Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
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Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Collaborations and top research areas from the last five years
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Development of peptoid-based b
Kim, J. (PI) & Emmitte, K. (CoI)
NIBIB: Nat Inst of Biomedical Imaging
15/08/24 → 31/05/27
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Discovery of synthetic flavonoids for the treatment of corneal injury
Karamichos, D. (PI) & Emmitte, K. (CoPI)
1/01/24 → 31/12/24
Project: Research
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Small Molecule Slack Channel Inhibitors for the Treatment of Epilepsies
Emmitte, K. (PI)
1/01/22 → 30/09/23
Project: Research
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Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway
Theriault, J. R., Felts, A. S., Bates, B. S., Perez, J. R., Palmer, M., Gilbert, S. R., Dawson, E. S., Engers, J. L., Lindsley, C. W. & Emmitte, K. A., 1 Jan 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 76-81 6 p.Research output: Contribution to journal › Article › peer-review
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Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1
Hornberger, K. R., Badiang, J. G., Salovich, J. M., Kuntz, K. W., Emmitte, K. A. & Cheung, M., 27 Oct 2008, In: Tetrahedron Letters. 49, 44, p. 6348-6351 4 p.Research output: Contribution to journal › Article › peer-review
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Recent progress in the discovery and development of negative allosteric modulators of mGluR5
Lindsley, C. W. & Emmitte, K. A., Jul 2009, In: Current Opinion in Drug Discovery and Development. 12, 4, p. 446-457 12 p.Research output: Contribution to journal › Review article › peer-review
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Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Felts, A. S., Rodriguez, A. L., Morrison, R. D., Bollinger, K. A., Venable, D. F., Blobaum, A. L., Byers, F. W., Thompson Gray, A., Daniels, J. S., Niswender, C. M., Jones, C. K., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 1 Nov 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4858-4866 9 p.Research output: Contribution to journal › Article › peer-review
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Structure–activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels
Qunies, A. M., Mishra, N. M., Spitznagel, B. D., Du, Y., Acuña, V. S., David Weaver, C. & Emmitte, K. A., 15 Nov 2022, In: Bioorganic and Medicinal Chemistry Letters. 76, 129013.Research output: Contribution to journal › Article › peer-review