• 889 Citations
  • 15 h-Index
20072022

Research output per year

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Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

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Projects

Research Output

  • 889 Citations
  • 15 h-Index
  • 19 Article
  • 2 Short survey
  • 1 Chapter
  • 1 Comment/debate

Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes

Singh, P. K., Kasetti, R. B., Zode, G. S., Goyal, A., Juzych, M. S. & Kumar, A., 1 May 2019, In : mSphere. 4, 3, e00173-19.

Research output: Contribution to journalArticle

Open Access
  • 2 Scopus citations

    Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

    Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

    Research output: Contribution to journalShort survey

  • 28 Scopus citations

    Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

    Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K. E., Staverosky, J. A., Murphy, C. J., Acott, T. & Vranka, J., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 444-459 16 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Methods for analyzing endoplasmic reticulum stress in the trabecular meshwork of glaucoma models

    Maddineni, P., Kasetti, R. B. & Zode, G. S., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 121-134 14 p. (Methods in Molecular Biology; vol. 1695).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Transforming growth factor 2 (TGF2) signaling plays a key role in glucocorticoid-induced ocular hypertension

    Kasetti, R. B., Maddineni, P., Patel, P. D., Searby, C., Sheffield, V. C. & Zode, G. S., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 25, p. 9854-9868 15 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations