Projects per year
Personal profile
Area of Expertise
My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.
Education/Academic qualification
PhD in Cell Biology & Genetics, UNT Health Science Center
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Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAG
30/09/18 → 30/06/22
Project: Research
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Targeting ER Stress Pathway using Sodium 4-phenylbutyrate for the Treatment of POAG
30/09/18 → 30/06/22
Project: Research
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Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/22
Project: Research
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Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/22
Project: Research
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Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin
Kasetti, R. B., Maddineni, P., Kiehlbauch, C., Patil, S., Searby, C. C., Levine, B., Sheffield, V. C. & Zode, G. S., 8 Mar 2021, In: JCI Insight. 6, 5, e143359.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension
Daneva, Z., Marziano, C., Ottolini, M., Chen, Y. L., Baker, T. M., Kuppusamy, M., Zhang, A., Ta, H. Q., Reagan, C. E., Mihalek, A. D., Kasetti, R. B., Shen, Y., Isakson, B. E., Minshall, R. D., Zode, G. S., Goncharova, E. A., Laubach, V. E. & Sonkusare, S. K., 27 Apr 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2023130118.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
Nair, K. S., Srivastava, C., Brown, R. V., Koli, S., Choquet, H., Kang, H. S., Kuo, Y. M., Grimm, S. A., Sutherland, C., Badea, A., Johnson, G. A., Zhao, Y., Yin, J., Okamoto, K., Clark, G., Borrás, T., Zode, G., Kizhatil, K., Chakrabarti, S., John, S. W. M. & 2 others, , Dec 2021, In: Nature Communications. 12, 1, 4877.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma
Patel, P. D., Chen, Y. L., Kasetti, R. B., Maddineni, P., Mayhew, W., Millar, J. C., Ellis, D. Z., Sonkusare, S. K. & Zode, G. S., 20 Apr 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 16, e2022461118.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Sodium 4-phenylbutyrate reduces ocular hypertension by degrading extracellular matrix deposition via activation of MMP9
Maddineni, P., Kasetti, R. B., Kodati, B., Yacoub, S. & Zode, G. S., Sep 2021, In: International journal of molecular sciences. 22, 18, 10095.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations