Projects per year
Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
URL
Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Dive into the research topics where Kyle Emmitte is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Discovery of synthetic flavonoids for the treatment of corneal injury
Emmitte, K. (PI)
1/01/24 → 31/12/25
Project: Research
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Discovery of synthetic flavonoids for the treatment of corneal injury
Karamichos, D. (PI) & Emmitte, K. (CoPI)
1/01/24 → 31/12/24
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Small Molecule Slack Channel Inhibitors for the Treatment of Epilepsies
Emmitte, K. (PI)
1/01/22 → 30/09/23
Project: Research
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Discovery of small molecule activators of the Slack potassium channel for use as cell-based probes for the study of fragile X syndrome
Emmitte, K. (PI) & WEAVER, D. (CoPI)
National Institute of Mental Health
1/12/20 → 31/10/21
Project: Research
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Partial mGlu 5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
Gould, R. W., Amato, R. J., Bubser, M., Joffe, M. E., Nedelcovych, M. T., Thompson, A. D., Nickols, H. H., Yuh, J. P., Zhan, X., Felts, A. S., Rodriguez, A. L., Morrison, R. D., Byers, F. W., Rook, J. M., Daniels, J. S., Niswender, C. M., Conn, P. J., Emmitte, K. A., Lindsley, C. W. & Jones, C. K., 1 Mar 2016, In: Neuropsychopharmacology. 41, 4, p. 1166-1178 13 p.Research output: Contribution to journal › Article › peer-review
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Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013
Schüß, C., Vu, O., Mishra, N. M., Tough, I. R., Du, Y., Stichel, J., Cox, H. M., Weaver, C. D., Meiler, J., Emmitte, K. A. & Beck-Sickinger, A. G., 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8745-8766 22 p.Research output: Contribution to journal › Article › peer-review
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1
Lansing, T. J., McConnell, R. T., Duckett, D. R., Spehar, G. M., Knick, V. B., Hassler, D. F., Noro, N., Furuta, M., Emmitte, K. A., Gilmer, T. M., Mook, R. A. & Cheung, M., Feb 2007, In: Molecular Cancer Therapeutics. 6, 2, p. 450-459 10 p.Research output: Contribution to journal › Article › peer-review
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Asymmetric total synthesis of (-)-isolaurallene [18]
Crimmins, M. T. & Emmitte, K. A., 21 Feb 2001, In: Journal of the American Chemical Society. 123, 7, p. 1533-1534 2 p.Research output: Contribution to journal › Letter › peer-review
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A convergent coupling strategy for the formation of polycyclic ethers: Stereoselective synthesis of the BCDE fragment of brevetoxin A
Crimmins, M. T., McDougall, P. J. & Emmitte, K. A., 1 Sep 2005, In: Organic Letters. 7, 18, p. 4033-4036 4 p.Research output: Contribution to journal › Article › peer-review