• 1835 Citations
  • 20 h-Index
1987 …2020

Research output per year

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Personal profile

Area of Expertise

My research focuses on two main topics.
The first is HIV-1-mediated aggravation of liver disease in HCV virus co-infectees. Due to the shared routes of infection, HIV-1/HCV co-infection is common, with 15~30% of all HIV-1-infected persons estimated to be co-infected with HCV. In the co-infected patients, HIV-1 is known to accelerate every stage of HCV-mediated liver disease progression. However, the molecular details regarding how co-infection of HIV-1 and HCV brings about a more severe deterioration of the liver than a single infection of HCV are unknown at present.
Second, HIV-1 viral proteins are generated in a stage-specific manner; that is, regulatory proteins, such as Tat, Rev, and Nef, are expressed at the early stage, while structural proteins, such as Gag, Pol, and Env, are produced at the late stage of virus infection. Molecular regulation of viral gene expression in protein production has been studied comprehensively, whereas the elimination processes using the ubiquitin proteasome system for the synthesized proteins after completion of their duties in the infected cells are generally unknown, representing a current gap in understanding the smooth stage-specific transitioning through the HIV-1 life cycle that is crucial to viral pathogenicity.

Education/Academic qualification

BS in Pharmacy, Kyung Hee University

PhD in Biochemistry, Louisiana State University

MS in Pharmacy, Seoul National University

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Projects

Research Output

  • 1835 Citations
  • 20 h-Index
  • 39 Article
  • 2 Review article
  • 1 Comment/debate

Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection

Proulx, J., Borgmann, K. & Park, I. W., Nov 2020, In : Virus Research. 289, 198142.

Research output: Contribution to journalReview article

  • The Perfect Storm: COVID-19 Health Disparities in US Blacks

    Phillips, N., Park, I. W., Robinson, J. R. & Jones, H. P., 2020, (Accepted/In press) In : Journal of racial and ethnic health disparities.

    Research output: Contribution to journalReview article

    Open Access
  • HIV-1 impairment via UBE3A and HIV-1 nef interactions utilizing the ubiquitin proteasome system

    Pyeon, D., Rojas, V. K., Price, L., Kim, S., Singh, M. & Park, I. W., 27 Nov 2019, In : Viruses. 11, 12, v11121098.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Role of the ubiquitin proteasome system (Ups) in the hiv-1 life cycle

    Rojas, V. K. & Park, I. W., 2 Jun 2019, In : International journal of molecular sciences. 20, 12, 2984.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and hcv co-infection

    Whitmill, A., Kim, S., Rojas, V., Gulraiz, F., Afreen, K., Jain, M., Singh, M. & Park, I. W., Aug 2018, In : PLoS ONE. 13, 8, e0202524.

    Research output: Contribution to journalArticle