Johnathan Tune, PhD

Research output

Research output per year 1997 2000 2002 2004 2005 2006 2007 2008 2010 2012 2013 2014 2016 2017 2023

• 92 Article
• 12 Review article
• 4 Short survey
• 3 Editorial
• 4 More
  • 1 Chapter
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Letter

Research output per year

Research output per year

Search results

• Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: Influence of obesity

  Owen, M. K., Witzmann, F. A., Mckenney, M. L., Lai, X., Berwick, Z. C., Moberly, S. P., Alloosh, M., Sturek, M. & Tune, J. D., 2 Jul 2013, In: Circulation. 128, 1, p. 9-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Smooth Muscle 100%
  • Adipose Tissue 84%
  • Obesity 70%
  • Swine 29%
  • Proteome 28%

• Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism

  Sassoon, D. J., Goodwill, A. G., Noblet, J. N., Conteh, A. M., Herring, B. P., McClintick, J. N., Tune, J. D. & Mather, K. J., 1 Jul 2016, In: Basic Research in Cardiology. 111, 4, 43.

  Research output: Contribution to journal › Article › peer-review

  • Glucagon-Like Peptide-1 Receptor 100%
  • Reperfusion 67%
  • Ischemia 58%
  • Obesity 54%
  • Exenatide 52%

• Altered calcium signaling in colonic smooth muscle of type 1 diabetic mice

  Touw, K., Chakraborty, S., Zhang, W., Obukhov, A. G., Tune, J. D., Gunst, S. J. & Paul Herring, B., Jan 2012, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1, p. G66-G76

  Research output: Contribution to journal › Article › peer-review

  • Calcium Signaling 100%
  • Smooth Muscle 74%
  • Type 1 Diabetes Mellitus 30%
  • Myosin-Light-Chain Phosphatase 25%
  • Phosphorylation 23%

• Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

  Moberly, S. P., Mather, K. J., Berwick, Z. C., Owen, M. K., Goodwill, A. G., Casalini, E. D., Hutchins, G. D., Green, M. A., Ng, Y., Considine, R. V., Perry, K. M., Chisholm, R. L. & Tune, J. D., Jul 2013, In: Basic Research in Cardiology. 108, 4, 365.

  Research output: Contribution to journal › Article › peer-review

  • Glucagon-Like Peptide 1 100%
  • Type 2 Diabetes Mellitus 64%
  • Obesity 59%
  • Swine 33%
  • p38 Mitogen-Activated Protein Kinases 21%

• Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction

  Knudson, J. D., Dincer, Ü. D., Dick, G. M., Shibata, H., Akahane, R., Saito, M. & Tune, J. D., Sep 2005, In: American Journal of Physiology - Heart and Circulatory Physiology. 289, 3 58-3, p. H1038-H1046

  Research output: Contribution to journal › Article › peer-review

  • Leptin 100%
  • Fats 75%
  • Dogs 72%
  • Acetylcholine 62%
  • Endothelium 44%

• Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow

  Moberly, S. P., Berwick, Z. C., Kohr, M., Svendsen, M., Mather, K. J. & Tune, J. D., Mar 2012, In: Experimental Biology and Medicine. 237, 3, p. 334-342 9 p.

  Research output: Contribution to journal › Article › peer-review

  • glucagon-like peptide 1 (7-36) 100%
  • Intracoronary 99%
  • Glucagon-Like Peptide 1 82%
  • Myocardium 43%
  • Perfusion 39%

• Glucagon-like peptide 1 receptor activation augments cardiac output and improves cardiac efficiency in obese swine after myocardial infarction

  Sassoon, D. J., Tune, J. D., Mather, K. J., Noblet, J. N., Eagleson, M. A., Conteh, A. M., Sturek, J. T. & Goodwill, A. G., Aug 2017, In: Diabetes. 66, 8, p. 2230-2240 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Liraglutide 100%
  • Glucagon-Like Peptide-1 Receptor 92%
  • Dobutamine 69%
  • Cardiac Output 67%
  • Swine 56%

• Contribution of Adenosine A_2A and A_2B Receptors to Ischemic Coronary Dilation: Role of K_V and K_ATP Channels

  Berwick, Z. C., Payne, G. A., Lynch, B., Dick, G. M., Sturek, M. & Tune, J. D., Nov 2010, In: Microcirculation. 17, 8, p. 600-607 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenosine A2B Receptors 100%
  • Adenosine A2A Receptors 86%
  • KATP Channels 78%
  • isoalloxazine 74%
  • 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 69%

• Coronary vasomotor reactivity to endothelin-1 in the prediabetic metabolic syndrome

  Knudson, J. D., Rogers, P. A., Dincer, Ü. D., Bratz, I. N., Araiza, A. G., Dick, G. M. & Tune, J. D., Apr 2006, In: Microcirculation. 13, 3, p. 209-218 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelin-1 100%
  • Metabolic Syndrome 84%
  • Arterioles 60%
  • Coronary Vessels 45%
  • Dogs 40%

• Adaptations in the balance between coronary blood flow and myocardial metabolism in endurance athletes

  Tune, J. D., 2008, In: Journal of Physiology. 586, 21, p. 5043 1 p.

  Research output: Contribution to journal › Article › peer-review

• Feedforward sympathetic coronary vasodilation in exercising dogs

  Gorman, M. W., Tune, J. D., Richmond, K. N. & Feigl, E. O., 2000, In: Journal of Applied Physiology. 89, 5, p. 1892-1902 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vasodilation 100%
  • Adrenergic Receptors 98%
  • Dogs 74%
  • Phentolamine 22%
  • Vasodilator Agents 19%

• H₂O₂-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K⁺ channels

  Rogers, P. A., Dick, G. M., Knudson, J. D., Focardi, M., Bratz, I. N., Swafford, A. N., Saitoh, S. I., Tune, J. D. & Chilian, W. M., 2006, In: American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2473-H2482

  Research output: Contribution to journal › Article › peer-review

  • 4-Aminopyridine 100%
  • Vasodilation 74%
  • Oxidation-Reduction 74%
  • Arterioles 50%
  • Sulfhydryl Compounds 33%

• Contribution of voltage-dependent K ⁺ channels to metabolic control of coronary blood flow

  Berwick, Z. C., Dick, G. M., Moberly, S. P., Kohr, M. C., Sturek, M. & Tune, J. D., Apr 2012, In: Journal of Molecular and Cellular Cardiology. 52, 4, p. 912-919 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Syndrome 100%
  • PO-2 72%
  • Swine 68%
  • Arterial Pressure 35%
  • Atherogenic Diet 31%

• K_ATP⁺ channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation

  Tune, J. D., Richmond, K. N., Gorman, M. W. & Feigl, E. O., Feb 2001, In: American Journal of Physiology - Heart and Circulatory Physiology. 280, 2 49-2, p. H868-H875

  Research output: Contribution to journal › Article › peer-review

  • KATP Channels 100%
  • Purinergic P1 Receptors 98%
  • Oxygen Consumption 77%
  • Adenosine 77%
  • Vasodilation 76%

• Coronary blood flow control is impaired at rest and during exercise in conscious diabetic dogs

  Tune, J. D., Yeh, C., Setty, S., Zong, P. & Downey, H. F., 2002, In: Basic Research in Cardiology. 97, 3, p. 248-257 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dogs 100%
  • Hyperemia 75%
  • Hyperglycemia 63%
  • Diabetes Mellitus 55%
  • Heart Rate 50%

• Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs

  Gorman, M. W., Tune, J. D., Richmond, K. N. & Feigl, E. O., 2000, In: Journal of Applied Physiology. 89, 5, p. 1903-1911 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Vasodilation 100%
  • Norepinephrine 87%
  • Dogs 74%
  • Epinephrine 53%
  • Adrenergic Receptors 32%

• Penitrem A as a tool for understanding the role of large conductance Ca²⁺/ voltage-sensitive K⁺ channels in vascular function

  Asano, S., Bratz, I. N., Berwick, Z. C., Fancher, I. S., Tune, J. D. & Dick, G. M., Aug 2012, In: Journal of Pharmacology and Experimental Therapeutics. 342, 2, p. 453-460 8 p.

  Research output: Contribution to journal › Article › peer-review

  • tremortin 100%
  • Large-Conductance Calcium-Activated Potassium Channels 51%
  • iberiotoxin 32%
  • Blood Vessels 30%
  • Canidae 12%

• Functional contribution of P2Y1 receptors to the control of coronary blood flow

  Bender, S. B., Berwick, Z. C., Laughlin, M. H. & Tune, J. D., Dec 2011, In: Journal of Applied Physiology. 111, 6, p. 1744-1750 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Purinergic P2Y1 Receptors 100%
  • N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate 67%
  • Vasodilation 63%
  • Pressure 25%
  • Endothelium 23%

• Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome

  Bratz, I. N., Dick, G. M., Tune, J. D., Edwards, J. M., Neeb, Z. P., Dincer, U. D. & Sturek, M., Jun 2008, In: American Journal of Physiology - Heart and Circulatory Physiology. 294, 6, p. H2489-H2496

  Research output: Contribution to journal › Article › peer-review

  • Capsaicin 100%
  • Metabolic Syndrome 80%
  • Coronary Vessels 71%
  • Swine 69%
  • Vasodilation 50%

• Hypoxia-induced vasodilation in the right coronary circulation of conscious dogs: Role of adrenergic activation

  Setty, S., Zong, P., Sun, W., Tune, J. D. & Downey, H. F., 29 Feb 2008, In: Autonomic Neuroscience: Basic and Clinical. 138, 1-2, p. 76-82 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Coronary Circulation 100%
  • Adrenergic Agents 74%
  • Vasodilation 74%
  • Hypoxia 60%
  • Dogs 55%

• Distinct hemodynamic responses to (pyr)apelin-13 in large animal models

  Tune, J. D., Baker, H. E., Berwick, Z., Moberly, S. P., Casalini, E. D., Noblet, J. N., Zhen, E., Kowala, M. C., Christe, M. E. & Goodwill, A. G., Apr 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H747-H755

  Research output: Contribution to journal › Article › peer-review

  • apelin-13 peptide 100%
  • Hemodynamics 42%
  • Animal Models 41%
  • Swine 28%
  • Stroke Volume 26%

• Insulin improves cardiac contractile function without further decline in energetics during moderate ischemia

  Tune, J. D., Mallet, R. T. & Downey, H. F., 20 Mar 1998, In: FASEB Journal. 12, 5, p. A1000

  Research output: Contribution to journal › Article › peer-review

  • Insulin Derivative 100%
  • Ischemia 73%
  • Insulin 66%
  • Creatine 52%
  • Phosphate 36%

• Role of K(ATP)/⁺ channels in local metabolic coronary vasodilation

  Richmond, K. N., Tune, J. D., Gorman, M. W. & Feigl, E. O., Dec 1999, In: American Journal of Physiology - Heart and Circulatory Physiology. 277, 6 46-6, p. H2115-H2123

  Research output: Contribution to journal › Article › peer-review

  • Vasodilation 100%
  • Adenosine 84%
  • Glyburide 80%
  • Adenosine Triphosphate 80%
  • Catecholamines 32%

• Dysfunction of cardiac ryanodine receptors in the metabolic syndrome

  Dincer, U. D., Araiza, A., Knudson, J. D., Shao, C. H., Bidasee, K. R. & Tune, J. D., Jul 2006, In: Journal of Molecular and Cellular Cardiology. 41, 1, p. 108-114 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ryanodine Receptor Calcium Release Channel 100%
  • Metabolic Syndrome 74%
  • Heart Ventricles 47%
  • Dogs 32%
  • Phosphorylation 24%

• Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction

  Knudson, J. D., Dincer, Ü. D., Zhang, C., Swafford, A. N., Koshida, R., Picchi, A., Focardi, M., Dick, G. M. & Tune, J. D., Jul 2005, In: American Journal of Physiology - Heart and Circulatory Physiology. 289, 1 58-1, p. H48-H56

  Research output: Contribution to journal › Article › peer-review

  • Leptin Receptors 100%
  • Leptin 76%
  • Coronary Vessels 63%
  • Zucker Rats 26%
  • Vasodilation 18%