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Personal profile

Area of Expertise

My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.

Education/Academic qualification

PhD in Cell Biology & Genetics, UNT Health Science Center

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Ocular Hypertension Medicine & Life Sciences
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Research Output 2007 2018

  • 736 Citations
  • 13 h-Index
  • 18 Article
  • 2 Short survey
  • 1 Chapter
  • 1 Comment/debate
3 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K. E., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. J. & 37 othersKnepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J. A., Wirtz, M. K., Yorio, T., Zhang, J., Zode, G., Fautsch, M. P., Peters, D. M., Acott, T. S. & Stamer, W. D., 1 Jun 2018, In : Experimental eye research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort surveyResearchpeer-review

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure
2 Citations (Scopus)

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K. E., Staverosky, J. A., Murphy, C. J., Acott, T. & Vranka, J., 15 Apr 2018, In : Acta Biomaterialia. 71, p. 444-459 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Trabecular Meshwork
Extracellular Matrix
Military electronic countermeasures
Glaucoma
Tissue
1 Citation (Scopus)

Methods for analyzing endoplasmic reticulum stress in the trabecular meshwork of glaucoma models

Maddineni, P., Kasetti, R. B. & Zode, G., 1 Jan 2018, Methods in Molecular Biology. Humana Press Inc., p. 121-134 14 p. (Methods in Molecular Biology; vol. 1695).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Trabecular Meshwork
Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Unfolded Protein Response
1 Citation (Scopus)

Transforming growth factor 2 (TGF2) signaling plays a key role in glucocorticoid-induced ocular hypertension

Kasetti, R. B., Maddineni, P., Patel, P. D., Searby, C., Sheffield, V. C. & Zode, G., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 25, p. 9854-9868 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ocular Hypertension
Transforming Growth Factors
Dexamethasone
Glucocorticoids
Trabecular Meshwork
19 Citations (Scopus)

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

Jain, A., Zode, G., Kasetti, R. B., Ran, F. A., Yan, W., Sharma, T. P., Bugge, K., Searby, C. C., Fingert, J. H., Zhang, F., Clark, A. & Sheffield, V. C., 17 Oct 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11199-11204 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Glaucoma
Intraocular Pressure
Trabecular Meshwork
Endoplasmic Reticulum Stress