• 447 Citations
  • 13 h-Index
20042021
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Research Output 2004 2019

  • 447 Citations
  • 13 h-Index
  • 27 Article
  • 1 Comment/debate
  • 1 Letter
  • 1 Review article
2019
Open Access
National Institute of Neurological Disorders and Stroke
Organized Financing
Astrocytes
Histones
Methylation

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Jan 2019, In : Journal of NeuroVirology.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Histones
Methylation
Lysine
HIV
2018
1 Citation (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
3' Untranslated Regions
Hematopoiesis
Untranslated RNA
Fetal Blood
Cleavage Stimulation Factor
Polyadenylation
3' Untranslated Regions
Fetal Blood
Blood Cells

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Timani, K. A., Gyorffy, B., Liu, Y., Mohammad, K. S. & He, J. J., 17 Aug 2018, In : Molecular Cancer. 17, 1, 124.

Research output: Contribution to journalLetterResearchpeer-review

Interleukin-8
Melanoma
Carcinogenesis
Autocrine Communication
Neoplasm Metastasis
2017
3 Citations (Scopus)

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Stem Cell Factor
Embryonic Stem Cells
Blastocyst
Down-Regulation
Embryonic Development
2016
3 Citations (Scopus)

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubiquitin-Specific Proteases
Viral Proteins
Proteolysis
HIV-1
Peptide Hydrolases
7 Citations (Scopus)

Tip110: Physical properties, primary structure, and biological functions

Whitmill, A., Timani, K. A., Liu, Y. & He, J. J., 15 Mar 2016, In : Life Sciences. 149, p. 79-95 17 p.

Research output: Contribution to journalReview articleResearchpeer-review

tat Gene Products
Physical properties
Proteins
RNA Precursors
Cell Biology
2015
9 Citations (Scopus)

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Sep 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoiesis
MicroRNAs
Fetal Blood
Blood Cells
Cell Differentiation

Regulation of viral RNA synthesis by the V protein of parainfluenza virus 5

Yang, Y., Zengel, J., Sun, M., Sleeman, K., Timani, K. A., Aligo, J., Rota, P., Wu, J. & He, B., 1 Jan 2015, In : Journal of Virology. 89, 23, p. 11845-11857 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Parainfluenza virus 5
Parainfluenza Virus 5
Viral RNA
RNA
Respirovirus
11 Citations (Scopus)

STAT3 and its phosphorylation are involved in HIV-1 tat-induced transactivation of glial fibrillary acidic protein

Fan, Y., Timani, K. A. & He, J. J., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3 Transcription Factor
Glial Fibrillary Acidic Protein
Transcriptional Activation
HIV-1
Phosphorylation
11 Citations (Scopus)

Tip110 regulates the cross talk between p53 and hypoxia-inducible factor 1α under hypoxia and promotes survival of cancer cells

Timani, K. A., Liu, Y., Fan, Y., Mohammad, K. S. & He, J. J., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 13, p. 2254-2264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia-Inducible Factor 1
Cell Survival
Neoplasms
Physiological Phenomena
Protein Stability
2014
16 Citations (Scopus)

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15

Timani, K. A., Liu, Y., Suvannasankha, A. & He, J. J., 1 Jan 2014, In : International Journal of Biochemistry and Cell Biology. 54, p. 10-19 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Degradation
Proteins
10 Citations (Scopus)

Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription

Zhao, W., Liu, Y., Timani, K. A. & He, J. J., 3 Jan 2014, In : Journal of Biological Chemistry. 289, 1, p. 190-202 13 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV Long Terminal Repeat
Phosphorylation
Terminal Repeat Sequences
RNA Polymerase II
Transcription
2013
17 Citations (Scopus)

C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells

Liu, Y., Timani, K. A., Ou, X., Broxmeyer, H. E. & He, J. J., 1 Mar 2013, In : Stem Cells and Development. 22, 5, p. 689-694 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Exons
tat Gene Products
Embryonal Carcinoma Stem Cells
Cell Line
Messenger RNA
10 Citations (Scopus)

Tip110 interacts with YB-1 and regulates each other's function

Timani, K. A., Liu, Y. & He, J. J., 4 Jul 2013, In : BMC Molecular Biology. 14, 14.

Research output: Contribution to journalArticleResearchpeer-review

HIV Long Terminal Repeat
Proteins
Y-Box-Binding Protein 1
RNA Precursors
Alternative Splicing
2012
19 Citations (Scopus)

Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Liu, Y., Lee, M. R., Timani, K. A., He, J. J. & Broxmeyer, H. E., 10 Apr 2012, In : Stem Cells and Development. 21, 6, p. 829-833 5 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
tat Gene Products
RNA-Binding Proteins
RNA Precursors
Hematopoiesis
2011
18 Citations (Scopus)

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K. A., Mantel, C., Fan, Y., Hangoc, G., Cooper, S., He, J. J. & Broxmeyer, H. E., 26 May 2011, In : Blood. 117, 21, p. 5643-5651 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoiesis
Hematopoietic Stem Cells
Stem cells
Genes
Cells
2008
57 Citations (Scopus)

Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses

Sun, M., Fuentes, S. M., Timani, K. A., Sun, D., Murphy, C., Lin, Y., August, A., Teng, M. N. & He, B., 1 Jan 2008, In : Journal of Virology. 82, 1, p. 105-114 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Parainfluenza virus 5
Parainfluenza Virus 5
RNA Viruses
Respirovirus
Viral RNA
21 Citations (Scopus)

A single amino acid residue change in the P protein of parainfluenza virus 5 elevates viral gene expression

Timani, K. A., Sun, D., Sun, M., Keim, C., Lin, Y., Schmitt, P. T., Schmitt, A. P. & He, B., 1 Sep 2008, In : Journal of Virology. 82, 18, p. 9123-9133 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Parainfluenza virus 5
Parainfluenza Virus 5
Viral Genes
Gene Expression
Amino Acids
2006
6 Citations (Scopus)

Establishment of stable HeLa cell lines expressing enzymatically active hepatitis C virus RNA polymerase

Kong, L. B., Ye, L. B., Ye, L., Timani, K. A., Zheng, Y., Liao, Q. J., Li, B. Z. & Gao, B., 1 Feb 2006, In : Archives of Virology. 151, 2, p. 361-367 7 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA-Directed RNA Polymerases
HeLa Cells
Hepacivirus
Cell Line
Polymerase Chain Reaction
44 Citations (Scopus)

Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein

Yan, X., Hao, Q., Mu, Y., Timani, K. A., Ye, L., Zhu, Y. & Wu, J., 8 May 2006, In : International Journal of Biochemistry and Cell Biology. 38, 8, p. 1417-1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

SARS Virus
CCAAT-Enhancer-Binding Proteins
Nucleocapsid Proteins
NF-kappa B
Cyclooxygenase 2
2005
20 Citations (Scopus)

Activation of NF-κB by the full-length nucleocapsid protein of the SARS coronavirus

Liao, Q. J., Ye, L. B., Timani, K. A., Zeng, Y. C., She, Y. L., Ye, L. & Wu, Z. H., 1 Sep 2005, In : Acta Biochimica et Biophysica Sinica. 37, 9, p. 607-612 6 p.

Research output: Contribution to journalArticleResearchpeer-review

SARS Virus
Nucleocapsid Proteins
NF-kappa B
Severe Acute Respiratory Syndrome
Chemical activation
11 Citations (Scopus)

Gene expression profiles of HeLa cells impacted by hepatitis C virus non-structural protein NS4B

Zheng, Y., Ye, L. B., Liu, J., Jing, W., Timani, K. A., Yang, X. J., Yang, F., Wang, W., Gao, B. & Wu, Z. H., 1 Dec 2005, In : Journal of Biochemistry and Molecular Biology. 38, 2, p. 151-160 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Viral Structural Proteins
Viruses
HeLa Cells
Transcriptome
Gene expression
14 Citations (Scopus)

Hepatitis C virus non-structural 5A protein can enhance full-length core protein-induced nuclear factor-κ B activation

Liao, Q. J., Ye, L. B., Timani, K. A., She, Y. L., Yang, X. J., Ye, L. & Wu, Z. H., 7 Nov 2005, In : World Journal of Gastroenterology. 11, 41, p. 6433-6439 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nuclear Proteins
Hepacivirus
Proteins
Virus Diseases
Western Blotting
30 Citations (Scopus)

Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus

Timani, K. A., Liao, Q., Ye, L., Zeng, Y., Liu, J., Zheng, Y., Ye, L., Yang, X., Lingbao, K., Gao, J. & Zhu, Y., 1 Dec 2005, In : Virus Research. 114, 1-2, p. 23-34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Nucleocapsid Proteins
Severe Acute Respiratory Syndrome
Coronavirus
Cytoplasm
Coronaviridae
24 Citations (Scopus)

Peptide domain involved in the interaction between membrane protein and nucleocapsid protein of SARS-associated coronavirus

Fang, X., Ye, L., Timani, K. A., Li, S., Zen, Y., Zhao, M., Zheng, H. & Wu, Z., 1 Dec 2005, In : Journal of Biochemistry and Molecular Biology. 38, 4, p. 381-385 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Nucleocapsid Proteins
Severe Acute Respiratory Syndrome
Coronavirus
Membrane Proteins
Peptides
8 Citations (Scopus)

Two cis-acting elements in negative RNA strand of hepatitis C virus involved in synthesis of positive RNA strand in vitro

Ye, L., Timani, K. A., Ye, L., Kong, L., Yang, X., Liao, Q. & Wu, J., 1 Dec 2005, In : Acta Virologica. 49, 2, p. 83-90 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hepacivirus
RNA
In Vitro Techniques
RNA Replicase
Mutagenesis
2004
32 Citations (Scopus)

Cloning, sequencing, expression, and purification of SARS-associated coronavirus nucleocapsid protein for serodiagnosis of SARS

Timani, K. A., Ye, L., Ye, L., Zhu, Y., Wu, Z. & Gong, Z., 1 Aug 2004, In : Journal of Clinical Virology. 30, 4, p. 309-312 4 p.

Research output: Contribution to journalArticleResearchpeer-review

SARS Virus
Serologic Tests
Organism Cloning
Serum
Enzyme-Linked Immunosorbent Assay
45 Citations (Scopus)

Possible mode of action of antiherpetic activities of a proteoglycan isolated from the mycelia of Ganoderma lucidum in vitro

Liu, J., Yang, F., Ye, L. B., Yang, X. J., Timani, K. A., Zheng, Y. & Wang, Y. H., 1 Dec 2004, In : Journal of Ethnopharmacology. 95, 2-3, p. 265-272 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Reishi
Mycelium
Proteoglycans
Antiviral Agents
Virus Diseases