Projects per year
Personal profile
Area of Expertise
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Network
Projects
- 10 Finished
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
Yan, L. & Liu, Y.
1/09/16 → 31/08/18
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
Liu, Y. & Yan, L.
1/09/16 → 31/08/18
Project: Research
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Pancreatic Mitochondrial Complex I as a Target for Diabetes Therapy
1/05/16 → 31/08/17
Project: Research
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Activation of peripheral group III metabotropic glutamate receptors suppressed formalin-induced nociception
Li, Y. L., Chang, X. R., Ma, J. T., Zhao, X., Yin, L. T., Yan, L. J., Guo, J. H., Zhang, C. & Yang, X. R., Feb 2022, In: Clinical and Experimental Pharmacology and Physiology. 49, 2, p. 319-326 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products
Iskander, A. & Yan, L. J., Aug 2022, In: Biomolecules. 12, 8, 1078.Research output: Contribution to journal › Review article › peer-review
Open Access -
Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease
Yan, L. J., Mar 2022, In: Biomolecules. 12, 3, 476.Research output: Contribution to journal › Editorial
Open Access -
The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features
Yan, L. J., Sep 2022, In: Biomolecules. 12, 9, 1225.Research output: Contribution to journal › Review article › peer-review
Open Access -
Cadmium-induced kidney injury: Oxidative damage as a unifying mechanism
Yan, L. J. & Allen, D. C., Nov 2021, In: Biomolecules. 11, 11, 1575.Research output: Contribution to journal › Review article › peer-review
Open Access32 Scopus citations