Projects per year
Personal profile
Research interests
Oxidative stress, age-related metabolic disorders, diabetic kidney disease and acute kidney injury
Area of Expertise
We are interested in understanding the molecular mechanisms of adaptive mitochondrial oxidative stress response in aging and aging-related metabolic disorders. The lab’s current projects focus on kidney diseases encompassing ischemia- and drug-induced acute kidney injury and diabetic kidney disease. The objective of these projects is to understand the molecular basis of oxidative stress and redox dysregulation in these kidney diseases, and identify novel targets for developing potential therapeutic approaches.
Education/Academic qualification
MS in Biochemistry, Chinese Academy of Sciences
BS in Biochemistry, Peking University
PhD in Biochemistry, University of California at Berkeley
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting mitochondrial complex I superoxide production to ameliorate diabetic kidney disease
Yan, L.-J. (PI)
1/01/23 → 31/12/23
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Texas Center of Minority Health, Education, Research and Outreach - Project 2
Clay, P. (PI), Yan, L.-J. (CoI) & Suzuki, S. (CoI)
NIMHD: Natl Institute on Minority Health
23/09/17 → 31/05/22
Project: Research
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Role of Transcellular Mitophagy in Diabetic Retinal Neurodegeneration
Liu, Y. (PI) & Yan, L.-J. (CoI)
1/09/16 → 31/08/18
Project: Research
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Identification of oxidized proteins based on sodium dodecyl sulfate- polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing
Yan, L. J., Orr, W. C. & Sohal, R. S., 1 Oct 1998, In: Analytical Biochemistry. 263, 1, p. 67-71 5 p.Research output: Contribution to journal › Article › peer-review
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Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease
Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L. J., Yu, P. & Chang, Y. Z., 10 May 2018, In: Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.Research output: Contribution to journal › Article › peer-review
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Erratum: Oxidative damage during aging targets mitochondrial aconitase (Proceeding of the National Academy Sciences United States of America (October 14, 1997) 94 (11168-11172))
Yan, L. J., Levine, R. L. & Sohal, R. S., 17 Feb 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 4, p. 1968 1 p.Research output: Contribution to journal › Comment/debate
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Comparison between copper-mediated and hypochlorite-mediated modifications of human low density lipoproteins evaluated by protein carbonyl formation
Yan, L. J., Lodge, J. K., Traber, M. G., Matsugo, S. & Packer, L., May 1997, In: Journal of Lipid Research. 38, 5, p. 992-1001 10 p.Research output: Contribution to journal › Article › peer-review
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Induction of Protein Oxidation in Human Low Lipoprotein by the Photosensitive Organic Hydroperoxide, N,N′-bis(2-Hydroxyperoxy-2-Methoxyethyl)-1,4,5,8-Naphthalene-Tetra-Carboxylic-Diimide
Matsugo, S., Yan, L. J., Han, D. & Packer, L., 5 Jan 1995, In: Biochemical and Biophysical Research Communications. 206, 1, p. 138-145 8 p.Research output: Contribution to journal › Article › peer-review