Projects per year
Personal profile
Area of Expertise
My area of expertise is in translational aging research. I am the Co-I of Health & Aging Brain among Latino Elders (HABLE) study (R01AG054073) and the Director of the Clinical and Outreach cores for this study. I have spent a great deal of time studying factors related to cognitive loss among Mexican-Americans with a specific emphasis on the link between depression and cognition. I have developed and cross-validated a depressive endophenotype (DepE) of cognitive aging across multiple national and international cohorts. This work has been translated into a proof of concept clinical trial (The DEMO trial). The DEMO trial utilizes a precision medicine approach to identify those individuals more likely to benefit from antidepressant treatment for prevention of memory loss and potentially Alzheimer’s disease.
Education/Academic qualification
BSW in Psychology, Louisiana State University
MSW, Louisiana State University
PhD in Social Work, University of Texas at Arlington
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Phase II randomized controlled trial of benfotiamine in early Alzheimers Disease
Johnson, L. (PI)
University of California, San Diego
1/07/23 → 30/06/27
Project: Research
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Health & Aging Brain Study - Health Disparities (HABS-HD)
O'Bryant, S. (PI), Johnson, L. (CoI) & Barber, R. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - Health Disparities (HABS-HD)
O'Bryant, S. (PI) & Johnson, L. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - Health Disparities (HABS-HD)
O'Bryant, S. (PI), Hall, J. (CoI), Johnson, L. (CoI), Mason, D. (CoI), Large, S. (CoI) & Petersen, M. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Health & Aging Brain Study - Health Disparities (HABS-HD)
O'Bryant, S. (PI) & Johnson, L. (CoI)
NIA: National Institute on Aging
1/09/22 → 31/08/27
Project: Research
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Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study
O'Bryant, S. E., Petersen, M., Zhang, F., Johnson, L., Mason, D. & Hall, J., Jan 2022, In: Parkinsonism and Related Disorders. 94, p. 15-21 7 p.Research output: Contribution to journal › Article › peer-review
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A depressive endophenotype for predicting cognitive decline among mexican American adults and elders
Johnson, L. A., Gamboa, A., Vintimilla, R., Edwards, M., Hall, J., Weiser, B., Yadav, M., Dickensheets, T. & O'Bryant, S. E., 23 Aug 2016, In: Journal of Alzheimer's Disease. 54, 1, p. 201-206 6 p.Research output: Contribution to journal › Article › peer-review
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Cognitive differences among depressed and non-depressed MCI participants: A project FRONTIER study
Johnson, L. A., Mauer, C., Jahn, D., Song, M., Wyshywaniuk, L., Hall, J. R., Balldin, V. H. & O'Bryant, S. E., Apr 2013, In: International Journal of Geriatric Psychiatry. 28, 4, p. 377-382 6 p.Research output: Contribution to journal › Article › peer-review
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Cognitive dysfunction and the 25-item National Eye Institute Visual Function Questionnaire
Mozdbar, S., Alber, J., Aryal, S., Johnson, L., Moroz, A., Rashik, M., Mostafavi, A. & O'Bryant, S., 2022, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 14, 1, e12378.Research output: Contribution to journal › Article › peer-review
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Hyperparameter Tuning with High Performance Computing Machine Learning for Imbalanced Alzheimer’s Disease Data
Zhang, F., Petersen, M., Johnson, L., Hall, J. & O’bryant, S. E., 1 Jul 2022, In: Applied Sciences (Switzerland). 12, 13, 6670.Research output: Contribution to journal › Article › peer-review