Research output per year
Research output per year
- 1 - 50 out of 81 results
Search results
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2022
Mass spectrometry-based retina proteomics
Prokai, L., Zaman, K. & Prokai-Tatrai, K., 2022, (Accepted/In press) In: Mass Spectrometry Reviews.Research output: Contribution to journal › Review article › peer-review
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2021
[β-glu2 ]trh is a functional antagonist of thyrotropin-releasing hormone (Trh) in the rodent brain
Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 2 Jun 2021, In: International journal of molecular sciences. 22, 12, 6230.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Proteomics-based retinal target engagement analysis and retina-targeted delivery of 17β-estradiol by the dhed prodrug for ocular neurotherapy in males
Prokai-Tatrai, K., Zaman, K., Nguyen, V., De La Cruz, D. L. & Prokai, L., Sep 2021, In: Pharmaceutics. 13, 9, 1392.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Proteomics complementation of the rat uterotrophic assay for estrogenic endocrine disruptors: A roadmap of advancing high resolution mass spectrometry-based shotgun survey to targeted biomarker quantifications
Prokai, L., Rahlouni, F., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., 2 Feb 2021, In: International journal of molecular sciences. 22, 4, p. 1-13 13 p., 1686.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The antagonist pGlu-βGlu-pro-NH2 binds to an allosteric site of the thyrotropin-releasing hormone receptor
De La Cruz, D. L., Prokai, L. & Prokai-Tatrai, K., Sep 2021, In: Molecules. 26, 17, 5397.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
17β-estradiol delivered in eye drops: Evidence of impact on protein networks and associated biological processes in the rat retina through quantitative proteomics
Prokai, L., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., Feb 2020, In: Pharmaceutics. 12, 2, 101.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Brain-selective estrogen therapy prevents androgen deprivation-associated hot flushes in a rat model
Merchenthaler, I., Lane, M., Stennett, C., Zhan, M., Nguyen, V., Prokai-Tatrai, K. & Prokai, L., Jun 2020, In: Pharmaceuticals. 13, 6, p. 1-10 10 p., 119.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6
Vanden Eynde, J. J., Mangoni, A. A., Rautio, J., Leprince, J., Azuma, Y. T., García-Sosa, A. T., Hulme, C., Jampilek, J., Karaman, R., Li, W., Gomes, P. A. C., Hadjipavlou-Litina, D., Capasso, R., Geronikaki, A., Cerchia, L., Sabatier, J. M., Ragno, R., Tuccinardi, T., Trabocchi, A., Winum, J. Y., & 22 others, 2020, In: Molecules. 25, 1, 119.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7
Gütschow, M., Eynde, J. J. V., Jampilek, J., Kang, C. B., Mangoni, A. A., Fossa, P., Karaman, R., Trabocchi, A., Scott, P. J. H., Reynisson, J., Rapposelli, S., Galdier, S., Winum, J. Y., Brullo, C., Prokai-Tatrai, K., Sharma, A. K., Schapira, M., Azuma, Y. T., Cerchia, L., Spete, M., & 28 others, Jul 2020, In: Molecules. 25, 13, 2968.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Retina-targeted delivery of 17β-estradiol by the topically applied dhed prodrug
Prokai-Tatrai, K., Nguyen, V., De La Cruz, D. L., Guerra, R., Zaman, K., Rahlouni, F. & Prokai, L., May 2020, In: Pharmaceutics. 12, 5, 456.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Topical estrogen therapy for hyperopia correction in vivo
Leshno, A., Prokai-Tatrai, K., Rotenstreich, Y., Magid, A., Bubis, E., Schwartz, S., Skaat, A., Zloto, O., Avni-Zauberman, N. & Barak, A., Jun 2020, In: Investigative Ophthalmology and Visual Science. 61, 6, 55.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2019
A novel prodrug approach for central nervous system-selective estrogen therapy
Prokai-Tatrai, K. & Prokai, L., 19 Nov 2019, In: Molecules. 24, 22, 4197.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach
Prokai-Tatrai, K., De La Cruz, D. L., Nguyen, V., Ross, B. P., Toth, I. & Prokai, L., Jul 2019, In: Pharmaceutics. 11, 7, 349.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5
Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M., & 6 others, 2019, In: Molecules. 24, 13, 2415.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4
Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C., & 5 others, 2019, In: Molecules. 24, 1Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
2018
10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy
Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In: ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease
Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., Feb 2018, In: Hormones and Behavior. 98, p. 16-21 6 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3
Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., 2018, In: Molecules. 23, 7, 1596.Research output: Contribution to journal › Review article › peer-review
Open Access -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2
Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 2018, In: Molecules. 23, 1, 65.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
2016
A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease
Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Prokai, L. & Ottinger, M. A., 1 Jul 2016, In: Hormones and Behavior. 83, p. 39-44 6 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery
Merchenthaler, I., Lane, M., Sabnis, G., Brodie, A., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., 1 Aug 2016, In: Scientific Reports. 6, 30721.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2015
The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders
Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P. & Prokai-Tatrai, K., 22 Jul 2015, In: Science Translational Medicine. 7, 297, 297ra113.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
2014
Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry
Szarka, S., Prokai-Tatrai, K. & Prokai, L., 15 Jul 2014, In: Analytical Chemistry. 86, 14, p. 7033-7040 8 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Selective chemoprecipitation to enrich nitropeptides from complex proteomes for mass-spectrometric analysis
Prokai, L., Guo, J. & Prokai-Tatrai, K., Apr 2014, In: Nature Protocols. 9, 4, p. 882-895 14 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2013
17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma
Prokai-Tatrai, K., Xin, H., Nguyen, V., Szarka, S., Blazics, B., Prokai, L. & Koulen, P., 5 Aug 2013, In: Molecular Pharmaceutics. 10, 8, p. 3253-3261 9 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
Design and exploratory neuropharmacological evaluation of novel thyrotropin-releasing hormone analogs and their brain-targeting bioprecursor prodrugs
Prokai-Tatrai, K., Nguyen, V., Szarka, S., Konya, K. & Prokai, L., 22 May 2013, In: Pharmaceutics. 5, 2, p. 318-328 11 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Quantitative structure-activity relationships predicting the antioxidant potency of 17β-estradiol-related polycyclic phenols to inhibit lipid peroxidation
Prokai, L., Rivera-Portalatin, N. M. & Prokai-Tatrai, K., Jan 2013, In: International journal of molecular sciences. 14, 1, p. 1443-1454 12 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC-MS/MS
Szarka, S., Nguyen, V., Prokai, L. & Prokai-Tatrai, K., Apr 2013, In: Analytical and bioanalytical chemistry. 405, 10, p. 3399-3406 8 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2012
Capture of the volatile carbonyl metabolite of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitation by stable-isotope dilution mass spectrometry coupled with chromatography
Prokai, L., Szarka, S., Wang, X. & Prokai-Tatrai, K., 6 Apr 2012, In: Journal of Chromatography A. 1232, p. 281-287 7 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Relative quantitation of protein nitration by liquid chromatography-mass spectrometry using isotope-coded dimethyl labeling and chemoprecipitation
Guo, J., Prokai-Tatrai, K. & Prokai, L., 6 Apr 2012, In: Journal of Chromatography A. 1232, p. 266-275 10 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2011
Prodrug Design for Brain Delivery of Small- and Medium-Sized Neuropeptides
Prokai-Tatrai, K. & Prokai, L., 2011, Neuropeptides: Methods and Protocols. Humana Press Inc., p. 313-336 24 p. (Methods in Molecular Biology; vol. 789).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
12 Scopus citations -
Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria
Guo, J., Prokai-Tatrai, K., Nguyen, V., Rauniyar, N., Ughy, B. & Prokai, L., 19 Oct 2011, In: Journal of Proteomics. 74, 11, p. 2370-2379 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Selective chemoprecipitation and subsequent release of tagged species for the analysis of nitropeptides by liquid chromatography - Tandem mass spectrometry
Prokai-Tatrai, K., Guo, J. & Prokai, L., Aug 2011, In: Molecular and Cellular Proteomics. 10, 8Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2010
