• 3822 Citations
  • 37 h-Index
19972020

Research output per year

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Research Output

2020

Disentangling the Gordian knot of local metabolic control of coronary blood flow

Tune, J. D., Goodwill, A. G., Kiel, A. M., Baker, H. E., Bender, S. B., Merkus, X. D. & Duncker, D. J., 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 1, p. H11-H24

Research output: Contribution to journalReview article

Distinct hemodynamic responses to (pyr)apelin-13 in large animal models

Tune, J. D., Baker, H. E., Berwick, Z., Moberly, S. P., Casalini, E. D., Noblet, J. N., Zhen, E., Kowala, M. C., Christe, M. E. & Goodwill, A. G., Apr 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H747-H755

Research output: Contribution to journalArticle

Experimental animal models of coronary microvascular dysfunction

Sorop, O., Van De Wouw, J., Chandler, S., Ohanyan, V., Tune, J. D., Chilian, W. M., Merkus, D., Bender, S. B. & Duncker, D. J., 1 Mar 2020, In : Cardiovascular Research. 116, 4, p. 756-770 15 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations
2019

Benefits of Empagliflozin Beyond Enhancing Myocardial Energetics?

Baker, H. E., Tune, J. D., Goodwill, A. G. & Mather, K. J., 13 Aug 2019, In : Journal of the American College of Cardiology. 74, 6, p. 825-826 2 p.

Research output: Contribution to journalLetter

Inhibition of sodium–glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization

Baker, H. E., Kiel, A. M., Luebbe, S. T., Simon, B. R., Earl, C. C., Regmi, A., Roell, W. C., Mather, K. J., Tune, J. D. & Goodwill, A. G., 1 May 2019, In : Basic Research in Cardiology. 114, 3, 25.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes

Mather, K. J., Considine, R. V., Hamilton, L., Patel, N. A., Mathias, C., Territo, W., Goodwill, A. G., Tune, J. D., Green, M. A. & Hutchins, G. D., 1 Sep 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 9, p. 3456-3465 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Local metabolic hypothesis is not sufficient to explain coronary autoregulatory behavior

Kiel, A. M., Goodwill, A. G., Baker, H. E., Dick, G. M. & Tune, J. D., 1 Sep 2018, In : Basic Research in Cardiology. 113, 5, 33.

Research output: Contribution to journalArticle

27 Scopus citations
2017

Cardiovascular consequences of metabolic syndrome

Tune, J. D., Goodwill, A. G., Sassoon, D. J. & Mather, K. J., 1 May 2017, In : Translational Research. 183, p. 57-70 14 p.

Research output: Contribution to journalReview article

85 Scopus citations

Dynamic regulation of the subunit composition of BK channels in smooth muscle

Dick, G. M. & Tune, J. D., 1 Sep 2017, In : Circulation research. 121, 6, p. 594-595 2 p.

Research output: Contribution to journalEditorial

Glucagon-like peptide 1 receptor activation augments cardiac output and improves cardiac efficiency in obese swine after myocardial infarction

Sassoon, D. J., Tune, J. D., Mather, K. J., Noblet, J. N., Eagleson, M. A., Conteh, A. M., Sturek, J. T. & Goodwill, A. G., Aug 2017, In : Diabetes. 66, 8, p. 2230-2240 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models

Touw, K., Ringus, D. L., Hubert, N., Wang, Y., Leone, V. A., Nadimpalli, A., Theriault, B. R., Huang, Y. E., Tune, J. D., Herring, P. B., Farrugia, G., Kashyap, P. C., Antonopoulos, D. A. & Chang, E. B., 1 Mar 2017, In : Physiological Reports. 5, 6, e13182.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Regulation of coronary blood flow

Goodwill, A. G., Dick, G. M., Kiel, A. M. & Tune, J. D., 1 Apr 2017, In : Comprehensive Physiology. 7, 2, p. 321-382 62 p.

Research output: Contribution to journalArticle

49 Scopus citations

Regulation of myocardial oxygen delivery in response to graded reductions in hematocrit: role of K+ channels

Kiel, A. M., Goodwill, A. G., Noblet, J. N., Barnard, A. L., Sassoon, D. J. & Tune, J. D., 1 Nov 2017, In : Basic Research in Cardiology. 112, 6, 65.

Research output: Contribution to journalArticle

8 Scopus citations

ROCK as a molecular bond connecting coronary microvascular and cardiac remodelling

Merkus, D. & Tune, J. D., 2017, In : Cardiovascular Research. 113, 11, p. 1273-1275 3 p.

Research output: Contribution to journalEditorial

Open Access
2016

Biphasic alterations in coronary smooth muscle Ca2+ regulation in a repeat cross-sectional study of coronary artery disease severity in metabolic syndrome

McKenney-Drake, M. L., Rodenbeck, S. D., Owen, M. K., Schultz, K. A., Alloosh, M., Tune, J. D. & Sturek, M., 1 Jun 2016, In : Atherosclerosis. 249, p. 1-9 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Critical contribution of KV1 channels to the regulation of coronary blood flow

Goodwill, A. G., Noblet, J. N., Sassoon, D., Fu, L., Kassab, G. S., Schepers, L., Herring, B. P., Rottgen, T. S., Tune, J. D. & Dick, G. M., 1 Sep 2016, In : Basic Research in Cardiology. 111, 5, 56.

Research output: Contribution to journalArticle

12 Scopus citations

Kv7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine

Goodwill, A. G., Fu, L., Noblet, J. N., Casalini, E. D., Sassoon, D., Berwick, Z. C., Kassab, G. S., Tune, J. D. & Dick, G. M., Mar 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 6, p. H693-H704

Research output: Contribution to journalArticle

12 Scopus citations

Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway

Noblet, J. N., Goodwill, A. G., Sassoon, D. J., Kiel, A. M. & Tune, J. D., 1 May 2016, In : Basic Research in Cardiology. 111, 3, 25.

Research output: Contribution to journalArticle

10 Scopus citations

Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism

Sassoon, D. J., Goodwill, A. G., Noblet, J. N., Conteh, A. M., Herring, B. P., McClintick, J. N., Tune, J. D. & Mather, K. J., 1 Jul 2016, In : Basic Research in Cardiology. 111, 4, 43.

Research output: Contribution to journalArticle

8 Scopus citations

Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine

McKenney-Drake, M. L., Rodenbeck, S. D., Owen, M. K., Schultz, K. A., Alloosh, M., Tune, J. D. & Sturek, M., 1 Jun 2016, In : Data in Brief. 7, p. 1393-1395 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Comparison of isoflurane and α-chloralose in an anesthetized swine model of acute pulmonary embolism producing right ventricular dysfunction

Beam, D. M., Neto-Neves, E. M., Stubblefield, W. B., Alves, N. J., Tune, J. D. & Kline, J. A., 1 Feb 2015, In : Comparative Medicine. 65, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: A pilot study

Handa, R. K., Liu, Z., Connors, B. A., Alloosh, M., Basile, D. P., Tune, J. D., Sturek, M., Evan, A. P. & Lingeman, J. E., 1 Apr 2015, In : Journal of Urology. 193, 4, p. 1409-1416 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels

Noblet, J. N., Owen, M. K., Goodwill, A. G., Sassoon, D. J. & Tune, J. D., 27 Jun 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1393-1400 8 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2014

Cardiovascular and hemodynamic effects of glucagon-like peptide-1

Goodwill, A. G., Mather, K. J., Conteh, A. M., Sassoon, D. J., Noblet, J. N. & Tune, J. D., Sep 2014, In : Reviews in Endocrine and Metabolic Disorders. 15, 3, p. 209-217 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Contribution of hydrogen sulfide to the control of coronary blood flow

