• 2063 Citations
  • 24 h-Index
1974 …2020

Research output per year

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Personal profile

Area of Expertise

My interest is to understand the molecular mechanism responsible for contraction of human ventricles. It is known that contraction is caused by the interaction between two major muscle proteins (actin and myosin), and that it involves the rolling motion of the myosin molecule on a “rail” of actin molecules, but the details of this process are unknown. I believe this process cannot be studied using an isolated cardiac myocyte because it is too large: it contains billions of myosin molecules. Averaging the signal originating from so many molecules erases any information about the dynamics of molecular motion. To understand molecular motion one must look at a single myosin molecule within a myocyte. This requires a special technique. I have been using a technique called Surface Plasmon Assisted Emission (SPAM - developed at this university), which greatly reduces the background signal from molecules other than myosin. I have built a microscope based on SPAM to investigate the motion of myosin in cardiac myocytes from human ventricles. The results provide specific information about the dynamics of the rolling motion of cardiac myosin.

Education/Academic qualification

PhD in Biophysics, Macquarie University

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Research Output

  • Differences in the spatial distribution of actin in the left and right ventricles of functioning rabbit hearts

    Nagwekar, J., Duggal, D., Rich, R., Fudala, R., Gryczynski, I., Raut, S., Gryczynski, Z. & Borejdo, J., Mar 2018, In : Medical Photonics. 27, p. 1-8 8 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Surface plasmon-assisted microscope

    Borejdo, J., Gryczynski, Z., Fudala, R., Joshi, C. R., Borgmann, K., Ghorpade, A. & Gryczynski, I., 1 Jun 2018, In : Journal of Biomedical Optics. 23, 6, 060502.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Imaging viscosity of intragranular mucin matrix in cystic fibrosis cells

    Requena, S., Ponomarchuk, O., Castillo, M., Rebik, J., Brochiero, E., Borejdo, J., Gryczynski, I., Dzyuba, S. V., Gryczynski, Z., Grygorczyk, R. & Fudala, R., 1 Dec 2017, In : Scientific Reports. 7, 1, 16761.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    No difference in myosin kinetics and spatial distribution of the lever arm in the left and right ventricles of human hearts

    Duggal, D., Requena, S., Nagwekar, J., Raut, S., Rich, R., Das, H., Patel, V., Gryczynski, I., Fudala, R., Gryczynski, Z., Blair, C., Campbell, K. S. & Borejdo, J., 13 Oct 2017, In : Frontiers in Physiology. 8, OCT, 732.

    Research output: Contribution to journalArticle