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Personal profile

Area of Expertise

My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.

Education/Academic qualification

PhD in Biochemistry, Louisiana State University

MS in Pharmacy, Seoul National University

BS in Pharmacy, Kyung Hee University

Fingerprint Dive into the research topics where InWoo Park is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
HIV-1 Medicine & Life Sciences
Simian Immunodeficiency Virus Medicine & Life Sciences
Human immunodeficiency virus 1 Agriculture & Biology
Viruses Chemical Compounds
T-Lymphocytes Medicine & Life Sciences
HIV Medicine & Life Sciences
Virus Replication Medicine & Life Sciences
Dependovirus Agriculture & Biology

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Projects 2014 2017

Research Output 1987 2019

  • 1741 Citations
  • 19 h-Index
  • 37 Article
  • 1 Comment/debate
  • 1 Review article

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Rojas, V. K. & Park, I., 19 Jun 2019, In : International journal of molecular sciences. 20, 12

Research output: Contribution to journalReview articleResearchpeer-review

Open Access
human immunodeficiency virus
Proteasome Endopeptidase Complex
Ubiquitin
Life Cycle Stages
Viruses

Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and hcv co-infection

Whitmill, A., Kim, S., Rojas, V., Gulraiz, F., Afreen, K., Jain, M., Singh, M. & Park, I., 1 Aug 2018, In : PLoS ONE. 13, 8, e0202524.

Research output: Contribution to journalArticleResearchpeer-review

liver diseases
Human immunodeficiency virus 1
Coinfection
mixed infection
Liver
3 Citations (Scopus)

Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubiquitin-Specific Proteases
Viral Proteins
Proteolysis
HIV-1
Peptide Hydrolases
1 Citation (Scopus)

Comparative molecular genetic analysis of simian and human HIV-1 integrase interactor INI1/SMARCB1/SNF5

Pyeon, D., Price, L. & Park, I., 8 Sep 2015, In : Archives of Virology. 160, 12, p. 3085-3091 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Biology
HIV-1
Protein Isoforms
Rhabdoid Tumor
Integrases
23 Citations (Scopus)

Exosomes are unlikely involved in intercellular Nef transfer

Luo, X., Fan, Y., Park, I. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

Research output: Contribution to journalArticleResearchpeer-review

exosomes
Exosomes
Detergents
Cells
T-cells