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Personal profile

Area of Expertise

The long term goal of our research is to investigate the biochemical mechanisms of redox imbalance stress and its role in adult-onset metabolic syndrome. In particular, we are studying how mitochondrial redox sensitive proteins respond to redox imbalance stress and explore such responses as potential therapeutic targets for fighting aging-related metabolic diseases. Our current projects are focused on two NADH/NAD-dependent mitochondrial proteins: dihydrolipoamide dehydrogenase (DLDH) and complex I (NADH-ubiquinone oxidoreductase), both of which can be simultaneously analyzed by blue native gel electrophoresis and also show adaptive responses to NADH/NAD redox imbalance stress under pathophysiological conditions.
The DLDH project studies its adaptive response as a viable druggable target for induction of stroke- or hypoxia tolerance and the mechanisms of this protein’s oxidative modifications in redox signaling and neuroprotection.
The complex I project on studies the mechanisms of complex I adaptive hyperactivity observed in diabetic pancreas and other tissues with the goal of exploring strategies that down-regulating complex I hyperactivity by restoring NADH/NAD redox balance may serve as a therapeutic approach for treating diabetes mellitus.

Education/Academic qualification

PhD in Biochemistry, University of California at Berkeley

MS in Biochemistry, Chinese Academy of Sciences

BS in Biochemistry, Peking University

Fingerprint Dive into the research topics where Liang-Jun Yan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Oxidative stress Chemical Compounds
Oxidative Stress Medicine & Life Sciences
Dihydrolipoamide Dehydrogenase Medicine & Life Sciences
Proteins Chemical Compounds
NAD Medicine & Life Sciences
Antioxidants Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences

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Projects 2012 2022

Research Output 1991 2020

Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

Jing, S. Q., Wang, S. S., Zhong, R. M., Zhang, J. Y., Wu, J. Z., Tu, Y. X., Pu, Y. & Yan, L. J., 1 Mar 2020, In : Neural Regeneration Research. 15, 3, p. 548-556 9 p.

Research output: Contribution to journalArticle

Open Access
Brain Ischemia
Brain Injuries
Reperfusion Injury

Chronic inhibition of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as an approach to managing diabetic oxidative stress

Yang, X., Song, J. & Yan, L. J., 1 Jan 2019, In : Antioxidants. 8, 2, 32.

Research output: Contribution to journalArticle

Open Access
Dihydrolipoamide Dehydrogenase
Oxidative stress
Oxidative Stress
Medical problems
Type 2 Diabetes Mellitus

Role of Catalase in Oxidative Stress- And Age-Associated Degenerative Diseases

Nandi, A., Yan, L. J., Jana, C. K. & Das, N., 1 Jan 2019, In : Oxidative Medicine and Cellular Longevity. 2019, 9613090.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Oxidative Stress
3 Citations (Scopus)
Open Access
Insulin Resistance
7 Citations (Scopus)

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., Wang, Z. Y., Zheng, X., Yan, L-J., Yu, P. & Chang, Y. Z., 10 May 2018, In : Antioxidants and Redox Signaling. 28, 14, p. 1323-1337 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease