Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
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Projects
- 2 Active
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Improvement of CRISPR-Cas9 specificity through allosteric modulation
National Heart, Lung, and Blood Institute
1/08/19 → 31/07/22
Project: Research
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Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
Liu, J. & Wang, Y.
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
Research output
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Novel Use of Hypoxia-Inducible Polymerizable Protein to Augment Chemotherapy for Pancreatic Cancer
Gdowski, A., Hayatshahi, H., Fudala, R., Joshi, R., Liu, J., Vishwanatha, J. K., Jeyarajah, R., Guzik, P. & Ranjan, A. P., Jan 2022, In: Pharmaceutics. 14, 1, 128.Research output: Contribution to journal › Article › peer-review
Open Access -
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects
Zuo, Z., Babu, K., Ganguly, C., Zolekar, A., Newsom, S., Rajan, R., Wang, Y. C. & Liu, J., Apr 2022, In: CRISPR Journal. 5, 2, p. 329-340 12 p.Research output: Contribution to journal › Article › peer-review
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Allosteric Modulation of Small Molecule Drugs on ACE2 Conformational Change upon Binding to SARS-CoV-2 Spike Protein
Wang, D. S., Hayatshahi, H. S., Jayasinghe-Arachchige, V. M. & Liu, J., 2021, Proceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021. Huang, Y., Kurgan, L., Luo, F., Hu, X. T., Chen, Y., Dougherty, E., Kloczkowski, A. & Li, Y. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 2587-2594 8 p. (Proceedings - 2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
1 Scopus citations -
A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors**
Yang, K. S., Ma, X. R., Ma, Y., Alugubelli, Y. R., Scott, D. A., Vatansever, E. C., Drelich, A. K., Sankaran, B., Geng, Z. Z., Blankenship, L. R., Ward, H. E., Sheng, Y. J., Hsu, J. C., Kratch, K. C., Zhao, B., Hayatshahi, H. S., Liu, J., Li, P., Fierke, C. A., Tseng, C. T. K. & 2 others, , 18 Mar 2021, In: ChemMedChem. 16, 6, p. 942-948 7 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence
Babu, K., Kathiresan, V., Kumari, P., Newsom, S., Parameshwaran, H. P., Chen, X., Liu, J., Qin, P. Z. & Rajan, R., 14 Dec 2021, In: Biochemistry. 60, 49, p. 3783-3800 18 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations