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Personal profile

Area of Expertise

My laboratory focuses on the mechanisms underlying regulation of aging on neurogenesis after stroke. Specifically, I will explore the roles of molecular pathways in neurogenesis during aging and in the aged brain after stroke. I am also interested in whether damaged brain tissue in the chronic phase after stroke can be repaired through a stem cell-based tissue engineering approach. In addition, I investigate whether hippocampal neurogenesis contributes to the neuropathology and cognitive impairment of Alzheimer's disease and whether modulating this process could provide a mechanistic and therapeutic approach to the disease.

Education/Academic qualification

PhD in Molecular Biology, Beijing University

MD , Wenzhou Medical University

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Projects 2011 2024

Research Output 1989 2019

Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury

Ni, H., Yang, S., Siaw-Debrah, F., Hu, J., Wu, K., He, Z., Yang, J., Pan, S., Lin, X., Ye, H., Xu, Z., Wang, F., Jin, K., Zhuge, Q. & Huang, L., 1 Jan 2019, In : Frontiers in Neuroscience. 13, JAN, 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Exosomes
Mesenchymal Stromal Cells
Bone and Bones
Microglia
Macrophages

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

Chen, X., Lin, S., Gu, L., Zhu, X., Zhang, Y., Zhang, H., Shao, B., Zhuge, Q. & Jin, K., 1 Jul 2019, In : Neurochemistry International. 127, p. 64-72 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
Stroke
Middle Cerebral Artery Infarction
Young Adult
Up-Regulation

Intracranial atherosclerotic disease

Wang, Y., Meng, R., Liu, G., Cao, C., Chen, F., Jin, K., Ji, X. & Cao, G., 1 Apr 2019, In : Neurobiology of Disease. 124, p. 118-132 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Intracranial Arteriosclerosis
Stroke
Therapeutics
Recurrence
Risk Management

Remote ischemic conditioning for stroke: clinical data, challenges, and future directions

Zhao, W., Li, S., Ren, C., Meng, R., Jin, K. & Ji, X., 1 Jan 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 186-196 11 p.

Research output: Contribution to journalReview articleResearchpeer-review

Stroke
Brain
Conditioning (Psychology)
Direction compound
Cerebral Small Vessel Diseases

The effect of age, sex and strains on the performance and outcome in animal models of stroke

Zhang, H., Lin, S., Chen, X., Gu, L., Zhu, X., Zhang, Y., Reyes, K., Wang, B. & Jin, K., 1 Jul 2019, In : Neurochemistry International. 127, p. 2-11 10 p.

Research output: Contribution to journalReview articleResearchpeer-review

Animal Models
Stroke
Rodentia
Cerebrovascular Circulation
Brain Infarction