• 937 Citations
  • 16 h-Index
20072020

Research output per year

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Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

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Projects

Research Output

  • 937 Citations
  • 16 h-Index
  • 21 Article
  • 2 Short survey
  • 1 Chapter
  • 1 Comment/debate

Endogenous ocular lipids as potential modulators of intraocular pressure

Edwards, G., Arcuri, J., Wang, H., Ziebarth, N., Zode, G., Lee, R. K. & Bhattacharya, S. K., 1 Apr 2020, In : Journal of Cellular and Molecular Medicine. 24, 7, p. 3856-3900 45 p.

Research output: Contribution to journalArticle

Open Access
  • Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries

    Ottolini, M., Daneva, Z., Chen, Y. L., Cope, E. L., Kasetti, R. B., Zode, G. S. & Sonkusare, S. K., 1 Jan 2020, (Accepted/In press) In : Journal of Physiology.

    Research output: Contribution to journalArticle

  • Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes

    Singh, P. K., Kasetti, R. B., Zode, G. S., Goyal, A., Juzych, M. S. & Kumar, A., 1 May 2019, In : mSphere. 4, 3, e00173-19.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

    Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

    Research output: Contribution to journalShort survey

  • 40 Scopus citations

    Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

    Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K. E., Staverosky, J. A., Murphy, C. J., Acott, T. & Vranka, J., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 444-459 16 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations