Katalin Prokai-Tatrai, PhD

Research output

Research output per year 1986 1990 1994 1998 2001 2003 2005 2007 2009 2010 2011 2013 2018 2019 2020 2021 2023

• 68 Article
• 12 Review article
• 1 Chapter
• 1 Editorial

Research output per year

Research output per year

Search results

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7

  Gütschow, M., Eynde, J. J. V., Jampilek, J., Kang, C. B., Mangoni, A. A., Fossa, P., Karaman, R., Trabocchi, A., Scott, P. J. H., Reynisson, J., Rapposelli, S., Galdier, S., Winum, J. Y., Brullo, C., Prokai-Tatrai, K., Sharma, A. K., Schapira, M., Azuma, Y. T., Cerchia, L., Spete, M., & 28 othersTorri, G., Collina, S., Geronikaki, A., García-Sosa, A. T., Helena Vasconcelos, M., Sousa, M. E., Kosalec, I., Tuccinardi, T., Duarte, I. F., Salvador, J. A. R., Bertinaria, M., Pellecchia, M., Amato, J., Rastelli, G., Gomes, P. A. C., Guedes, R. C., Sabatier, J. M., Estévez-Braun, A., Pagano, B., Mangani, S., Ragno, R., Kokotos, G., Brindisi, M., González, F. V., Borges, F., Miloso, M., Rautio, J. & Muñoz-Torrero, D., Jul 2020, In: Molecules. 25, 13, 2968.

  Research output: Contribution to journal › Review article › peer-review

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2

  Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 2018, In: Molecules. 23, 1, 65.

  Research output: Contribution to journal › Review article › peer-review

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3

  Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., 2018, In: Molecules. 23, 7, 1596.

  Research output: Contribution to journal › Review article › peer-review

• Targeting drugs to the brain by redox chemical delivery systems

  Prokai, L., Prokai-Tatrai, K. & Bodor, N., 14 Sep 2000, In: Medicinal Research Reviews. 20, 5, p. 367-416 50 p.

  Research output: Contribution to journal › Review article › peer-review

  • Drug Delivery Systems 100%
  • Oxidation-Reduction 97%
  • Central Nervous System Agents 72%
  • Pyridinium Salt 65%
  • Antiviral Agent 65%

• Retina-targeted delivery of 17β-estradiol by the topically applied dhed prodrug

  Prokai-Tatrai, K., Nguyen, V., De La Cruz, D. L., Guerra, R., Zaman, K., Rahlouni, F. & Prokai, L., May 2020, In: Pharmaceutics. 12, 5, 456.

  Research output: Contribution to journal › Article › peer-review

  • Prodrug 95%
  • Estradiol 78%
  • Retina 78%
  • Rabbits 48%
  • Hormone 44%

• Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues

  Prokai-Tatrai, K., Perjési, P., Zharikova, A. D., Li, X. & Prokai, L., 19 Aug 2002, In: Bioorganic and Medicinal Chemistry Letters. 12, 16, p. 2171-2174 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Protirelin Derivative 100%
  • Thyrotropin-Releasing Hormone 71%
  • Prodrug 60%
  • Thyrotropin Releasing Hormone Receptors 45%
  • Central Nervous System Stimulants 41%

• Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis

  Prokai, L., Guo, J. & Prokai-Tatrai, K., Apr 2014, In: Nature Protocols. 9, 4, p. 882-895 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteome 100%
  • Peptides 61%
  • Peptide 55%
  • Nitro Group 49%
  • Amino Groups 40%

• Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative

  Prokai-Tatrai, K., Perjesi, P., Rivera-Portalatin, N. M., Simpkins, J. W. & Prokai, L., Mar 2008, In: Steroids. 73, 3, p. 280-288 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotective 100%
  • Hydroquinones 88%
  • Estrogen 84%
  • Estrogens 64%
  • Antioxidant Agent 59%

• Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

  Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In: Journal of Proteomics. 74, 11, p. 2370-2379 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Carbonylation 100%
  • 2-nonenal 92%
  • 4-hydroxy-2-nonenal 90%
  • Liver Mitochondrion 86%
  • Carbonylation 76%

• Synthesis and biological evaluation of 17β-alkoxyestra-1,3,5(10)-trienes as potential neuroprotectants against oxidative stress

  Prokai, L., Oon, S. M., Prokai-Tatrai, K., Abboud, K. A. & Simpkins, J. W., 4 Jan 2001, In: Journal of Medicinal Chemistry. 44, 1, p. 110-114 5 p.

  Research output: Contribution to journal › Article › peer-review

  • ethyl methyl ether 100%
  • Neuroprotective Agents 68%
  • Oxidative Stress 66%
  • Estradiol 58%
  • sodium hydride 48%

• Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

  Prokai, L., Prokai-Tatrai, K., Perjesi, P., Zharikova, A. D., Perez, E. J., Liu, R. & Simpkins, J. W., 30 Sep 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 20, p. 11741-11746 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydroquinones 100%
  • Neuroprotection 62%
  • Estrogens 48%
  • Antioxidants 43%
  • Reactive Oxygen Species 15%

• Cardiovascular effects of neuropeptide FF antagonists

  Prokai, L., Zharikova, A. D., Juhasz, A. & Prokai-Tatrai, K., May 2006, In: Peptides. 27, 5, p. 1015-1019 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuropeptide FF 100%
  • phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide 90%
  • Antagonist 48%
  • Blood Pressure 44%
  • argininamide 38%

• A novel prodrug approach for central nervous system-selective estrogen therapy

  Prokai-Tatrai, K. & Prokai, L., 19 Nov 2019, In: Molecules. 24, 22, 4197.

