Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting mitochondrial comple
Yan, L.-J. (PI)
Diabetes Action Research and Education
1/01/23 → 31/12/24
Project: Research
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Protein redox modification as a cellular defense mechanism against tissue ischemic injury
Yan, L. J., 2014, In: Oxidative Medicine and Cellular Longevity. 2014, 343154.Research output: Contribution to journal › Review article › peer-review
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Pathogenesis of chronic hyperglycemia: From reductive stress to oxidative stress
Yan, L. J., 2014, In: Journal of Diabetes Research. 2014, 137919.Research output: Contribution to journal › Review article › peer-review
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Apolipoprotein B carbonyl formation is enhanced by lipid peroxidation during copper-mediated oxidation of human low-density lipoproteins
Yan, L. J., Lodge, J. K., Traber, M. G. & Packer, L., 1 Mar 1997, In: Archives of Biochemistry and Biophysics. 339, 1, p. 165-171 7 p.Research output: Contribution to journal › Article › peer-review
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Comparison of antioxidant and antiproliferative activity between Kunlun Chrysanthemum flowers polysaccharides (KCCP) and fraction PII separated by column chromatography
Jing, S., Chai, W., Guo, G., Zhang, X., Dai, J. & Yan, L. J., 15 Apr 2016, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1019, p. 169-177 9 p.Research output: Contribution to journal › Article › peer-review
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Comment on kobroob et al. Effectiveness of n-acetylcysteine in the treatment of renal deterioration caused by long-term exposure to bisphenol a. biomolecules 2021, 11, 655
Yan, L. J., Jun 2021, In: Biomolecules. 11, 6, 888.Research output: Contribution to journal › Article › peer-review