Projects per year
Personal profile
Area of Expertise
My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
Education/Academic qualification
BS in Pharmacy, Kyung Hee University
PhD in Biochemistry, Louisiana State University
MS in Pharmacy, Seoul National University
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 2 Finished
Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
NIDDK: Diabetes & Digestive & Kidney
5/02/14 → 31/12/18
Project: Research
Research Output
Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection
Proulx, J., Borgmann, K. & Park, I. W., Nov 2020, In : Virus Research. 289, 198142.Research output: Contribution to journal › Review article
The Perfect Storm: COVID-19 Health Disparities in US Blacks
Phillips, N., Park, I. W., Robinson, J. R. & Jones, H. P., 2020, (Accepted/In press) In : Journal of racial and ethnic health disparities.Research output: Contribution to journal › Review article
Open Access
HIV-1 impairment via UBE3A and HIV-1 nef interactions utilizing the ubiquitin proteasome system
Pyeon, D., Rojas, V. K., Price, L., Kim, S., Singh, M. & Park, I. W., 27 Nov 2019, In : Viruses. 11, 12, v11121098.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
Role of the ubiquitin proteasome system (Ups) in the hiv-1 life cycle
Rojas, V. K. & Park, I. W., 2 Jun 2019, In : International journal of molecular sciences. 20, 12, 2984.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and hcv co-infection
Whitmill, A., Kim, S., Rojas, V., Gulraiz, F., Afreen, K., Jain, M., Singh, M. & Park, I. W., Aug 2018, In : PLoS ONE. 13, 8, e0202524.Research output: Contribution to journal › Article