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Jin Liu, PhD

  • 788 Citations
  • 17 h-Index
20042020

Research output per year

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Personal profile

Area of Expertise

My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.

Education/Academic qualification

PhD in Chemistry, Ohio State University

BS in Chemistry, Peking University

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Projects

Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation

Liu, J. & Wang, Y.

NHLBI: Nat Heart, Lung & Blood Institute

1/08/19 → 31/07/22

Project: Research

Research Output

  • 788 Citations
  • 17 h-Index
  • 27 Article
  • 3 Review article
  • 2 Editorial
  • 1 Comment/debate

Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

Zuo, Z. & Liu, J., Jun 2020, In : Current Opinion in Structural Biology. 62, p. 166-174 9 p.

Research output: Contribution to journal › Review article

    • 1 Scopus citations

    Editorial overview: Allosteric assemblies

    Liu, J. & Lai, L., Jun 2020, In : Current Opinion in Structural Biology. 62, p. vi-vii

    Research output: Contribution to journal › Editorial

    A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library

    Wang, X. S., Chen, P. H. C., Hampton, J. T., Tharp, J. M., Reed, C. A., Das, S. K., Wang, D. S., Hayatshahi, H. S., Shen, Y., Liu, J. & Liu, W. R., 28 Oct 2019, In : Angewandte Chemie - International Edition. 58, 44, p. 15904-15909 6 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    Assessing the Performance of the Nonbonded Mg2+ Models in a Two-Metal-Dependent Ribonuclease

    Zuo, Z. & Liu, J., 28 Jan 2019, In : Journal of Chemical Information and Modeling. 59, 1, p. 399-408 10 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

    Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations