Projects per year
Personal profile
Research Interests
Substance use disorders.
Aging
Alzheimers disease
In vivo small animal imaging
Cognition in neuropsychiatric disorders
URL
Area of Expertise
My research focuses on determining the neural changes associated with neuropsychiatric disorders particularly with an special emphasis on substance use disorders. I integrate computational neuroscience methods to broad applications in neuropsychiatric disorders and preclinical models of mental health disorders. I specifically work in the field of neuroimaging and the recent neuroscience filed of “connectomics.” In this area, we seek to quantitatively identify important insights about brain networks’ physical properties or “connectomes” to gain new insights on behavior and cognition. To date, my research initiatives have focused on developing and applying quantitative neuroimaging tools to study the brain’s structure and function. Specifically, we merge diffusion and functional MRI with complex network analysis, which is the field of physics devoted to understanding the properties of networks, to reveal topological features of brain connectivity. More recently, we are focused on computational neuroscience approaches to investigate disease-related brain topology, particularly in animal models of substance use disorders.
Techniques
MRI, Connectomics, Functional connectivity
Tractography, Network neuroscience, Graph theory, Resting state fMRI
Education/Academic qualification
PhD Physics, University of Florida
BS Physics, University of Puerto Rico
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Determining the effects of "bath salts" on cognitive control and functional brain connectivity
Colon-Perez, L. & COLON-PEREZ, L.
National Institute on Drug Abuse
1/04/19 → 31/03/24
Project: Research
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Oxytocin receptors are expressed by glutamatergic prefrontal cortical neurons that selectively modulate social recognition
Tan, Y., Singhal, S. M., Harden, S. W., Cahill, K. M., Nguyen, D. T. M., Colon-Perez, L. M., Sahagian, T. J., Thinschmidt, J. S., De Kloet, A. D., Febo, M., Frazier, C. J. & Krause, E. G., 24 Apr 2019, In: Journal of Neuroscience. 39, 17, p. 3249-3263 15 p.Research output: Contribution to journal › Article › peer-review
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Detection of axonal degeneration in a mouse model of Huntington’s disease: comparison between diffusion tensor imaging and anomalous diffusion metrics
Gatto, R. G., Ye, A. Q., Colon-Perez, L., Mareci, T. H., Lysakowski, A., Price, S. D., Brady, S. T., Karaman, M., Morfini, G. & Magin, R. L., 1 Aug 2019, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 32, 4, p. 461-471 11 p.Research output: Contribution to journal › Article › peer-review
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A single angiotensin Ii hypertensive stimulus is associated with prolonged neuronal and immune system activation in Wistar-Kyoto rats
Zubcevic, J., Santisteban, M. M., Perez, P. D., Arocha, R., Hiller, H., Malphurs, W. L., Colon-Perez, L. M., Sharma, R. K., de Kloet, A., Krause, E. G., Febo, M. & Raizada, M. K., 31 Aug 2017, In: Frontiers in Physiology. 8, AUG, p. 592 1 p., 592.Research output: Contribution to journal › Article › peer-review
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On random walks and entropy in diffusion-weighted magnetic resonance imaging studies of neural tissue
Ingo, C., Magin, R. L., Colon-Perez, L., Triplett, W. & Mareci, T. H., Feb 2014, In: Magnetic Resonance in Medicine. 71, 2, p. 617-627 11 p.Research output: Contribution to journal › Article › peer-review
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Editorial: Novel tools for the study of structural and functional networks in the brain
Colon-Perez, L. M., Mareci, T. & Ding, M., 21 Feb 2018, In: Frontiers in Physics. 5, FEB, 11.Research output: Contribution to journal › Editorial