Research Output per year
Personal profile
Area of Expertise
My lab is broadly interested in the development and application of computational methods to solve problems in pharmaceutical sciences. We integrate pharmaceutical sciences with computer sciences, chemistry, biology, and physics to develop new biotechnologies, understand molecular mechanisms underlying diseases, and design new drugs. Specifically, we are interested in protein allostery study, computer-aided drug design, CRISPR-Cas9 technology improvement, artificial intelligence (AI) for drug discovery, and big data analysis of health disparity diseases. We extensively engage in dynamic collaborations with various experimental labs with a goal to bridge the interface of computational, experimental, and clinical research.
Education/Academic qualification
PhD in Chemistry, Ohio State University
BS in Chemistry, Peking University
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Cullin Proteins
Medicine & Life Sciences
Ubiquitin-Protein Ligases
Medicine & Life Sciences
Ubiquitination
Medicine & Life Sciences
Molecular Dynamics Simulation
Medicine & Life Sciences
Ubiquitin
Medicine & Life Sciences
Binding Sites
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Polyubiquitin
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2004 2019
Assessing the Performance of the Nonbonded Mg 2+ Models in a Two-Metal-Dependent Ribonuclease
Zuo, Z. & Liu, J., 28 Jan 2019, In : Journal of Chemical Information and Modeling. 59, 1, p. 399-408 10 p.Research output: Contribution to journal › Article › Research › peer-review
Ribonucleases
Metals
performance
Lennard-Jones potential
Molecular dynamics
Analogues of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity
Hayatshahi, H. S., Xu, K., Griffin, S. A., Taylor, M., Mach, R. H., Liu, J. & Luedtke, R. T., 19 Dec 2018, In : ACS Chemical Neuroscience. 9, 12, p. 2972-2983 12 p.Research output: Contribution to journal › Article › Research › peer-review
Dopamine D3 Receptors
Ligands
Dopamine D2 Receptors
Dopamine Receptors
Nitrogen
3
Citations
(Scopus)
Identification of a unique Ca 2+ -binding site in rat acid-sensing ion channel 3
Zuo, Z., Smith, R. N., Chen, Z., Agharkar, A. S., Snell, H. D., Huang, R-Q., Liu, J. & Gonzales, E. B., 1 Dec 2018, In : Nature Communications. 9, 1, 2082.Research output: Contribution to journal › Article › Research › peer-review
Acid Sensing Ion Channels
rats
Binding Sites
acids
Rats
Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1
Zolekar, A., Lin, V. J. T., Mishra, N. M., Ho, Y. Y., Hayatshahi, H. S., Parab, A., Sampat, R., Liao, X., Hoffmann, P., Liu, J., Emmitte, K. A. & Wang, Y-C., 11 Dec 2018, In : British Journal of Cancer. 119, 12, p. 1538-1551 14 p.Research output: Contribution to journal › Article › Research › peer-review
Interferons
Melanoma
Apoptosis
Neoplasms
Systems Biology
3
Citations
(Scopus)
Cullin neddylation may allosterically tune polyubiquitin chain length and topology
Onel, M., Sumbul, F., Liu, J., Nussinov, R. & Haliloglu, T., 1 Mar 2017, In : Biochemical Journal. 474, 5, p. 781-795 15 p.Research output: Contribution to journal › Article › Research › peer-review
Cullin Proteins
Polyubiquitin
Chain length
Ubiquitin-Protein Ligases
Ubiquitination