Projects per year
Personal profile
Research Interests
Substance use disorders.
Aging
Alzheimers disease
In vivo small animal imaging
Cognition in neuropsychiatric disorders
URL
Area of Expertise
My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.
Techniques
MRI, Connectomics, Functional connectivity
Tractography, Network neuroscience, Graph theory, Resting state fMRI
Education/Academic qualification
PhD Physics, University of Florida
BS Physics, University of Puerto Rico
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Determining the Effects of Bath Salts on Cognitive Control and Functional Brain Connectivity
Colon-Perez, L. (PI)
NIDA: National Institute on Drug Abuse
1/04/22 → 31/03/24
Project: Research
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Longitudinal biophysical markers of neuroinflammation due to morphine self-administration
Colon-Perez, L. (PI)
Brain & Behavior Research Foundation
3/01/22 → 14/01/23
Project: Research
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Determining the effects of "bath salts" on cognitive control and functional brain connectivity
COLON-PEREZ, L. (CoPI) & Colon-Perez, L. (PI)
National Institute on Drug Abuse
1/04/19 → 31/03/24
Project: Research
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A single angiotensin Ii hypertensive stimulus is associated with prolonged neuronal and immune system activation in Wistar-Kyoto rats
Zubcevic, J., Santisteban, M. M., Perez, P. D., Arocha, R., Hiller, H., Malphurs, W. L., Colon-Perez, L. M., Sharma, R. K., de Kloet, A., Krause, E. G., Febo, M. & Raizada, M. K., 31 Aug 2017, In: Frontiers in Physiology. 8, AUG, p. 592 1 p., 592.Research output: Contribution to journal › Article › peer-review
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Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence
Barter, J., Kumar, A., Rani, A., Colon-Perez, L. M., Febo, M. & Foster, T. C., 1 Oct 2020, In: Molecular Neurobiology. 57, 10, p. 4045-4059 15 p.Research output: Contribution to journal › Article › peer-review
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Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition
Tan, Y., Singhal, S. M., Harden, S. W., Cahill, K. M., Nguyen, D. T. M., Colon-Perez, L. M., Sahagian, T. J., Thinschmidt, J. S., De Kloet, A. D., Febo, M., Frazier, C. J. & Krause, E. G., 24 Apr 2019, In: Journal of Neuroscience. 39, 17, p. 3249-3263 15 p.Research output: Contribution to journal › Article › peer-review
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Cognition and connectomes in nondementia idiopathic parkinson’s disease
Colon-Perez, L. M., Tanner, J. J., Couret, M., Goicochea, S., Mareci, T. H. & Price, C. C., 1 Mar 2018, In: Network Neuroscience. 2, 1, p. 106-124 19 p.Research output: Contribution to journal › Article › peer-review
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Classification of fractional order biomarkers for anomalous diffusion using q-space entropy
Magin, R. L., Ingo, C., Triplett, W., Colon-Perez, L. & Mareci, T. H., 2014, In: Critical Reviews in Biomedical Engineering. 42, 1, p. 63-83 21 p.Research output: Contribution to journal › Article › peer-review