Projects per year
Personal profile
Area of Expertise
My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
Education/Academic qualification
BS in Pharmacy, Kyung Hee University
PhD in Biochemistry, Louisiana State University
MS in Pharmacy, Seoul National University
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Projects
- 3 Finished
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
Park, I. & PARK, I.
National Institute of Diabetes and Digestive and Kidney Diseases
5/02/14 → 31/12/19
Project: Research
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
NIDDK: Diabetes & Digestive & Kidney
5/02/14 → 31/12/18
Project: Research
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HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers
Proulx, J., Ghaly, M., Park, I. W. & Borgmann, K., Apr 2022, In: Biomedicines. 10, 4, 768.Research output: Contribution to journal › Review article › peer-review
Open Access -
Sex-difference in air pollution-related acute circulatory and respiratory mortality and hospitalization
Shin, H. H., Maquiling, A., Thomson, E. M., Park, I. W., Stieb, D. M. & Dehghani, P., 1 Feb 2022, In: Science of the Total Environment. 806, 150515.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Proulx, J., Park, I. W. & Borgmann, K., 21 Oct 2021, In: Frontiers in Neuroscience. 15, 715945.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Role of virally‐encoded deubiquitinating enzymes in regulation of the virus life cycle
Proulx, J., Borgmann, K. & Park, I. W., 1 May 2021, In: International journal of molecular sciences. 22, 9, 4438.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
The many faces of innate immunity in SARS-CoV-2 infection
Hanan, N., Doud, R. L., Park, I. W., Jones, H. P. & Mathew, S. O., Jun 2021, In: Vaccines. 9, 6, 596.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations