• 5664 Citations
  • 26 h-Index
19982022
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Personal profile

Area of Expertise

Occlusive arterial disease, or the pathological obstruction of arteries, is very common and prevalent in Western countries. Major risk factors of this disease include aging, smoking, hypertension, diabetes, high-fat/high-cholesterol diet, and in-stent surgical procedures.
My lab examines why the smooth muscle layer of the arterial wall thickens as a result of these risk factors, leading to vessel constriction and pathological obstruction. We use a rat model of blood vessel wall thickening to study how interference with the expression of these inheritable traits/factors can possibly reduce and/or alleviate this arterial constriction. The underlying mechanism from risk factor to arterial smooth muscle remodeling is not well understood. Therefore, we want to identify the molecular players and cellular pathways responsible for this narrowing of blood vessels. Interfering with these genes and pathways may reduce the risk of this type of blood vessel constriction and, thus, become primary targets to inhibit or reduce the onset of occlusive arterial disease.

Education/Academic qualification

PhD in Cell and Molecular Biology, Johns Hopkins University

BS in Chemical Engineering, Cornell University

Fingerprint Dive into the research topics where Joseph Yuan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2011 2022

Research Output 1998 2019

  • 5664 Citations
  • 26 h-Index
  • 28 Article
  • 3 Chapter
  • 3 Review article

Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging

Balapattabi, K., Farmer, G. E., Knapp, B. A., Little, J. T., Bachelor, M., Yuan, J. P. & Cunningham, J. T., 1 Jan 2019, In : Journal of Neuroendocrinology. e12752.

Research output: Contribution to journalArticleResearchpeer-review

Supraoptic Nucleus
Vasopressins
Chlorides
Arginine Vasopressin
Salts

Sniffer cells for the detection of neural Angiotensin II in vitro

Farmer, G. E., Amune, A., Bachelor, M. E., Duong, P., Yuan, J. P. & Cunningham, J. T., 1 Dec 2019, In : Scientific Reports. 9, 1, 8820.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Neuropeptides
Angiotensin II
Cultured Cells
Angiotensin III
Optogenetics
2 Citations (Scopus)

Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation

Jia, S., Rodriguez, M., Williams, A. G. & Yuan, J. P., 1 Dec 2017, In : Scientific Reports. 7, 1, 5075.

Research output: Contribution to journalArticleResearchpeer-review

Transient Receptor Potential Channels
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement

Methods to study TRPC channel regulation by interacting proteins

Kiselyov, K., Lee, K. P., Yuan, J. P. & Muallem, S., 19 Apr 2016, TRP Channels. CRC Press, p. 21-42 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Proteins
28 Citations (Scopus)

High glucose and diabetes enhanced store-operated Ca2+ entry and increased expression of its signaling proteins in mesangial cells

Chaudhari, S., Wu, P., Wang, Y., Ding, Y., Yuan, J. P., Begg, M. & Ma, R., 1 May 2014, In : American Journal of Physiology - Renal Physiology. 306, 9

Research output: Contribution to journalArticleResearchpeer-review

Mesangial Cells
Glucose
Proteins
Cultured Cells
Inositol 1,4,5-Trisphosphate