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Personal profile

Area of Expertise

My research interests include cancer biology aimed at understanding the molecular and cellular mechanisms that contribute to tumor progression and metastasis. My research is focused on the role of a protein called Tip110/Sart3 in melanoma (skin cancer) and glioblastoma (brain cancer) development and regulation of the protein in a subset population of cells called tumor-initiating cells that are resistant to cancer treatment. The function of Tip110 is multifarious, ranging from modulation of tumor antigenicity, gene regulation, and stem cell biology to development of the embryo.
My team demonstrated that Tip110 interacts with and/or regulates several oncogenic proteins that have the potential to cause cancer, including cytokines--inflammatory proteins which are known to play an important role in cancer progression. Our data showed a strong correlation between the Tip110 expression level and the clinical outcome in people with melanoma and glioblastoma. Based on these findings, we employ multifaceted experimental approaches, using animal models, to investigate the molecular mechanisms and biological significance of Tip110 in controlling cellular processes, including cancer, and we hope to provide new clues for future therapeutics strategies.

Education/Academic qualification

PhD in Biochemistry & Molecular Biology, Wuhan University

MS in Biochemistry, Aigarh Mo University

BS in Biochemistry, Aigarh Mo University

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Projects 2015 2020

Research Output 2004 2019

  • 447 Citations
  • 13 h-Index
  • 27 Article
  • 1 Letter
  • 1 Review article

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Jan 2019, In : Journal of NeuroVirology.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Histones
Methylation
Lysine
HIV
1 Citation (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
3' Untranslated Regions
Hematopoiesis
Untranslated RNA
Fetal Blood
Cleavage Stimulation Factor
Polyadenylation
3' Untranslated Regions
Fetal Blood
Blood Cells

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

Timani, K. A., Gyorffy, B., Liu, Y., Mohammad, K. S. & He, J. J., 17 Aug 2018, In : Molecular Cancer. 17, 1, 124.

Research output: Contribution to journalLetterResearchpeer-review

Interleukin-8
Melanoma
Carcinogenesis
Autocrine Communication
Neoplasm Metastasis
3 Citations (Scopus)

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Stem Cell Factor
Embryonic Stem Cells
Blastocyst
Down-Regulation
Embryonic Development