Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Targeting mitochondrial comple
Yan, L.-J. (PI)
Diabetes Action Research and Education
1/01/23 → 31/12/24
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Antioxidative and hypoglycemic effect of ta-ermi extracts on streptozotocin-induced diabetes
Jing, S., Zhao, Z., Wu, J. & Yan, L. J., 2020, In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13, p. 2147-2155 9 p.Research output: Contribution to journal › Article › peer-review
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The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features
Yan, L. J., Sep 2022, In: Biomolecules. 12, 9, 1225.Research output: Contribution to journal › Review article › peer-review
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Redox Imbalance and Mitochondrial Abnormalities in Kidney Disease—Volume II
Diep, T. N., Liu, H., Wang, Y., Wang, Y., Hoogewijs, D. & Yan, L. J., Aug 2024, In: Biomolecules. 14, 8, 973.Research output: Contribution to journal › Editorial
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Efficacy of bio-catalyzer α.ρ no.11 (bio-normalizer) supplementation against peroxyl radical-induced oxidative damage in rat organ homogenates
Marcocci, L., D'Anna, R., Yan, L. J., Haramaki, N. & Packer, L., 1996, In: Biochemistry and Molecular Biology International. 38, 3, p. 535-541 7 p.Research output: Contribution to journal › Article › peer-review
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Effects of aging and hyperoxia on oxidative damage to cytochrome C in the housefly, Musca domestica
Yan, L. J., Levine, R. L. & Sohal, R. S., 1 Jul 2000, In: Free Radical Biology and Medicine. 29, 1, p. 90-97 8 p.Research output: Contribution to journal › Article › peer-review