[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice
Nguyen, V., Zharikova, A. D., Prokai-Tatrai, K. & Prokai, L., Apr 2010, In: Brain Research Bulletin. 82, 1-2, p. 83-86 4 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Identification of carbonylation sites in apomyoglobin after exposure to 4-hydroxy-2-nonenal by solid-phase enrichment and liquid chromatography- electrospray ionization tandemmass spectrometry
Rauniyar, N., Prokai-Tatraia, K. & Prokai, L., Apr 2010, In: Journal of Mass Spectrometry. 45, 4, p. 398-410 13 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Simultaneous measurement of 17β-estradiol, 17α-estradiol and estrone by GC-isotope dilution MS-MS
Prokai-Tatrai, K., Bonds, D. & Prokai, L., Feb 2010, In: Chromatographia. 71, 3-4, p. 311-315 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2009
Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography - Tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS 3 versus neutral loss-driven electron capture dissociation
Rauniyar, N., Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., 15 Jan 2009, In: Analytical Chemistry. 81, 2, p. 782-789 8 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress
Prokai-Tatrai, K., Prokai, L., Simpkins, J. W. & Jung, M. E., Apr 2009, In: International journal of molecular sciences. 10, 4, p. 1773-1787 15 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents
Prokai-Tatrai, K. & Prokai, L., Feb 2009, In: Molecules. 14, 2, p. 633-654 22 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations -
2008
Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics
Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., Dec 2008, In: Molecular and Cellular Proteomics. 7, 12, p. 2442-2451 10 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative
Prokai-Tatrai, K., Perjesi, P., Rivera-Portalatin, N. M., Simpkins, J. W. & Prokai, L., Mar 2008, In: Steroids. 73, 3, p. 280-288 9 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
2007
A facile microwave-assisted synthesis of p-quinols by lead(IV) acetate oxidation
Prokai-Tatrai, K., Rivera-Portalatin, N. M., Rauniyar, N. & Prokai, L., 1 Jun 2007, In: Letters in Organic Chemistry. 4, 4, p. 265-267 3 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Comparison of estrogen-derived ortho-quinone and para-quinol concerning induction of oxidative stress
Rivera-Portalatin, N. M., Vera-Serrano, J. L., Prokai-Tatrai, K. & Prokai, L., Jun 2007, In: Journal of Steroid Biochemistry and Molecular Biology. 105, 1-5, p. 71-75 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Exploratory neuropharmacological evaluation of a conformationally constrained thyrotropin-releasing hormone analogue
Teixidó, M., Prokai-Tatrai, K., Wang, X., Nguyen, V. & Prokai, L., 15 Jun 2007, In: Brain Research Bulletin. 73, 1-3, p. 103-107 5 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2006
Cardiovascular effects of neuropeptide FF antagonists
Prokai, L., Zharikova, A. D., Juhasz, A. & Prokai-Tatrai, K., May 2006, In: Peptides. 27, 5, p. 1015-1019 5 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2005
A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.
Prokai-Tatrai, K., Teixido, M., Nguyen, V., Zharikova, A. D. & Prokai, L., Mar 2005, In: Medicinal chemistry. 1, 2, p. 141-152 12 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Impact of metabolism on the safety of estrogen therapy
Prokai-Tatrai, K. & Prokai, L., 2005, In: Annals of the New York Academy of Sciences. 1052, p. 243-257 15 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Mechanistic insights into the direct antioxidant effects of estrogens
Prokai, L., Prokai-Tatrai, K., Perjési, P. & Simpkins, J. W., 1 Oct 2005, In: Drug Development Research. 66, 2, p. 118-125 8 p.Research output: Contribution to journal › Review article › peer-review
52 Scopus citations -
Screening of combinatorial libraries for substrate preference by mass spectrometry
Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., 15 Jan 2005, In: Analytical Chemistry. 77, 2, p. 698-701 4 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2004
Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium
Prokai, L., Prokai-Tatrai, K., Zharikova, A. D., Nguyen, V., Perjesi, P. & Stevens, S. M., 18 Nov 2004, In: Journal of Medicinal Chemistry. 47, 24, p. 6025-6033 9 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations