Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.