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Gulab Zode, PhD

  • 741 Citations
  • 13 h-Index
20072022
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Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

Fingerprint Dive into the research topics where Gulab Zode is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Trabecular Meshwork Medicine & Life Sciences
Glaucoma Medicine & Life Sciences
Extracellular Matrix Proteins Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences
Optic Disk Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Ocular Hypertension Medicine & Life Sciences
Intraocular Pressure Medicine & Life Sciences

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Projects 2013 2022

Targeting ER Stress Pathway using Sodium 4-phenylbutyrate for the Treatment of POAG

Zode, G.

NEI: National Eye Institute

30/09/18 → 30/06/22

Project: Research

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of Glaucoma

Zode, G.

NEI: National Eye Institute

1/03/16 → 28/02/21

Project: Research

Targeting ER Stress for the Treatment of Steroid and Myocilin Glaucoma

Zode, G.

BrightFocus Foundation

1/07/17 → 30/06/19

Project: Research

Design and Characterization of Novel Sodium 4-Phenylbutyrate (Pba) Analogs for Reduction of Myocilin Misfolding and the Treatment Of Primary Open Angle Glaucoma

Emmitte, K. & Zode, G.

Intramural Research(UNTHSC)

1/09/16 → 31/08/17

Project: Research

Design and Characterization of Novel Sodium 4-Phenylbutyrate (Pba) Analogs for Reduction of Myocilin Misfolding and the Treatment Of Primary Open Angle Glaucoma

Zode, G. & Emmitte, K.

Intramural Research(UNTHSC)

1/09/16 → 31/08/17

Project: Research

Research Output 2007 2019

  • 741 Citations
  • 13 h-Index
  • 19 Article
  • 2 Short survey
  • 1 Chapter
  • 1 Comment/debate

Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes

Singh, P. K., Kasetti, R. B., Zode, G., Goyal, A., Juzych, M. S. & Kumar, A., 1 May 2019, In : mSphere. 4, 3, e00173-19.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
Trabecular Meshwork
Glaucoma
Pathology
Interferons
Optic Nerve
4 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 othersKnepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journal › Short survey › Research › peer-review

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure
2 Citations (Scopus)

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K. E., Staverosky, J. A., Murphy, C. J., Acott, T. & Vranka, J., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 444-459 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Trabecular Meshwork
Extracellular Matrix
Military electronic countermeasures
Glaucoma
Tissue
1 Citation (Scopus)

Methods for analyzing endoplasmic reticulum stress in the trabecular meshwork of glaucoma models

Maddineni, P., Kasetti, R. B. & Zode, G., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 121-134 14 p. (Methods in Molecular Biology; vol. 1695).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Trabecular Meshwork
Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Unfolded Protein Response
1 Citation (Scopus)

Transforming growth factor 2 (TGF2) signaling plays a key role in glucocorticoid-induced ocular hypertension

Kasetti, R. B., Maddineni, P., Patel, P. D., Searby, C., Sheffield, V. C. & Zode, G., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 25, p. 9854-9868 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Ocular Hypertension
Transforming Growth Factors
Dexamethasone
Glucocorticoids
Trabecular Meshwork