• 14117 Citations
  • 56 h-Index
1975 …2022

Research output per year

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Personal profile

Area of Expertise

My research interests cover fluorescence spectroscopy and its applications in biochemistry and biology. I am developing advanced fluorescence-based techniques for ultra-sensitive detection of analytes and biomedical agents. In particular, we have developed a FRET-based method for the selective detection of a metalloproteinase 9 enzyme (MMP-9) and micro RNAs. The enhanced detection of minute amounts of dye molecules has been achieved with a Metal Enhanced Fluorescence (MEF). Several plasmonic platforms have been developed and tested for MEF. These include silver island films, silver fractals, and silver nanowires deposited on glass/sapphire substrates. We demonstrated several hundredfold enhancements of the fluorescence signals by using our plasmonic platforms. We also applied surface plasmon coupled emission (SPCE) in fluorescence microscopy. SPCE transforms an isotropic fluorescence emission into a directional, fully polarized radiation. The SPCE radiation preserves all spectral properties of used fluorophores and offers a significant reduction of unwanted fluorescence background because of minimization of the excitation volume.

Education/Academic qualification

PhD in Physics, University of Gdańsk

Award Date: 1 Jan 2001

MS in Physics, University of Gdańsk

Award Date: 1 Jan 2000

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Projects

Research Output

Photophysical properties of 2-Phenylindole in poly (vinyl alcohol) film at room temperature. Enhanced phosphorescence anisotropy with direct triplet state excitation

Gryczynski, Z., Kimball, J., Fudala, R., Chavez, J., Ceresa, L., Szabelski, M., Borejdo, J. & Gryczynski, I., 1 Jan 2020, In : Methods and Applications in Fluorescence. 8, 1, 014008.

Research output: Contribution to journalArticle

  • Fluorescence anisotropy imaging in drug discovery

    Vinegoni, C., Feruglio, P. F., Gryczynski, I., Mazitschek, R. & Weissleder, R., 1 Nov 2019, In : Advanced Drug Delivery Reviews. 151-152, p. 262-288 27 p.

    Research output: Contribution to journalReview article

  • 5 Scopus citations

    Non-fluorescent filters for fluorescence detection with in-line geometry

    Kimball, J., Chavez, J., Ceresa, L., Shah, S., Gryczynski, I. & Gryczynski, Z., 16 May 2019, In : Methods and Applications in Fluorescence. 7, 3, 037001.

    Research output: Contribution to journalArticle

  • Photophysical properties and detection of Valrubicin on plasmonic platforms

    Synak, A., Szczepańska, E., Grobelna, B., Gondek, J., Mońka, M., Gryczynski, I. & Bojarski, P., Apr 2019, In : Dyes and Pigments. 163, p. 623-627 5 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Spectroscopic method for estimation of MMP-9 enzyme concentration and activity

    Synak, A., Serdiuk, I. E., Grobelna, B., Fudala, R., Gryczynski, I. & Bojarski, P., 15 Jul 2019, In : Journal of Molecular Liquids. 286, 110936.

    Research output: Contribution to journalArticle