Projects per year
Personal profile
Area of Expertise
The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
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Pancreatic Mitochondrial Complex I as a Target for Diabetes Therapy
1/05/16 → 31/08/17
Project: Research
Research output
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Comment on kobroob et al. Effectiveness of n-acetylcysteine in the treatment of renal deterioration caused by long-term exposure to bisphenol a. biomolecules 2021, 11, 655
Yan, L. J., Jun 2021, In: Biomolecules. 11, 6, 888.Research output: Contribution to journal › Article › peer-review
Open Access -
NADH/NAD+ redox imbalance and diabetic kidney disease
Yan, L. J., May 2021, In: Biomolecules. 11, 5, 730.Research output: Contribution to journal › Review article › peer-review
Open Access -
Antioxidative and hypoglycemic effect of ta-ermi extracts on streptozotocin-induced diabetes
Jing, S., Zhao, Z., Wu, J. & Yan, L. J., 2020, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13, p. 2147-2155 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Editorial: Diabetes and Obesity Effects on Lung Function
Chen, X. F., Yan, L. J., Lecube, A. & Tang, X., 16 Jul 2020, In: Frontiers in Endocrinology. 11, 462.Research output: Contribution to journal › Editorial
Open Access2 Scopus citations -
Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke
Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In: Behavioural Brain Research. 378, 112278.Research output: Contribution to journal › Article › peer-review
1 Scopus citations