Johnny He, PhD

  • 4266 Citations
  • 30 h-Index
1995 …2023
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Research Output 1995 2019

  • 4266 Citations
  • 30 h-Index
  • 81 Article
  • 7 Review article
  • 4 Comment/debate
  • 1 Letter
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Article
2019

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Jan 2019, In : Journal of NeuroVirology.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
Histones
Methylation
Lysine
HIV
2018
1 Citation (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
3' Untranslated Regions
Hematopoiesis
Untranslated RNA
Fetal Blood

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Chen, X., Chen, W., Chen, G., Han, C., He, J. J., Zhou, X., Yu, Z., Dai, C. & Song, X., 1 Jan 2018, In : Phytochemistry. 145, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Scutellaria
Clerodane Diterpenes
Stereochemistry
Diterpenes
stereochemistry
Cleavage Stimulation Factor
Polyadenylation
3' Untranslated Regions
Fetal Blood
Blood Cells
2017
4 Citations (Scopus)

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., Florio, J., Rockenstein, E., He, J. J. & Masliah, E., 1 Apr 2017, In : Journal of NeuroVirology. 23, 2, p. 290-303 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
HIV-1
Pharmaceutical Preparations
HIV
Transgenic Mice
3 Citations (Scopus)

Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2

Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. & He, J. J., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Stem Cell Factor
Embryonic Stem Cells
Blastocyst
Down-Regulation
Embryonic Development
2016
15 Citations (Scopus)

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

Rahimian, P. & He, J. J., 1 Dec 2016, In : Journal of NeuroVirology. 22, 6, p. 774-788 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Human Immunodeficiency Virus tat Gene Products
Exosomes
HIV-1
Astrocytes
HIV Long Terminal Repeat
3 Citations (Scopus)

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubiquitin-Specific Proteases
Viral Proteins
Proteolysis
HIV-1
Peptide Hydrolases
18 Citations (Scopus)
Unfolded Protein Response
Endoplasmic Reticulum Stress
Glial Fibrillary Acidic Protein
Astrocytes
HIV-1
7 Citations (Scopus)

HIV-1 tat promotes lysosomal exocytosis in astrocytes and contributes to astrocyte-mediated tat neurotoxicity

Fan, Y. & He, J. J., 21 Oct 2016, In : Journal of Biological Chemistry. 291, 43, p. 22830-22840 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Exocytosis
Astrocytes
HIV-1
Endoplasmic Reticulum Stress
Proteins
13 Citations (Scopus)

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

Rahimian, P. & He, J. J., 15 Sep 2016, In : Journal of Neuroinflammation. 13, 1, 247.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNAs
Astrocytes
HIV-1
Gene Expression
Neurites
10 Citations (Scopus)

HIV Tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway

Fan, Y., Gao, X., Chen, J., Liu, Y. & He, J. J., 2 Nov 2016, In : Journal of Neuroscience. 36, 44, p. 11362-11373 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurogenesis
HIV
Ligands
Neurons
Stem Cells
2015
23 Citations (Scopus)

Exosomes are unlikely involved in intercellular Nef transfer

Luo, X., Fan, Y., Park, I. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

Research output: Contribution to journalArticleResearchpeer-review

exosomes
Exosomes
Detergents
Cells
T-cells
40 Citations (Scopus)

HIV-1 tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: Implications for HIV-associated neurocognitive disorders

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., He, J. J. & Masliah, E., 1 Jan 2015, In : Journal of Neuroscience. 35, 5, p. 1921-1938 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Autophagy
Lysosomes
HIV-1
HIV
Lysosome-Associated Membrane Glycoproteins
5 Citations (Scopus)

Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase

Visalli, R. J., Ziobrowski, H., Badri, K. R., He, J. J., Zhang, X., Arumugam, S. R. & Zhao, H., 3 Jul 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3168-3171 4 p., 22789.