  Research output: Contribution to journal › Article › peer-review

  • estrogens 100%
  • central nervous system 84%
  • Estrogen 63%
  • Prodrug 63%
  • therapy 56%

• Peptide transport and delivery into the central nervous system: Foreword by the editors

  Prokai, L. & Prokai-Tatrai, K., 9 Oct 2003, In: Progress in Drug Research. 61

  Research output: Contribution to journal › Editorial

• Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress

  Prokai-Tatrai, K., Prokai, L., Simpkins, J. W. & Jung, M. E., Apr 2009, In: International journal of molecular sciences. 10, 4, p. 1773-1787 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress 100%
  • neurons 57%
  • Ethanol 57%
  • Oxidative Stress 57%
  • ethyl alcohol 56%

• Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography - Tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS ³ versus neutral loss-driven electron capture dissociation

  Rauniyar, N., Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., 15 Jan 2009, In: Analytical Chemistry. 81, 2, p. 782-789 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Electron-Capture Dissociation 100%
  • Tandem Mass Spectrometry 43%
  • Peptide 40%
  • Oxidative Stress 34%
  • Modification 29%

• Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents

  Prokai-Tatrai, K. & Prokai, L., Feb 2009, In: Molecules. 14, 2, p. 633-654 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Central Nervous System Agent 100%
  • Central Nervous System Agents 80%
  • central nervous system 80%
  • hormones 79%
  • Thyrotropin-Releasing Hormone 71%

• The antagonist pGlu-βGlu-pro-NH₂ binds to an allosteric site of the thyrotropin-releasing hormone receptor

  De La Cruz, D. L., Prokai, L. & Prokai-Tatrai, K., Sep 2021, In: Molecules. 26, 17, 5397.

  Research output: Contribution to journal › Article › peer-review

  • Thyrotropin Releasing Hormone Receptors 100%
  • Allosteric Site 88%
  • hormones 88%
  • releasing 75%
  • Antagonist 57%

• Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC-MS/MS

  Szarka, S., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., Apr 2013, In: Analytical and bioanalytical chemistry. 405, 10, p. 3399-3406 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogens 100%
  • Estrone 74%
  • Assays 69%
  • Estrogen 63%
  • Estradiol 51%

• Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics

  Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., Dec 2008, In: Molecular and Cellular Proteomics. 7, 12, p. 2442-2451 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Firearms 100%
  • Tyrosine 81%
  • Proteomics 80%
  • Tandem Mass Spectrometry 73%
  • Peptides 56%

• Proteomics-based retinal target engagement analysis and retina-targeted delivery of 17β-estradiol by the dhed prodrug for ocular neurotherapy in males

  Prokai-Tatrai, K., Zaman, K., Nguyen, V., De La Cruz, D. L. & Prokai, L., Sep 2021, In: Pharmaceutics. 13, 9, 1392.

  Research output: Contribution to journal › Article › peer-review

  • 3,16-dihydroxyandrost-5-ene-17,19-dione 100%
  • Ocular 90%
  • Retinal 80%
  • Prodrug 75%
  • Eye Drop 68%

• An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

  Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., Feb 2018, In: Hormones and Behavior. 98, p. 16-21 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 3,16-dihydroxyandrost-5-ene-17,19-dione 100%
  • Estrogens 36%
  • Alzheimer Disease 34%
  • Brain 21%
  • Estradiol 19%

• Application of a Brain-Targeting Chemical Delivery System to 9-Amino-1,2,3,4-Tetrahydroacridine

  Pop, E., Prókai-Tátrai, K., Scott, J. D., Brewster, M. E. & Bodor, N., Jun 1990, In: Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7, 6, p. 658-664 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tacrine 100%
  • Pyridinium Salt 99%
  • Cholinesterase Inhibitor 93%
  • Pyridine Ring 82%
  • Lipophilicity 81%

• Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5

  Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M., & 6 othersKokotos, G., Siciliano, C., Capasso, R., Agrofoglio, L. A., Ragno, R. & Muñoz-Torrero, D., 2019, In: Molecules. 24, 13, 2415.

  Research output: Contribution to journal › Review article › peer-review

• Long range transmission of polar effects in cholinergic 3-arylideneanabaseines. Conformations calculated by molecular modelling

  Zoltewicz, J. A., Prokai-Tatrai, K., Bloom, L. B. & Kem, W. R., 1 Jan 1993, In: Heterocycles. 35, 1, p. 171-180 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyrrolidines 100%
  • Molecular Conformation 95%
  • Tetrahydropyridine 85%
  • Polar Effect 81%
  • Cholinergic 76%