Projects per year
Personal profile
Area of Expertise
The research in my laboratory is focused on medicinal chemistry-based drug design and delivery into the central nervous system with translational medicine in mind. We focus on agents (neuropeptides and estrogens) that are beneficial for brain and retinal health. Our projects involve pharmacokinetics, metabolism and drug distribution studies in early-phase drug discovery, and the development of neuroactive/neuroprotective agents for the protection of the aging/diseased brain and retina.
Education/Academic qualification
BS in Chemical Engineering, University of Veszprem
MS in Chemistry, University of Veszprem
PhD in Organic Chemistry, University of Veszprem
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Collaborations and top research areas from the last five years
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Projects
- 6 Finished
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A Novel Neuroprotective Approach for Glaucoma
Prokai-Tatrai, K. & Prokai, L.
1/08/16 → 31/07/21
Project: Research
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Novel Molecular Probes for Membrane Progesterone Receptors
NIA: National Institute on Aging
15/03/10 → 28/02/13
Project: Research
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Novel Treatment of Menopausal Hot Flushes with an Estradiol Prodrug
Prokai, L. & Prokai-Tatrai, K.
University of Maryland, Baltimore
30/09/09 → 29/02/12
Project: Research
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Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry
Szarka, S., Prokai-Tatrai, K. & Prokai, L., 15 Jul 2014, In: Analytical Chemistry. 86, 14, p. 7033-7040 8 p.Research output: Contribution to journal › Article › peer-review
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Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics
Stevens, S. M., Prokai-Tatrai, K. & Prokai, L., Dec 2008, In: Molecular and Cellular Proteomics. 7, 12, p. 2442-2451 10 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotective effects of a novel non-receptor-binding estrogen analogue: In vitro and in vivo analysis
Liu, R., Yang, S. H., Perez, E., Yi, K. D., Wu, S. S., Eberst, K., Prokai, L., Prokai-Tatrai, K., Cai, Z. Y., Covey, D. F., Day, A. L. & Simpkins, J. W., 1 Oct 2002, In: Stroke. 33, 10, p. 2485-2491 7 p.Research output: Contribution to journal › Article › peer-review
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Metabolism-based brain-targeting system for a thyrotropin-releasing hormone analogue
Prokai, L., Prokai-Tatrai, K., Ouyang, X., Kim, H. S., Wu, W. M., Zharikova, A. & Bodor, N., 4 Nov 1999, In: Journal of Medicinal Chemistry. 42, 22, p. 4563-4571 9 p.Research output: Contribution to journal › Article › peer-review
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Preparation of redox derivatives of 3α-hydroxy-5α-pregnane-11, 20-dione
Pop, E., Brewster, M. E., Prokai-Tatrai, K. & Bodor, N., 1 Jan 1994, In: Organic Preparations and Procedures International. 26, 3, p. 379-382 4 p.Research output: Contribution to journal › Article › peer-review