Research output: Contribution to journalArticleResearchpeer-review

Human Herpesvirus 2
Viruses
Inhibitory Concentration 50
Antiviral Agents
Derivatives
25 Citations (Scopus)

Mechanisms of HIV-1 tat neurotoxicity via CDK5 translocation and hyper-activation: Role in HIV-associated neurocognitive disorders

Fields, J. A., Dumaop, W., Crews, L., Adame, A., Spencer, B., Metcalf, J., He, J. J., Rockenstein, E. & Masliah, E., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 43-54 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
HIV
Cytoplasm
Cyclin-Dependent Kinase 5
AIDS Dementia Complex
9 Citations (Scopus)

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Sep 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoiesis
MicroRNAs
Fetal Blood
Blood Cells
Cell Differentiation
11 Citations (Scopus)

STAT3 and its phosphorylation are involved in HIV-1 tat-induced transactivation of glial fibrillary acidic protein

Fan, Y., Timani, K. A. & He, J. J., 1 Jan 2015, In : Current HIV Research. 13, 1, p. 55-63 9 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3 Transcription Factor
Glial Fibrillary Acidic Protein
Transcriptional Activation
HIV-1
Phosphorylation
4 Citations (Scopus)

Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

Liu, Y., Liu, J., Wang, Z. & He, J. J., 23 Jul 2015, In : Cell and Bioscience. 5, 1, 40.

Research output: Contribution to journalArticleResearchpeer-review

RNA Precursors
RNA
Nuclear Localization Signals
Assays
Spliceosomes
11 Citations (Scopus)

Tip110 regulates the cross talk between p53 and hypoxia-inducible factor 1α under hypoxia and promotes survival of cancer cells

Timani, K. A., Liu, Y., Fan, Y., Mohammad, K. S. & He, J. J., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 13, p. 2254-2264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypoxia-Inducible Factor 1
Cell Survival
Neoplasms
Physiological Phenomena
Protein Stability
2014
14 Citations (Scopus)

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

Luo, X. & He, J. J., 1 Jan 2014, In : Journal of NeuroVirology. 21, 1, p. 66-80 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Virus Diseases
Astrocytes
HIV
Endocytosis
Central Nervous System
31 Citations (Scopus)

Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice

Paris, J. J., Carey, A. N., Shay, C. F., Gomes, S. M., He, J. J. & McLaughlin, J. P., 1 Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 380-388 9 p.

Research output: Contribution to journalArticleResearchpeer-review

tat Gene Products
Reward
Cocaine
HIV-1
Doxycycline
37 Citations (Scopus)

Exosome-associated hepatitis C virus in cell cultures and patient plasma

Liu, Z., Zhang, X., Yu, Q. & He, J. J., 12 Dec 2014, In : Biochemical and Biophysical Research Communications. 455, 3-4, p. 218-222 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Exosomes
Satellite Viruses
Viruses
Cell culture
Hepacivirus
16 Citations (Scopus)

Hepatitis C Virus (HCV) interaction with astrocytes: Nonproductive infection and induction of IL-18

Liu, Z., Zhao, F. & He, J. J., 1 Jan 2014, In : Journal of NeuroVirology. 20, 3, p. 278-293 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-18
Astrocytes
Hepacivirus
Infection
Virus Diseases
10 Citations (Scopus)

HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication

Park, I., Fan, Y., Luo, X., Ryou, M. G., Liu, J., Green, L. & He, J. J., 9 Jun 2014, In : PLoS ONE. 9, 6, e99545.

Research output: Contribution to journalArticleResearchpeer-review

T-cells
Human immunodeficiency virus 1
Liver
HIV-1
T-lymphocytes
8 Citations (Scopus)

Involvement of miR-196a in HIV-associated neurocognitive disorders

Bagashev, A., Mukerjee, R., Santerre, M., Del Carpio-Cano, F. E., Shrestha, J., Wang, Y., He, J. J. & Sawaya, B. E., 1 Jan 2014, In : Apoptosis. 19, 8, p. 1202-1214 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Trans-Activators
Transcription
MicroRNAs
HIV
HIV-1
16 Citations (Scopus)

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15

Timani, K. A., Liu, Y., Suvannasankha, A. & He, J. J., 1 Jan 2014, In : International Journal of Biochemistry and Cell Biology. 54, p. 10-19 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Degradation
Proteins
10 Citations (Scopus)

Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription

Zhao, W., Liu, Y., Timani, K. A. & He, J. J., 3 Jan 2014, In : Journal of Biological Chemistry. 289, 1, p. 190-202 13 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV Long Terminal Repeat
Phosphorylation
Terminal Repeat Sequences
RNA Polymerase II
Transcription
2013
17 Citations (Scopus)

Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors

Liu, Z. & He, J. J., 30 Jul 2013, In : Journal of Virology. 87, 15, p. 8545-8558 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Virus Receptors
Hepatitis C virus
Hepacivirus
Infection
infection
17 Citations (Scopus)

C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells

Liu, Y., Timani, K. A., Ou, X., Broxmeyer, H. E. & He, J. J., 1 Mar 2013, In : Stem Cells and Development. 22, 5, p. 689-694 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Exons
tat Gene Products
Embryonal Carcinoma Stem Cells
Cell Line
Messenger RNA
3 Citations (Scopus)

HIV-1 Nef-mediated T-cell activation and chemotaxis are decoupled using a HIV-1/SIVpbj1.9. chimeric nef variant

Park, I. & He, J. J., 1 Jan 2013, In : Archives of Virology. 158, 4, p. 845-852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Chemotaxis
HIV-1
T-Lymphocytes
Primates
Cell Movement
10 Citations (Scopus)

Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation

Park, I., Ndjomou, J., Wen, Y., Liu, Z., Ridgway, N. D., Kao, C. C. & He, J. J., 16 Sep 2013, In : PLoS ONE. 8, 9, e75648.

Research output: Contribution to journalArticleResearchpeer-review

Hepatitis C virus
Virus Replication
virus replication
Viruses
Hepacivirus
6 Citations (Scopus)

Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant

Gao, G., Wu, X., Zhou, J., He, M., He, J. J. & Guo, D., 17 May 2013, In : Journal of Biological Chemistry. 288, 20, p. 14297-14309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Cyclin T
Transcription
HIV-1
Peptide Elongation Factors
Terminal Repeat Sequences
10 Citations (Scopus)

Tip110 interacts with YB-1 and regulates each other's function

Timani, K. A., Liu, Y. & He, J. J., 4 Jul 2013, In : BMC Molecular Biology. 14, 14.

Research output: Contribution to journalArticleResearchpeer-review

HIV Long Terminal Repeat
Proteins
Y-Box-Binding Protein 1
RNA Precursors
Alternative Splicing
2012
32 Citations (Scopus)

CD59 incorporation protects hepatitis C virus against complement-mediated destruction

Amet, T., Ghabril, M., Chalasani, N., Byrd, D., Hu, N., Grantham, A., Liu, Z., Qin, X., He, J. J. & Yu, Q., 1 Feb 2012, In : Hepatology. 55, 2, p. 354-363 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Hepacivirus
Virion
Complement Activation
Antibodies
Viruses
19 Citations (Scopus)

Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Liu, Y., Lee, M. R., Timani, K. A., He, J. J. & Broxmeyer, H. E., 10 Apr 2012, In : Stem Cells and Development. 21, 6, p. 829-833 5 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
tat Gene Products
RNA-Binding Proteins
RNA Precursors
Hematopoiesis
2011
27 Citations (Scopus)

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: New insights into astrocyte-mediated Tat neurotoxicity

Fan, Y., Zou, W., Green, L. A., Kim, B. O. & He, J. J., 1 Mar 2011, In : Journal of Neuroimmune Pharmacology. 6, 1, p. 121-129 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Astrocytes
HIV-1
Growth
Glial Fibrillary Acidic Protein
Early Growth Response Protein 1
49 Citations (Scopus)

HIV-1 tat protein promotes neuronal dysfunction through disruption of microRNAs

Chang, J. R., Mukerjee, R., Bagashev, A., Del Valle, L., Chabrashvili, T., Hawkins, B. J., He, J. J. & Sawaya, B. E., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 41125-41134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human Immunodeficiency Virus tat Gene Products
tat Gene Products
MicroRNAs
HIV-1
Deregulation
18 Citations (Scopus)

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K. A., Mantel, C., Fan, Y., Hangoc, G., Cooper, S., He, J. J. & Broxmeyer, H. E., 26 May 2011, In : Blood. 117, 21, p. 5643-5651 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoiesis
Hematopoietic Stem Cells
Stem cells
Genes
Cells
37 Citations (Scopus)

Translational regulation of HIV-1 replication by HIV-1 rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3

Liu, J., Henao-Mejia, J., Liu, H., Zhao, Y. & He, J. J., 1 Jun 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 308-321 14 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
RNA
Reporter Genes
Gene Expression
Cell Nucleus Active Transport
2010
13 Citations (Scopus)

HIV-1 is budded from CD4+ T lymphocytes independently of exosomes

Park, I. & He, J. J., 20 Sep 2010, In : Virology Journal. 7, 234.

