Projects per year
Personal profile
Area of Expertise
Chronic inflammation has been implicated in the development of hypertension (high blood pressure). The primary focus of my research is to understand and enhance endogenous nervous and immune system interactions that control inflammation in order to halt the progression of hypertension. To investigate this, we use lupus as the disease model since chronic inflammation contributes to the prevalent hypertension and renal injury in this devastating autoimmune disease that primarily affects young women.
I am currently the PI of a federally-funded grant from the National Heart, Lung, and Blood Institute and a private grant from the Lupus Research Alliance. The federal grant will investigate the regulation of inflammation in the kidney that, if accumulated and left unchecked, can lead to hypertension and renal injury. The private grant will test the efficacy of a cholinergic agonist as an anti-inflammatory therapy in lupus mice and determine whether this drug has positive outcomes on behavior. Work in my lab will include integrative physiological approaches complimented with molecular, cellular, and immunological techniques. A goal of the lab is to take what is learned in the animal model of lupus hypertension and translate it into human studies that could benefit both lupus and hypertensive populations.
I am currently the PI of a federally-funded grant from the National Heart, Lung, and Blood Institute and a private grant from the Lupus Research Alliance. The federal grant will investigate the regulation of inflammation in the kidney that, if accumulated and left unchecked, can lead to hypertension and renal injury. The private grant will test the efficacy of a cholinergic agonist as an anti-inflammatory therapy in lupus mice and determine whether this drug has positive outcomes on behavior. Work in my lab will include integrative physiological approaches complimented with molecular, cellular, and immunological techniques. A goal of the lab is to take what is learned in the animal model of lupus hypertension and translate it into human studies that could benefit both lupus and hypertensive populations.
Education/Academic qualification
MS in Physiology, LSU Health Science Center
PhD in Physiology, LSU Health Science Center
MS in Applied Physics, Purdue University
BS in Physics, Southern University
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Neuroimmune Mechanisms Involved in the Pathogenesis of Hypertension and Renal Injury
NHLBI: Nat Heart, Lung & Blood Institute
1/01/18 → 31/12/22
Project: Research
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Neuroimmune Mechanisms Involved in the Pathogenesis of Hypertension and Renal Injury
National Heart, Lung, and Blood Institute
1/01/18 → 31/12/22
Project: Research
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Control of Renal Inflammation in Hypertension
National Heart, Lung, and Blood Institute
14/05/21 → 30/04/22
Project: Research
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Targeting Nicotinic Receptors to Reduce Inflammation Associated with SLE
Mathis, K. & Uteshev, V.
1/03/18 → 28/02/21
Project: Research
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Neuroimmune Mechanisms Involved in the Pathogenesis of Hypertension and Renal Injury
Mathis, K. & MATHIS, K. W.
National Heart, Lung, and Blood Institute
1/01/18 → 31/12/21
Project: Research
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Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus
Morales, J. Y., Young-Stubbs, C. M., Shimoura, C. G., Kem, W. R., Uteshev, V. V. & Mathis, K. W., 13 Apr 2021, In: Frontiers in Medicine. 8, 642960.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus
Pham, G. S., Shimoura, C. G., Chaudhari, S., Kulp, D. V. & Mathis, K. W., Aug 2020, In: American Journal of Physiology - Renal Physiology. 319, 2, p. F155-F161Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
When memory does not serve you well
Shimoura, C. G. & Mathis, K. W., 13 Mar 2020, In: Circulation research. p. 722-724 3 p.Research output: Contribution to journal › Review article › peer-review
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Autoimmunity, estrogen, and lupus
Pham, G. S. & Mathis, K. W., 1 Jan 2019, Sex Differences in Cardiovascular Physiology and Pathophysiology. Elsevier, p. 219-237 19 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats
Rodriguez, R., Lee, A., Mathis, K. W., Broome, H. J., Thorwald, M., Martinez, B., Nakano, D., Nishiyama, A., Ryan, M. J. & Ortiz, R. M., 2018, In: American Journal of Physiology - Renal Physiology. 315, 4, p. F1081-F1090Research output: Contribution to journal › Article › peer-review
2 Scopus citations