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Personal profile

Area of Expertise

The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.

Education/Academic qualification

PhD in Biochemistry, University of California at Berkeley

MS in Biochemistry, Chinese Academy of Sciences

BS in Biochemistry, Peking University

Fingerprint Dive into the research topics where Liang-Jun Yan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Oxidative stress Chemical Compounds
Dihydrolipoamide Dehydrogenase Medicine & Life Sciences
Oxidative Stress Medicine & Life Sciences
Proteins Chemical Compounds
NAD Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Antioxidants Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences

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Projects 2012 2022

Research Output 1991 2020

Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In : Neural Regeneration Research. 15, 3, p. 548-556 9 p.

Research output: Contribution to journalArticle

Open Access
Cyperus
Brain Ischemia
Brain Injuries
Reperfusion
Reperfusion Injury

Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress

Yang, X., Song, J. & Yan, L-J., 1 Jan 2019, In : Antioxidants. 8, 2, 32.

Research output: Contribution to journalArticle

Open Access
Dihydrolipoamide Dehydrogenase
Oxidative stress
Oxidative Stress
Medical problems
Type 2 Diabetes Mellitus
Open Access
Fructose
Liver
Insulin Resistance
Obesity
Eating
7 Citations (Scopus)

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L-J., Yu, P. & Chang, Y. Z., 10 May 2018, In : Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.

Research output: Contribution to journalArticle

Ceruloplasmin
Alzheimer Disease
Therapeutics
Iron
Hippocampus
1 Citation (Scopus)

Humanin attenuates NMDA-induced excitotoxicity by inhibiting ROS-dependent JNK/p38 MAPK pathway

Yang, X., Zhang, H., Wu, J., Yin, L., Yan, L-J. & Zhang, C., 1 Oct 2018, In : International journal of molecular sciences. 19, 10, 2982.

Research output: Contribution to journalArticle

aspartates
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
N-Methylaspartate
Reactive Oxygen Species