Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
BSW in Psychology, Louisiana State University
MSW, Louisiana State University
PhD in Social Work, University of Texas at Arlington
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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AHEAD 3-45 Study: A Placebo-Co
Johnson, L. (PI)
University of Southern California
1/01/25 → 31/12/25
Project: Research
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Phase II randomized controlled
Johnson, L. (PI)
University of California, San Diego
1/07/23 → 30/06/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI) & Johnson, L. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI), Johnson, L. (CoI) & Barber, R. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI), Hall, J. (CoI), Johnson, L. (CoI), Mason, D. (CoI), Large, S. (CoI) & Petersen, M. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study
for the HABLE Study Team, 2022, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 14, 1, e12267.Research output: Contribution to journal › Article › peer-review
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Recursive Support Vector Machine Biomarker Selection for Alzheimer's Disease
Zhang, F., Petersen, M., Johnson, L., Hall, J. & O'Bryant, S. E., 2021, In: Journal of Alzheimer's Disease. 79, 4, p. 1691-1700 10 p.Research output: Contribution to journal › Article › peer-review
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A Machine Learning-Based Multiple Imputation Method for the Health and Aging Brain Study–Health Disparities
Zhang, F., Petersen, M., Johnson, L., Hall, J., Palmer, R. F. & O’Bryant, S. E., Dec 2023, In: Informatics. 10, 4, 77.Research output: Contribution to journal › Article › peer-review
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Characteristics of cognitively normal Mexican-Americans with cognitive complaints
Hall, J. R., Wiechmann, A., Johnson, L. A., Edwards, M. & O'Bryant, S. E., 2018, In: Journal of Alzheimer's Disease. 61, 4, p. 1485-1492 8 p.Research output: Contribution to journal › Article › peer-review
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Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline
Lista, S., Molinuevo, J. L., Cavedo, E., Rami, L., Amouyel, P., Teipel, S. J., Garaci, F., Toschi, N., Habert, M. O., Blennow, K., Zetterberg, H., O'Bryant, S. E., Johnson, L., Galluzzi, S., Bokde, A. L. W., Broich, K., Herholz, K., Bakardjian, H., Dubois, B. & Jessen, F. & 3 others, , 24 Sep 2015, In: Journal of Alzheimer's Disease. 48, S1, p. S171-S191Research output: Contribution to journal › Review article › peer-review