Casalini, E. D., Goodwill, A. G., Owen, M. K., Moberly, S. P., Berwick, Z. C. & Tune, J. D., Feb 2014, In : Microcirculation. 21, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Glucagon-like peptide-1 (7–36) but not (9–36) augments cardiac output during myocardial ischemia via a Frank–Starling mechanism

Goodwill, A. G., Tune, J. D., Noblet, J. N., Conteh, A. M., Sassoon, D., Casalini, E. D. & Mather, K. J., 10 Sep 2014, In : Basic Research in Cardiology. 109, 5

Research output: Contribution to journalArticle

10 Scopus citations

Impairment of exercise hyperaemia in familial hypercholesterolaemia: Complex interplay of vasodilators vs. vasoconstrictors

Tune, J. D., 15 Apr 2014, In : Journal of Physiology. 592, 8, p. 1723-1724 2 p.

Research output: Contribution to journalComment/debate

Leptin-induced endothelial dysfunction: A target for therapeutic interventions

Payne, G. A., Tune, J. D. & Knudson, J. D., 2014, In : Current Pharmaceutical Design. 20, 4, p. 603-608 6 p.

Research output: Contribution to journalReview article

19 Scopus citations

Mechanisms underlying capsaicin effects in canine coronary artery: Implications for coronary spasm

Hiett, S. C., Owen, M. K., Li, W., Chen, X., Riley, A., Noblet, J., Flores, S., Sturek, M., Tune, J. D. & Obukhov, A. G., 2014, In : Cardiovascular Research. 103, 4, p. 607-618 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Perivascular adipose tissue and coronary vascular disease

Owen, M. K., Noblet, J. N., Sassoon, D. J., Conteh, A. M., Goodwill, A. G. & Tune, J. D., Aug 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 8, p. 1643-1649 7 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2013

Contribution of electromechanical coupling between KV and CaV1.2 channels to coronary dysfunction in obesity

Berwick, Z. C., Dick, G. M., O'Leary, H. A., Bender, S. B., Goodwill, A. G., Moberly, S. P., Owen, M. K., Miller, S. J., Obukhov, A. G. & Tune, J. D., 2013, In : Basic Research in Cardiology. 108, 5, 370.

Research output: Contribution to journalArticle

12 Scopus citations
249 Scopus citations

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

Moberly, S. P., Mather, K. J., Berwick, Z. C., Owen, M. K., Goodwill, A. G., Casalini, E. D., Hutchins, G. D., Green, M. A., Ng, Y., Considine, R. V., Perry, K. M., Chisholm, R. L. & Tune, J. D., 2013, In : Basic Research in Cardiology. 108, 4, 365.

Research output: Contribution to journalArticle

35 Scopus citations

Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: Influence of obesity

Owen, M. K., Witzmann, F. A., Mckenney, M. L., Lai, X., Berwick, Z. C., Moberly, S. P., Alloosh, M., Sturek, M. & Tune, J. D., 2 Jul 2013, In : Circulation. 128, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Regulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element

Chen, M., Zhang, W., Lu, X., Hoggatt, A. M., Gunst, S. J., Kassab, G. S., Tune, J. D. & Herring, B. P., 29 Nov 2013, In : Journal of Biological Chemistry. 288, 48, p. 34647-34657 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2012

Altered calcium signaling in colonic smooth muscle of type 1 diabetic mice

Touw, K., Chakraborty, S., Zhang, W., Obukhov, A. G., Tune, J. D., Gunst, S. J. & Paul Herring, B., Jan 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1, p. G66-G76

Research output: Contribution to journalArticle

21 Scopus citations

Bi-ventricular pacing improves pump function only with adequate myocardial perfusion in canine hearts with pseudo-left bundle branch block

Svendsen, M., Prinzen, F. W., Das, M. K., Berwick, Z., Rybka, M., Tune, J. D., Combs, W., Berbari, E. J. & Kassab, G. S., Jun 2012, In : Experimental Biology and Medicine. 237, 6, p. 644-651 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Contribution of voltage-dependent K + and Ca 2+ channels to coronary pressure-flow autoregulation

Berwick, Z. C., Moberly, S. P., Kohr, M. C., Morrical, E. B., Kurian, M. M., Dick, G. M. & Tune, J. D., 2012, In : Basic Research in Cardiology. 107, 3, 0264.

