• 372 Citations
  • 10 h-Index
20062022

Research output per year

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Personal profile

Area of Expertise

Chronic inflammation has been implicated in the development of hypertension (high blood pressure). The primary focus of my research is to understand and enhance endogenous nervous and immune system interactions that control inflammation in order to halt the progression of hypertension. To investigate this, we use lupus as the disease model since chronic inflammation contributes to the prevalent hypertension and renal injury in this devastating autoimmune disease that primarily affects young women.
I am currently the PI of a federally-funded grant from the National Heart, Lung, and Blood Institute and a private grant from the Lupus Research Alliance. The federal grant will investigate the regulation of inflammation in the kidney that, if accumulated and left unchecked, can lead to hypertension and renal injury. The private grant will test the efficacy of a cholinergic agonist as an anti-inflammatory therapy in lupus mice and determine whether this drug has positive outcomes on behavior. Work in my lab will include integrative physiological approaches complimented with molecular, cellular, and immunological techniques. A goal of the lab is to take what is learned in the animal model of lupus hypertension and translate it into human studies that could benefit both lupus and hypertensive populations.

Education/Academic qualification

PhD in Physiology, LSU Health Science Center

Award Date: 1 Jan 2004

MS in Physiology, LSU Health Science Center

Award Date: 1 Jan 2002

MS in Applied Physics, Purdue University

Award Date: 1 Jan 2001

BS in Physics, Southern University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 372 Citations
  • 10 h-Index
  • 20 Article
  • 5 Review article
  • 1 Chapter
  • 1 Letter

Autoimmunity, estrogen, and lupus

Pham, G. S. & Mathis, K. W., 1 Jan 2019, Sex Differences in Cardiovascular Physiology and Pathophysiology. Elsevier, p. 219-237 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

  • Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats

    Rodriguez, R., Lee, A., Mathis, K. W., Broome, H. J., Thorwald, M., Martinez, B., Nakano, D., Nishiyama, A., Ryan, M. J. & Ortiz, R. M., 1 Jan 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F1081-F1090

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Buffering chronic kidney disease with sodium bicarbonate

    Williams, E. N. & Mathis, K. W., 1 Sep 2018, In : Clinical Science. 132, 17, p. 1999-2001 3 p.

    Research output: Contribution to journalReview article

  • Complementing T Regulatory Cells to Combat Hypertension

    Mathis, K. W., 30 Mar 2018, In : Circulation Research. 122, 7, p. 911-912 2 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations