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Personal profile

Area of Expertise

My laboratory focuses on the mechanisms underlying regulation of aging on neurogenesis after stroke. Specifically, I will explore the roles of molecular pathways in neurogenesis during aging and in the aged brain after stroke. I am also interested in whether damaged brain tissue in the chronic phase after stroke can be repaired through a stem cell-based tissue engineering approach. In addition, I investigate whether hippocampal neurogenesis contributes to the neuropathology and cognitive impairment of Alzheimer's disease and whether modulating this process could provide a mechanistic and therapeutic approach to the disease.

Education/Academic qualification

PhD in Molecular Biology, Beijing University

MD , Wenzhou Medical University

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  • 18 Similar Profiles
Neurogenesis Medicine & Life Sciences
Brain Medicine & Life Sciences
Stroke Medicine & Life Sciences
Brain Ischemia Medicine & Life Sciences
Neurons Medicine & Life Sciences
Ischemia Medicine & Life Sciences
Middle Cerebral Artery Infarction Medicine & Life Sciences
Vascular Endothelial Growth Factor A Medicine & Life Sciences

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Projects 2011 2024

Research Output 1989 2019

AMPK signaling regulates the age-related decline of hippocampal neurogenesis

Wang, B. Z., Yang, J. J., Zhang, H., Smith, C. A. & Jin, K., 1 Jan 2019, In : Aging and Disease. 10, 5, p. 1058-1074 17 p.

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Intrinsic Factor
8 Citations (Scopus)

Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury

Ni, H., Yang, S., Siaw-Debrah, F., Hu, J., Wu, K., He, Z., Yang, J., Pan, S., Lin, X., Ye, H., Xu, Z., Wang, F., Jin, K., Zhuge, Q. & Huang, L., 1 Jan 2019, In : Frontiers in Neuroscience. 13, JAN, 14.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Bone and Bones

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

Chen, X., Lin, S., Gu, L., Zhu, X., Zhang, Y., Zhang, H., Shao, B., Zhuge, Q. & Jin, K., Jul 2019, In : Neurochemistry International. 127, p. 64-72 9 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Young Adult

Intracranial atherosclerotic disease

Wang, Y., Meng, R., Liu, G., Cao, C., Chen, F., Jin, K., Ji, X. & Cao, G., Apr 2019, In : Neurobiology of Disease. 124, p. 118-132 15 p.

Research output: Contribution to journalArticle

Intracranial Arteriosclerosis
Risk Management

Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?

Tao, X., Yang, W., Zhu, S., Que, R., Liu, C., Fan, T., Wang, J., Mo, D., Zhang, Z., Tan, J., Jin, K., Yenarih, M. A., Song, T. & Wang, Q., Dec 2019, In : Experimental Neurology. 322, 113060.

Research output: Contribution to journalReview article

Animal Models