL
Area of Expertise
My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.
Techniques
MRI, Connectomics, Functional connectivity
Tractography, Network neuroscience, Graph theory, Resting state fMRI
Education/Academic qualification
PhD Physics, University of Florida
BS Physics, University of Puerto Rico
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Collaborations and top research areas from the last five years
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Determining the Effects of Bat
Colon-Perez, L. (PI)
NIDA: National Institute on Drug Abuse
1/04/22 → 31/03/25
Project: Research
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Longitudinal biophysical markers of neuroinflammation due to morphine self-administration
Colon-Perez, L. (PI)
Brain & Behavior Research Foundation
3/01/22 → 14/01/23
Project: Research
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Determining the effects of "bath salts" on cognitive control and functional brain connectivity
COLON-PEREZ, L. (CoPI) & Colon-Perez, L. (PI)
National Institute on Drug Abuse
1/04/19 → 31/03/24
Project: Research
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Editorial: Novel tools for the study of structural and functional networks in the brain
Colon-Perez, L. M., Mareci, T. & Ding, M., 21 Feb 2018, In: Frontiers in Physics. 5, FEB, 11.Research output: Contribution to journal › Editorial
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Sustained captopril-induced reduction in blood pressure is associated with alterations in Gut-Brain axis in the spontaneously hypertensive rat
Yang, T., Aquino, V., Lobaton, G. O., Li, H., Colon-Perez, L., Goel, R., Qi, Y., Zubcevic, J., Febo, M., Richards, E. M., Pepine, C. J. & Raizada, M. K., 2019, In: Journal of the American Heart Association. 8, 4, e010721.Research output: Contribution to journal › Article › peer-review
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High-field magnetic resonance imaging of the human temporal lobe
Colon-Perez, L. M., King, M., Parekh, M., Boutzoukas, A., Carmona, E., Couret, M., Klassen, R., Mareci, T. H. & Carney, P. R., 17 Aug 2015, In: NeuroImage: Clinical. 9, p. 58-68 11 p.Research output: Contribution to journal › Article › peer-review
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Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits
Nephew, B. C., Febo, M., Huang, W., Colon-Perez, L. M., Payne, L., Poirier, G. L., Greene, O. & King, J. A., 15 Mar 2018, In: Journal of Affective Disorders. 229, p. 213-223 11 p.Research output: Contribution to journal › Article › peer-review
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Small worldness in dense and weighted connectomes
Colon-Perez, L. M., Couret, M., Triplett, W., Price, C. C. & Mareci, T. H., 10 May 2016, In: Frontiers in Physics. 4, MAY, 14.Research output: Contribution to journal › Article › peer-review