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Personal profile

Area of Expertise

My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.

Education/Academic qualification

PhD in Social Work, University of Texas at Arlington

MSW, Louisiana State University

BSW in Psychology, Louisiana State University

Fingerprint Dive into the research topics where Leigh Johnson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 16 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Cognition Medicine & Life Sciences
Depression Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Hispanic Americans Medicine & Life Sciences
Endophenotypes Medicine & Life Sciences
Dementia Medicine & Life Sciences
Proteomics Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 2011 2019

  • 575 Citations
  • 14 h-Index
  • 46 Article
  • 2 Short survey
  • 1 Review article
1 Citation (Scopus)

A proteomic signature for dementia with Lewy bodies

O'Bryant, S. E., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M. & Graff-Radford, N. R., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 270-276 7 p.

Research output: Contribution to journalArticle

Open Access
Lewy Body Disease
Parkinson Disease
Sensitivity and Specificity

Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

Silzer, T., Barber, R., Sun, J., Pathak, G., Johnson, L., O’Bryant, S. & Phillips, N., Mar 2019, In : PLoS ONE. 14, 3, e0213527.

Research output: Contribution to journalArticle

Open Access
Mexican Americans
Medical problems
Mitochondrial DNA
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus

Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities

Pathak, G. A., Silzer, T. K., Sun, J., Zhou, Z., Daniel, A. A., Johnson, L., O'Bryant, S., Phillips, N. R. & Barber, R. C., 1 Jan 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 733-749 17 p.

Research output: Contribution to journalArticle

Alzheimer Disease
8 Citations (Scopus)

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 292-312 21 p.

Research output: Contribution to journalShort survey

Alzheimer Disease

Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study

O'Bryant, S. E., Edwards, M., Zhang, F., Johnson, L. A., Hall, J., Kuras, Y. & Scherzer, C. R., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 374-382 9 p.

Research output: Contribution to journalArticle

Open Access
Neurodegenerative Diseases
Parkinson Disease
Alzheimer Disease