Projects per year
Personal profile
Area of Expertise
The research in my laboratory is focused on medicinal chemistry-based drug design and delivery into the central nervous system with translational medicine in mind. We focus on agents (neuropeptides and estrogens) that are beneficial for brain and retinal health. Our projects involve pharmacokinetics, metabolism and drug distribution studies in early-phase drug discovery, and the development of neuroactive/neuroprotective agents for the protection of the aging/diseased brain and retina.
Education/Academic qualification
BS in Chemical Engineering, University of Veszprem
MS in Chemistry, University of Veszprem
PhD in Organic Chemistry, University of Veszprem
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Projects
- 6 Finished
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A Novel Neuroprotective Approach for Glaucoma
Prokai-Tatrai, K. & Prokai, L.
1/08/16 → 31/07/21
Project: Research
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Novel Molecular Probes for Membrane Progesterone Receptors
NIA: National Institute on Aging
15/03/10 → 28/02/13
Project: Research
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Novel Treatment of Menopausal Hot Flushes with an Estradiol Prodrug
Prokai, L. & Prokai-Tatrai, K.
University of Maryland, Baltimore
30/09/09 → 29/02/12
Project: Research
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[β-glu2 ]trh is a functional antagonist of thyrotropin-releasing hormone (Trh) in the rodent brain
Prokai-Tatrai, K., Nguyen, V. & Prokai, L., 2 Jun 2021, In: International journal of molecular sciences. 22, 12, 6230.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomics-based retinal target engagement analysis and retina-targeted delivery of 17β-estradiol by the dhed prodrug for ocular neurotherapy in males
Prokai-Tatrai, K., Zaman, K., Nguyen, V., De La Cruz, D. L. & Prokai, L., Sep 2021, In: Pharmaceutics. 13, 9, 1392.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomics complementation of the rat uterotrophic assay for estrogenic endocrine disruptors: A roadmap of advancing high resolution mass spectrometry-based shotgun survey to targeted biomarker quantifications
Prokai, L., Rahlouni, F., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., 2 Feb 2021, In: International journal of molecular sciences. 22, 4, p. 1-13 13 p., 1686.Research output: Contribution to journal › Article › peer-review
Open Access -
The antagonist pGlu-βGlu-pro-NH2 binds to an allosteric site of the thyrotropin-releasing hormone receptor
De La Cruz, D. L., Prokai, L. & Prokai-Tatrai, K., Sep 2021, In: Molecules. 26, 17, 5397.Research output: Contribution to journal › Article › peer-review
Open Access -
17β-estradiol delivered in eye drops: Evidence of impact on protein networks and associated biological processes in the rat retina through quantitative proteomics
Prokai, L., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., Feb 2020, In: Pharmaceutics. 12, 2, 101.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations