Projects per year
Personal profile
Area of Expertise
My laboratory research focuses on two intersecting areas:
1) Molecular progression of breast and prostate cancers to aggressive phenotype,
2) Nanotechnology approaches for targeted therapeutics. In one of our studies, we are determining the role of exosomal annexin A2 in metastatic progression of breast and prostate cancers. In another project, we are studying how MIEN1 (a protein that was discovered in our lab) promotes migration and invasion of cancer cells leading to metastatic progression. We are also utilizing novel targeted nanodevices for treatment of bone metastatic prostate cancer and for metastatic triple negative breast cancer.
1) Molecular progression of breast and prostate cancers to aggressive phenotype,
2) Nanotechnology approaches for targeted therapeutics. In one of our studies, we are determining the role of exosomal annexin A2 in metastatic progression of breast and prostate cancers. In another project, we are studying how MIEN1 (a protein that was discovered in our lab) promotes migration and invasion of cancer cells leading to metastatic progression. We are also utilizing novel targeted nanodevices for treatment of bone metastatic prostate cancer and for metastatic triple negative breast cancer.
Education/Academic qualification
BS in Genetics, University of Agricultural Sciences, Bangalore
MS in Genetics, University of Agricultural Sciences, Bangalore
PhD in Biology, University of South Carolina
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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UT Southwestern Center for Tra
Vishwanatha, J. (PI)
UTSW Center for Translational Medicine
1/05/23 → 30/04/26
Project: Research
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UT Southwestern Center for Tra
Vishwanatha, J. (PI)
UTSW Center for Translational Medicine
1/05/23 → 30/04/26
Project: Research
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Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution
Basha, R., Connelly, S. F., Sankpal, U. T., Nagaraju, G. P., Patel, H., Vishwanatha, J. K., Shelake, S., Tabor-Simecka, L., Shoji, M., Simecka, J. W. & El-Rayes, B., 1 May 2016, In: Journal of Nutritional Biochemistry. 31, p. 77-87 11 p.Research output: Contribution to journal › Article › peer-review
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Association of Sp1 and survivin in epithelial ovarian cancer: Sp1 inhibitor and cisplatin, a novel combination for inhibiting epithelial ovarian cancer cell proliferation
Sankpal, U. T., Ingersoll, S. B., Ahmad, S., Holloway, R. W., Bhat, V. B., Simecka, J. W., Daniel, L., Kariali, E., Vishwanatha, J. K. & Basha, R., 1 Oct 2016, In: Tumor Biology. 37, 10, p. 14259-14269 11 p.Research output: Contribution to journal › Article › peer-review
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Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells
Hurtado, M., Prokai, L., Sankpal, U. T., Levesque, B., Maram, R., Chhabra, J., Brown, D. T., Gurung, R. K., Holder, A. A., Vishwanatha, J. K. & Basha, R., Feb 2020, In: Process Biochemistry. 89, p. 155-164 10 p.Research output: Contribution to journal › Article › peer-review
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Evaluation of the putative tumor suppressor gene FHIT in prostate carcinoma
Vishwanatha, J. K., 1997, In: FASEB Journal. 11, 9, p. A1428Research output: Contribution to journal › Article › peer-review
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Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway
Tripathi, A. K., Desai, P. P., Tyagi, A., Lampe, J. B., Srivastava, Y., Donkor, M., Jones, H. P., Dzyuba, S. V., Crossley, E., Williams, N. S. & Vishwanatha, J. K., Mar 2024, In: Journal of Biological Chemistry. 300, 3, 105680.Research output: Contribution to journal › Article › peer-review