Projects per year
Personal profile
Area of Expertise
The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.
Education/Academic qualification
PhD in Biochemistry, University of California at Berkeley
Award Date: 1 Jan 2002
MS in Biochemistry, Chinese Academy of Sciences
Award Date: 1 Jan 2001
BS in Biochemistry, Peking University
Award Date: 1 Jan 2000
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Projects
Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P., Yan, L. & Suzuki, S.
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
1/09/16 → 31/08/18
Project: Research
Pancreatic Mitochondrial Complex I as a Target for Diabetes Therapy
1/05/16 → 31/08/17
Project: Research
Research Output
Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury
Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In : Neural Regeneration Research. 15, 3, p. 548-556 9 p.Research output: Contribution to journal › Article
Open Access
Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity
Yang, X., Sun, X., Wu, J., Ma, J., Si, P., Yin, L., Zhang, Y., Yan, L. J. & Zhang, C., 1 Apr 2020, In : Toxicology Letters. 322, p. 66-76 11 p.Research output: Contribution to journal › Article
Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress
Yang, X., Song, J. & Yan, L. J., 1 Jan 2019, In : Antioxidants. 8, 2, 32.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Role of Catalase in Oxidative Stress- And Age-Associated Degenerative Diseases
Nandi, A., Yan, L. J., Jana, C. K. & Das, N., 1 Jan 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 9613090.Research output: Contribution to journal › Article
Open Access
The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
Mai, B. H. & Yan, L. J., 1 Jan 2019, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 821-826 6 p.Research output: Contribution to journal › Review article
Open Access
4
Scopus
citations