Projects per year
Personal profile
Research Interests
Substance use disorders.
Aging
Alzheimers disease
In vivo small animal imaging
Cognition in neuropsychiatric disorders
URL
Area of Expertise
My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.
Techniques
MRI, Connectomics, Functional connectivity
Tractography, Network neuroscience, Graph theory, Resting state fMRI
Education/Academic qualification
PhD Physics, University of Florida
BS Physics, University of Puerto Rico
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Determining the Effects of Bat
Colon-Perez, L. (PI)
NIDA: National Institute on Drug Abuse
1/04/22 → 31/03/25
Project: Research
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Longitudinal biophysical markers of neuroinflammation due to morphine self-administration
Colon-Perez, L. (PI)
Brain & Behavior Research Foundation
3/01/22 → 14/01/23
Project: Research
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Determining the effects of "bath salts" on cognitive control and functional brain connectivity
COLON-PEREZ, L. (CoPI) & Colon-Perez, L. (PI)
National Institute on Drug Abuse
1/04/19 → 31/03/24
Project: Research
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Multifunctional Nanotherapeutics for the Treatment of neuroAIDS in Drug Abusers
Jayant, R. D., Tiwari, S., Atluri, V., Kaushik, A., Tomitaka, A., Yndart, A., Colon-Perez, L., Febo, M. & Nair, M., 1 Dec 2018, In: Scientific Reports. 8, 1, 12991.Research output: Contribution to journal › Article › peer-review
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Classification of fractional order biomarkers for anomalous diffusion using q-space entropy
Magin, R. L., Ingo, C., Triplett, W., Colon-Perez, L. & Mareci, T. H., 2014, In: Critical Reviews in Biomedical Engineering. 42, 1, p. 63-83 21 p.Research output: Contribution to journal › Article › peer-review
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Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1
Thinschmidt, J. S., Colon Perez, L. M., Febo, M., Caballero, S., King, M. A., White, F. A. & Grant, M. B., 26 Feb 2016, In: Neuroscience letters. 615, p. 21-27 7 p.Research output: Contribution to journal › Article › peer-review
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Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats
Gaynor, L. S., Ravi, M., Zequeira, S., Hampton, A. M., Pyon, W. S., Smith, S., Colon-Perez, L. M., Pompilus, M., Bizon, J. L., Maurer, A. P., Febo, M. & Burke, S. N., Feb 2023, In: eNeuro. 10, 2, ENEURO.0329-22.2023.Research output: Contribution to journal › Article › peer-review
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Multiscale imaging reveals aberrant functional connectome organization and elevated dorsal striatal arc expression in advanced age
Colon-Perez, L. M., Turner, S. M., Lubke, K. N., Pompilus, M., Febo, M. & Burke, S. N., 1 Nov 2019, In: eNeuro. 6, 6, ENEURO.0047-19.2019.Research output: Contribution to journal › Article › peer-review