Research output: Contribution to journalArticle

26 Scopus citations

Contribution of voltage-dependent K + channels to metabolic control of coronary blood flow

Berwick, Z. C., Dick, G. M., Moberly, S. P., Kohr, M. C., Sturek, M. & Tune, J. D., Apr 2012, In : Journal of Molecular and Cellular Cardiology. 52, 4, p. 912-919 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Dynamic micro-and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome

Trask, A. J., Katz, P. S., Kelly, A. P., Galantowicz, M. L., Cismowski, M. J., West, T. A., Neeb, Z. P., Berwick, Z. C., Goodwill, A. G., Alloosh, M., Tune, J. D., Sturek, M. & Lucchesi, P. A., 1 Oct 2012, In : Journal of Applied Physiology. 113, 7, p. 1128-1140 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Epicardial perivascular adipose tissue as a therapeutic target in obesity-related coronary artery disease

Payne, G. A., Kohr, M. C. & Tune, J. D., Feb 2012, In : British Journal of Pharmacology. 165, 3, p. 659-669 11 p.

Research output: Contribution to journalReview article

Open Access
75 Scopus citations

Heart of the matter: Coronary dysfunction in metabolic syndrome

Berwick, Z. C., Dick, G. M. & Tune, J. D., Apr 2012, In : Journal of Molecular and Cellular Cardiology. 52, 4, p. 848-856 9 p.

Research output: Contribution to journalReview article

35 Scopus citations

Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow

Moberly, S. P., Berwick, Z. C., Kohr, M., Svendsen, M., Mather, K. J. & Tune, J. D., Mar 2012, In : Experimental Biology and Medicine. 237, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Penitrem A as a tool for understanding the role of large conductance Ca2+/ voltage-sensitive K+ channels in vascular function

Asano, S., Bratz, I. N., Berwick, Z. C., Fancher, I. S., Tune, J. D. & Dick, G. M., Aug 2012, In : Journal of Pharmacology and Experimental Therapeutics. 342, 2, p. 453-460 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

The effect of aging on adrenergic and nonadrenergic receptor expression and responsiveness in canine skeletal muscle

DeLorey, D. S., Clifford, P. S., Mittelstadt, S., Anton, M. M., Kluess, H. A., Tune, J. D., Dincer, U. D. & Buckwalter, J. B., Mar 2012, In : Journal of Applied Physiology. 112, 5, p. 841-848 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Bromoenol lactone inhibits voltage-gated Ca 2+ and transient receptor potential canonical channels

Chakraborty, S., Berwick, Z. C., Bartlett, P. J., Kumar, S., Thomas, A. P., Sturek, M., Tune, J. D. & Obukhov, A. G., Nov 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 329-340 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Contribution of IKCa) channels to the control of coronary blood flow

Kurian, M. M., Berwick, Z. C. & Tune, J. D., May 2011, In : Experimental Biology and Medicine. 236, 5, p. 621-627 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Functional contribution of P2Y1 receptors to the control of coronary blood flow

Bender, S. B., Berwick, Z. C., Laughlin, M. H. & Tune, J. D., Dec 2011, In : Journal of Applied Physiology. 111, 6, p. 1744-1750 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

SWI/SNF complexes containing brahma Brahma-related gene 1 play distinct roles in smooth muscle development

Zhang, M., Chen, M., Kim, J. R., Zhou, J., Jones, R. E., Tune, J. D., Kassab, G. S., Metzger, D., Ahlfeld, S., Conway, S. J. & Herring, B. P., Jul 2011, In : Molecular and Cellular Biology. 31, 13, p. 2618-2631 14 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations