Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Collaborations and top research areas from the last five years
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Targeting mitochondrial comple
Yan, L.-J. (PI)
Diabetes Action Research and Education
1/01/23 → 31/12/24
Project: Research
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Editorial: Diabetes and obesity effects on lung function, volume II
Zheng, H., Ma, W., Tang, X., Lecube, A. & Yan, L. J., 2023, In: Frontiers in Endocrinology. 14, 1345489.Research output: Contribution to journal › Editorial
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Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease—Volume II
Diep, T. N., Liu, H., Wang, Y., Wang, Y., Hoogewijs, D. & Yan, L. J., Aug 2024, In: Biomolecules. 14, 8, 973.Research output: Contribution to journal › Editorial
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Spectrophotometric method for determination of carbonyls in oxidatively modified apolipoprotein B of human low-density lipoproteins
Yan, L. J., Traber, M. G. & Packer, L., 1995, In: Analytical Biochemistry. 228, 2, p. 349-351 3 p.Research output: Contribution to journal › Article › peer-review
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Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease
Yan, L. J., Mar 2022, In: Biomolecules. 12, 3, 476.Research output: Contribution to journal › Editorial
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Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins
Yan, L. J. & Sohal, R. S., 1 Dec 2000, In: Free Radical Biology and Medicine. 29, 11, p. 1143-1150 8 p.Research output: Contribution to journal › Article › peer-review