Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
BSW in Psychology, Louisiana State University
MSW, Louisiana State University
PhD in Social Work, University of Texas at Arlington
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Collaborations and top research areas from the last five years
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Projects
- 20 Finished
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Genetic Architecture of Alzheimer’s disease Proteinopathies
Johnson, L., CRUCHAGA, C., CRUCHAGA, C. & KAMBOH, I.
15/04/21 → 28/02/23
Project: Research
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Amyloid Burden among Mexican Americans
RISSMAN, R., TOGA, A., RISSMAN, R., TOGA, A., Johnson, L., O'Bryant, S., O'BRYANT, S., O'Bryant, S., JOHNSON, L., O'BRYANT, S., JOHNSON, L., RISSMAN, R. & TOGA, A.
30/09/18 → 30/04/22
Project: Research
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Amyloid Burden among Mexican Americans
O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.
NIA: National Institute on Aging
30/09/18 → 31/08/19
Project: Research
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An Alzheimer's Blood Test for Primary Care
O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.
NIA: National Institute on Aging
1/06/18 → 31/05/21
Project: Research
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A Blood Test for Screening into Alzheimer's Prevention Trials
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
15/09/17 → 30/06/22
Project: Research
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Total cholesterol and neuropsychiatric symptoms in Alzheimer's disease: The impact of total cholesterol level and gender
Hall, J. R., Wiechmann, A. R., Johnson, L. A., Edwards, M., Barber, R. C., Cunningham, R., Singh, M., O'Bryant, S. E., Doody, R., Roundtree, S., Pavlik, V., Chan, W., Massman, P., Darby, E., Evans, T., Williams, B., Schrimsher, G., Dentino, A., Orozco, R., Fairchild, T., & 16 others, 7 Nov 2014, In: Dementia and Geriatric Cognitive Disorders. 38, p. 300-309 10 p.Research output: Contribution to journal › Article › peer-review
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Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts
Royall, D. R., Bishnoi, R. J., Palmer, R. F., Pavlik, V., Massman, P., Darby, E., Rodriguear, M., Ansari, A. K., DeToledo, J. C., Reddy, H., Wilms, H., Johnson, K., Perez, V., Fairchild, T., Knebl, J., O'Bryant, S. E., Hall, J. R., Johnson, L., Barber, R. C., Mains, D., & 22 others, Dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 763-774 12 p.Research output: Contribution to journal › Article › peer-review
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A depressive endophenotype for predicting cognitive decline among mexican American adults and elders
Johnson, L. A., Gamboa, A., Vintimilla, R., Edwards, M., Hall, J., Weiser, B., Yadav, M., Dickensheets, T. & O'Bryant, S. E., 23 Aug 2016, In: Journal of Alzheimer's Disease. 54, 1, p. 201-206 6 p.Research output: Contribution to journal › Article › peer-review
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APOEε4 Genotype Is Related to Brain Amyloid Among Mexican Americans in the HABS-HD Study
The HABS-HD Study Team, 15 Jun 2022, In: Frontiers in Neurology. 13, 834685.Research output: Contribution to journal › Article › peer-review
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A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research
for the HABLE Study Team, Jan 2022, In: Alzheimer's and Dementia. 18, 1, p. 77-87 11 p.Research output: Contribution to journal › Article › peer-review