Katalin Prokai-Tatrai, PhD

Research output

Research output per year 1986 1990 1994 1998 2001 2003 2005 2007 2009 2010 2011 2013 2018 2019 2020 2021 2023 2024 2025

• 72 Article
• 13 Review article
• 2 Chapter
• 1 Editorial

Research output per year

Research output per year

Search results

• Metabolism-based drug design and drug targeting

  Prokai, L. & Prokai-Tatrai, K., 1 Nov 1999, In: Pharmaceutical Science and Technology Today. 2, 11, p. 457-462 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Drug Metabolism 100%
  • Metabolism 100%
  • Drug Target 100%
  • Drug Design 100%
  • Drug Development 100%

• Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents

  Prokai-Tatrai, K. & Prokai, L., Feb 2009, In: Molecules. 14, 2, p. 633-654 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prodrug 100%
  • Thyrotropin 100%
  • Central Nervous System Agents 100%
  • Protirelin 100%
  • Central Nervous System Agent 100%

• Peptide transport and delivery into the central nervous system: Foreword by the editors

  Prokai, L. & Prokai-Tatrai, K., 2003, In: Progress in Drug Research. 61, p. vii-viii

  Research output: Contribution to journal › Editorial

• Topical estrogen therapy for hyperopia correction in vivo

  Leshno, A., Prokai-Tatrai, K., Rotenstreich, Y., Magid, A., Bubis, E., Schwartz, S., Skaat, A., Zloto, O., Avni-Zauberman, N. & Barak, A., Jun 2020, In: Investigative Ophthalmology and Visual Science. 61, 6, 55.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen 100%
  • Treatment Group 100%
  • Topical Estrogen 100%
  • Hyperopia Correction 100%
  • Side Effect 100%

• A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.

  Prokai-Tatrai, K., Teixido, M., Nguyen, V., Zharikova, A. D. & Prokai, L., Mar 2005, In: Medicinal chemistry. 1, 2, p. 141-152 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Prodrug 100%
  • Thyrotropin 100%
  • Central Nervous System Agents 100%
  • Tripeptide 100%
  • Pyridinium 100%

• Novel redox derivatives of tryptophan

  Pop, E., Brewster, M. E., Prókai-Tátrai, K. & Bodor, N., 1 Sep 1994, In: Heterocycles. 38, 9, p. 2051-2064 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Tryptophan 100%
  • Redox 100%
  • Carboxamide 50%
  • Carbamates 50%
  • Dihydropyridine 50%

• Long range transmission of polar effects in cholinergic 3-arylideneanabaseines. Conformations calculated by molecular modelling

  Zoltewicz, J. A., Prokai-Tatrai, K., Bloom, L. B. & Kem, W. R., 1 Jan 1993, In: Heterocycles. 35, 1, p. 171-180 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ortho 100%
  • Molecular Modeling 100%
  • Long-distance Transmission 100%
  • Tetrahydropyridine 100%
  • Polar Effect 100%

• Integration of mass spectrometry into early-phase discovery and development of central nervous system agents

  Prokai, L., Zharikova, A., Janky, T., Li, X., Braddy, A. C., Perjsi, P., Matveeva, L., Powell, D. H. & Prokai-Tatrai, K., 2001, In: Journal of Mass Spectrometry. 36, 11, p. 1211-1219 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass Spectrometry 100%
  • Central Nervous System Agents 100%
  • Central Nervous System Agent 100%
  • Central Nervous System 33%
  • Rodents 33%

• The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma

  Kapic, A., Zaman, K., Nguyen, V., Neagu, G. C., Sumien, N., Prokai, L. & Prokai-Tatrai, K., Jul 2024, In: Cells. 13, 13, 1126.

  Research output: Contribution to journal › Article › peer-review

  • Glaucoma 100%
  • Ocular Hypertension 100%
  • Retina 100%
  • Retinal Ganglion Cells 100%
  • 17-estradiol 100%

• Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

  Zaman, K., Nguyen, V., Prokai-Tatrai, K. & Prokai, L., Aug 2023, In: International journal of molecular sciences. 24, 16, 12592.

  Research output: Contribution to journal › Article › peer-review

  • Elevated Intraocular Pressure 100%
  • Glaucomatous 100%
  • Proteomics 100%
  • Experimental Glaucoma 100%
  • Saline Injection 100%

• Simultaneous measurement of 17β-estradiol, 17α-estradiol and estrone by GC-isotope dilution MS-MS

  Prokai-Tatrai, K., Bonds, D. & Prokai, L., Feb 2010, In: Chromatographia. 71, 3-4, p. 311-315 5 p.

  Research output: Contribution to journal › Article › peer-review

  • 17-estradiol 100%
  • Estradiol-17 100%
  • Estrone 100%
  • Simultaneous Measurement 100%
  • MS-MS 100%

• Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics

  Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., Dec 2008, In: Molecular and Cellular Proteomics. 7, 12, p. 2442-2451 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Misidentification 100%
  • MS-MS 100%
  • Shotgun Proteomics 100%
  • Tyrosine Nitration 100%
  • Tyrosine 100%

• Synthesis and biological evaluation of 17β-alkoxyestra-1,3,5(10)-trienes as potential neuroprotectants against oxidative stress

  Prokai, L., Oon, S. M., Prokai-Tatrai, K., Abboud, K. A. & Simpkins, J. W., 4 Jan 2001, In: Journal of Medicinal Chemistry. 44, 1, p. 110-114 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative Stress 100%
  • Estradiol 100%
  • Butyl 100%
  • Neuroprotectant 100%
  • Trienes 100%

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2

  Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 2018, In: Molecules. 23, 1, 65.

