Projects per year
Personal profile
Area of Expertise
Currently there are no clinically-effective treatments or prophylactic-preventative agents for Alzheimer’s disease (AD). My current research involves identification of molecular mechanisms of neuronal cell death in AD and developing cost-effective, clinically-useful drug therapies for prevention of neuronal cell death and the treatment of AD. We are testing the effects of drugs that prevent neuronal cell death and improve memory in the genetically-engineered mouse model of AD. The identification of novel pathways that these potential drugs regulate for neuroprotection in these genetically-engineered mice, could provide new therapeutic avenues for AD. The anticipated outcomes of our mouse studies are likely to provide strong justification for the continued development and future clinical trials of these drugs for the treatment of AD.
Education/Academic qualification
Bachelor in Mathematics, University of Calcutta
MS in Chemistry, University of Calcutta
PhD, University of Nebraska
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Projects
- 4 Finished
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A Novel Mouse Model to Study Alcoholic Premature Brain Aging
Das, H. & Jung, E. (.
1/10/13 → 31/08/16
Project: Research
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A Novel Mouse Model to Study Alcoholic Premature Brain Aging
Jung, E. (. & Das, H.
1/10/13 → 31/08/16
Project: Research
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HEPATIC REGULATION OF THE HUMAN APO-B GENE
National Heart, Lung, and Blood Institute
1/09/93 → 30/09/03
Project: Research
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HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol
Hussain, I., Deb, P., Chini, A., Obaid, M., Bhan, A., Ansari, K. I., Mishra, B. P., Bobzean, S. A., Udden, S. M. N., Alluri, P. G., Das, H. K., Brothers, R. M., Perrotti, L. I. & Mandal, S. S., 15 Dec 2020, In: Frontiers in Genetics. 11, 592436.Research output: Contribution to journal › Article › peer-review
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Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK
Das, H. K. & Hontiveros, S. S., 1 Mar 2020, In: Frontiers in Bioscience - Landmark. 25, 7, p. 1297-1304 8 p.Research output: Contribution to journal › Article › peer-review
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Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling
Das, H. K. & Hontiveros, S. S., 1 Mar 2020, In: Frontiers in Bioscience - Landmark. 25, 6, p. 1172-1183 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
No difference in myosin kinetics and spatial distribution of the lever arm in the left and right ventricles of human hearts
Duggal, D., Requena, S., Nagwekar, J., Raut, S., Rich, R., Das, H., Patel, V., Gryczynski, I., Fudala, R., Gryczynski, Z., Blair, C., Campbell, K. S. & Borejdo, J., 13 Oct 2017, In: Frontiers in Physiology. 8, OCT, 732.Research output: Contribution to journal › Article › peer-review
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The role of presenilin-1 in the excitotoxicity of ethanol withdrawal
Jung, M. E., Metzger, D. B. & Das, H. K., Sep 2016, In: Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 516-526 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations