• 1796 Citations
  • 20 h-Index
1987 …2019

Research output per year

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Personal profile

Area of Expertise

My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.

Education/Academic qualification

PhD in Biochemistry, Louisiana State University

Award Date: 1 Jan 2002

MS in Pharmacy, Seoul National University

Award Date: 1 Jan 2001

BS in Pharmacy, Kyung Hee University

Award Date: 1 Jan 2000

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Projects

Research Output

  • 1796 Citations
  • 20 h-Index
  • 38 Article
  • 1 Comment/debate

Role of the ubiquitin proteasome system (Ups) in the hiv-1 life cycle

Rojas, V. K. & Park, I. W., 2 Jun 2019, In : International journal of molecular sciences. 20, 12, 2984.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and hcv co-infection

    Whitmill, A., Kim, S., Rojas, V., Gulraiz, F., Afreen, K., Jain, M., Singh, M. & Park, I. W., Aug 2018, In : PLoS ONE. 13, 8, e0202524.

    Research output: Contribution to journalArticle

  • Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation

    Pyeon, D., Timani, K. A., Gulraiz, F., He, J. J. & Park, I. W., 2 Sep 2016, In : Virus Research. 223, p. 161-169 9 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Comparative molecular genetic analysis of simian and human HIV-1 integrase interactor INI1/SMARCB1/SNF5

    Pyeon, D., Price, L. & Park, I. W., 8 Sep 2015, In : Archives of Virology. 160, 12, p. 3085-3091 7 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Exosomes are unlikely involved in intercellular Nef transfer

    Luo, X., Fan, Y., Park, I. W. & He, J. J., 28 Apr 2015, In : PLoS ONE. 10, 4, e0124436.

    Research output: Contribution to journalArticle

  • 26 Scopus citations