Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
Fingerprint
Dive into the research topics where Jin Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
-
De novo development of small CRISPR-Cas proteins using artificial intelligence algorithms
Liu, J. (PI)
NIGMS: General Medical Sciences
1/01/22 → 31/12/24
Project: Research
-
Covid-19 Therapeutic Development for Elderly Patients by the Development of Allosteric Ligands for the Sigma-1 Receptor
Liu, J. (PI)
1/08/21 → 31/01/23
Project: Research
-
Improvement of CRISPR-Cas9 specificity through allosteric modulation
Liu, J. (PI)
National Heart, Lung, and Blood Institute
1/08/19 → 31/07/22
Project: Research
-
Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
Liu, J. (PI) & Wang, Y.-C. (CoI)
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
-
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence
Babu, K., Kathiresan, V., Kumari, P., Newsom, S., Parameshwaran, H. P., Chen, X., Liu, J., Qin, P. Z. & Rajan, R., 14 Dec 2021, In: Biochemistry. 60, 49, p. 3783-3800 18 p.Research output: Contribution to journal › Article › peer-review
-
A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library
Wang, X. S., Chen, P. H. C., Hampton, J. T., Tharp, J. M., Reed, C. A., Das, S. K., Wang, D. S., Hayatshahi, H. S., Shen, Y., Liu, J. & Liu, W. R., 28 Oct 2019, In: Angewandte Chemie - International Edition. 58, 44, p. 15904-15909 6 p.Research output: Contribution to journal › Article › peer-review
-
Molecular Dynamics Reveal the Essential Role of Linker Motions in the Function of Cullin-RING E3 Ligases
Liu, J. & Nussinov, R., 2010, In: Journal of Molecular Biology. 396, 5, p. 1508-1523 16 p.Research output: Contribution to journal › Article › peer-review
-
Structure and Dynamics of Cas9 HNH Domain Catalytic State
Zuo, Z. & Liu, J., 1 Dec 2017, In: Scientific Reports. 7, 1, 17271.Research output: Contribution to journal › Article › peer-review
-
Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain
Zuo, Z., Zolekar, A., Babu, K., Lin, V. J. T., Hayatshahi, H. S., Rajan, R., Wang, Y. C. & Liu, J., Jul 2019, In: eLife. 8, e46500.Research output: Contribution to journal › Article › peer-review