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Gulab Zode, PhD

  • 1027 Citations
  • 17 h-Index
20072020

Research output per year

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Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

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Projects

Targeting ER Stress Pathway using Sodium 4-phenylbutyrate for the Treatment of POAG

Zode, G.

NEI: National Eye Institute

30/09/18 → 30/06/22

Project: Research

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of Glaucoma

Zode, G.

NEI: National Eye Institute

1/03/16 → 28/02/21

Project: Research

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of Glaucoma

Zode, G.

NEI: National Eye Institute

1/03/16 → 28/02/21

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Zode, G.

University of Iowa

1/07/19 → 30/04/20

Project: Research

Novel Genome Editing for the Treatment of Glaucoma

Clark, A., Zode, G. & SHEFFIELD, V.

1/07/19 → 30/04/20

Project: Research

Research Output

  • 1027 Citations
  • 17 h-Index
  • 22 Article
  • 2 Short survey
  • 1 Chapter
  • 1 Comment/debate

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Maddineni, P., Kasetti, R. B., Patel, P. D., Millar, J. C., Kiehlbauch, C., Clark, A. F. & Zode, G. S., 27 Aug 2020, In : Molecular Neurodegeneration. 15, 1, 48.

Research output: Contribution to journal › Article

Open Access

    • Endogenous ocular lipids as potential modulators of intraocular pressure

    Edwards, G., Arcuri, J., Wang, H., Ziebarth, N., Zode, G., Lee, R. K. & Bhattacharya, S. K., 1 Apr 2020, In : Journal of Cellular and Molecular Medicine. 24, 7, p. 3856-3900 45 p.

    Research output: Contribution to journal › Article

    Open Access

    • Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries

    Ottolini, M., Daneva, Z., Chen, Y. L., Cope, E. L., Kasetti, R. B., Zode, G. S. & Sonkusare, S. K., 1 Sep 2020, In : Journal of Physiology. 598, 17, p. 3577-3596 20 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes

    Singh, P. K., Kasetti, R. B., Zode, G. S., Goyal, A., Juzych, M. S. & Kumar, A., 1 May 2019, In : mSphere. 4, 3, e00173-19.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

    Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

    Research output: Contribution to journal › Short survey

    • 49 Scopus citations