Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting mitochondrial comple
Yan, L.-J. (PI)
Diabetes Action Research and Education
1/01/23 → 31/12/24
Project: Research
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Chemical probes for analysis of carbonylated proteins: A review
Yan, L. J. & Forster, M. J., 15 May 2011, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 17-18, p. 1308-1315 8 p.Research output: Contribution to journal › Review article › peer-review
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Mitochondrial dihydrolipoamide dehydrogenase is upregulated in response to intermittent hypoxic preconditioning
Li, R., Luo, X., Wu, J., Thangthaeng, N., Jung, M. E., Jing, S., Li, L., Ellis, D. Z., Liu, L., Ding, Z., Forster, M. J. & Yan, L. J., 23 May 2015, In: International Journal of Medical Sciences. 12, 5, p. 432-440 9 p.Research output: Contribution to journal › Article › peer-review
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Identification of oxidized proteins based on sodium dodecyl sulfate- polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing
Yan, L. J., Orr, W. C. & Sohal, R. S., 1 Oct 1998, In: Analytical Biochemistry. 263, 1, p. 67-71 5 p.Research output: Contribution to journal › Article › peer-review
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[Effects of hsf1 genotype on the constitutive expression of alphaB-crystallin in mice myocardium].
Liu, L., Zhang, H. H., Ding, G. X., Cheng, Y. L., Yan, L. J. & Benjamin, I. J., Feb 2004, In: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 20, 1, p. 30-33 4 p.Research output: Contribution to journal › Article › peer-review
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Hypoxia-inducible factor 2α regulates expression of the mitochondrial aconitase chaperone protein frataxin
Oktay, Y., Dioum, E., Matsuzaki, S., Ding, K., Yan, L. J., Haller, R. G., Szweda, L. I. & Garcia, J. A., 20 Apr 2007, In: Journal of Biological Chemistry. 282, 16, p. 11750-11756 7 p.Research output: Contribution to journal › Article › peer-review