Projects per year
Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
URL
Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of peptoid-based b
Kim, J. (PI) & Emmitte, K. (CoI)
NIBIB: Nat Inst of Biomedical Imaging
15/08/24 → 31/05/27
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Discovery of synthetic flavonoids for the treatment of corneal injury
Karamichos, D. (PI) & Emmitte, K. (CoPI)
1/01/24 → 31/12/24
Project: Research
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Small Molecule Slack Channel Inhibitors for the Treatment of Epilepsies
Emmitte, K. (PI)
1/01/22 → 30/09/23
Project: Research
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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu 1
Manka, J. T., Rodriguez, A. L., Morrison, R. D., Venable, D. F., Cho, H. P., Blobaum, A. L., Daniels, J. S., Niswender, C. M., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 15 Sep 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 18, p. 5091-5096 6 p.Research output: Contribution to journal › Article › peer-review
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Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels
Mishra, N. M., Spitznagel, B. D., Du, Y., Mohamed, Y. K., Qin, Y., Weaver, C. D. & Emmitte, K. A., Dec 2024, In: Molecules. 29, 23, 5494.Research output: Contribution to journal › Article › peer-review
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Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs
Engers, J. L., Bollinger, K. A., Weiner, R. L., Rodriguez, A. L., Long, M. F., Breiner, M. M., Chang, S., Bollinger, S. R., Bubser, M., Jones, C. K., Morrison, R. D., Bridges, T. M., Blobaum, A. L., Niswender, C. M., Conn, P. J., Emmitte, K. A. & Lindsley, C. W., 14 Sep 2017, In: ACS Medicinal Chemistry Letters. 8, 9, p. 925-930 6 p.Research output: Contribution to journal › Article › peer-review
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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
Wood, M. R., Noetzel, M. J., Engers, J. L., Bollinger, K. A., Melancon, B. J., Tarr, J. C., Han, C., West, M., Gregro, A. R., Lamsal, A., Chang, S., Ajmera, S., Smith, E., Chase, P., Hodder, P. S., Bubser, M., Jones, C. K., Hopkins, C. R., Emmitte, K. A. & Niswender, C. M. & 5 others, , 1 Jul 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3029-3033 5 p.Research output: Contribution to journal › Article › peer-review
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Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1
Zolekar, A., Lin, V. J. T., Mishra, N. M., Ho, Y. Y., Hayatshahi, H. S., Parab, A., Sampat, R., Liao, X., Hoffmann, P., Liu, J., Emmitte, K. A. & Wang, Y. C., 11 Dec 2018, In: British Journal of Cancer. 119, 12, p. 1538-1551 14 p.Research output: Contribution to journal › Article › peer-review