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Research activity per year

Personal profile

Research Interests

Substance use disorders.


Alzheimers disease

In vivo small animal imaging

Cognition in neuropsychiatric disorders


Area of Expertise

My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.



MRI, Connectomics, Functional connectivity

Tractography, Network neuroscience, Graph theory, Resting state fMRI

Education/Academic qualification

PhD Physics, University of Florida

BS Physics, University of Puerto Rico


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Collaborations and top research areas from the last five years

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  • The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences

    Middlebrooks, E. H., Quisling, R. G., King, M. A., Carney, P. R., Roper, S., Colon-Perez, L. M. & Mareci, T. H., 1 Oct 2017, In: Surgical and Radiologic Anatomy. 39, 10, p. 1149-1159 11 p.

    Research output: Contribution to journalArticlepeer-review

  • Multiscale imaging reveals aberrant functional connectome organization and elevated dorsal striatal arc expression in advanced age

    Colon-Perez, L. M., Turner, S. M., Lubke, K. N., Pompilus, M., Febo, M. & Burke, S. N., 1 Nov 2019, In: eNeuro. 6, 6, ENEURO.0047-19.2019.

    Research output: Contribution to journalArticlepeer-review

  • High magnetic field fmri compliant carbon nanofiber neural probes

    Fang, S. P., Colon-Perez, L., Zhou, J., Demarse, T. B., Febo, M., Carney, P. R. & Yoon, Y. K. Y. K., 26 Jul 2017, TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc., p. 1707-1710 4 p. 7994395. (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

  • Mechanism of manganese dysregulation of dopamine neuronal activity

    Lin, M., Colon-Perez, L. M., Sambo, D. O., Miller, D. R., Lebowitz, J. J., Jimenez-Rondan, F., Cousins, R. J., Horenstein, N., Aydemir, T. B., Febo, M. & Khoshbouei, H., 22 Jul 2020, In: Journal of Neuroscience. 40, 30, p. 5871-5891 21 p.

    Research output: Contribution to journalArticlepeer-review

  • A consensus protocol for functional connectivity analysis in the rat brain

    Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D. A., Blockx, I., Bortel, A., Broadwater, M., Cardoso, B. M., Célestine, M., Chavez-Negrete, J. E., Choi, S., Christiaen, E., Clavijo, P., Colon-Perez, L., Cramer, S., Daniele, T., Dempsey, E., Diao, Y., & 189 othersDoelemeyer, A., Dopfel, D., Dvořáková, L., Falfán-Melgoza, C., Fernandes, F. F., Fowler, C. F., Fuentes-Ibañez, A., Garin, C., Gelderman, E., Golden, C. E. M., Guo, C. C. G., Henckens, M. J. A. G., Hennessy, L. A., Herman, P., Hofwijks, N., Horien, C., Ionescu, T. M., Jones, J., Kaesser, J., Kim, E., Lambers, H., Lazari, A., Lee, S. H., Lillywhite, A., Liu, Y., Liu, Y. Y., López -Castro, A., López-Gil, X., Ma, Z., MacNicol, E., Madularu, D., Mandino, F., Marciano, S., McAuslan, M. J., McCunn, P., McIntosh, A., Meng, X., Meyer-Baese, L., Missault, S., Moro, F., Naessens, D. M. P., Nava-Gomez, L. J., Nonaka, H., Ortiz, J. J., Paasonen, J., Peeters, L. M., Pereira, M., Perez, P. D., Pompilus, M., Prior, M., Rakhmatullin, R., Reimann, H. M., Reinwald, J., Del Rio, R. T., Rivera-Olvera, A., Ruiz-Pérez, D., Russo, G., Rutten, T. J., Ryoke, R., Sack, M., Salvan, P., Sanganahalli, B. G., Schroeter, A., Seewoo, B. J., Selingue, E., Seuwen, A., Shi, B., Sirmpilatze, N., Smith, J. A. B., Smith, C., Sobczak, F., Stenroos, P. J., Straathof, M., Strobelt, S., Sumiyoshi, A., Takahashi, K., Torres-García, M. E., Tudela, R., van den Berg, M., van der Marel, K., van Hout, A. T. B., Vertullo, R., Vidal, B., Vrooman, R. M., Wang, V. X., Wank, I., Watson, D. J. G., Yin, T., Zhang, Y., Zurbruegg, S., Achard, S., Alcauter, S., Auer, D. P., Barbier, E. L., Baudewig, J., Beckmann, C. F., Beckmann, N., Becq, G. J. P. C., Blezer, E. L. A., Bolbos, R., Boretius, S., Bouvard, S., Budinger, E., Buxbaum, J. D., Cash, D., Chapman, V., Chuang, K. H., Ciobanu, L., Coolen, B. F., Dalley, J. W., Dhenain, M., Dijkhuizen, R. M., Esteban, O., Faber, C., Febo, M., Feindel, K. W., Forloni, G., Fouquet, J., Garza-Villarreal, E. A., Gass, N., Glennon, J. C., Gozzi, A., Gröhn, O., Harkin, A., Heerschap, A., Helluy, X., Herfert, K., Heuser, A., Homberg, J. R., Houwing, D. J., Hyder, F., Ielacqua, G. D., Jelescu, I. O., Johansen-Berg, H., Kaneko, G., Kawashima, R., Keilholz, S. D., Keliris, G. A., Kelly, C., Kerskens, C., Khokhar, J. Y., Kind, P. C., Langlois, J. B., Lerch, J. P., López-Hidalgo, M. A., Manahan-Vaughan, D., Marchand, F., Mars, R. B., Marsella, G., Micotti, E., Muñoz-Moreno, E., Near, J., Niendorf, T., Otte, W. M., Pais-Roldán, P., Pan, W. J., Prado-Alcalá, R. A., Quirarte, G. L., Rodger, J., Rosenow, T., Sampaio-Baptista, C., Sartorius, A., Sawiak, S. J., Scheenen, T. W. J., Shemesh, N., Shih, Y. Y. I., Shmuel, A., Soria, G., Stoop, R., Thompson, G. J., Till, S. M., Todd, N., Van Der Linden, A., van der Toorn, A., van Tilborg, G. A. F., Vanhove, C., Veltien, A., Verhoye, M., Wachsmuth, L., Weber-Fahr, W., Wenk, P., Yu, X., Zerbi, V., Zhang, N., Zhang, B. B., Zimmer, L., Devenyi, G. A., Chakravarty, M. M. & Hess, A., Apr 2023, In: Nature Neuroscience. 26, 4, p. 673-681 9 p.

    Research output: Contribution to journalArticlepeer-review