• 2678 Citations
  • 29 h-Index
1984 …2020

Research output per year

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Research Output

  • 2678 Citations
  • 29 h-Index
  • 78 Article
  • 4 Review article
  • 1 Comment/debate
2020

Epidemic ribotypes of Clostridium (now Clostridioides) difficile are likely to be more virulent than non-epidemic ribotypes in animal models

Vitucci, J. C., Pulse, M., Tabor-Simecka, L. & Simecka, J., 5 Feb 2020, In : BMC Microbiology. 20, 1, 27.

Research output: Contribution to journalArticle

Open Access
2019

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells

Shelake, S., Sankpal, U. T., Eslin, D., Bowman, W. P., Simecka, J. W., Raut, S., Ray, A. & Basha, R., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Copper-tolfenamic acid: evaluation of stability and anti-cancer activity

Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Primary care clinics can be a source of exposure to virulent Clostridium (now Clostridioides) difficile: An environmental screening study of hospitals and clinics in Dallas-Fort Worth region

Simecka, J. W., Fulda, K. G., Pulse, M., Lee, J. H., Vitucci, J., Nguyen, P., Taylor, P., Filipetto, F., Espinoza, A. M. & Sharma, S., 2019, In : PLoS ONE. 14, 8, e0220646.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis

Weiss, W. J., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J. W., Valtierra, D., Sabet, M. & Griffith, D. C., Jan 2018, In : Antimicrobial agents and chemotherapy. 62, 1, e01439.

Research output: Contribution to journalArticle

9 Scopus citations

Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis

Mize, M. T., Sun, X. L. & Simecka, J. W., 1 Sep 2018, In : Infection and Immunity. 86, 9, e00292-18.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation

Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J. W., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Sankpal, U. T., Nagaraju, G. P., Gottipolu, S. R., Hurtado, M., Jordan, C. G., Simecka, J. W., Shoji, M., El-Rayes, B. & Basha, R., 1 Jan 2016, In : Oncotarget. 7, 3, p. 3186-3200 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Regulatory CD4+ CD25+ T cells dampen inflammatory disease in murine mycoplasma pneumonia and promote IL-17 and IFN-γ Responses

Odeh, A. N. & Simecka, J. W., May 2016, In : PLoS ONE. 11, 5, e0155648.

Research output: Contribution to journalArticle

10 Scopus citations
22 Scopus citations

Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 protein function

Shin, J. Y., Wey, M., Umutesi, H. G., Sun, X., Simecka, J. & Heo, J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13699-13714 16 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Antigen-pulsed bone marrow-derived and pulmonary dendritic cells promote Th2 cell responses and immunopathology in lungs during the pathogenesis of murine mycoplasma pneumonia

Dobbs, N. A., Zhou, X., Pulse, M., Hodge, L. M., Schoeb, T. R. & Simecka, J., 1 Aug 2014, In : Journal of Immunology. 193, 3, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Dendritic Cells Are the Major Antigen Presenting Cells in Inflammatory Lesions of Murine Mycoplasma Respiratory Disease

Sun, X., Jones, H. P., Dobbs, N., Bodhankar, S. & Simecka, J. W., 4 Feb 2013, In : PLoS ONE. 8, 2, e55984.

Research output: Contribution to journalArticle

11 Scopus citations

Interleukin-23 (IL-23) deficiency disrupts Th17 and Th1-related defenses against Streptococcus pneumoniae infection

Kim, B. J., Lee, S., Berg, R. E., Simecka, J. W. & Jones, H. P., 1 Oct 2013, In : Cytokine. 64, 1, p. 375-381 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252

Parsons, J. B., Kukula, M., Jackson, P., Pulse, M., Simecka, J., Valtierra, D., Weiss, W., Kaplan, N. & Rock, C. O., 1 May 2013, In : Antimicrobial agents and chemotherapy. 57, 5, p. 2182-2190 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2 Scopus citations
2012

Oral Inoculation of Young Dairy Calves with Mycoplasma bovis Results in Colonization of Tonsils, Development of Otitis Media and Local Immunity

Maunsell, F., Brown, M. B., Powe, J., Ivey, J., Woolard, M., Love, W. & Simecka, J. W., 6 Sep 2012, In : PLoS ONE. 7, 9, e44523.

Research output: Contribution to journalArticle

27 Scopus citations
2011
10 Scopus citations

Small molecule inhibitors of staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

Olson, P. D., Kuechenmeister, L. J., Anderson, K. L., Daily, S., Beenken, K. E., Roux, C. M., Reniere, M. L., Lewis, T. L., Weiss, W. J., Pulse, M., Nguyen, P., Simecka, J. W., Morrison, J. M., Sayood, K., Asojo, O. A., Smeltzer, M. S., Skaar, E. P. & Dunman, P. M., Feb 2011, In : PLoS Pathogens. 7, 2, e1001287.

Research output: Contribution to journalArticle

41 Scopus citations
2010
15 Scopus citations

Peri- and intra-operative management of the goat during acute surgical experimentation

Flaherty, D. C., Hoxha, B., Nelson, S., Sun, J., Gurji, H., Simecka, J., Mallet, R. T., Yurvati, A. & Daniels, E. Q., 1 Mar 2010, In : Lab Animal. 39, 3, p. 80-85 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pyruvate-enriched resuscitation protects hindlimb muscle from ischemia-reperfusion injury

Flaherty, D. C., Hoxha, B., Sun, J., Gurji, H., Simecka, J. W., Olivencia-Yurvati, A. H. & Mallet, R. T., Dec 2010, In : Military Medicine. 175, 12, p. 1020-1026 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
24 Scopus citations

Toll-like receptor 2 (TLR2) plays a major role in innate resistance in the lung against murine mycoplasma

Love, W., Dobbs, N., Tabor, L. & Simecka, J. W., 2010, In : PLoS ONE. 5, 5, e10739.

Research output: Contribution to journalArticle

27 Scopus citations
2009

A novel IL-17-dependent mechanism of cross protection: Respiratory infection with mycoplasma protects against a secondary listeria infection

Sieve, A. N., Meeks, K. D., Bodhankar, S., Lee, S., Kolls, J. K., Simecka, J. W. & Berg, R. E., 2009, In : European Journal of Immunology. 39, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization

Bodhankar, S., Woolard, M. D., Sun, X. & Simecka, J. W., 15 Aug 2009, In : Journal of Immunology. 183, 4, p. 2622-2631 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

The multifaceted role of T cell-mediated immunity in pathogenesis and resistance to mycoplasma respiratory disease

Dobbs, N. A., Odeh, A. N., Sun, X. & Simecka, J. W., 1 Dec 2009, In : Current Trends in Immunology. 10, p. 1-19 19 p.

Research output: Contribution to journalReview article

11 Scopus citations
2008

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice

Kudchodkar, B., Jones, H., Simecka, J. & Dory, L., 1 Sep 2008, In : Clinical Immunology. 128, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2007

Abdominal lymphatic pump treatment increases leukocyte count and flux in thoracic duct lymph

Hodge, L. M., King, H. H., Williams, A. G., Reder, S. J., Belavadi, T., Simecka, J., Stoll, S. T. & Downey, H. F., 1 Jun 2007, In : Lymphatic Research and Biology. 5, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins

Kim, I. H., Combrink, K. D., Ma, Z., Chapo, K., Yan, D., Renick, P., Morris, T. W., Pulse, M., Simecka, J. W. & Ding, C. Z., 1 Mar 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1181-1184 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2006
31 Scopus citations
2005

NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp.

Woolard, M. D., Hudig, D., Tabor, L., Ivey, J. A. & Simecka, J. W., Oct 2005, In : Infection and Immunity. 73, 10, p. 6742-6751 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2004

IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease

Woolard, M. D., Doug Hardy, R. & Simecka, J., 1 Sep 2004, In : Journal of Allergy and Clinical Immunology. 114, 3, p. 645-649 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
33 Scopus citations
2003
16 Scopus citations
2002

Biofilm formation and dispersal under the influence of the global regulator CsrA of Escherichia coli

Jackson, D. W., Suzuki, K., Oakford, L., Simecka, J. W., Hart, M. E. & Romeo, T., 4 Jan 2002, In : Journal of Bacteriology. 184, 1, p. 290-301 12 p.

Research output: Contribution to journalArticle

289 Scopus citations

Catabolite repression of Escherichia coli biofilm formation

Jackson, D. W., Simecka, J. W. & Romeo, T., 8 Jun 2002, In : Journal of Bacteriology. 184, 12, p. 3406-3410 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination

Sun, X. L., Hodge, L. M., Jones, H., Tabor, L. & Simecka, J., 31 Jan 2002, In : Vaccine. 20, 9-10, p. 1466-1474 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Depletion of CD8+ T cells exacerbates CD4+ Th cell-associated inflammatory lesions during murine mycoplasma respiratory disease

Jones, H. P., Tabor, L., Sun, X., Woolard, M. D. & Simecka, J. W., 1 Apr 2002, In : Journal of Immunology. 168, 7, p. 3493-3501 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
25 Scopus citations
2001

Gender is a major factor in determining the severity of mycoplasma respiratory disease in mice

Yancey, A. L., Watson, H. L., Cartner, S. C. & Simecka, J. W., 2 May 2001, In : Infection and Immunity. 69, 5, p. 2865-2871 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Immunoglobulin a (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization

Hodge, L. M., Marinaro, M., Jones, H. P., McGhee, J. R., Kiyono, H. & Simecka, J. W., 5 Apr 2001, In : Infection and Immunity. 69, 4, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Positive regulation of motility and flhDC expression by the RNA-binding protein CsrA of Escherichia coli

Wei, B. L., Brun-Zinkernagel, A. M., Simecka, J., Prüß, B. M., Babitzke, P. & Romeo, T., 30 Apr 2001, In : Molecular Microbiology. 40, 1, p. 245-256 12 p.

Research output: Contribution to journalArticle

261 Scopus citations
53 Scopus citations

Variations in the surface proteins and restriction enzyme systems of Mycoplasma pulmonis in the respiratory tract of infected rats

Gumulak-Smith, J., Teachman, A., Tu, A. H. T., Simecka, J., Russell Lindsey, J. & Dybvig, K., 21 Jun 2001, In : Molecular Microbiology. 40, 4, p. 1037-1044 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2000

Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract

Simecka, J. W., Jackson, R. J., Kiyono, H. & McGhee, J. R., 1 Feb 2000, In : Infection and Immunity. 68, 2, p. 672-679 8 p.

Research output: Contribution to journalArticle

39 Scopus citations
1999

Antibody responses after Sendai virus infection and their role in upper and lower respiratory tract disease in rats

Liang, S. C., Simecka, J., Lindsey, J. R., Cassell, G. H. & Davis, J. K., 8 Sep 1999, In : Laboratory Animal Science. 49, 4, p. 385-394 10 p.

Research output: Contribution to journalComment/debate

13 Scopus citations

β-chemokines are produced in lungs of mice with mycoplasma respiratory disease

Simecka, J., 24 Aug 1999, In : Current Microbiology. 39, 3, p. 163-167 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
1998

Mucosal immunity of the gastrointestinal tract and oral tolerance

Simecka, J., 1 Dec 1998, In : Advanced Drug Delivery Reviews. 34, 2-3, p. 235-259 25 p.

Research output: Contribution to journalReview article

55 Scopus citations

Roles of innate and adaptive immunity in respiratory mycoplasmosis

Cartner, S. C., Lindsey, J. R., Gibbs-Erwin, J., Cassell, G. H. & Simecka, J. W., Aug 1998, In : Infection and Immunity. 66, 8, p. 3485-3491 7 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations