Projects per year
Personal profile
Area of Expertise
Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.
Education/Academic qualification
BA in Biology, University of North Texas
PhD in Physiology, University of North Texas Health Science Center
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Short-term training program in biomedical sciences
Tune, J., Blum, J., CARLESSO, N., Blum, J., CARLESSO, N., CHAN, R., HERBERT, B., Lahm, T., HERBERT, B., Lahm, T., BLUM, J. S., CARLESSO, N., BLUM, J. S. & CARLESSO, N.
National Heart, Lung, and Blood Institute
1/03/12 → 28/02/22
Project: Research
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Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
Tune, J., MATHER, K., Mather, K. J., TUNE, J. D., Mather, K. J., TUNE, J. D. & Tune, J.
National Heart, Lung, and Blood Institute
1/02/13 → 31/01/19
Project: Research
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Mechanisms of coronary microvascular dysfunction in metabolic syndrome
Tune, J. & TUNE, J. D.
National Heart, Lung, and Blood Institute
1/09/09 → 31/05/14
Project: Research
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Coronary dysfunction in obesity and insulin resistance
Tune, J., TUNE, J. D. & TUNE, J. D.
National Heart, Lung, and Blood Institute
1/02/04 → 30/06/08
Project: Research
Research output
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Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels
Goodwill, A. G., Baker, H. E., Dick, G. M., McCallinhart, P. E., Bailey, C. A., Brown, S. M., Man, J. J., Tharp, D. L., Clark, H. E., Blaettner, B. S., Jaffe, I. Z., Bowles, D. K., Trask, A. J., Tune, J. D. & Bender, S. B., Dec 2021, In: Basic Research in Cardiology. 116, 1, 35.Research output: Contribution to journal › Article › peer-review
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Disentangling the Gordian knot of local metabolic control of coronary blood flow
Tune, J. D., Goodwill, A. G., Kiel, A. M., Baker, H. E., Bender, S. B., Merkus, X. D. & Duncker, D. J., 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 1, p. H11-H24Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Distinct hemodynamic responses to (pyr)apelin-13 in large animal models
Tune, J. D., Baker, H. E., Berwick, Z., Moberly, S. P., Casalini, E. D., Noblet, J. N., Zhen, E., Kowala, M. C., Christe, M. E. & Goodwill, A. G., Apr 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H747-H755Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Experimental animal models of coronary microvascular dysfunction
Sorop, O., Van De Wouw, J., Chandler, S., Ohanyan, V., Tune, J. D., Chilian, W. M., Merkus, D., Bender, S. B. & Duncker, D. J., 1 Mar 2020, In: Cardiovascular Research. 116, 4, p. 756-770 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations -
Benefits of Empagliflozin Beyond Enhancing Myocardial Energetics?
Baker, H. E., Tune, J. D., Goodwill, A. G. & Mather, K. J., 13 Aug 2019, In: Journal of the American College of Cardiology. 74, 6, p. 825-826 2 p.Research output: Contribution to journal › Letter › peer-review