Projects per year
Personal profile
Area of Expertise
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.
Education/Academic qualification
BS in Pharmacy, Kyung Hee University
PhD in Biochemistry, Louisiana State University
MS in Pharmacy, Seoul National University
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Engineering simian-compatible
Park, I. (PI) & Bunnell, B. (CoI)
NIAID: Allergy and Infectious Diseases
21/08/24 → 30/06/26
Project: Research
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
Park, I. (PI)
NIDDK: Diabetes & Digestive & Kidney
5/02/14 → 31/12/18
Project: Research
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
Park, I. (PI)
5/02/14 → 31/12/19
Project: Research
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Role of HIV-1 Nef in Acceleration of HCV-Mediated Liver Disease
Park, I. (PI) & PARK, I.-W. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
5/02/14 → 31/12/19
Project: Research
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Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Proulx, J., Park, I. W. & Borgmann, K., 21 Oct 2021, In: Frontiers in Neuroscience. 15, 715945.Research output: Contribution to journal › Review article › peer-review
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Expression of exogenous Sam68, the 68-kilodalton Src-associated protein in mitosis, is able to alleviate impaired Rev function in astrocytes
Li, J., Liu, Y., Park, I. W. & He, J. J., 2002, In: Journal of virology. 76, 9, p. 4526-4535 10 p.Research output: Contribution to journal › Article › peer-review
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Targeting a foreign protein into virion particles by fusion with the Vpx protein of simian immunodeficiency virus
Park, I. W. & Sodroski, J., 1996, In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 11, 4, p. 341-350 10 p.Research output: Contribution to journal › Article › peer-review
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Expression and utilization of co-receptors in HIV and simian immunodeficiency virus infection of megakaryocytes
Park, I. W., Wang, J. F. & Groopman, J. E., 1999, In: AIDS. 13, 15, p. 2023-2032 10 p.Research output: Contribution to journal › Article › peer-review
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Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation
Park, I. W., Ndjomou, J., Wen, Y., Liu, Z., Ridgway, N. D., Kao, C. C. & He, J. J., 16 Sep 2013, In: PLoS ONE. 8, 9, e75648.Research output: Contribution to journal › Article › peer-review