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Personal profile

Area of Expertise

Chronic inflammation has been implicated in the development of hypertension (high blood pressure). The primary focus of my research is to understand and enhance endogenous nervous and immune system interactions that control inflammation in order to halt the progression of hypertension. To investigate this, we use lupus as the disease model since chronic inflammation contributes to the prevalent hypertension and renal injury in this devastating autoimmune disease that primarily affects young women.
I am currently the PI of a federally-funded grant from the National Heart, Lung, and Blood Institute and a private grant from the Lupus Research Alliance. The federal grant will investigate the regulation of inflammation in the kidney that, if accumulated and left unchecked, can lead to hypertension and renal injury. The private grant will test the efficacy of a cholinergic agonist as an anti-inflammatory therapy in lupus mice and determine whether this drug has positive outcomes on behavior. Work in my lab will include integrative physiological approaches complimented with molecular, cellular, and immunological techniques. A goal of the lab is to take what is learned in the animal model of lupus hypertension and translate it into human studies that could benefit both lupus and hypertensive populations.

Education/Academic qualification

PhD in Physiology, LSU Health Science Center

MS in Physiology, LSU Health Science Center

MS in Applied Physics, Purdue University

BS in Physics, Southern University

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Projects 2014 2022

Research Output 2006 2018

  • 318 Citations
  • 10 h-Index
  • 21 Article
  • 4 Review article
  • 1 Letter

Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats

Rodriguez, R., Lee, A., Mathis, K., Broome, H. J., Thorwald, M., Martinez, B., Nakano, D., Nishiyama, A., Ryan, M. J. & Ortiz, R. M., 1 Oct 2018, In : American journal of physiology. Renal physiology. 315, 4, p. F1081-F1090

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin Receptors
Glucose Intolerance
Tumor Necrosis Factor-alpha
Blood Pressure
Angiotensin Type 1 Receptor

Buffering chronic kidney disease with sodium bicarbonate

Williams, E. N. & Mathis, K., 1 Sep 2018, In : Clinical Science. 132, 17, p. 1999-2001 3 p.

Research output: Contribution to journalReview articleResearchpeer-review

Sodium Bicarbonate
Chronic Renal Insufficiency
Kidney
Glomerular Filtration Rate
Chronic Kidney Failure

Complementing T Regulatory Cells to Combat Hypertension

Mathis, K., 30 Mar 2018, In : Circulation Research. 122, 7, p. 911-912 2 p.

Research output: Contribution to journalReview articleResearchpeer-review

Regulatory T-Lymphocytes
Hypertension
2 Citations (Scopus)

Lipopolysaccharide challenge reveals hypothalamic-pituitary-adrenal axis dysfunction in murine systemic lupus erythematosus

Pham, G. S. & Mathis, K., 4 Oct 2018, In : Brain Sciences. 8, 10, 184.

Research output: Contribution to journalArticleResearchpeer-review

Systemic Lupus Erythematosus
Lipopolysaccharides
Paraventricular Hypothalamic Nucleus
Corticosterone
Adrenocorticotropic Hormone

Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

Chaudhari, S., Cushen, S. C., Osikoya, O., Jaini, P. A., Posey, R., Mathis, K. & Goulopoulou, S., 13 Dec 2018, In : Comprehensive Physiology. 9, 1, p. 375-411 37 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiovascular Diseases
Sex Characteristics
Cardiovascular Physiological Phenomena
Estrogens
Androgens