Projects per year
Personal profile
Area of Expertise
My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
Education/Academic qualification
BS in Pharmacy, Kyung Hee University
PhD in Biochemistry, Louisiana State University
MS in Pharmacy, Seoul National University
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Projects
- 3 Finished
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
Park, I. & PARK, I.
National Institute of Diabetes and Digestive and Kidney Diseases
5/02/14 → 31/12/19
Project: Research
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
NIDDK: Diabetes & Digestive & Kidney
5/02/14 → 31/12/18
Project: Research
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Erratum: Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector (Journal of Virology 71:5 (4071-4078))
Inouye, R. T., Du, B., Boldt-Houle, D., Ferrante, A., Park, I. W., Hammer, S. M., Duan, L., Groopman, J. E., Pomerantz, R. J. & Terwilliger, E. F., 1998, In: Journal of virology. 72, 4, p. 3506 1 p.Research output: Contribution to journal › Comment/debate
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Role of virally‐encoded deubiquitinating enzymes in regulation of the virus life cycle
Proulx, J., Borgmann, K. & Park, I. W., 1 May 2021, In: International journal of molecular sciences. 22, 9, 4438.Research output: Contribution to journal › Review article › peer-review
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Effects of human immunodeficiency virus type 1 infection on programmed cell death in the presence or absence of Bcl-2
Park, I. W., Kondo, E., Bergeron, L., Park, J. & Sodroski, J., 1996, In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 12, 4, p. 321-328 8 p.Research output: Contribution to journal › Article › peer-review
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HIV-1 impairment via UBE3A and HIV-1 nef interactions utilizing the ubiquitin proteasome system
Pyeon, D., Rojas, V. K., Price, L., Kim, S., Singh, M. & Park, I. W., 27 Nov 2019, In: Viruses. 11, 12, v11121098.Research output: Contribution to journal › Article › peer-review
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Interaction between Nef and INI1/SMARCB1 augments replicability of HIV-1 in resting human peripheral blood mononuclear cells
Pyeon, D. & Park, I. W., Mar 2015, In: Archives of Virology. 160, 3, p. 727-737 11 p.Research output: Contribution to journal › Article › peer-review