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Personal profile

Area of Expertise

Areas of research and interests include:
1) protein oxidative modifications in aging-associated disease;
2) mechanisms of stroke prevention and stroke injury protection;
3) mitochondrial dysfunction and diabetes.

Education/Academic qualification

PhD in Biochemistry, University of California at Berkeley

MS in Biochemistry, Chinese Academy of Sciences

BS in Biochemistry, Peking University

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Dihydrolipoamide Dehydrogenase Medicine & Life Sciences
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Reactive Oxygen Species Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 1991 2019

Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress

Yang, X., Song, J. & Yan, L-J., 1 Jan 2019, In : Antioxidants. 8, 2, 32.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Dihydrolipoamide Dehydrogenase
Oxidative stress
Oxidative Stress
Medical problems
Type 2 Diabetes Mellitus
2 Citations (Scopus)

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L-J., Yu, P. & Chang, Y. Z., 10 May 2018, In : Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ceruloplasmin
Alzheimer Disease
Therapeutics
Iron
Hippocampus

Humanin attenuates NMDA-induced excitotoxicity by inhibiting ROS-dependent JNK/p38 MAPK pathway

Yang, X., Zhang, H., Wu, J., Yin, L., Yan, L-J. & Zhang, C., 1 Oct 2018, In : International Journal of Molecular Sciences. 19, 10, 2982.

Research output: Contribution to journalArticleResearchpeer-review

aspartates
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
N-Methylaspartate
Reactive Oxygen Species
5 Citations (Scopus)
Oxidative stress
Reperfusion
Oxidative Stress
Stroke
Wounds and Injuries
1 Citation (Scopus)

Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

Yan, L-J., 1 Jan 2018, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 11, p. 183-186 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoglycemic Agents
Dihydrolipoamide Dehydrogenase
Glucose
Gluconeogenesis
Cricetulus