Johnny He, PhD

  • 4529 Citations
  • 33 h-Index
19952020

Research output per year

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Personal profile

Area of Expertise

Introduction of new HIV drugs has greatly improved the lifespan and the quality of life for people with HIV infection. However, it has also created new problems. Although the virus becomes undetectable when treated, it is not cured and continues to encode some molecules. Therefore, we have focused our research on these molecules.
First, we wish to understand how these molecules affect the cells in the brain and the function of the brain where the HIV drugs have limited access. We are using specific mice that are modified to encode these molecules in our research.
Second, we want to understand if or how these molecules affect the emergence of the “undetectable” virus in the cells and how we could harness those molecules to achieve HIV cure.
Lastly, with increased lifespan and increased incidence of substance abuse in people with HIV infection, we are also interested in figuring out how these molecules alone or along with substances of abuse would affect the ageing process, the emergence of “undetectable virus, and development of HIV cure.
Our research approach is mainly a combination of molecular biology, virology, cell biology, and genetically modified mice. Our ultimate goal is to contribute to development of a complete HIV cure.

Education/Academic qualification

MS in Microbiology, China Agricultural University

MS in Molecular Biology, New York University

PhD in Molecular Biology, New York University

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Projects

Research Output

  • 4529 Citations
  • 33 h-Index
  • 81 Article
  • 8 Review article
  • 4 Comment/debate
  • 1 Letter

Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging

Zhao, X., Fan, Y., Vann, P. H., Wong, J. M., Sumien, N. & He, J. J., 1 Feb 2020, In : Aging and Disease. 11, 1, p. 93-107 15 p.

Research output: Contribution to journalReview article

Open Access
  • Open Access
  • Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

    Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Aug 2019, In : Journal of NeuroVirology. 25, 4, p. 508-519 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

    Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

    Research output: Contribution to journalReview article

  • 9 Scopus citations

    miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

    Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations