• 788 Citations
  • 17 h-Index
20042020

Research output per year

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Research Output

  • 788 Citations
  • 17 h-Index
  • 27 Article
  • 3 Review article
  • 2 Editorial
  • 1 Comment/debate
2020

Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

Zuo, Z. & Liu, J., Jun 2020, In : Current Opinion in Structural Biology. 62, p. 166-174 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Editorial overview: Allosteric assemblies

Liu, J. & Lai, L., Jun 2020, In : Current Opinion in Structural Biology. 62, p. vi-vii

Research output: Contribution to journalEditorial

2019

A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library

Wang, X. S., Chen, P. H. C., Hampton, J. T., Tharp, J. M., Reed, C. A., Das, S. K., Wang, D. S., Hayatshahi, H. S., Shen, Y., Liu, J. & Liu, W. R., 28 Oct 2019, In : Angewandte Chemie - International Edition. 58, 44, p. 15904-15909 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Assessing the Performance of the Nonbonded Mg2+ Models in a Two-Metal-Dependent Ribonuclease

Zuo, Z. & Liu, J., 28 Jan 2019, In : Journal of Chemical Information and Modeling. 59, 1, p. 399-408 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Probing Protein Allostery as a Residue-Specific Concept via Residue Response Maps

Hayatshahi, H. S., Ahuactzin, E., Tao, P., Wang, S. & Liu, J., 1 Jan 2019, (Accepted/In press) In : Journal of Chemical Information and Modeling.

Research output: Contribution to journalArticle

3 Scopus citations

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

Zuo, Z., Zolekar, A., Babu, K., Lin, V. J. T., Hayatshahi, H. S., Rajan, R., Wang, Y. C. & Liu, J., Jul 2019, In : eLife. 8, e46500.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity

Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. R., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3

Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.

Research output: Contribution to journalArticle

8 Scopus citations

Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1

Zolekar, A., Lin, V. J. T., Mishra, N. M., Ho, Y. Y., Hayatshahi, H. S., Parab, A., Sampat, R., Liao, X., Hoffmann, P., Liu, J., Emmitte, K. A. & Wang, Y. C., 11 Dec 2018, In : British Journal of Cancer. 119, 12, p. 1538-1551 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Cullin neddylation may allosterically tune polyubiquitin chain length and topology

Onel, M., Sumbul, F., Liu, J., Nussinov, R. & Haliloglu, T., 1 Mar 2017, In : Biochemical Journal. 474, 5, p. 781-795 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Energetic redistribution in allostery to execute protein function

Liu, J. & Nussinov, R., 18 Jul 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 29, p. 7480-7482 3 p.

Research output: Contribution to journalComment/debate

18 Scopus citations

Structure and Dynamics of Cas9 HNH Domain Catalytic State

Zuo, Z. & Liu, J., 1 Dec 2017, In : Scientific Reports. 7, 1, 17271.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Allostery: An Overview of Its History, Concepts, Methods, and Applications

Liu, J. & Nussinov, R., Jun 2016, In : PLoS Computational Biology. 12, 6, e1004966.

Research output: Contribution to journalEditorial

64 Scopus citations

Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations

Zuo, Z. & Liu, J., 22 Nov 2016, In : Scientific Reports. 5, 37584.

Research output: Contribution to journalArticle

30 Scopus citations

Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery

Kalescky, R., Zhou, H., Liu, J. & Tao, P., Apr 2016, In : PLoS Computational Biology. 12, 4, e1004893.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Häussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Südhof, T. C. & Rizo, J., 9 Jul 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555-564 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Identifying key residues for protein allostery through rigid residue scan

Kalescky, R., Liu, J. & Tao, P., 5 Mar 2015, In : Journal of Physical Chemistry A. 119, 9, p. 1689-1700 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Principles of allosteric interactions in cell signaling

Nussinov, R., Tsai, C. J. & Liu, J., 24 Dec 2014, In : Journal of the American Chemical Society. 136, 51, p. 17692-17701 10 p.

Research output: Contribution to journalReview article

69 Scopus citations
2013

Identifying cytochrome P450 functional networks and their allosteric regulatory elements

Liu, J., Tawa, G. J. & Wallqvist, A., 3 Dec 2013, In : PLoS ONE. 8, 12, e81980.

Research output: Contribution to journalArticle

24 Scopus citations

The role of allostery in the ubiquitin-proteasome system

Liu, J. & Nussinov, R., 1 Mar 2013, In : Critical Reviews in Biochemistry and Molecular Biology. 48, 2, p. 89-97 9 p.

Research output: Contribution to journalReview article

21 Scopus citations
2012

2D SMARTCyp reactivity-based site of metabolism prediction for major drug-metabolizing cytochrome P450 enzymes

Liu, R., Liu, J., Tawa, G. & Wallqvist, A., 25 Jun 2012, In : Journal of Chemical Information and Modeling. 52, 6, p. 1698-1712 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantitative Predictions of Binding Free Energy Changes in Drug-Resistant Influenza Neuraminidase

Ripoll, D. R., Khavrutskii, I. V., Chaudhury, S., Liu, J., Kuschner, R. A., Wallqvist, A. & Reifman, J., Aug 2012, In : PLoS Computational Biology. 8, 8, e1002665.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination

Liu, J. & Nussinov, R., 25 Nov 2011, In : Journal of Biological Chemistry. 286, 47, p. 40934-40942 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Molecular Dynamics Reveal the Essential Role of Linker Motions in the Function of Cullin-RING E3 Ligases

Liu, J. & Nussinov, R., 5 Feb 2010, In : Journal of Molecular Biology. 396, 5, p. 1508-1523 16 p.

Research output: Contribution to journalArticle

29 Scopus citations

Rb×1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation

Liu, J. & Nussinov, R., 4 Aug 2010, In : Biophysical Journal. 99, 3, p. 736-744 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009
40 Scopus citations
2008
65 Scopus citations
2007

Surface complexes of phthalic acid at the hematite/water interface

Hwang, Y. S., Liu, J., Lenhart, J. J. & Hadad, C. M., 1 Mar 2007, In : Journal of Colloid and Interface Science. 307, 1, p. 124-134 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
2006

"Similarity Trap" in Protein-Protein Interactions Could Be Carcinogenic: Simulations of p53 Core Domain Complexed with 53BP1 and BRCA1 BRCT Domains

Liu, J., Pan, Y., Ma, B. & Nussinov, R., 1 Dec 2006, In : Structure. 14, 12, p. 1811-1821 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Study of singlet and triplet 2,6-difluorophenylnitrene by time-resolved infrared spectroscopy

Mandel, S., Liu, J., Hadad, C. M. & Platz, M. S., 31 Mar 2005, In : Journal of Physical Chemistry A. 109, 12, p. 2816-2821 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The reaction of triplet nitrenes with oxygen: A computational study

Liu, J., Hadad, C. M. & Platz, M. S., 17 Feb 2005, In : Organic Letters. 7, 4, p. 549-552 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2004

A comparison of acetyl- and methoxycarbonylnitrenes by computational methods and a laser flash photolysis study of benzoylnitrene

Liu, J., Mandel, S., Hadad, C. M. & Platz, M. S., 10 Dec 2004, In : Journal of Organic Chemistry. 69, 25, p. 8583-8593 11 p.

Research output: Contribution to journalArticle

70 Scopus citations