Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
PhD in Social Work, University of Texas at Arlington
MSW, Louisiana State University
BSW in Psychology, Louisiana State University
Fingerprint Dive into the research topics where Leigh Johnson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 16 Similar Profiles
Alzheimer Disease
Medicine & Life Sciences
Cognition
Medicine & Life Sciences
Depression
Medicine & Life Sciences
Biomarkers
Medicine & Life Sciences
Hispanic Americans
Medicine & Life Sciences
Endophenotypes
Medicine & Life Sciences
Dementia
Medicine & Life Sciences
Proteomics
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2022
An Alzheimer's Blood Test for Primary Care
O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.
NIA: National Institute on Aging
1/06/18 → 31/05/21
Project: Research
A Blood Test for Screening into Alzheimer's Prevention Trials
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
15/09/17 → 30/06/22
Project: Research
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
1/09/17 → 31/05/22
Project: Research
A Pro-Inflammatory Endophenotype to Predict Treatment Response to NSAID Therapy in AD
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
1/09/16 → 31/03/21
Project: Research
Amyloid Burden among Mexican Americans
O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.
NIA: National Institute on Aging
30/09/18 → 31/08/19
Project: Research
Research Output 2011 2019
1
Citation
(Scopus)
A proteomic signature for dementia with Lewy bodies
O'Bryant, S. E., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M. & Graff-Radford, N. R., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 270-276 7 p.Research output: Contribution to journal › Article
Open Access
Lewy Body Disease
Proteomics
Parkinson Disease
Dementia
Sensitivity and Specificity
Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans
Silzer, T., Barber, R., Sun, J., Pathak, G., Johnson, L., O’Bryant, S. & Phillips, N., Mar 2019, In : PLoS ONE. 14, 3, e0213527.Research output: Contribution to journal › Article
Open Access
Mexican Americans
Medical problems
Mitochondrial DNA
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities
Pathak, G. A., Silzer, T. K., Sun, J., Zhou, Z., Daniel, A. A., Johnson, L., O'Bryant, S., Phillips, N. R. & Barber, R. C., 1 Jan 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 733-749 17 p.Research output: Contribution to journal › Article
Methylation
Alzheimer Disease
Genome
Morbidity
Phenotype
8
Citations
(Scopus)
Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need
International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 292-312 21 p.Research output: Contribution to journal › Short survey
Dementia
Alzheimer Disease
Research
Population
Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study
O'Bryant, S. E., Edwards, M., Zhang, F., Johnson, L. A., Hall, J., Kuras, Y. & Scherzer, C. R., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 374-382 9 p.Research output: Contribution to journal › Article
Open Access
Neurodegenerative Diseases
Proteomics
Parkinson Disease
Biomarkers
Alzheimer Disease