  Research output: Contribution to journal › Review article › peer-review

• Proteomics-based retinal target engagement analysis and retina-targeted delivery of 17β-estradiol by the dhed prodrug for ocular neurotherapy in males

  Prokai-Tatrai, K., Zaman, K., Nguyen, V., De La Cruz, D. L. & Prokai, L., Sep 2021, In: Pharmaceutics. 13, 9, 1392.

  Research output: Contribution to journal › Article › peer-review

  • Retina 100%
  • 17-estradiol 100%
  • Prodrug 100%
  • Target Engagement 100%
  • Targeted Delivery 100%

• Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

  Prokai, L., Prokai-Tatrai, K., Perjesi, P., Zharikova, A. D., Perez, E. J., Liu, R. & Simpkins, J. W., 30 Sep 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 20, p. 11741-11746 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen 100%
  • Neuroprotection 100%
  • Quinol 100%
  • Antioxidant Mechanism 100%
  • Antioxidant 100%

• Brain delivery of thyrotropin-releasing hormone via a novel prodrug approach

  Prokai-Tatrai, K., De La Cruz, D. L., Nguyen, V., Ross, B. P., Toth, I. & Prokai, L., Jul 2019, In: Pharmaceutics. 11, 7, 349.

  Research output: Contribution to journal › Article › peer-review

  • Prodrug 100%
  • Thyrotropin 100%
  • Prodrug Strategy 100%
  • Brain Delivery 100%
  • Protirelin 100%

• Neuroprotective effects of a novel non-receptor-binding estrogen analogue: In vitro and in vivo analysis

  Liu, R., Yang, S. H., Perez, E., Yi, K. D., Wu, S. S., Eberst, K., Prokai, L., Prokai-Tatrai, K., Cai, Z. Y., Covey, D. F., Day, A. L. & Simpkins, J. W., 1 Oct 2002, In: Stroke. 33, 10, p. 2485-2491 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotective Effect 100%
  • Transient Middle Cerebral Artery Occlusion (tMCAO) 100%
  • Receptor Binding 100%
  • Estrogen Analogs 100%
  • In Vivo Analysis 100%

• Cardiovascular effects of neuropeptide FF antagonists

  Prokai, L., Zharikova, A. D., Juhasz, A. & Prokai-Tatrai, K., May 2006, In: Peptides. 27, 5, p. 1015-1019 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cardiovascular Effects 100%
  • Neuropeptide FF 100%
  • Blood Pressure 100%
  • Cardiovascular Effect 100%
  • Neuropeptide 100%

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4

  Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D. & Siciliano, C. & 5 others, Gütschow, M., Ragno, R., Gomes, P. A. C., Agrofoglio, L. A. & Muñoz-Torrero, D., 2019, In: Molecules. 24, 1

  Research output: Contribution to journal › Review article › peer-review

• Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6

  Vanden Eynde, J. J., Mangoni, A. A., Rautio, J., Leprince, J., Azuma, Y. T., García-Sosa, A. T., Hulme, C., Jampilek, J., Karaman, R., Li, W., Gomes, P. A. C., Hadjipavlou-Litina, D., Capasso, R., Geronikaki, A., Cerchia, L., Sabatier, J. M., Ragno, R., Tuccinardi, T., Trabocchi, A. & Winum, J. Y. & 22 others, Luque, F. J., Prokai-Tatrai, K., Spetea, M., Gütschow, M., Kosalec, I., Guillou, C., Vasconcelos, M. H., Kokotos, G., Rastelli, G., De Sousa, M. E., Manera, C., Gemma, S., Mangani, S., Siciliano, C., Galdiero, S., Liu, H., Scott, P. J. H., De Los Ríos, C., Agrofoglio, L. A., Collina, S., Guedes, R. C. & Muñoz-Torrero, D., 2020, In: Molecules. 25, 1, 119.

  Research output: Contribution to journal › Review article › peer-review

• Targeting drugs to the brain by redox chemical delivery systems

  Prokai, L., Prokai-Tatrai, K. & Bodor, N., 2000, In: Medicinal Research Reviews. 20, 5, p. 367-416 50 p.

  Research output: Contribution to journal › Review article › peer-review

  • Redox 100%
  • Targeted Drugs 100%
  • Chemical Delivery System 100%
  • Metabolic 100%
  • Pharmacokinetics 100%

• Analogs of tryptophan

  Pop, E., Prókai-Tátrai, K., Brewster, M. E. & Bodor, N., Dec 1994, In: Organic Preparations and Procedures International. 26, 6, p. 687-690 4 p.

  Research output: Contribution to journal › Article › peer-review

• Hydroformylation of methyl methacrylate via "in-situ" phosphinerhodium catalysis

  Prókai-Tátrai, K., Torös, S. & Heil, B., 6 Oct 1987, In: Journal of Organometallic Chemistry. 332, 3, p. 331-335 5 p.

  Research output: Contribution to journal › Article › peer-review

  • In Situ 100%
  • Methyl Acrylate 100%
  • Hydroformylation 100%
  • Methyl Methacrylate 100%
  • Rhodium 50%

• Retina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause

  Prokai-Tatrai, K., Zaman, K., Kapic, A., Hogan, K., Sanchez-Rodriguez, G., Silverio, A. E., Nguyen, V., Prokai, L. & Feola, A. J., Mar 2025, In: International journal of molecular sciences. 26, 5, 1846.

  Research output: Contribution to journal › Article › peer-review

  • Neuroprotective Agent 100%
  • Nerve Crush 100%
  • Rat Model 100%
  • Diethylstilbestrol 100%
  • Prodrug 100%