Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
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Collaborations and top research areas from the last five years
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De novo development of small C
Liu, J. (PI)
NIGMS: General Medical Sciences
1/01/22 → 31/12/24
Project: Research
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Covid-19 Therapeutic Development for Elderly Patients by the Development of Allosteric Ligands for the Sigma-1 Receptor
Liu, J. (PI)
1/08/21 → 31/01/23
Project: Research
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Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
Liu, J. (PI) & Wang, Y.-C. (CoI)
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
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Improvement of CRISPR-Cas9 specificity through allosteric modulation
Liu, J. (PI)
National Heart, Lung, and Blood Institute
1/08/19 → 31/07/22
Project: Research
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Study of singlet and triplet 2,6-difluorophenylnitrene by time-resolved infrared spectroscopy
Mandel, S., Liu, J., Hadad, C. M. & Platz, M. S., 31 Mar 2005, In: Journal of Physical Chemistry A. 109, 12, p. 2816-2821 6 p.Research output: Contribution to journal › Article › peer-review
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Novel Use of Hypoxia-Inducible Polymerizable Protein to Augment Chemotherapy for Pancreatic Cancer
Gdowski, A., Hayatshahi, H., Fudala, R., Joshi, R., Liu, J., Vishwanatha, J. K., Jeyarajah, R., Guzik, P. & Ranjan, A. P., Jan 2022, In: Pharmaceutics. 14, 1, 128.Research output: Contribution to journal › Article › peer-review
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Probing Protein Allostery as a Residue-Specific Concept via Residue Response Maps
Hayatshahi, H. S., Ahuactzin, E., Tao, P., Wang, S. & Liu, J., 25 Nov 2019, In: Journal of Chemical Information and Modeling. 59, 11, p. 4691-4705 15 p.Research output: Contribution to journal › Article › peer-review
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Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination
Liu, J. & Nussinov, R., 25 Nov 2011, In: Journal of Biological Chemistry. 286, 47, p. 40934-40942 9 p.Research output: Contribution to journal › Article › peer-review
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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution
Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Häussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Südhof, T. C. & Rizo, J., 9 Jul 2015, In: Nature Structural and Molecular Biology. 22, 7, p. 555-564 10 p.Research output: Contribution to journal › Article › peer-review