Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Collaborations and top research areas from the last five years
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Projects
- 10 Finished
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
Yan, L. & Liu, Y.
1/09/16 → 31/08/18
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
Liu, Y. & Yan, L.
1/09/16 → 31/08/18
Project: Research
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Pancreatic Mitochondrial Complex I as a Target for Diabetes Therapy
1/05/16 → 31/08/17
Project: Research
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Apolipoprotein B carbonyl formation is enhanced by lipid peroxidation during copper-mediated oxidation of human low-density lipoproteins
Yan, L. J., Lodge, J. K., Traber, M. G. & Packer, L., 1 Mar 1997, In: Archives of Biochemistry and Biophysics. 339, 1, p. 165-171 7 p.Research output: Contribution to journal › Article › peer-review
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Role of RAGE in Alzheimer’s Disease
Cai, Z., Liu, N., Wang, C., Qin, B., Zhou, Y., Xiao, M., Chang, L., Yan, L. J. & Zhao, B., 1 May 2016, In: Cellular and Molecular Neurobiology. 36, 4, p. 483-495 13 p.Research output: Contribution to journal › Review article › peer-review
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Comparison of antioxidant and antiproliferative activity between Kunlun Chrysanthemum flowers polysaccharides (KCCP) and fraction PII separated by column chromatography
Jing, S., Chai, W., Guo, G., Zhang, X., Dai, J. & Yan, L. J., 15 Apr 2016, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1019, p. 169-177 9 p.Research output: Contribution to journal › Article › peer-review
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The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
Yang, X., Si, P., Qin, H., Yin, L., Yan, L. J. & Zhang, C., 2017, In: Oxidative Medicine and Cellular Longevity. 2017, 2823454.Research output: Contribution to journal › Article › peer-review
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Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury
Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In: Neural Regeneration Research. 15, 3, p. 548-556 9 p.Research output: Contribution to journal › Article › peer-review