Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
BSW in Psychology, Louisiana State University
MSW, Louisiana State University
PhD in Social Work, University of Texas at Arlington
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A Blood Test for Screening into Alzheimer's Prevention Trials
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
15/09/17 → 30/06/22
Project: Research
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Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
O'Bryant, S., Hall, J. & Johnson, L.
NIA: National Institute on Aging
1/09/17 → 31/05/22
Project: Research
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Administrative Supplement: Improving AI/ML-Readiness of data generated from HALBE or other NIH-funded research
Johnson, L., RISSMAN, R., TOGA, A., TOGA, A., Johnson, L., RISSMAN, R., O'BRYANT, S., O'BRYANT, S., Johnson, L. & JOHNSON, L.
1/08/20 → 30/04/22
Project: Research
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Amyloid Burden among Mexican Americans
O'Bryant, S., Hall, J., Johnson, L. & Nandy, R.
NIA: National Institute on Aging
30/09/18 → 31/08/19
Project: Research
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Amyloid Burden among Mexican Americans
RISSMAN, R., TOGA, A., RISSMAN, R., TOGA, A., Johnson, L., O'Bryant, S., O'BRYANT, S., O'Bryant, S., JOHNSON, L., O'BRYANT, S., JOHNSON, L., RISSMAN, R. & TOGA, A.
30/09/18 → 30/04/22
Project: Research
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Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study
O'Bryant, S. E., Petersen, M., Zhang, F., Johnson, L., Mason, D. & Hall, J., Jan 2022, In: Parkinsonism and Related Disorders. 94, p. 15-21 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study
for the HABLE Study Team, Feb 2022, In: Alzheimer's and Dementia. 18, 2, p. 240-250 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: Important considerations for clinical trials and practice
for the HABS-HD Study Team, 2022, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
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Metabolic Factors Are Related to Brain Amyloid Among Mexican Americans: A HABS-HD Study
O'Bryant, S. E., Petersen, M. E., Hall, J. & Johnson, L. A., 2022, In: Journal of Alzheimer's Disease. 86, 4, p. 1745-1750 6 p.Research output: Contribution to journal › Article › peer-review
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Proteomic Profiles of Neurodegeneration among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study
O'Bryant, S. E., Zhang, F., Petersen, M. E., Hall, J., Johnson, L. A., Yaffe, K., Braskie, M., Vig, R., Toga, A. W. & Rissman, R. A., 2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1243-1254 12 p.Research output: Contribution to journal › Article › peer-review