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Personal profile

Area of Expertise

The focus of my research over the past few years has been on Alzheimer’s disease and the identification of blood-based biomarkers that can be used in the early diagnosis of the disease. I have focused on investigating risk factors for cognitive decline and dementia in the Mexican-American elderly. I have also investigated the occurrence and identification of factors leading to neuropsychiatric symptoms of Alzheimer’s such as depression, anxiety, and inappropriate behavior. Alzheimer’s is a major public health concern, and developing accessible means to predict the disease and potentially allow for intervention to prevent or slow the disease is of upmost importance. Additionally, being able to identify those with the disease who are most likely to develop neuropsychiatric symptoms (the primary cause of caregiver stress and nursing home placement) can lead to early intervention and provide the groundwork for understanding the pathophysiology of neuropsychiatric symptoms of dementia. Developing treatment approaches for the pre-clinical stage of Alzheimer’s disease to reduce the risk of developing neurodegenerative diseases is crucial to our aging population.

Education/Academic qualification

PhD in Clinical Psychology, University of Nevada, Reno

BA in History, University of Iowa

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Alzheimer Disease Medicine & Life Sciences
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Endophenotypes Medicine & Life Sciences
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Geriatrics Medicine & Life Sciences

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Projects 2015 2022

Research Output 2006 2019

  • 1419 Citations
  • 19 h-Index
  • 68 Article
  • 2 Review article
  • 1 Short survey

A proteomic signature for dementia with Lewy bodies

O'Bryant, S., Ferman, T. J., Zhang, F., Hall, J., Pedraza, O., Wszolek, Z. K., Como, T., Julovich, D., Mattevada, S., Johnson, L. A., Edwards, M. & Graff-Radford, N. R., 1 Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 270-276 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Lewy Body Disease
Proteomics
Parkinson Disease
Dementia
Sensitivity and Specificity

Vascular Depression and Cognition in Mexican Americans

Johnson, L. A., Large, S. E., Izurieta Munoz, H., Hall, J. & O'Bryant, S., 1 Jan 2019, In : Dementia and Geriatric Cognitive Disorders. p. 68-78 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cognition
Blood Vessels
Depression
Geriatrics
Short-Term Memory

A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease

O'Bryant, S., Zhang, F., Johnson, L. A., Hall, J., Edwards, M., Grammas, P., Oh, E., Lyketsos, C. G. & Rissman, R. A., 1 Jan 2018, In : Journal of Alzheimer's disease : JAD. 66, 1, p. 97-104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Precision Medicine
Non-Steroidal Anti-Inflammatory Agents
Alzheimer Disease
Naproxen
Proteomics
2 Citations (Scopus)

Characteristics of cognitively normal Mexican-Americans with cognitive complaints

Hall, J., Wiechmann, A. R., Johnson, L. A., Edwards, M. & O'Bryant, S., 1 Jan 2018, In : Journal of Alzheimer's Disease. 61, 4, p. 1485-1492 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Affective Symptoms
Research
Proteomics
Cognition
Population
Neuropsychological Tests
Language
Hispanic Americans
Statistical Factor Analysis
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