Johnny He, PhD

  • 4397 Citations
  • 31 h-Index
1995 …2023
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Personal profile

Area of Expertise

Introduction of new HIV drugs has greatly improved the lifespan and the quality of life for people with HIV infection. However, it has also created new problems. Although the virus becomes undetectable when treated, it is not cured and continues to encode some molecules. Therefore, we have focused our research on these molecules.
First, we wish to understand how these molecules affect the cells in the brain and the function of the brain where the HIV drugs have limited access. We are using specific mice that are modified to encode these molecules in our research.
Second, we want to understand if or how these molecules affect the emergence of the “undetectable” virus in the cells and how we could harness those molecules to achieve HIV cure.
Lastly, with increased lifespan and increased incidence of substance abuse in people with HIV infection, we are also interested in figuring out how these molecules alone or along with substances of abuse would affect the ageing process, the emergence of “undetectable virus, and development of HIV cure.
Our research approach is mainly a combination of molecular biology, virology, cell biology, and genetically modified mice. Our ultimate goal is to contribute to development of a complete HIV cure.

Education/Academic qualification

PhD in Molecular Biology, New York University

MS in Molecular Biology, New York University

MS in Microbiology, China Agricultural University

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HIV-1 Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
HIV Medicine & Life Sciences
tat Gene Products Medicine & Life Sciences
Viruses Chemical Compounds
Human Immunodeficiency Virus tat Gene Products Medicine & Life Sciences
Human immunodeficiency virus 1 Agriculture & Biology
MicroRNAs Medicine & Life Sciences

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Projects 2011 2023

Research Output 1995 2019

  • 4397 Citations
  • 31 h-Index
  • 81 Article
  • 7 Review article
  • 4 Comment/debate
  • 1 Letter
Open Access
National Institute of Neurological Disorders and Stroke
Organized Financing

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

Liu, Y., Niu, Y., Li, L., Timani, K. A., He, V. L., Sanburns, C., Xie, J. & He, J. J., 1 Aug 2019, In : Journal of NeuroVirology. 25, 4, p. 508-519 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Langford, D., Kim, B. O., Zou, W., Fan, Y., Rahimain, P., Liu, Y. & He, J. J., 15 Nov 2018, In : Journal of NeuroVirology. 24, 2, p. 168-179 12 p.

Research output: Contribution to journalReview article

Transgenic Mice
2 Citations (Scopus)

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 1 Jan 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
Untranslated RNA
Fetal Blood

Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana

Chen, X., Chen, W., Chen, G., Han, C., He, J. J., Zhou, X., Yu, Z., Dai, C. & Song, X., Jan 2018, In : Phytochemistry. 145, p. 1-9 9 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes