• 630 Citations
  • 14 h-Index
20112022

Research output per year

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Personal profile

Area of Expertise

My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.

Education/Academic qualification

PhD in Social Work, University of Texas at Arlington

Award Date: 1 Jan 2002

MSW, Louisiana State University

Award Date: 1 Jan 2001

BSW in Psychology, Louisiana State University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 630 Citations
  • 14 h-Index
  • 47 Article
  • 2 Short survey
  • 1 Review article

The impact of comorbid depression-diabetes on proteomic outcomes among community-dwelling Mexican Americans with mild cognitive impairment

Johnson, L. A., Zhang, F., Large, S., Hall, J. & O'bryant, S. E., 1 Jan 2020, In : International Psychogeriatrics. 32, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    A proteomic signature for dementia with Lewy bodies

    O'Bryant, S. E., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M. & Graff-Radford, N. R., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 270-276 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

    Silzer, T., Barber, R., Sun, J., Pathak, G., Johnson, L., O’Bryant, S. & Phillips, N., Mar 2019, In : PLoS ONE. 14, 3, e0213527.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities

    Pathak, G. A., Silzer, T. K., Sun, J., Zhou, Z., Daniel, A. A., Johnson, L., O'Bryant, S., Phillips, N. R. & Barber, R. C., 1 Jan 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 733-749 17 p.

    Research output: Contribution to journalArticle

  • Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

    International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 292-312 21 p.

    Research output: Contribution to journalShort survey

  • 14 Scopus citations