• 5324 Citations
  • 36 h-Index
1991 …2020

Research output per year

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Personal profile

Area of Expertise

The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.

Education/Academic qualification

MS in Biochemistry, Chinese Academy of Sciences

BS in Biochemistry, Peking University

PhD in Biochemistry, University of California at Berkeley

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Projects

Research Output

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke

Sumien, N., Huang, R., Chen, Z., Vann, P. H., Wong, J. M., Li, W., Yang, S., Forster, M. J. & Yan, L. J., 27 Jan 2020, In : Behavioural Brain Research. 378, 112278.

Research output: Contribution to journalArticle

  • Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia

    Gao, B., Deng, J., Zhang, X., Sun, H., Jia, G., Li, J., Zhang, K., Wan, C., Wang, L., Yan, L. J., Cai, Z. & Ma, J., 10 Jan 2020, In : Neuroscience letters. 715, 1 p.

    Research output: Contribution to journalArticle

  • Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

    Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In : Neural Regeneration Research. 15, 3, p. 548-556 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy

    Ma, W. X., Li, C. Y., Tao, R., Wang, X. P. & Yan, L. J., 1 Jan 2020, In : Oxidative Medicine and Cellular Longevity. 2020, 5136957.

    Research output: Contribution to journalReview article

    Open Access
  • Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity

    Yang, X., Sun, X., Wu, J., Ma, J., Si, P., Yin, L., Zhang, Y., Yan, L. J. & Zhang, C., 1 Apr 2020, In : Toxicology Letters. 322, p. 66-76 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations