Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
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Collaborations and top research areas from the last five years
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Projects
- 2 Finished
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Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
Liu, J. & Wang, Y.
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
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Improvement of CRISPR-Cas9 specificity through allosteric modulation
National Heart, Lung, and Blood Institute
1/08/19 → 31/07/22
Project: Research
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Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain
Zuo, Z., Zolekar, A., Babu, K., Lin, V. J. T., Hayatshahi, H. S., Rajan, R., Wang, Y. C. & Liu, J., Jul 2019, In: eLife. 8, e46500.Research output: Contribution to journal › Article › peer-review
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Cullin neddylation may allosterically tune polyubiquitin chain length and topology
Onel, M., Sumbul, F., Liu, J., Nussinov, R. & Haliloglu, T., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 781-795 15 p.Research output: Contribution to journal › Article › peer-review
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"Similarity Trap" in Protein-Protein Interactions Could Be Carcinogenic: Simulations of p53 Core Domain Complexed with 53BP1 and BRCA1 BRCT Domains
Liu, J., Pan, Y., Ma, B. & Nussinov, R., Dec 2006, In: Structure. 14, 12, p. 1811-1821 11 p.Research output: Contribution to journal › Article › peer-review
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Probing Protein Allostery as a Residue-Specific Concept via Residue Response Maps
Hayatshahi, H. S., Ahuactzin, E., Tao, P., Wang, S. & Liu, J., 25 Nov 2019, In: Journal of Chemical Information and Modeling. 59, 11, p. 4691-4705 15 p.Research output: Contribution to journal › Article › peer-review
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Surface complexes of phthalic acid at the hematite/water interface
Hwang, Y. S., Liu, J., Lenhart, J. J. & Hadad, C. M., 1 Mar 2007, In: Journal of Colloid and Interface Science. 307, 1, p. 124-134 11 p.Research output: Contribution to journal › Article › peer-review