Research output: Contribution to journalArticleResearchpeer-review

Exosomes
HIV-1
T-Lymphocytes
Virion
Multivesicular Bodies
17 Citations (Scopus)

Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes

Zou, W., Wang, Z., Liu, Y., Fan, Y., Zhou, B. Y., Yang, X. F. & He, J. J., 1 Oct 2010, In : GLIA. 58, 13, p. 1640-1648 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Glial Fibrillary Acidic Protein
Astrocytes
HIV-1
HIV Infections
Up-Regulation
28 Citations (Scopus)

Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi

Xu, H., He, M., He, J. J. & Yang, X. F., 1 Jul 2010, In : Infection and Immunity. 78, 7, p. 2910-2918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Borrelia burgdorferi
Ticks
Lipoproteins
Mammals
Spirochaetales
2009
5 Citations (Scopus)

Hepatitis C virus is restricted at both entry and replication in mouse hepatocytes

Park, I., Ndjomou, J., Fan, Y., Henao-Mejia, J. & He, J. J., 25 Sep 2009, In : Biochemical and Biophysical Research Communications. 387, 3, p. 489-493 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Viruses
Hepacivirus
Hepatocytes
Hepatocellular Carcinoma
RNA
26 Citations (Scopus)

HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants

Park, I. & He, J. J., 1 Nov 2009, In : Journal of Leukocyte Biology. 86, 5, p. 1171-1178 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell Movement
HIV-1
T-Lymphocytes
Transendothelial and Transepithelial Migration
Lymphocyte Function-Associated Antigen-1
30 Citations (Scopus)

HIV-1 tat contributes to Alzheimer's disease-like pathology in PSAPP mice

Giunta, B., Hou, H., Zhu, Y., Rrapo, E., Tian, J., Takashi, M., Commins, D., Singer, E., He, J. J., Fernandez, F. & Tan, J., 19 Jun 2009, In : International Journal of Clinical and Experimental Pathology. 2, 5, p. 433-443 11 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
Alzheimer Disease
Pathology
Doxycycline
Amyloid
17 Citations (Scopus)

Inhibition of HIV-1 entry by extracts derived from traditional Chinese medicinal herbal plants

Park, I., Han, C., Song, X., Green, L. A., Wang, T., Liu, Y., Cen, C., Song, X., Yang, B., Chen, G. & He, J. J., 5 Aug 2009, In : BMC Complementary and Alternative Medicine. 9, 29.

Research output: Contribution to journalArticleResearchpeer-review

Medicinal Plants
HIV-1
HIV
Acquired Immunodeficiency Syndrome
Jurkat Cells
15 Citations (Scopus)

Inhibition of HIV-1 infection and replication by enhancing viral incorporation of innate anti-HIV-1 protein A3G: A non-pathogenic Nef mutant-based anti-HIV strategy

Green, L. A., Liu, Y. & He, J. J., 15 May 2009, In : Journal of Biological Chemistry. 284, 20, p. 13363-13372 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Human Immunodeficiency Virus Proteins
Virus Diseases
Virus Replication
Viruses
Virion
20 Citations (Scopus)

Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1

Henao-Mejia, J. & He, J. J., 15 Nov 2009, In : Experimental Cell Research. 315, 19, p. 3381-3395 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytoplasmic Granules
HIV-1
Oxidative Stress
T-Lymphocytes
Antigens
36 Citations (Scopus)

Suppression of HIV-1 Nef Translation by Sam68 Mutant-Induced Stress Granules and nef mRNA Sequestration

Henao-Mejia, J., Liu, Y., Park, I., Zhang, J., Sanford, J. & He, J. J., 16 Jan 2009, In : Molecular Cell. 33, 1, p. 87-96 10 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV-1
Messenger RNA
HIV
RNA Splicing
Viral DNA