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Personal profile

Area of Expertise

Dr. Prokai is the first Chair in Biochemistry endowed by the Houston-based Welch Foundation, one of the United States’ oldest and largest private funding sources for basic research, at UNT Health Science Center. He is affiliated with UNTHSC’s Department of Pharmacology and Neuroscience, and with the Institute of Healthy Aging. Dr. Prokai also is Adjunct Professor at the Department of Chemistry and Biochemistry, University of Texas at Arlington, as well as Adjunct Professor and Associate Member of the Graduate Faculty at the Department of Chemistry and Biochemistry of Texas Christian University.
His interests focus on chemistry-driven multidisciplinary research and include the discovery, chemical biology, bioorganic, and medicinal chemistry of central nervous system agents, as well as neuropeptides, proteomics, and mass spectrometry.
Dr. Prokai has maintained an actively funded research program from grant support by the National Institutes of Health (NIH) as well as through collaborations with pharmaceutical and chemical companies. Dr. Prokai was the recipient of the 2017 Wilfred T. Doherty Award of the Dallas/Fort Worth Section of the American Chemical Society (ACS) and the 2017 Southwest ACS Regional Award.

Education/Academic qualification

PhD in Radiochemistry, University of Veszprem

BS in Chemical Engineering, University of Veszprem

MS in Chemistry, University of Veszprem

Fingerprint Dive into the research topics where Laszlo Prokai is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Mass spectrometry Chemical Compounds
Electrospray ionization Chemical Compounds
Brain Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Peptides Medicine & Life Sciences
Thyrotropin-Releasing Hormone Medicine & Life Sciences
Estrogens Medicine & Life Sciences
Liquid chromatography Chemical Compounds

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Projects 2009 2022

Research Output 1984 2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids

Different reactivity to glutathione but similar tumor cell toxicity of chalcones and their quinolinone analogues

d’Oliveira, G. D. C., Custodio, J. M. F., Moura, A. F., Napolitano, H. B., Pérez, C. N., Moraes, M. O., Prokai, L. & Perjési, P., 1 Sep 2019, In : Medicinal Chemistry Research. 28, 9, p. 1448-1460 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Chalcones
Chalcone
Quinolones
Glutathione
Toxicity

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Brain
Estrogens
Neurology
2 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor

Risk-associated and pathway-based method to detect association with Alzheimer's disease

Mitchel, J., Prokai, L., Deng, Y., Zhang, F. & Barber, R. C., 1 Jan 2018, In : International Journal of Computational Biology and Drug Design. 11, 1-2

Research output: Contribution to journalEditorialResearch

Alzheimer Disease
Alleles
Genome-Wide Association Study
Databases
Genes