Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
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Projects
- 2 Active
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Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
Liu, J. & Wang, Y.
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
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Improvement of CRISPR-Cas9 specificity through allosteric modulation
National Heart, Lung, and Blood Institute
1/08/19 → 31/07/22
Project: Research
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A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors**
Yang, K. S., Ma, X. R., Ma, Y., Alugubelli, Y. R., Scott, D. A., Vatansever, E. C., Drelich, A. K., Sankaran, B., Geng, Z. Z., Blankenship, L. R., Ward, H. E., Sheng, Y. J., Hsu, J. C., Kratch, K. C., Zhao, B., Hayatshahi, H. S., Liu, J., Li, P., Fierke, C. A., Tseng, C. T. K. & 2 others, , 18 Mar 2021, In: ChemMedChem. 16, 6, p. 942-948 7 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Factors Governing Selectivity of Dopamine Receptor Binding Compounds for D2R and D3R Subtypes
Hayatshahi, H. S., Luedtke, R. R., Taylor, M., Chen, P. J., Blass, B. E. & Liu, J., 28 Jun 2021, In: Journal of Chemical Information and Modeling. 61, 6, p. 2829-2843 15 p.Research output: Contribution to journal › Article › peer-review
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Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage
Zuo, Z. & Liu, J., Jun 2020, In: Current Opinion in Structural Biology. 62, p. 166-174 9 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Editorial overview: Allosteric assemblies
Liu, J. & Lai, L., Jun 2020, In: Current Opinion in Structural Biology. 62, p. vi-viiResearch output: Contribution to journal › Editorial
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Filtering out low-affinity bitropic ligands for dopamine receptors based on ligand conformation
Hayatshahi, H. S. & Liu, J., 2 Sep 2020, In: ACS Chemical Neuroscience. 11, 17, p. 2523-2527 5 p.Research output: Contribution to journal › Article › peer-review