Projects per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
Fingerprint Dive into the research topics where Jin Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Cullin Proteins
Medicine & Life Sciences
Ubiquitin-Protein Ligases
Medicine & Life Sciences
Ubiquitination
Medicine & Life Sciences
Molecular Dynamics Simulation
Medicine & Life Sciences
Ubiquitin
Medicine & Life Sciences
Guide RNA
Medicine & Life Sciences
Dopamine D3 Receptors
Medicine & Life Sciences
Proteins
Engineering & Materials Science
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2019 2022
- 1 Active
Improvement of CRISPR-Cas9 Specificity Through Allosteric Modulation
NHLBI: Nat Heart, Lung & Blood Institute
1/08/19 → 31/07/22
Project: Research
Research Output 2004 2019
1
Citation
(Scopus)
A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library
Wang, X. S., Chen, P. H. C., Hampton, J. T., Tharp, J. M., Reed, C. A., Das, S. K., Wang, D. S., Hayatshahi, H. S., Shen, Y., Liu, J. & Liu, W. R., 28 Oct 2019, In : Angewandte Chemie - International Edition. 58, 44, p. 15904-15909 6 p.Research output: Contribution to journal › Article
Peptide Library
Cyclic Peptides
Bacteriophages
Peptides
Cysteine
1
Citation
(Scopus)
Assessing the Performance of the Nonbonded Mg2+ Models in a Two-Metal-Dependent Ribonuclease
Zuo, Z. & Liu, J., 28 Jan 2019, In : Journal of Chemical Information and Modeling. 59, 1, p. 399-408 10 p.Research output: Contribution to journal › Article
Ribonucleases
Metals
performance
Lennard-Jones potential
Molecular dynamics
Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands
Chen, P. J., Taylor, M., Griffin, S. A., Amani, A., Hayatshahi, H., Korzekwa, K., Ye, M., Mach, R. H., Liu, J., Luedtke, R. R., Gordon, J. C. & Blass, B. E., 15 Sep 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 18, p. 2690-2694 5 p.Research output: Contribution to journal › Article
Benzamides
Dopamine D3 Receptors
Pharmacokinetics
Dopamine Receptors
Substance-Related Disorders
Probing Protein Allostery as a Residue-Specific Concept via Residue Response Maps
Hayatshahi, H. S., Ahuactzin, E., Tao, P., Wang, S. & Liu, J., 1 Jan 2019, (Accepted/In press) In : Journal of Chemical Information and Modeling.Research output: Contribution to journal › Article
learning method
Proteins
PDS
event
neural network
Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain
Zuo, Z., Zolekar, A., Babu, K., Lin, V. J. T., Hayatshahi, H. S., Rajan, R., Wang, Y. C. & Liu, J., Jul 2019, In : eLife. 8, e46500.Research output: Contribution to journal › Article
Open Access
Guide RNA
DNA Cleavage
Streptococcus pyogenes
Catalysis
Clustered Regularly Interspaced Short Palindromic Repeats