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Personal profile

Area of Expertise

Currently there are no clinically-effective treatments or prophylactic-preventative agents for Alzheimer’s disease (AD). My current research involves identification of molecular mechanisms of neuronal cell death in AD and developing cost-effective, clinically-useful drug therapies for prevention of neuronal cell death and the treatment of AD. We are testing the effects of drugs that prevent neuronal cell death and improve memory in the genetically-engineered mouse model of AD. The identification of novel pathways that these potential drugs regulate for neuroprotection in these genetically-engineered mice, could provide new therapeutic avenues for AD. The anticipated outcomes of our mouse studies are likely to provide strong justification for the continued development and future clinical trials of these drugs for the treatment of AD.

Education/Academic qualification

PhD, University of Nebraska

MS in Chemistry, University of Calcutta

Bachelor in Mathematics, University of Calcutta

Fingerprint Dive into the research topics where Hriday Das is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Presenilin-1 Medicine & Life Sciences
Genes Chemical Compounds
Transcription Chemical Compounds
Proto-Oncogene Proteins c-ets Medicine & Life Sciences
Reticulocytes Medicine & Life Sciences
Apolipoproteins B Medicine & Life Sciences
Proteins Medicine & Life Sciences
Trans-Activators Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2016

Research Output 1979 2017

  • 1078 Citations
  • 17 h-Index
  • 42 Article
  • 3 Review article

No difference in myosin kinetics and spatial distribution of the lever arm in the left and right ventricles of human hearts

Duggal, D., Requena, S., Nagwekar, J., Raut, S., Rich, R., Das, H., Patel, V., Gryczynski, I., Fudala, R., Gryczynski, Z., Blair, C., Campbell, K. S. & Borejdo, J., 13 Oct 2017, In : Frontiers in Physiology. 8, OCT, 732.

Research output: Contribution to journalArticle

Heart Ventricles
Muscle Cells
Ventricular Myosins
Muscle Proteins
2 Citations (Scopus)

The role of presenilin-1 in the excitotoxicity of ethanol withdrawal

Jung, M. E., Metzger, D. B. & Das, H. K., Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 516-526 11 p.

Research output: Contribution to journalArticle

Glutamic Acid
Dizocilpine Maleate
Amyloid Precursor Protein Secretases
4 Citations (Scopus)

Effect of a myosin regulatory light chain mutation K104E on actin-myosin interactions

Duggal, D., Nagwekar, J., Rich, R., Huang, W., Midde, K., Fudala, R., Das, H., Gryczynski, I., Szczesna-Cordary, D. & Borejdo, J., 15 May 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 10, p. H1248-H1257

Research output: Contribution to journalArticle

Myosin Light Chains
Familial Hypertrophic Cardiomyopathy
5 Citations (Scopus)
Fluorescence Spectrometry
Energy Transfer
Energy transfer
18 Citations (Scopus)

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

Rahman, M., Zhang, Z., Mody, A. A., Su, D. M. & Das, H. K., 11 Apr 2012, In : Brain Research. 1448, p. 117-128 12 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Intraperitoneal Injections