Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting mitochondrial comple
Yan, L.-J. (PI)
Diabetes Action Research and Education
1/01/23 → 31/12/24
Project: Research
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Telomere Shortening and Alzheimer's Disease
Cai, Z., Yan, L. J. & Ratka, A., Mar 2013, In: NeuroMolecular Medicine. 15, 1, p. 25-48 24 p.Research output: Contribution to journal › Review article › peer-review
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Role of insulin resistance in Alzheimer’s disease
Cai, Z., Xiao, M., Chang, L. & Yan, L. J., 1 Aug 2015, In: Metabolic Brain Disease. 30, 4, p. 839-851 13 p., A001.Research output: Contribution to journal › Review article › peer-review
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Changes in dihydrolipoamide dehydrogenase expression and activity during postnatal development and aging in the rat brain
Yan, L. J., Thangthaeng, N. & Forster, M. J., May 2008, In: Mechanisms of Ageing and Development. 129, 5, p. 282-290 9 p.Research output: Contribution to journal › Article › peer-review
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Resolving mitochondrial protein complexes using nongradient blue native polyacrylamide gel electrophoresis
Yan, L. J. & Forster, M. J., 15 Jun 2009, In: Analytical Biochemistry. 389, 2, p. 143-149 7 p.Research output: Contribution to journal › Article › peer-review
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Two dimensional blue native/SDS-PAGE to identify mitochondrial complex I subunits modified by 4-hydroxynonenal (HNE)
Wu, J., Luo, X. & Yan, L. J., 2015, In: Frontiers in Physiology. 6, MAR, 098.Research output: Contribution to journal › Article › peer-review