Projects per year
Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
URL
Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Collaborations and top research areas from the last five years
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Projects
- 13 Finished
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Discovery of small molecule activators of the Slack potassium channel for use as cell-based probes for the study of fragile X syndrome
WEAVER, D., WEAVER, C., EMMITTE, K., Emmitte, K. & Emmitte, K.
1/12/20 → 31/10/22
Project: Research
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Discovery of small molecule activators of the Slack potassium channel for use as cell-based probes for the study of fragile X syndrome
Emmitte, K. & WEAVER, D.
National Institute of Mental Health
1/12/20 → 31/10/21
Project: Research
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Slack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies
Emmitte, K., WEAVER, D., Emmitte, K., EMMITTE, K., Emmitte, K. & WEAVER, C.
1/01/20 → 31/12/22
Project: Research
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Slack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies
Emmitte, K., WEAVER, D., WEAVER, D. & EMMITTE, K.
National Institute of Neurological Disorders and Stroke
15/12/18 → 31/12/21
Project: Research
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Slack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies
15/12/18 → 30/11/19
Project: Research
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Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5
Felts, A. S., Saleh, S. A., Le, U., Rodriguez, A. L., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 1 Dec 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6623-6626 4 p.Research output: Contribution to journal › Article › peer-review
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Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1
Hornberger, K. R., Badiang, J. G., Salovich, J. M., Kuntz, K. W., Emmitte, K. A. & Cheung, M., 27 Oct 2008, In: Tetrahedron Letters. 49, 44, p. 6348-6351 4 p.Research output: Contribution to journal › Article › peer-review
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Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies
Qunies, AA. M. & Emmitte, K. A., Mar 2022, In: Pharmaceutical Patent Analyst. 11, 2, p. 45-56 12 p.Research output: Contribution to journal › Review article › peer-review
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Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery
Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., 23 Feb 2012, In: Journal of Medicinal Chemistry. 55, 4, p. 1445-1464 20 p.Research output: Contribution to journal › Review article › peer-review
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The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate
Panarese, J. D., Engers, D. W., Wu, Y. J., Guernon, J. M., Chun, A., Gregro, A. R., Bender, A. M., Capstick, R. A., Wieting, J. M., Bronson, J. J., Macor, J. E., Westphal, R., Soars, M., Engers, J. E., Felts, A. S., Rodriguez, A. L., Emmitte, K. A., Jones, C. K., Blobaum, A. L., Jeffrey Conn, P., & 3 others, 15 Jan 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 342-346 5 p.Research output: Contribution to journal › Article › peer-review