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Personal profile

Area of Expertise

My laboratory focuses on the mechanisms underlying regulation of aging on neurogenesis after stroke. Specifically, I will explore the roles of molecular pathways in neurogenesis during aging and in the aged brain after stroke. I am also interested in whether damaged brain tissue in the chronic phase after stroke can be repaired through a stem cell-based tissue engineering approach. In addition, I investigate whether hippocampal neurogenesis contributes to the neuropathology and cognitive impairment of Alzheimer's disease and whether modulating this process could provide a mechanistic and therapeutic approach to the disease.

Education/Academic qualification

PhD in Molecular Biology, Beijing University

MD , Wenzhou Medical University

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Projects 2011 2024

Research Output 1989 2019

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

Chen, X., Lin, S., Gu, L., Zhu, X., Zhang, Y., Zhang, H., Shao, B., Zhuge, Q. & Jin, K., 1 Jan 2019, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
Stroke
Middle Cerebral Artery Infarction
Young Adult
Up-Regulation

Intracranial atherosclerotic disease

Wang, Y., Meng, R., Liu, G., Cao, C., Chen, F., Jin, K., Ji, X. & Cao, G., 1 Apr 2019, In : Neurobiology of Disease. 124, p. 118-132 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Intracranial Arteriosclerosis
Stroke
Therapeutics
Recurrence
Risk Management

Remote ischemic conditioning for stroke: clinical data, challenges, and future directions

Zhao, W., Li, S., Ren, C., Meng, R., Jin, K. & Ji, X., 1 Jan 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 186-196 11 p.

Research output: Contribution to journalReview articleResearchpeer-review

Stroke
Brain
Conditioning (Psychology)
Direction compound
Cerebral Small Vessel Diseases

Ac-YVAD-CMK inhibits pyroptosis and improves functional outcome after intracerebral hemorrhage

Lin, X., Ye, H., Siaw-Debrah, F., Pan, S., He, Z., Ni, H., Xu, Z., Jin, K., Zhuge, Q. & Huang, L., 1 Jan 2018, In : BioMed Research International. 2018, 3706047.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral Hemorrhage
Cell death
Chemical activation
Cell Death
Inflammasomes
1 Citation (Scopus)

Aging health and R & D for healthy longevity must be included into the WHO work program

Stambler, I., Jin, K., Lederman, S., Barzilai, N., Jay Olshansky, S., Omokaro, E., Barratt, J., Anisimov, V. N., Rattan, S., Yang, S., Forster, M. J. & Byles, J., 1 Apr 2018, In : Aging and Disease. 9, 2, p. 331-333 3 p.

Research output: Contribution to journalEditorialResearch

Health