Projects per year
Personal profile
Area of Expertise
Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.
Education/Academic qualification
BA in Biology, University of North Texas
PhD in Physiology, University of North Texas Health Science Center
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Collaborations and top research areas from the last five years
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Myocardial O2 supply/demand balance in post partum period
Tune, J. (PI)
1/01/23 → 31/12/24
Project: Research
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Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale Modeling
BEARD, D. (CoPI), Figueroa, C. (PI) & Tune, J. (CoPI)
National Heart, Lung, and Blood Institute
15/03/22 → 28/02/25
Project: Research
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Leptin-induced endothelial dysfunction: A target for therapeutic interventions
Payne, G. A., Tune, J. D. & Knudson, J. D., 2014, In: Current Pharmaceutical Design. 20, 4, p. 603-608 6 p.Research output: Contribution to journal › Review article › peer-review
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Control of coronary blood flow during exercise
Tune, J. D., Richmond, K. N., Gorman, M. W. & Feigl, E. O., Apr 2002, In: Experimental Biology and Medicine. 227, 4, p. 238-250 13 p.Research output: Contribution to journal › Short survey › peer-review
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Comparison of isoflurane and α-chloralose in an anesthetized swine model of acute pulmonary embolism producing right ventricular dysfunction
Beam, D. M., Neto-Neves, E. M., Stubblefield, W. B., Alves, N. J., Tune, J. D. & Kline, J. A., 1 Feb 2015, In: Comparative Medicine. 65, 1, p. 54-61 8 p.Research output: Contribution to journal › Article › peer-review
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Impairment of exercise hyperaemia in familial hypercholesterolaemia: Complex interplay of vasodilators vs. vasoconstrictors
Tune, J. D., 15 Apr 2014, In: Journal of Physiology. 592, 8, p. 1723-1724 2 p.Research output: Contribution to journal › Comment/debate
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Matching coronary blood flow to myocardial oxygen consumption
Tune, J. D., Gorman, M. W. & Feigl, E. O., Jul 2004, In: Journal of Applied Physiology. 97, 1, p. 404-415 12 p.Research output: Contribution to journal › Review article › peer-review