Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
URL
Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Collaborations and top research areas from the last five years
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Development of peptoid-based b
Kim, J. (PI) & Emmitte, K. (CoI)
NIBIB: Nat Inst of Biomedical Imaging
15/08/24 → 31/05/27
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Discovery of synthetic flavonoids for the treatment of corneal injury
Karamichos, D. (PI) & Emmitte, K. (CoPI)
1/01/24 → 31/12/24
Project: Research
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Small Molecule Slack Channel Inhibitors for the Treatment of Epilepsies
Emmitte, K. (PI)
1/01/22 → 30/09/23
Project: Research
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Discovery of GSK461364: A Polo-Like Kinase 1 Inhibitor for the Treatment of Cancer
Kuntz, K. W. & Emmitte, K. A., 28 Sep 2009, Kinase Inhibitor Drugs. John Wiley & Sons, Inc., p. 351-364 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Corrigendum to "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding" [Bioorg. Med. Chem. Lett. 19 (2009) 1694] (DOI:10.1016/j.bmcl.2009.01.094)
Emmitte, K. A., Adjabeng, G. M., Webb Andrews, C., Badiang Alberti, J. G., Bambal, R., Chamberlain, S. D., Davis-Ward, R. G., Dickson, H. D., Hassler, D. F., Hornberger, K. R., Jackson, J. R., Kuntz, K. W., Lansing, T. J., Mook, R. A., Nailor, K. E., Pobanz, M. A., Smith, S. C., Sung, C. M. & Cheung, M., 1 May 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 9, p. 2604 1 p.Research output: Contribution to journal › Comment/debate
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Co-activation of metabotropic glutamate receptor 3 and beta-adrenergic receptors modulates cyclic-AMP and long-term potentiation, and disrupts memory reconsolidation
Walker, A. G., Sheffler, D. J., Lewis, A. S., Dickerson, J. W., Foster, D. J., Senter, R. K., Moehle, M. S., Lv, X., Stansley, B. J., Xiang, Z., Rook, J. M., Emmitte, K. A., Lindsley, C. W. & Conn, P. J., 1 Dec 2017, In: Neuropsychopharmacology. 42, 13, p. 2553-2566 14 p.Research output: Contribution to journal › Article › peer-review
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Evaluating the disposition of a mixed aldehyde oxidase/cytochrome P450 substrate in rats with attenuated P450 activity
Crouch, R. D., Morrison, R. D., Byers, F. W., Lindsley, C. W., Emmitte, K. A. & Daniels, J. S., Aug 2016, In: Drug Metabolism and Disposition. 44, 8, p. 1296-1303 8 p.Research output: Contribution to journal › Article › peer-review
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(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: Discovery of a new tool compound with activity in the OSS mouse model of addiction
Lindsley, C. W., Bates, B. S., Menon, U. N., Jadhav, S. B., Kane, A. S., Jones, C. K., Rodriguez, A. L., Conn, P. J., Olsen, C. M., Winder, D. G. & Emmitte, K. A., 17 Aug 2011, In: ACS Chemical Neuroscience. 2, 8, p. 471-482 12 p.Research output: Contribution to journal › Article › peer-review