• 1100 Citations
  • 18 h-Index
1979 …2020

Research output per year

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Personal profile

Area of Expertise

Currently there are no clinically-effective treatments or prophylactic-preventative agents for Alzheimer’s disease (AD). My current research involves identification of molecular mechanisms of neuronal cell death in AD and developing cost-effective, clinically-useful drug therapies for prevention of neuronal cell death and the treatment of AD. We are testing the effects of drugs that prevent neuronal cell death and improve memory in the genetically-engineered mouse model of AD. The identification of novel pathways that these potential drugs regulate for neuroprotection in these genetically-engineered mice, could provide new therapeutic avenues for AD. The anticipated outcomes of our mouse studies are likely to provide strong justification for the continued development and future clinical trials of these drugs for the treatment of AD.

Education/Academic qualification

Bachelor in Mathematics, University of Calcutta

MS in Chemistry, University of Calcutta

PhD, University of Nebraska

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Projects

Research Output

  • 1100 Citations
  • 18 h-Index
  • 44 Article
  • 3 Review article

Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK

Das, H. K. & Hontiveros, S. S., 1 Mar 2020, In : Frontiers in Bioscience - Landmark. 25, 7, p. 1297-1304 8 p.

Research output: Contribution to journalArticle

  • Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling

    Das, H. K. & Hontiveros, S. S., 1 Mar 2020, In : Frontiers in Bioscience - Landmark. 25, 6, p. 1172-1183 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    No difference in myosin kinetics and spatial distribution of the lever arm in the left and right ventricles of human hearts

    Duggal, D., Requena, S., Nagwekar, J., Raut, S., Rich, R., Das, H., Patel, V., Gryczynski, I., Fudala, R., Gryczynski, Z., Blair, C., Campbell, K. S. & Borejdo, J., 13 Oct 2017, In : Frontiers in Physiology. 8, OCT, 732.

    Research output: Contribution to journalArticle

  • The role of presenilin-1 in the excitotoxicity of ethanol withdrawal

    Jung, M. E., Metzger, D. B. & Das, H. K., Sep 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 516-526 11 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Effect of a myosin regulatory light chain mutation K104E on actin-myosin interactions

    Duggal, D., Nagwekar, J., Rich, R., Huang, W., Midde, K., Fudala, R., Das, H., Gryczynski, I., Szczesna-Cordary, D. & Borejdo, J., 15 May 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 10, p. H1248-H1257

    Research output: Contribution to journalArticle

  • 4 Scopus citations