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Personal profile

Area of Expertise

Present interests in Dr. Dory's laboratory include the therapeutic effects (and related mechanisms) of intermittent hyperbaric oxygen treatment on reducing oxidative stress and inflammatory responses in various diseases including cognitive decline, such as Alzheimer's disease. His laboratory uses a hyperbaric chamber designed specifically for small animals. End points are assessed by tools of molecular biology and immunoassays to examine the expression of various target genes (RT-PCR, western blots, and ELISAs) and behavioral studies in collaboration with Dr. Sumien.
In the recent past Dr. Dory pioneered work on the effects of hyperbaric oxygen on the development and regression of atherosclerosis in animal models. Those studies led to a body of work on the role of extracellular superoxide dismutase (ecSOD) in various diseases involving oxidative stress, including bacterial infection, asbestosis, irritable bowel disease, and colon cancer. His laboratory discovered a new allele of murine extracellular superoxide dismutase with profound effects on disease resistance.
He is also an internationally recognized investigator in the area of atherosclerosis, specifically reverse cholesterol transport and apolipoprotein E metabolism. He was one of the leaders of characterizing interstitial fluid lipoproteins, peripheral HDL formation, and was the first to demonstrate, in vivo, the synthesis of apoE by peripheral (non-hepatic) tissues, as part of cholesterol efflux and peripheral HDL formation.

Education/Academic qualification

PhD in Biochemistry, McGill University

BS in Organic Chemistry, University of Manitoba

Fingerprint Dive into the research topics where Ladislav Dory is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Apolipoproteins E Medicine & Life Sciences
Macrophages Chemical Compounds
Cholesterol Medicine & Life Sciences
Lipoproteins Medicine & Life Sciences
Lymph Medicine & Life Sciences
HDL Lipoproteins Medicine & Life Sciences
Superoxide Dismutase Medicine & Life Sciences
Extracellular Fluid Medicine & Life Sciences

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Projects 2013 2018

Research Output 1978 2016

  • 1146 Citations
  • 19 h-Index
  • 39 Article
  • 2 Review article
1 Citation (Scopus)

Extracellular superoxide dismutase enhances recruitment of immature neutrophils to the liver

Break, T. J., Witter, A. R., Indramohan, M., Mummert, M. E., Dory, L. & Berg, R., 1 Jan 2016, In : Infection and Immunity. 84, 12, p. 3302-3312 11 p.

Research output: Contribution to journalArticle

Neutrophil Infiltration
Listeria monocytogenes
Superoxide Dismutase
Neutrophils
Liver
26 Citations (Scopus)

Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection

Break, T. J., Jun, S., Indramohan, M., Carr, K. D., Sieve, A. N., Dory, L. & Berg, R., 1 Apr 2012, In : Journal of Immunology. 188, 7, p. 3342-3350 9 p.

Research output: Contribution to journalArticle

Bacterial Infections
Innate Immunity
Superoxide Dismutase
Neutrophils
Liver
4 Citations (Scopus)

Allele-specific effects of ecSOD on asbestos-induced fibroproliferative lung disease in mice

Jun, S., Fattman, C. L., Kim, B. J., Jones, H. & Dory, L., 15 May 2011, In : Free Radical Biology and Medicine. 50, 10, p. 1288-1296 9 p.

Research output: Contribution to journalArticle

Pulmonary diseases
Asbestos
Lung Diseases
Superoxide Dismutase
Alleles
5 Citations (Scopus)

Extracellular superoxide dismutase polymorphism in mice: Allele-specific effects on phenotype

Jun, S., Pierce, A. & Dory, L., 15 Feb 2010, In : Free Radical Biology and Medicine. 48, 4, p. 590-596 7 p.

Research output: Contribution to journalArticle

Polymorphism
Superoxide Dismutase
Alleles
Phenotype
Congenic Mice
22 Citations (Scopus)

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice

Kudchodkar, B., Jones, H., Simecka, J. & Dory, L., 1 Sep 2008, In : Clinical Immunology. 128, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Knockout Mice
Oxygen
Atherosclerosis
Cytokines