Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
BSW in Psychology, Louisiana State University
MSW, Louisiana State University
PhD in Social Work, University of Texas at Arlington
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Collaborations and top research areas from the last five years
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Phase II randomized controlled
Johnson, L. (PI)
University of California, San Diego
1/07/23 → 30/06/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI), Hall, J. (CoI), Johnson, L. (CoI), Mason, D. (CoI), Large, S. (CoI) & Petersen, M. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI) & Johnson, L. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI) & Johnson, L. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - H
O'Bryant, S. (PI), Johnson, L. (CoI) & Barber, R. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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A blood screening test for Dementia with Lewy Bodies for Primary Care
Petersen, M., Ferman, T. J., Zhang, F., Pedraza, O., Wszolek, Z. K., Ross, O. A., Como, T., Julovich, D., Johnson, L., Hall, J., Graff-Radford, N. R. & O'Bryant, S., 2023, In: Journal of Alzheimers Disease & Parkinsonism. 13, 6, 6 p.Research output: Contribution to journal › Article › peer-review
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The differential impact of depressive symptom clusters on cognition in a rural multi-ethnic cohort: A Project FRONTIER study
O'Bryant, S. E., Hall, J. R., Cukrowicz, K. C., Edwards, M., Johnson, L. A., Lefforge, D., Jenkins, M. & Dentino, A., Feb 2011, In: International Journal of Geriatric Psychiatry. 26, 2, p. 199-205 7 p.Research output: Contribution to journal › Article › peer-review
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Vascular depression and cognition in Mexican Americans
Johnson, L. A., Large, S. E., Izurieta Munoz, H., Hall, J. R. & O'Bryant, S. E., 1 May 2019, In: Dementia and Geriatric Cognitive Disorders. 47, 1-2, p. 68-78 11 p.Research output: Contribution to journal › Article › peer-review
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Cardiovascular risk factors in Mexico and the United States: A comparative cross-sectional study between the hable and MHAS participants
Vintimilla, R., Reyes, M., Johnson, L., Hall, J. & O’bryant, S., 1 Jan 2020, In: Gaceta medica de Mexico. 156, 1, p. 16-20 5 p.Research output: Contribution to journal › Article › peer-review
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Risk factors for mild cognitive impairment among Mexican Americans
O'Bryant, S. E., Johnson, L., Reisch, J., Edwards, M., Hall, J., Barber, R., Devous, M. D., Royall, D. & Singh, M., Nov 2013, In: Alzheimer's and Dementia. 9, 6, p. 622-631.e1Research output: Contribution to journal › Article › peer-review