Projects per year
Personal profile
Research Interests
Drug Discovery, Medicinal Chemistry, and Neuroscience
URL
Area of Expertise
The Emmitte laboratory employs multiple types of medicinal chemistry strategies to design, synthesize, and optimize biologically active small molecules to serve as in vivo probes, drug discovery leads, and optimized preclinical compounds. Research in the Emmitte laboratory is highly collaborative and works on several different types of drug target classes across several therapeutic areas.
Techniques
Parallel, solution-phase organic synthesis; Microwave-Assisted Organic Synthesis; Hit Optimization; Lead Optimization; Scaffold-hopping, Rational drug design, 1H and 13C NMR analysis, HRMS analysis, normal and reverse phase chromatography
Education/Academic qualification
BS in Chemistry, Texas A & M University
PhD in Organic Chemistry, University of North Carolina at Chapel Hill
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Collaborations and top research areas from the last five years
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Development of peptoid-based b
Kim, J. (PI) & Emmitte, K. (CoI)
NIBIB: Nat Inst of Biomedical Imaging
15/08/24 → 30/05/27
Project: Research
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UNTHSC Team Science - Team-based discovery and preclinical evaluation of cocaine addiction treatments
Colon-Perez, L. (CoPI), Forster, M. (CoPI), Emmitte, K. (CoPI), Siderovski, D. (CoPI) & Shetty, R. (CoI)
UNT Health Science Center Division of Research and Innovation
1/08/23 → …
Project: Research
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Discovery of synthetic flavonoids for the treatment of corneal injury
Karamichos, D. (PI) & Emmitte, K. (CoPI)
1/01/24 → 31/12/24
Project: Research
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Small Molecule Slack Channel Inhibitors for the Treatment of Epilepsies
Emmitte, K. (PI)
1/01/22 → 30/09/23
Project: Research
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A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors
Cho, H. P., Engers, D. W., Venable, D. F., Niswender, C. M., Lindsley, C. W., Conn, P. J., Emmitte, K. A. & Rodriguez, A. L., 16 Jul 2014, In: ACS Chemical Neuroscience. 5, 7, p. 597-610 14 p.Research output: Contribution to journal › Article › peer-review
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Corrigendum to "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding" [Bioorg. Med. Chem. Lett. 19 (2009) 1694] (DOI:10.1016/j.bmcl.2009.01.094)
Emmitte, K. A., Adjabeng, G. M., Webb Andrews, C., Badiang Alberti, J. G., Bambal, R., Chamberlain, S. D., Davis-Ward, R. G., Dickson, H. D., Hassler, D. F., Hornberger, K. R., Jackson, J. R., Kuntz, K. W., Lansing, T. J., Mook, R. A., Nailor, K. E., Pobanz, M. A., Smith, S. C., Sung, C. M. & Cheung, M., 1 May 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 9, p. 2604 1 p.Research output: Contribution to journal › Comment/debate
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Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5
Felts, A. S., Saleh, S. A., Le, U., Rodriguez, A. L., Weaver, C. D., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 1 Dec 2009, In: Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6623-6626 4 p.Research output: Contribution to journal › Article › peer-review
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Total Synthesis of (+)-laurencin: An Asymmetric Alkylation - Ring-closing Metathesis Approach to Medium Ring Ethers
Crimmins, M. T. & Emmitte, K. A., 16 Dec 1999, In: Organic Letters. 1, 12, p. 2029-2032 4 p.Research output: Contribution to journal › Article › peer-review
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu 5: Identification of easily prepared tool compounds with CNS exposure in rats
Felts, A. S., Lindsley, S. R., Lamb, J. P., Rodriguez, A. L., Menon, U. N., Jadhav, S., Jones, C. K., Conn, P. J., Lindsley, C. W. & Emmitte, K. A., 1 Aug 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 15, p. 4390-4394 5 p.Research output: Contribution to journal › Article › peer-review