Projects per year
Personal profile
Area of Expertise
The research in my laboratory is focused on medicinal chemistry-based drug design and delivery into the central nervous system with translational medicine in mind. We focus on agents (neuropeptides and estrogens) that are beneficial for brain and retinal health. Our projects involve pharmacokinetics, metabolism and drug distribution studies in early-phase drug discovery, and the development of neuroactive/neuroprotective agents for the protection of the aging/diseased brain and retina.
Education/Academic qualification
PhD in Organic Chemistry, University of Veszprem
MS in Chemistry, University of Veszprem
BS in Chemical Engineering, University of Veszprem
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Prodrugs
Medicine & Life Sciences
Thyrotropin-Releasing Hormone
Medicine & Life Sciences
Estrogens
Medicine & Life Sciences
Brain
Medicine & Life Sciences
Mass spectrometry
Chemical Compounds
Estradiol
Medicine & Life Sciences
Peptides
Medicine & Life Sciences
Hydroquinones
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2009 2021
A Novel Neuroprotective Approach for Glaucoma
Prokai-Tatrai, K. & Prokai, L.
1/08/16 → 31/07/21
Project: Research
Novel Molecular Probes for Membrane Progesterone Receptors
NIA: National Institute on Aging
15/03/10 → 29/02/12
Project: Research
Novel Treatment of Menopausal Hot Flushes with an Estradiol Prodrug
Prokai, L. & Prokai-Tatrai, K.
University of Maryland, Baltimore
30/09/09 → 31/08/11
Project: Research
Research Output 1986 2019
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4
Mangoni, A. A., Guillou, C., Eynde, J. J. V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M. E., Sabatier, J. M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C. & 5 others, 1 Jan 2019, In : Molecules. p. 1-12 12 p.Research output: Contribution to journal › Review article › Research › peer-review
Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations
10β,17α-Dihydroxyestra-1,4-dien-3-one: A Bioprecursor Prodrug Preferentially Producing 17α-Estradiol in the Brain for Targeted Neurotherapy
Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 21 Nov 2018, In : ACS Chemical Neuroscience. 9, 11, p. 2528-2533 6 p.Research output: Contribution to journal › Article › Research › peer-review
Prodrugs
Estradiol
Brain
Estrogens
Neurology
2
Citations
(Scopus)
An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease
Tschiffely, A. E., Schuh, R. A., Prokai-Tatrai, K., Ottinger, M. A. & Prokai, L., 1 Feb 2018, In : Hormones and Behavior. 98, p. 16-21 6 p.Research output: Contribution to journal › Article › Research › peer-review
Alzheimer Disease
Estrogens
Brain
Estradiol
Amyloid beta-Protein Precursor
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3
Mangoni, A. A., Tuccinardi, T., Collina, S., Vanden Eynde, J. J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L. A., Sabatier, J. M., Hulme, C., Kokotos, G., You, Q. & Gomes, P. A. C., 1 Jan 2018, In : Molecules. 23, 7, 1596.Research output: Contribution to journal › Review article › Research › peer-review
Pharmaceutical Chemistry
drugs
chemistry
Pharmaceutical Preparations
1
Citation
(Scopus)
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2
Muñoz-Torrero, D., Mangoni, A. A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M. E., Prokai-Tatrai, K., Sabatier, J. M., Siciliano, C., Luque, F. J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M. G. & Agrofoglio, L. A., 1 Jan 2018, In : Molecules. 23, 1, 65.Research output: Contribution to journal › Review article › Research › peer-review
Molecular Targeted Therapy
Pharmaceutical Chemistry
Drug Discovery
drugs
chemistry