Projects per year
Personal profile
Area of Expertise
Research in the Tune laboratory focuses on the regulation of myocardial oxygen delivery, contractile function and metabolism in health and disease. The primary goal centers on elucidating mechanisms of impaired coronary and cardiac function in the setting of obesity and diabetes. More specifically, experiments are designed to delineate putative mechanisms responsible for the regulation of coronary blood flow, identify factors that contribute to the initiation and progression of coronary vascular dysfunction and disease, and protecting the heart from irreversible ischemic damage. Studies routinely include a series of highly integrative experimental approaches which utilize both in vivo and in vitro approaches in large animal models of disease.
Education/Academic qualification
BA in Biology, University of North Texas
PhD in Physiology, University of North Texas Health Science Center
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale Modeling
Tune, J., BEARD, D. & Figueroa, C.
National Heart, Lung, and Blood Institute
15/03/22 → 28/02/23
Project: Research
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Short-Term Training Program In Biomedical Sciences
Tune, J., HERBERT, B., Lahm, T., Blum, J., CARLESSO, N., Blum, J., CARLESSO, N., CHAN, R., HERBERT, B., Lahm, T., HERBERT, B. & Machado, R.
National Heart, Lung, and Blood Institute
1/03/12 → 28/02/23
Project: Research
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Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
Tune, J., MATHER, K., Mather, K. J., TUNE, J. D., Mather, K. J., TUNE, J. D. & Tune, J.
National Heart, Lung, and Blood Institute
1/02/13 → 31/01/19
Project: Research
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Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
Tune, J., Tune, J. & MATHER, K.
1/02/13 → 31/01/19
Project: Research
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Short-term training program in biomedical sciences
Tune, J., Blum, J., CARLESSO, N., Blum, J., CARLESSO, N., CHAN, R., HERBERT, B., Lahm, T., HERBERT, B., Lahm, T., BLUM, J. S., CARLESSO, N., BLUM, J. S. & CARLESSO, N.
National Heart, Lung, and Blood Institute
1/03/12 → 28/02/22
Project: Research
Research output
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Multiscale model of the physiological control of myocardial perfusion to delineate putative metabolic feedback mechanisms
Gharahi, H., Figueroa, C. A., Tune, J. D. & Beard, D. A., 15 Apr 2022, In: Journal of Physiology. 600, 8, p. 1913-1932 20 p.Research output: Contribution to journal › Article › peer-review
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Bioengineering systems for modulating notch signaling in cardiovascular development, disease, and regeneration
Gomez, A. H., Joshi, S., Yang, Y., Tune, J. D., Zhao, M. T. & Yang, H., Oct 2021, In: Journal of Cardiovascular Development and Disease. 8, 10, 125.Research output: Contribution to journal › Review article › peer-review
Open Access -
Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels
Goodwill, A. G., Baker, H. E., Dick, G. M., McCallinhart, P. E., Bailey, C. A., Brown, S. M., Man, J. J., Tharp, D. L., Clark, H. E., Blaettner, B. S., Jaffe, I. Z., Bowles, D. K., Trask, A. J., Tune, J. D. & Bender, S. B., Dec 2021, In: Basic Research in Cardiology. 116, 1, 35.Research output: Contribution to journal › Article › peer-review
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Disentangling the Gordian knot of local metabolic control of coronary blood flow
Tune, J. D., Goodwill, A. G., Kiel, A. M., Baker, H. E., Bender, S. B., Merkus, X. D. & Duncker, D. J., 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 1, p. H11-H24Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Distinct hemodynamic responses to (pyr)apelin-13 in large animal models
Tune, J. D., Baker, H. E., Berwick, Z., Moberly, S. P., Casalini, E. D., Noblet, J. N., Zhen, E., Kowala, M. C., Christe, M. E. & Goodwill, A. G., Apr 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H747-H755Research output: Contribution to journal › Article › peer-review
2 Scopus citations