Projects per year
Personal profile
Area of Expertise
My laboratory is interested in understanding the pathological mechanisms involved in glaucomatous damage to trabecular meshwork (TM) and retinal ganglion cells (RGCs). Our primary focus is to understand the role of protein misfolding and its associated cellular processes including endoplasmic reticulum (ER) stress and autophagy in the glaucomatous TM damage.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.
We have developed two novel glaucoma mouse models and have established various genetic tools to study protein misfolding and biological functions of unfolded protein response pathway and autophagy in glaucoma pathogenesis. We are currently pursuing gene therapy via CRISPR genome editing and small chemicals to develop targeted treatment for primary open angle glaucoma.
Education/Academic qualification
PhD in Cell Biology & Genetics, UNT Health Science Center
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Novel Genome Editing for the Treatment of Glaucoma
Zode, G., SHEFFIELD, V., Zode, G., Clark, A., CLARK, A. F. & SHEFFIELD, V.
1/07/19 → 30/04/23
Project: Research
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Crosstalk between chronic ER stress and mitophagy for the treatment of POAG
Zode, G. & ZODE, G.
1/03/16 → 30/04/23
Project: Research
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Novel Genome Editing for the Treatment of Glaucoma
Clark, A., Zode, G. & SHEFFIELD, V.
1/07/19 → 30/04/22
Project: Research
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Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAG
30/09/18 → 30/06/22
Project: Research
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A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery
Patil, S. V., Kasetti, R. B., Millar, J. C. & Zode, G. S., 1 Jul 2022, In: International journal of molecular sciences. 23, 13, 6883.Research output: Contribution to journal › Article › peer-review
Open Access -
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
McDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Cameron Millar, J., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., Fuchshofer, R., & 60 others, Feb 2022, In: Investigative Ophthalmology and Visual Science. 63, 2, 12.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury
Tao, Y., Chaudhari, S., Shotorbani, P. Y., Ding, Y., Chen, Z., Kasetti, R., Zode, G. & Ma, R., 1 Jun 2022, In: Journal of Biological Chemistry. 298, 6, 101990.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells
Chaudhari, S., Shotorbani, P. Y., Tao, Y., Kasetti, R., Zode, G., Mathis, K. W. & Ma, R., Jul 2022, In: American Journal of Physiology - Cell Physiology. 323, 1, p. C226-C235Research output: Contribution to journal › Article › peer-review
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Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin
Kasetti, R. B., Maddineni, P., Kiehlbauch, C., Patil, S., Searby, C. C., Levine, B., Sheffield, V. C. & Zode, G. S., 8 Mar 2021, In: JCI Insight. 6, 5, e143359.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations