• 2095 Citations
  • 24 h-Index
1974 …2020

Research output per year

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Personal profile

Area of Expertise

My interest is to understand the molecular mechanism responsible for contraction of human ventricles. It is known that contraction is caused by the interaction between two major muscle proteins (actin and myosin), and that it involves the rolling motion of the myosin molecule on a “rail” of actin molecules, but the details of this process are unknown. I believe this process cannot be studied using an isolated cardiac myocyte because it is too large: it contains billions of myosin molecules. Averaging the signal originating from so many molecules erases any information about the dynamics of molecular motion. To understand molecular motion one must look at a single myosin molecule within a myocyte. This requires a special technique. I have been using a technique called Surface Plasmon Assisted Emission (SPAM - developed at this university), which greatly reduces the background signal from molecules other than myosin. I have built a microscope based on SPAM to investigate the motion of myosin in cardiac myocytes from human ventricles. The results provide specific information about the dynamics of the rolling motion of cardiac myosin.

Education/Academic qualification

PhD in Biophysics, Macquarie University

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Projects

Research Output

On the origin and correction for inner filter effects in fluorescence Part I: Primary inner filter effect-the proper approach for sample absorbance correction

Kimball, J., Chavez, J., Ceresa, L., Kitchner, E., Nurekeyev, Z., Doan, H., Szabelski, M., Borejdo, J., Gryczynski, I., Gryczynski, Z. & Gryczynski, Z., Jul 2020, In : Methods and Applications in Fluorescence. 8, 3, 033002.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    On the possibility of direct triplet state excitation of indole

    Chavez, J., Ceresa, L., Kitchner, E., Kimball, J., Shtoyko, T., Fudala, R., Borejdo, J., Gryczynski, Z. & Gryczynski, I., Jul 2020, In : Journal of Photochemistry and Photobiology B: Biology. 208, 111897.

    Research output: Contribution to journalArticle

  • Probing the assembly of HDL mimetic, drug carrying nanoparticles using intrinsic fluorescences

    Raut, S., Garud, A., Nagarajan, B., Sabnis, N., Remaley, A., Fudala, R., Gryczynski, I., Gryczynski, Z., Dzyuba, S. V., Borejdo, J. & Lacko, A., 1 Apr 2020, In : Journal of Pharmacology and Experimental Therapeutics. 373, 1, p. 113-121 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Differences in the spatial distribution of actin in the left and right ventricles of functioning rabbit hearts

    Nagwekar, J., Duggal, D., Rich, R., Fudala, R., Gryczynski, I., Raut, S., Gryczynski, Z. & Borejdo, J., Mar 2018, In : Medical Photonics. 27, p. 1-8 8 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations