Projects per year
Personal profile
Area of Expertise
The research in my laboratory is focused on medicinal chemistry-based drug design and delivery into the central nervous system with translational medicine in mind. We focus on agents (neuropeptides and estrogens) that are beneficial for brain and retinal health. Our projects involve pharmacokinetics, metabolism and drug distribution studies in early-phase drug discovery, and the development of neuroactive/neuroprotective agents for the protection of the aging/diseased brain and retina.
Education/Academic qualification
BS in Chemical Engineering, University of Veszprem
MS in Chemistry, University of Veszprem
PhD in Organic Chemistry, University of Veszprem
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Projects
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A Novel Neuroprotective Approach for Glaucoma
Prokai-Tatrai, K. & Prokai, L.
1/08/16 → 31/07/21
Project: Research
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Novel Molecular Probes for Membrane Progesterone Receptors
NIA: National Institute on Aging
15/03/10 → 28/02/13
Project: Research
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Novel Treatment of Menopausal Hot Flushes with an Estradiol Prodrug
Prokai, L. & Prokai-Tatrai, K.
University of Maryland, Baltimore
30/09/09 → 29/02/12
Project: Research
Research output
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Proteomics complementation of the rat uterotrophic assay for estrogenic endocrine disruptors: A roadmap of advancing high resolution mass spectrometry-based shotgun survey to targeted biomarker quantifications
Prokai, L., Rahlouni, F., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., 2 Feb 2021, In: International journal of molecular sciences. 22, 4, p. 1-13 13 p., 1686.Research output: Contribution to journal › Article › peer-review
Open Access -
17β-estradiol delivered in eye drops: Evidence of impact on protein networks and associated biological processes in the rat retina through quantitative proteomics
Prokai, L., Zaman, K., Nguyen, V. & Prokai-Tatrai, K., Feb 2020, In: Pharmaceutics. 12, 2, 101.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Brain-selective estrogen therapy prevents androgen deprivation-associated hot flushes in a rat model
Merchenthaler, I., Lane, M., Stennett, C., Zhan, M., Nguyen, V., Prokai-Tatrai, K. & Prokai, L., Jun 2020, In: Pharmaceuticals. 13, 6, p. 1-10 10 p., 119.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6
Vanden Eynde, J. J., Mangoni, A. A., Rautio, J., Leprince, J., Azuma, Y. T., García-Sosa, A. T., Hulme, C., Jampilek, J., Karaman, R., Li, W., Gomes, P. A. C., Hadjipavlou-Litina, D., Capasso, R., Geronikaki, A., Cerchia, L., Sabatier, J. M., Ragno, R., Tuccinardi, T., Trabocchi, A., Winum, J. Y. & 22 others, , 2020, In: Molecules. 25, 1, 119.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Retina-targeted delivery of 17β-estradiol by the topically applied dhed prodrug
Prokai-Tatrai, K., Nguyen, V., De La Cruz, D. L., Guerra, R., Zaman, K., Rahlouni, F. & Prokai, L., May 2020, In: Pharmaceutics. 12, 5, 456.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations