Projects per year
Personal profile
Area of Expertise
Pre-Clinical Services evaluate new therapies against infections using animal models. These studies are done in collaboration with pharmaceutical and academic researchers, and several of these therapies are now being used clinically to treat patients.
Education/Academic qualification
PhD in Microbiology, University of Alabama
BS in Biology, University of California at Irvine
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- 3 Similar Profiles
Mycoplasma pulmonis
Medicine & Life Sciences
Mycoplasma
Medicine & Life Sciences
Lung
Medicine & Life Sciences
Mycoplasma Infections
Medicine & Life Sciences
Respiratory System
Medicine & Life Sciences
Immunization
Medicine & Life Sciences
Antibody Formation
Medicine & Life Sciences
Inbred F344 Rats
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2011 2022
Development and Validation of a Chronic Murine Lung Infection Model with P. aeruginosa
18/04/19 → 17/04/20
Project: Research
TP-6076 Single Dose Pharmacokinetic Study in Mice for Ex Vivo Plasma Protein Binding
Tetraphase Pharmaceuticals Inc.
1/10/18 → 30/09/19
Project: Research
Pre-Clinical Services Agreements
Pre-Clinical Services Funding Pool
1/09/18 → 31/08/19
Project: Research
PK/PD of Novel Test Article(s) in the Murine Thigh Infection Model with Klebsiella pneumoniae isolates
28/08/18 → 27/08/19
Project: Research
Research Output 1984 2019
1
Citation
(Scopus)
Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells
Shelake, S., Sankpal, U. T., Eslin, D., Bowman, P., Simecka, J., Raut, S. L., Ray, A. & Basha, R. M., 15 Feb 2019, In : Apoptosis. 24, 1-2, p. 21-32 12 p.Research output: Contribution to journal › Article › Research › peer-review
Ewing's Sarcoma
Vincristine
Cells
Caspase 7
Cell Survival
1
Citation
(Scopus)
Copper-tolfenamic acid: evaluation of stability and anti-cancer activity
Hurtado, M., Sankpal, U. T., Chhabra, J., Brown, D. T., Maram, R., Patel, R., Gurung, R. K., Simecka, J., Holder, A. A. & Basha, R. M., 15 Feb 2019, In : Investigational New Drugs. 37, 1, p. 27-34 8 p.Research output: Contribution to journal › Article › Research › peer-review
Copper
Neoplasms
Powders
tolfenamic acid
Cell Line
6
Citations
(Scopus)
Activity of meropenem-vaborbactam against carbapenem- resistant enterobacteriaceae in a murine model of pyelonephritis
Weiss, W., Pulse, M. E., Nguyen, P., Peterson, K., Silva, J., Simecka, J., Valtierra, D., Sabet, M. & Griffith, D. C., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01439.Research output: Contribution to journal › Article › Research › peer-review
meropenem
Carbapenems
Pyelonephritis
Enterobacteriaceae
Klebsiella pneumoniae
1
Citation
(Scopus)
Interleukin-17A exacerbates disease severity in BALB/c mice susceptible to lung infection with Mycoplasma pulmonis
Mize, M. T., Sun, X. L. & Simecka, J., 1 Sep 2018, In : Infection and Immunity. 86, 9, e00292-18.Research output: Contribution to journal › Article › Research › peer-review
Mycoplasma pulmonis
Interleukin-17
Lung
Mycoplasma Infections
Infection
11
Citations
(Scopus)
Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation
Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R. M., 1 Oct 2016, In : Tumor Biology. 37, 10, p. 14259-14269 11 p.Research output: Contribution to journal › Article › Research › peer-review
Cisplatin
Cell Proliferation
Proteins
Proteomics
Reactive Oxygen Species