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Personal profile

Area of Expertise

My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.

Education/Academic qualification

PhD in Social Work, University of Texas at Arlington

MSW, Louisiana State University

BSW in Psychology, Louisiana State University

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  • 16 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Cognition Medicine & Life Sciences
Depression Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Endophenotypes Medicine & Life Sciences
Hispanic Americans Medicine & Life Sciences
Dementia Medicine & Life Sciences
Language Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 2011 2019

  • 464 Citations
  • 13 h-Index
  • 43 Article
  • 2 Short survey
  • 1 Review article

A proteomic signature for dementia with Lewy bodies

O'Bryant, S., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M. & Graff-Radford, N. R., 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 270-276 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Lewy Body Disease
Parkinson Disease
Sensitivity and Specificity

Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

Silzer, T., Barber, R. C., Sun, J., Pathak, G., Johnson, L. A., O'Bryant, S. & Phillips, N. R., 1 Mar 2019, In : PLoS ONE. 14, 3, e0213527.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Mexican Americans
Medical problems
Mitochondrial DNA
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus

Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, 1 Feb 2019, In : Alzheimer's and Dementia. 15, 2, p. 292-312 21 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Alzheimer Disease

Vascular Depression and Cognition in Mexican Americans

Johnson, L. A., Large, S. E., Izurieta Munoz, H., Hall, J. & O'Bryant, S., 1 Jan 2019, In : Dementia and Geriatric Cognitive Disorders. p. 68-78 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Blood Vessels
Short-Term Memory

A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease

O'Bryant, S., Zhang, F., Johnson, L. A., Hall, J., Edwards, M., Grammas, P., Oh, E., Lyketsos, C. G. & Rissman, R. A., 1 Jan 2018, In : Journal of Alzheimer's disease : JAD. 66, 1, p. 97-104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Precision Medicine
Non-Steroidal Anti-Inflammatory Agents
Alzheimer Disease