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Area of Expertise

Dr. Prokai is the first Chair in Biochemistry endowed by the Houston-based Welch Foundation, one of the United States’ oldest and largest private funding sources for basic research, at UNT Health Science Center. He is affiliated with UNTHSC’s Department of Pharmacology and Neuroscience, and with the Institute of Healthy Aging. Dr. Prokai also is Adjunct Professor at the Department of Chemistry and Biochemistry, University of Texas at Arlington, as well as Adjunct Professor and Associate Member of the Graduate Faculty at the Department of Chemistry and Biochemistry of Texas Christian University.
His interests focus on chemistry-driven multidisciplinary research and include the discovery, chemical biology, bioorganic, and medicinal chemistry of central nervous system agents, as well as neuropeptides, proteomics, and mass spectrometry.
Dr. Prokai has maintained an actively funded research program from grant support by the National Institutes of Health (NIH) as well as through collaborations with pharmaceutical and chemical companies. Dr. Prokai was the recipient of the 2017 Wilfred T. Doherty Award of the Dallas/Fort Worth Section of the American Chemical Society (ACS) and the 2017 Southwest ACS Regional Award.

Education/Academic qualification

PhD in Radiochemistry, University of Veszprem

BS in Chemical Engineering, University of Veszprem

MS in Chemistry, University of Veszprem

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Mass spectrometry Chemical Compounds
Electrospray ionization Chemical Compounds
Brain Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Peptides Medicine & Life Sciences
Thyrotropin-Releasing Hormone Medicine & Life Sciences
Estrogens Medicine & Life Sciences
Liquid chromatography Chemical Compounds

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Projects 2009 2022

Research Output 1984 2019

[ 99 mTc-HYNIC-N-dodecylamide]:a new hydrophobic tracer for labelling reconstituted high-density lipoproteins (rHDL) for radioimaging

Isaac-Olivé, K., Ocampo-García, B. E., Aranda-Lara, L., Santos-Cuevas, C. L., Jiménez-Mancilla, N. P., Luna-Gutiérrez, M. A., Medina, L. A., Nagarajan, B., Sabnis, N., Raut, S. L., Prokai, L. & Lacko, A. G., 14 Jan 2019, In : Nanoscale. 11, 2, p. 541-551 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoproteins
HDL Lipoproteins
Labeling
Imaging techniques
Acids

10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy

Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodrugs
Estradiol
Brain
Estrogens
Neurology
2 Citations (Scopus)

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor

Risk-associated and pathway-based method to detect association with Alzheimer's disease

Mitchel, J., Prokai, L., Deng, Y., Zhang, F. & Barber, R. C., 1 Jan 2018, In : International Journal of Computational Biology and Drug Design. 11, 1-2

Research output: Contribution to journalEditorialResearch

Alzheimer Disease
Alleles
Genome-Wide Association Study
Databases
Genes

Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

Urbanski, H. F., Sorwell, K. G., Prokai, L. & Kohama, S. G., 1 Jul 2017, In : Neurobiology of Aging. 55, p. 172-174 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Dehydroepiandrosterone
Macaca mulatta
Estrogens
Estradiol
Hippocampus