Currently there are no clinically-effective treatments or prophylactic-preventative agents for Alzheimer’s disease (AD). My current research involves identification of molecular mechanisms of neuronal cell death in AD and developing cost-effective, clinically-useful drug therapies for prevention of neuronal cell death and the treatment of AD. We are testing the effects of drugs that prevent neuronal cell death and improve memory in the genetically-engineered mouse model of AD. The identification of novel pathways that these potential drugs regulate for neuroprotection in these genetically-engineered mice, could provide new therapeutic avenues for AD. The anticipated outcomes of our mouse studies are likely to provide strong justification for the continued development and future clinical trials of these drugs for the treatment of AD.