Projects per year
Personal profile
Area of Expertise
The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Projects
- 10 Finished
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
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Pancreatic Mitochondrial Complex I as a Target for Diabetes Therapy
1/05/16 → 31/08/17
Project: Research
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Activation of peripheral group III metabotropic glutamate receptors suppressed formalin-induced nociception
Li, Y. L., Chang, X. R., Ma, J. T., Zhao, X., Yin, L. T., Yan, L. J., Guo, J. H., Zhang, C. & Yang, X. R., Feb 2022, In: Clinical and Experimental Pharmacology and Physiology. 49, 2, p. 319-326 8 p.Research output: Contribution to journal › Article › peer-review
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Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease
Yan, L. J., Mar 2022, In: Biomolecules. 12, 3, 476.Research output: Contribution to journal › Editorial
Open Access -
Cadmium-induced kidney injury: Oxidative damage as a unifying mechanism
Yan, L. J. & Allen, D. C., Nov 2021, In: Biomolecules. 11, 11, 1575.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Comment on kobroob et al. Effectiveness of n-acetylcysteine in the treatment of renal deterioration caused by long-term exposure to bisphenol a. biomolecules 2021, 11, 655
Yan, L. J., Jun 2021, In: Biomolecules. 11, 6, 888.Research output: Contribution to journal › Article › peer-review
Open Access -
Folic acid-induced animal model of kidney disease
Yan, L. J., Dec 2021, In: Animal Models and Experimental Medicine. 4, 4, p. 329-342 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations