Projects per year
Personal profile
Area of Expertise
In my laboratory research, I am working in translational research of cancer to develop multiple methods for gene and cell therapy, particularly in the use of virus-based and nanoparticle delivery vehicles. I have worked extensively with oncolytic virus vectors for many years, and my laboratory is modifying capsid proteins on virus vectors for cancer retargeting, as well as developing cancer vaccines and conditionally replicating virus vectors for cancer therapy. I have extensive experience in analysis of gene expression using quantitative RT-PCR. In support of translational cancer studies in my laboratory, I have extensive experience immortalizing cell lines from primary tumors and performing co-culture experiments. I have established small animal imaging capability, and I have worked to develop methods for non-invasive monitoring of oncolytic virus and nanoparticle biodistribution in vivo. Among the various methods I have developed are novel modifications of virus capsid proteins to allow SPECT (single photon emission computed tomography) imaging in vivo.
Education/Academic qualification
MHA, Louisiana State University
BS in Chemistry, Texas A & M University
EdD, University of Alabama
PhD Biochemistry, University of Texas Southwestern Medical Center
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Collaborations and top research areas from the last five years
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Astrocyte-TAAR1 & METH in HAND
Ghorpade, A., Mathis, J. M. & Borgmann, K.
NINDS: Neurological Disorders & Stroke
1/08/15 → 31/07/20
Project: Research
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Aberrant methylation during cervical carcinogenesis
Virmani, A. K., Muller, C., Rathi, A., Zoechbauer-Mueller, S., Mathis, J. M. & Gazdar, A. F., 1 Jan 2001, In: Clinical Cancer Research. 7, 3, p. 584-589 6 p.Research output: Contribution to journal › Article › peer-review
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Differential regulation of 11β-hydroxylase and aldosterone synthase in human adrenocortical H295R cells
Denner, K., Rainey, W. E., Pezzi, V., Bird, I. M., Bernhardt, R. & Mathis, J. M., 23 Jul 1996, In: Molecular and Cellular Endocrinology. 121, 1, p. 87-91 5 p.Research output: Contribution to journal › Article › peer-review
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Angiotensin increases aldosterone synthase mRNA levels in human NCI-H295 cells
Holland, O. B., Mathis, J. M., Bird, I. M. & Rainey, W. E., Aug 1993, In: Molecular and Cellular Endocrinology. 94, 2, p. R9-R13Research output: Contribution to journal › Article › peer-review
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Advanced generation adenoviral virotherapy agents embody enhanced potency based upon CAR-independent tropism
Mathis, J. M., Stewart, P. L., Zhu, Z. B. & Curiel, D. T., 1 May 2006, In: Clinical Cancer Research. 12, 9, p. 2651-2656 6 p.Research output: Contribution to journal › Comment/debate
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Placebo-controlled trial of indole-3-carbinol in the treatment of CIN
Bell, M. C., Crowley-Nowick, P., Bradlow, H. L., Sepkovic, D. W., Schmidt-Grimminger, D., Howell, P., Mayeaux, E. J., Tucker, A., Turbat-Herrera, E. A. & Mathis, J. M., 2000, In: Gynecologic Oncology. 78, 2, p. 123-129 7 p.Research output: Contribution to journal › Article › peer-review