Gulab Zode, PhD — UNT Health Science Center

Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

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Trabecular Meshwork Medicine & Life Sciences

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Ocular Hypertension Medicine & Life Sciences

Intraocular Pressure Medicine & Life Sciences

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Projects 2013 2022

3 Active
6 Finished

Targeting ER Stress Pathway using Sodium 4-phenylbutyrate for the Treatment of POAG

Zode, G.

NEI: National Eye Institute

30/09/18 → 30/06/22

Project: Research

Targeting ER Stress for the Treatment of Steroid and Myocilin Glaucoma

Zode, G.

BrightFocus Foundation

1/07/17 → 30/06/19

Project: Research

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of Glaucoma

Zode, G.

NEI: National Eye Institute

1/03/16 → 28/02/21

Project: Research

Design and Characterization of Novel Sodium 4-Phenylbutyrate (Pba) Analogs for Reduction of Myocilin Misfolding and the Treatment Of Primary Open Angle Glaucoma

Zode, G. & Emmitte, K.

Intramural Research(UNTHSC)

1/09/16 → 31/08/17

Project: Research

Design and Characterization of Novel Sodium 4-Phenylbutyrate (Pba) Analogs for Reduction of Myocilin Misfolding and the Treatment Of Primary Open Angle Glaucoma

Emmitte, K. & Zode, G.

Intramural Research(UNTHSC)

1/09/16 → 31/08/17

Project: Research

Research Output 2007 2018

736 Citations
13 h-Index
18 Article
2 Short survey
1 Chapter
1 Comment/debate

3 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 othersKnepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journal › Short survey › Research › peer-review

Trabecular Meshwork

Cell Separation

Cell Culture Techniques

Ocular Hypertension

Intraocular Pressure

2 Citations (Scopus)

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K. E., Staverosky, J. A., Murphy, C. J., Acott, T. & Vranka, J., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 444-459 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Trabecular Meshwork

Extracellular Matrix

Military electronic countermeasures

Glaucoma

Tissue

1 Citation (Scopus)

Methods for analyzing endoplasmic reticulum stress in the trabecular meshwork of glaucoma models

Maddineni, P., Kasetti, R. B. & Zode, G., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 121-134 14 p. (Methods in Molecular Biology; vol. 1695).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Trabecular Meshwork

Endoplasmic Reticulum Stress

Glaucoma

Intraocular Pressure

Unfolded Protein Response

1 Citation (Scopus)

Transforming growth factor 2 (TGF2) signaling plays a key role in glucocorticoid-induced ocular hypertension

Kasetti, R. B., Maddineni, P., Patel, P. D., Searby, C., Sheffield, V. C. & Zode, G., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 25, p. 9854-9868 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Ocular Hypertension

Transforming Growth Factors

Dexamethasone

Glucocorticoids

Trabecular Meshwork

19 Citations (Scopus)

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Jain, A., Zode, G., Kasetti, R. B., Ran, F. A., Yan, W., Sharma, T. P., Bugge, K., Searby, C. C., Fingert, J. H., Zhang, F., Clark, A. & Sheffield, V. C., 17 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11199-11204 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Clustered Regularly Interspaced Short Palindromic Repeats

Glaucoma

Intraocular Pressure

Trabecular Meshwork

Endoplasmic Reticulum Stress