Projects per year
Personal profile
Area of Expertise
Currently there are no clinically-effective treatments or prophylactic-preventative agents for Alzheimer’s disease (AD). My current research involves identification of molecular mechanisms of neuronal cell death in AD and developing cost-effective, clinically-useful drug therapies for prevention of neuronal cell death and the treatment of AD. We are testing the effects of drugs that prevent neuronal cell death and improve memory in the genetically-engineered mouse model of AD. The identification of novel pathways that these potential drugs regulate for neuroprotection in these genetically-engineered mice, could provide new therapeutic avenues for AD. The anticipated outcomes of our mouse studies are likely to provide strong justification for the continued development and future clinical trials of these drugs for the treatment of AD.
Education/Academic qualification
PhD, University of Nebraska
MS in Chemistry, University of Calcutta
Bachelor in Mathematics, University of Calcutta
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Presenilin-1
Medicine & Life Sciences
Genes
Chemical Compounds
Transcription
Chemical Compounds
Proto-Oncogene Proteins c-ets
Medicine & Life Sciences
Reticulocytes
Medicine & Life Sciences
Apolipoproteins B
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Trans-Activators
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2014
- 2 Finished
Research Output 1979 2017
No difference in myosin kinetics and spatial distribution of the lever arm in the left and right ventricles of human hearts
Duggal, D., Requena, S., Nagwekar, J., Raut, S. L., Rich, R., Das, H., Patel, V., Gryczynski, I., Fudala, R., Gryczynski, Z., Blair, C., Campbell, K. S. & Borejdo, J., 13 Oct 2017, In : Frontiers in Physiology. 8, OCT, 732.Research output: Contribution to journal › Article › Research › peer-review
Myosins
Heart Ventricles
Muscle Cells
Ventricular Myosins
Muscle Proteins
2
Citations
(Scopus)
The role of presenilin-1 in the excitotoxicity of ethanol withdrawal
Jung, E., Metzger, D. B. & Das, H., 1 Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 516-526 11 p.Research output: Contribution to journal › Article › Research › peer-review
Presenilin-1
Ethanol
Glutamic Acid
Dizocilpine Maleate
Amyloid Precursor Protein Secretases
4
Citations
(Scopus)
Effect of a myosin regulatory light chain mutation K104E on actin-myosin interactions
Duggal, D., Nagwekar, J., Rich, R., Huang, W., Midde, K., Fudala, R., Das, H., Gryczynski, I., Szczesna-Cordary, D. & Borejdo, J., 1 Jan 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 10, p. H1248-H1257Research output: Contribution to journal › Article › Research › peer-review
Myosin Light Chains
Myosins
Familial Hypertrophic Cardiomyopathy
Actins
Mutation
5
Citations
(Scopus)
Membrane Topology of Human Presenilin-1 in SK-N-SH Cells Determined by Fluorescence Correlation Spectroscopy and Fluorescent Energy Transfer
Midde, K., Rich, R., Saxena, A., Gryczynski, I., Borejdo, J. & Das, H., 2 Oct 2014, In : Cell Biochemistry and Biophysics. 70, 2, p. 923-932 10 p.Research output: Contribution to journal › Article › Research › peer-review
Presenilin-1
Fluorescence Spectrometry
Energy Transfer
Energy transfer
Fluorescence
18
Citations
(Scopus)
Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis
Rahman, M., Zhang, Z., Mody, A. A., Su, D. M. & Das, H., 11 Apr 2012, In : Brain Research. 1448, p. 117-128 12 p.Research output: Contribution to journal › Article › Research › peer-review
Presenilin-1
JNK Mitogen-Activated Protein Kinases
Intraperitoneal Injections
Apoptosis
Brain