I study ion channels in the smooth muscle cells of coronary arteries and arterioles. I am especially interested in how these ion channels regulate vascular tone and control coronary blood flow. I am trying to determine how these mechanism work on a beat-to-beat basis in the normal heart as well as what goes wrong over the long-term with obesity, diabetes, and other pathological conditions. My goal is to provide a better understanding of coronary vascular regulation in health and disease.