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Johnathan Tune, PhD

  • 3799 Citations
  • 36 h-Index
19972020

Research output per year

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Personal profile

Area of Expertise

Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.

Education/Academic qualification

BA in Biology, University of North Texas

PhD in Physiology

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Projects

Short-Term Training Program In Biomedical Sciences

Tune, J. & Blum, J.

1/03/17 → 28/02/18

Project: Research

Cardiovascular effects of GLP-1 in obesity/metabolic syndrome

Tune, J. & MATHER, K.

1/02/13 → 31/01/14

Project: Research

Mechanisms of coronary microvascular dysfunction in metabolic syndrome

Tune, J.

1/09/09 → 31/05/10

Project: Research

Coronary dysfunction in obesity and insulin resistance

Tune, J.

1/07/04 → 30/06/05

Project: Research

Research Output

Disentangling the Gordian knot of local metabolic control of coronary blood flow

Tune, J. D., Goodwill, A. G., Kiel, A. M., Baker, H. E., Bender, S. B., Merkus, X. D. & Duncker, D. J., 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 1, p. H11-H24

Research output: Contribution to journal › Review article

    • Distinct hemodynamic responses to (pyr)apelin-13 in large animal models

    Tune, J. D., Baker, H. E., Berwick, Z., Moberly, S. P., Casalini, E. D., Noblet, J. N., Zhen, E., Kowala, M. C., Christe, M. E. & Goodwill, A. G., Apr 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H747-H755

    Research output: Contribution to journal › Article

    • Experimental animal models of coronary microvascular dysfunction

    Sorop, O., Van De Wouw, J., Chandler, S., Ohanyan, V., Tune, J. D., Chilian, W. M., Merkus, D., Bender, S. B. & Duncker, D. J., 1 Mar 2020, In : Cardiovascular Research. 116, 4, p. 756-770 15 p.

    Research output: Contribution to journal › Review article

    Open Access
    • 4 Scopus citations

    Benefits of Empagliflozin Beyond Enhancing Myocardial Energetics?

    Baker, H. E., Tune, J. D., Goodwill, A. G. & Mather, K. J., 13 Aug 2019, In : Journal of the American College of Cardiology. 74, 6, p. 825-826 2 p.

    Research output: Contribution to journal › Letter

    Inhibition of sodium–glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization

    Baker, H. E., Kiel, A. M., Luebbe, S. T., Simon, B. R., Earl, C. C., Regmi, A., Roell, W. C., Mather, K. J., Tune, J. D. & Goodwill, A. G., 1 May 2019, In : Basic Research in Cardiology. 114, 3, 25.

    Research output: Contribution to journal › Article

    • 15 Scopus citations